GREMLIN Database
GERE - Spore germination protein GerE
UniProt: P11470 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 74 (64)
Sequences: 7028 (3833)
Seq/√Len: 479.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_K35_E3.2601.00
65_E69_M3.1561.00
15_R18_E2.2931.00
23_L47_I2.2271.00
20_F62_A2.2111.00
41_K48_S2.1211.00
30_K40_E2.0391.00
56_V65_E1.9211.00
17_R21_E1.8811.00
38_I43_V1.8011.00
60_S63_V1.7511.00
16_E53_K1.5941.00
41_K44_R1.5651.00
25_Q35_E1.5281.00
41_K45_N1.5151.00
47_I51_M1.3461.00
22_L35_E1.3061.00
23_L62_A1.2961.00
19_V36_L1.2791.00
20_F66_L1.2651.00
20_F50_A1.2461.00
45_N49_N1.2221.00
27_K31_E1.1861.00
22_L27_K1.1751.00
22_L25_Q1.1541.00
57_K61_Q1.1071.00
51_M62_A1.0741.00
65_E68_R1.0671.00
28_T31_E1.0591.00
49_N52_Q1.0261.00
40_E44_R1.0091.00
46_H49_N0.9721.00
23_L32_I0.9581.00
58_G61_Q0.9451.00
47_I59_R0.9431.00
19_V46_H0.9231.00
60_S64_V0.9191.00
25_Q68_R0.9171.00
54_L65_E0.9151.00
64_V67_L0.8931.00
56_V61_Q0.8911.00
67_L72_L0.8901.00
34_S37_F0.8891.00
54_L62_A0.8851.00
16_E49_N0.8841.00
23_L63_V0.8771.00
17_R71_E0.8661.00
19_V38_I0.8631.00
9_K65_E0.8621.00
61_Q64_V0.8191.00
58_G64_V0.8061.00
9_K69_M0.7921.00
21_E25_Q0.7861.00
31_E34_S0.7731.00
30_K34_S0.7521.00
13_T46_H0.7471.00
15_R38_I0.7431.00
51_M56_V0.7421.00
39_S45_N0.7411.00
29_T44_R0.7401.00
64_V68_R0.7261.00
52_Q55_G0.7191.00
31_E57_K0.7061.00
29_T59_R0.7051.00
58_G67_L0.6951.00
15_R46_H0.6931.00
42_T46_H0.6921.00
33_A37_F0.6881.00
48_S52_Q0.6661.00
24_V72_L0.6621.00
9_K17_R0.6581.00
22_L36_L0.6581.00
50_A62_A0.6451.00
63_V67_L0.6421.00
21_E24_V0.6271.00
38_I46_H0.6060.99
31_E35_E0.6050.99
44_R59_R0.5990.99
21_E71_E0.5820.99
47_I62_A0.5750.99
18_E21_E0.5700.99
51_M64_V0.5490.99
24_V67_L0.5440.99
48_S61_Q0.5400.99
21_E35_E0.5390.99
12_L50_A0.5370.99
14_K18_E0.5350.98
38_I45_N0.5340.98
44_R66_L0.5250.98
34_S40_E0.5240.98
40_E56_V0.5160.98
12_L62_A0.5090.98
45_N48_S0.5080.98
28_T58_G0.5070.98
11_L17_R0.5000.98
33_A40_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sztA 2 0.9865 99.7 0.26 Contact Map
4lfuA 2 0.973 99.7 0.263 Contact Map
2q0oA 2 0.973 99.7 0.278 Contact Map
1l3lA 2 0.973 99.6 0.284 Contact Map
3qp6A 2 1 99.6 0.29 Contact Map
3cloA 2 0.973 99.6 0.302 Contact Map
3c3wA 2 0.9865 99.6 0.305 Contact Map
4gvpA 1 0.973 99.6 0.308 Contact Map
1a04A 1 0.9189 99.6 0.322 Contact Map
3ulqB 1 0.7838 99.5 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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