GREMLIN Database
RISB - 6,7-dimethyl-8-ribityllumazine synthase
UniProt: P11998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (142)
Sequences: 3247 (1620)
Seq/√Len: 135.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_Q106_T3.3421.00
74_A143_A3.1471.00
16_G66_M3.0441.00
49_D72_Y2.5811.00
31_L50_V2.5431.00
37_A137_V2.2981.00
19_V31_L2.2371.00
13_L147_A2.0731.00
64_K106_T2.0201.00
68_E108_G2.0201.00
10_G43_V2.0161.00
51_A66_M2.0051.00
63_A77_T1.9861.00
25_F125_I1.8571.00
35_E39_L1.8391.00
77_T100_I1.8361.00
12_G47_D1.8361.00
83_R119_E1.8191.00
37_A141_V1.7801.00
64_K68_E1.7791.00
95_E98_K1.7721.00
135_K138_D1.7441.00
59_I115_I1.7241.00
24_D28_S1.7241.00
38_L43_V1.7041.00
21_R145_E1.6591.00
85_A126_E1.6411.00
98_K102_Q1.6041.00
61_F150_N1.5591.00
25_F121_I1.5401.00
13_L151_R1.5401.00
112_I142_S1.5271.00
96_A115_I1.4631.00
87_T90_D1.4601.00
15_I147_A1.4351.00
122_E126_E1.4011.00
81_V92_V1.3991.00
64_K105_N1.3961.00
29_K32_S1.3831.00
28_S52_W1.3761.00
65_K108_G1.3751.00
16_G72_Y1.3731.00
61_F104_A1.3721.00
57_F113_F1.3681.00
18_V63_A1.3491.00
119_E123_Q1.2961.00
19_V50_V1.2941.00
67_A107_T1.2541.00
90_D93_C1.2501.00
26_I80_T1.2441.00
87_T91_Y1.2391.00
41_H144_I1.2141.00
44_D47_D1.1790.99
81_V93_C1.1480.99
53_V62_A1.1430.99
67_A75_I1.1400.99
18_V59_I1.1380.99
128_A134_N1.1360.99
35_E48_I1.1250.99
65_K150_N1.1110.99
94_N98_K1.1020.99
89_Y93_C1.1010.99
20_G27_T1.0970.99
15_I38_L1.0940.99
112_I139_C1.0920.99
91_Y94_N1.0780.99
64_K108_G1.0780.99
67_A109_V1.0770.99
38_L76_I1.0740.99
62_A150_N1.0670.99
96_A113_F1.0630.99
19_V27_T1.0550.99
38_L140_A1.0490.99
37_A40_R1.0480.99
87_T119_E1.0350.99
60_P99_G1.0350.99
126_E130_T1.0160.98
78_L114_G0.9910.98
121_I130_T0.9830.98
82_I121_I0.9660.98
69_T72_Y0.9660.98
143_A147_A0.9580.98
36_D40_R0.9580.98
63_A75_I0.9550.98
64_K107_T0.9460.98
26_I125_I0.9410.97
37_A41_H0.9380.97
68_E107_T0.9340.97
54_P146_M0.9300.97
83_R87_T0.9200.97
31_L35_E0.9140.97
32_S36_D0.9130.97
67_A103_A0.9110.97
15_I143_A0.9110.97
114_G139_C0.9100.97
112_I143_A0.9040.97
101_A104_A0.8910.96
35_E50_V0.8760.96
103_A111_V0.8760.96
137_V141_V0.8680.96
28_S32_S0.8670.96
97_A113_F0.8500.95
24_D52_W0.8500.95
11_T44_D0.8490.95
32_S35_E0.8470.95
23_N80_T0.8440.95
31_L52_W0.8350.95
60_P101_A0.8290.95
10_G13_L0.8290.95
129_G132_A0.8260.95
89_Y119_E0.8210.94
39_L48_I0.8180.94
16_G51_A0.8020.94
121_I125_I0.7940.93
19_V52_W0.7890.93
17_I31_L0.7820.93
49_D71_K0.7750.92
26_I121_I0.7720.92
102_Q105_N0.7670.92
57_F97_A0.7590.92
23_N27_T0.7530.91
75_I109_V0.7490.91
63_A100_I0.7440.91
65_K68_E0.7400.91
30_L33_G0.7390.91
99_G103_A0.7380.91
61_F103_A0.7360.90
14_K47_D0.7330.90
59_I77_T0.7330.90
61_F65_K0.7250.90
68_E106_T0.7240.90
125_I130_T0.7210.89
118_T124_A0.7160.89
99_G105_N0.7100.89
74_A112_I0.7030.88
85_A130_T0.6890.87
14_K44_D0.6880.87
15_I74_A0.6860.87
54_P145_E0.6840.87
27_T80_T0.6830.87
57_F91_Y0.6790.87
73_D151_R0.6710.86
66_M72_Y0.6690.86
51_A62_A0.6670.86
124_A127_R0.6640.85
94_N97_A0.6570.85
69_T109_V0.6550.85
33_G134_N0.6540.84
146_M150_N0.6510.84
20_G59_I0.6490.84
91_Y113_F0.6430.83
17_I34_A0.6410.83
148_N152_S0.6410.83
88_H127_R0.6390.83
13_L16_G0.6360.83
146_M149_L0.6350.83
59_I100_I0.6340.83
61_F64_K0.6320.82
74_A147_A0.6310.82
21_R28_S0.6300.82
13_L148_N0.6290.82
29_K130_T0.6280.82
37_A144_I0.6280.82
95_E99_G0.6270.82
62_A146_M0.6260.82
85_A97_A0.6260.82
130_T133_G0.6240.82
33_G114_G0.6150.81
18_V75_I0.6120.80
14_K71_K0.6100.80
75_I110_P0.6080.80
61_F105_N0.6030.79
26_I128_A0.6020.79
59_I96_A0.6000.79
135_K139_C0.6000.79
10_G15_I0.5980.79
9_V148_N0.5980.79
13_L73_D0.5940.78
139_C142_S0.5870.77
125_I128_A0.5870.77
20_G118_T0.5870.77
19_V78_L0.5860.77
87_T93_C0.5790.77
89_Y116_V0.5760.76
15_I76_I0.5750.76
71_K109_V0.5730.76
14_K70_K0.5660.75
33_G136_G0.5630.75
86_T127_R0.5580.74
63_A103_A0.5510.73
83_R90_D0.5450.72
85_A121_I0.5420.72
57_F92_V0.5390.71
122_E125_I0.5390.71
9_V12_G0.5360.71
61_F146_M0.5330.71
29_K128_A0.5320.70
70_K109_V0.5290.70
120_N123_Q0.5290.70
26_I124_A0.5250.69
20_G53_V0.5250.69
141_V145_E0.5250.69
56_A81_V0.5230.69
57_F101_A0.5210.69
15_I140_A0.5170.68
61_F108_G0.5150.68
114_G124_A0.5130.68
38_L48_I0.5120.67
17_I76_I0.5090.67
18_V66_M0.5090.67
76_I140_A0.5030.66
76_I139_C0.5030.66
104_A107_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rvvA 6 1 100 0.053 Contact Map
1hqkA 6 1 100 0.054 Contact Map
3nq4A 6 0.9935 100 0.055 Contact Map
1c2yA 6 0.9935 100 0.071 Contact Map
1kz1A 5 0.9416 100 0.078 Contact Map
1di0A 5 0.9351 100 0.085 Contact Map
2obxA 4 0.961 100 0.086 Contact Map
2i0fA 3 0.9156 100 0.097 Contact Map
1ejbA 3 1 100 0.098 Contact Map
1c41A 6 0.9805 100 0.098 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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