GREMLIN Database
OGT - Methylated-DNA--protein-cysteine methyltransferase, constitutive
UniProt: P11742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (154)
Sequences: 5998 (4493)
Seq/√Len: 362.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_G141_T3.5141.00
60_E66_R3.2621.00
83_K108_S3.0311.00
153_F157_I2.7741.00
87_A90_R2.7261.00
97_R105_A2.6711.00
100_A136_K2.5291.00
19_E74_S2.4241.00
77_G85_W2.3921.00
97_R101_D2.2981.00
8_E13_E2.2401.00
152_A156_N2.2031.00
75_Q128_V2.1251.00
100_A104_A2.0101.00
19_E22_R2.0001.00
97_R102_I1.9991.00
87_A102_I1.9651.00
87_A105_A1.8661.00
18_E51_L1.8641.00
57_Q69_F1.8231.00
5_T55_K1.8031.00
60_E65_E1.7931.00
101_D104_A1.7111.00
7_A59_Q1.6651.00
78_T81_Q1.6321.00
16_I23_I1.6101.00
88_L119_N1.5991.00
26_L127_F1.5961.00
77_G81_Q1.5911.00
108_S111_A1.5411.00
19_E24_T1.5371.00
6_T13_E1.5311.00
81_Q121_R1.5241.00
91_I97_R1.5111.00
53_E57_Q1.4881.00
86_Q89_E1.4601.00
112_V116_G1.4601.00
97_R133_V1.4541.00
53_E56_Q1.4481.00
28_L150_I1.4281.00
100_A112_V1.3901.00
57_Q71_L1.3831.00
90_R105_A1.3741.00
10_P62_F1.3651.00
84_V102_I1.3541.00
120_K141_T1.3491.00
22_R74_S1.3491.00
125_P145_G1.3461.00
91_I133_V1.3461.00
156_N159_R1.3421.00
142_G147_K1.2911.00
87_A106_V1.2671.00
117_Q120_K1.2641.00
140_L147_K1.2351.00
153_F156_N1.2331.00
82_Q86_Q1.2291.00
57_Q66_R1.2161.00
54_A127_F1.2021.00
16_I54_A1.1891.00
28_L125_P1.1811.00
17_A25_R1.1591.00
86_Q90_R1.1241.00
120_K146_S1.1201.00
7_A55_K1.1201.00
55_K59_Q1.1181.00
9_T14_L1.1161.00
21_D74_S1.1091.00
149_E152_A1.0871.00
117_Q141_T1.0731.00
75_Q82_Q1.0631.00
18_E54_A1.0561.00
75_Q123_D1.0521.00
30_Q150_I1.0511.00
117_Q121_R1.0491.00
73_L124_L1.0481.00
104_A109_P1.0441.00
47_E52_A1.0321.00
17_A24_T1.0241.00
79_P82_Q1.0151.00
71_L127_F1.0101.00
96_S155_L1.0061.00
57_Q70_S0.9961.00
89_E128_V0.9911.00
119_N143_Y0.9891.00
18_E48_T0.9871.00
56_Q60_E0.9841.00
75_Q124_L0.9761.00
58_L62_F0.9731.00
116_G120_K0.9691.00
9_T12_G0.9681.00
6_T15_I0.9581.00
48_T51_L0.9581.00
119_N134_I0.9451.00
23_I54_A0.9441.00
15_I29_S0.9361.00
11_L153_F0.9321.00
59_Q63_A0.9271.00
13_E29_S0.9091.00
50_N72_P0.9071.00
141_T147_K0.9061.00
61_Y157_I0.9061.00
80_F118_A0.9051.00
106_V115_V0.8951.00
11_L150_I0.8901.00
57_Q67_K0.8901.00
81_Q85_W0.8871.00
16_I51_L0.8821.00
67_K93_Y0.8781.00
102_I119_N0.8781.00
80_F114_A0.8691.00
156_N160_I0.8681.00
50_N53_E0.8501.00
135_G139_A0.8311.00
5_T52_A0.8311.00
135_G142_G0.8281.00
14_L26_L0.8251.00
150_I153_F0.8181.00
81_Q117_Q0.8181.00
122_N130_C0.8171.00
119_N125_P0.8141.00
100_A116_G0.8141.00
120_K144_A0.8101.00
5_T51_L0.8011.00
87_A97_R0.7961.00
18_E50_N0.7901.00
80_F84_V0.7891.00
79_P83_K0.7891.00
92_P95_E0.7801.00
140_L152_A0.7721.00
26_L125_P0.7721.00
106_V111_A0.7601.00
83_K86_Q0.7561.00
50_N54_A0.7521.00
11_L14_L0.7471.00
125_P144_A0.7271.00
16_I26_L0.7251.00
26_L124_L0.7251.00
24_T76_K0.7251.00
15_I27_F0.7150.99
26_L58_L0.7110.99
84_V106_V0.7050.99
18_E21_D0.6970.99
51_L54_A0.6910.99
42_N45_H0.6880.99
40_V43_T0.6840.99
84_V115_V0.6830.99
83_K106_V0.6720.99
27_F125_P0.6720.99
93_Y157_I0.6680.99
41_Q44_E0.6660.99
125_P150_I0.6660.99
73_L89_E0.6620.99
76_K82_Q0.6610.99
31_E35_D0.6590.99
102_I116_G0.6570.99
96_S160_I0.6550.99
61_Y126_I0.6550.99
22_R50_N0.6520.99
61_Y69_F0.6520.99
135_G140_L0.6460.99
14_L28_L0.6420.99
7_A16_I0.6390.99
91_I119_N0.6370.99
111_A114_A0.6300.99
97_R119_N0.6200.99
57_Q60_E0.6170.98
22_R72_P0.6060.98
25_R125_P0.6060.98
27_F34_V0.6030.98
96_S134_I0.6020.98
16_I55_K0.6020.98
54_A57_Q0.6020.98
126_I154_L0.6020.98
101_D105_A0.5980.98
75_Q85_W0.5980.98
124_L128_V0.5960.98
102_I106_V0.5920.98
62_F157_I0.5910.98
6_T29_S0.5860.98
147_K152_A0.5860.98
85_W88_L0.5850.98
23_I127_F0.5820.98
98_S136_K0.5810.98
61_Y93_Y0.5810.98
112_V117_Q0.5780.98
66_R70_S0.5740.98
56_Q59_Q0.5720.97
124_L127_F0.5700.97
58_L127_F0.5670.97
126_I157_I0.5660.97
88_L102_I0.5620.97
58_L126_I0.5570.97
33_W121_R0.5570.97
141_T144_A0.5550.97
66_R93_Y0.5520.97
122_N146_S0.5510.97
75_Q89_E0.5500.97
25_R116_G0.5450.97
49_P52_A0.5420.97
66_R69_F0.5420.97
31_E34_V0.5400.96
7_A14_L0.5390.96
43_T46_K0.5350.96
102_I115_V0.5340.96
77_G82_Q0.5320.96
103_A109_P0.5310.96
102_I105_A0.5300.96
59_Q62_F0.5300.96
98_S135_G0.5290.96
58_L61_Y0.5290.96
110_K116_G0.5270.96
27_F31_E0.5270.96
60_E67_K0.5260.96
53_E71_L0.5230.96
22_R73_L0.5230.96
10_P153_F0.5220.96
130_C146_S0.5220.96
61_Y64_G0.5180.96
24_T74_S0.5170.95
64_G93_Y0.5170.95
119_N133_V0.5120.95
92_P97_R0.5100.95
53_E70_S0.5080.95
85_W119_N0.5080.95
54_A71_L0.5080.95
103_A115_V0.5060.95
33_W37_K0.5030.95
52_A56_Q0.5030.95
78_T113_R0.5030.95
23_I124_L0.5010.95
119_N144_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sfeA 1 0.9697 100 0.137 Contact Map
4bhbA 1 0.9697 100 0.146 Contact Map
1wrjA 1 0.903 100 0.161 Contact Map
3l00A 1 0.903 100 0.17 Contact Map
1eh6A 1 0.9394 100 0.171 Contact Map
2g7hA 1 0.9394 100 0.297 Contact Map
1mgtA 1 0.9273 100 0.301 Contact Map
2kifA 1 0.5333 100 0.403 Contact Map
3gvaA 1 0.5394 100 0.404 Contact Map
3ugoA 1 0.4061 61.9 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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