GREMLIN Database
HPR - HTH-type transcriptional regulator Hpr
UniProt: P11065 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (181)
Sequences: 100 (58)
Seq/√Len: 4.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_K117_L4.4400.91
16_F132_S4.2410.89
161_M171_I2.9520.63
18_Q117_L2.9260.62
16_F20_M2.5820.52
11_K177_S2.4530.48
30_S126_N2.4400.48
111_T114_F2.3940.46
129_F146_A2.3590.45
135_L150_C2.3010.43
67_A164_F2.2860.43
104_V158_D2.2760.43
89_Y132_S2.2210.41
128_V177_S2.2150.41
122_D148_M2.1490.39
37_Q131_G2.1460.39
13_A146_A2.1050.38
91_R97_N2.0790.37
113_V136_Y2.0460.36
30_S146_A2.0240.35
89_Y137_H1.8980.32
31_I145_V1.8750.31
27_L71_V1.8440.31
36_Q74_V1.8320.30
150_C154_H1.8260.30
60_G92_F1.8160.30
46_I165_E1.7830.29
29_K36_Q1.7810.29
62_S167_S1.7170.28
67_A151_M1.7160.28
67_A142_F1.7090.27
59_N105_Q1.7000.27
160_F164_F1.6700.26
62_S123_P1.6390.26
131_G172_D1.6030.25
58_L165_E1.5960.25
139_F153_R1.5330.23
133_Q142_F1.5200.23
29_K74_V1.5200.23
121_F165_E1.4880.22
19_K91_R1.4690.22
126_N151_M1.4680.22
12_E150_C1.4500.22
114_F119_E1.4360.21
89_Y166_T1.4360.21
12_E135_L1.4090.21
134_P161_M1.4030.21
67_A81_S1.3970.21
20_M43_D1.3960.21
69_F86_E1.3840.20
177_S182_L1.3830.20
19_K106_L1.3810.20
117_L145_V1.3700.20
87_R155_I1.3310.19
145_V148_M1.2900.19
117_L129_F1.2880.18
20_M132_S1.2830.18
40_K61_A1.2700.18
56_Y114_F1.2580.18
169_T183_K1.2480.18
65_E126_N1.2410.18
124_T162_E1.2400.18
13_A125_R1.2270.17
46_I68_K1.2170.17
65_E185_K1.1920.17
33_K46_I1.1900.17
21_A36_Q1.1810.17
14_L18_Q1.1800.17
96_L123_P1.1640.16
13_A154_H1.1590.16
116_S136_Y1.1430.16
41_P139_F1.1000.15
16_F123_P1.1000.15
55_A122_D1.0790.15
65_E144_E1.0780.15
11_K147_E1.0730.15
127_A133_Q1.0700.15
12_E154_H1.0610.15
42_Y117_L1.0530.15
14_L141_K1.0500.15
137_H174_D1.0500.15
104_V109_E1.0460.15
51_I83_K1.0400.14
65_E105_Q1.0380.14
108_E111_T1.0300.14
20_M116_S1.0290.14
67_A160_F1.0020.14
106_L145_V0.9990.14
13_A129_F0.9980.14
141_K182_L0.9880.14
57_Q154_H0.9800.14
131_G153_R0.9730.13
70_G82_K0.9660.13
132_S153_R0.9510.13
109_E185_K0.9510.13
66_I150_C0.9410.13
7_P179_N0.9360.13
42_Y91_R0.9290.13
15_V108_E0.9280.13
124_T130_K0.9270.13
127_A165_E0.9250.13
19_K149_M0.9230.13
171_I181_K0.9190.13
124_T173_N0.9170.13
65_E114_F0.9110.13
7_P178_V0.9010.12
54_I159_D0.8980.12
148_M168_L0.8940.12
81_S140_G0.8930.12
11_K180_G0.8910.12
173_N183_K0.8860.12
62_S106_L0.8850.12
61_A90_L0.8820.12
121_F177_S0.8790.12
13_A18_Q0.8760.12
113_V116_S0.8750.12
27_L68_K0.8690.12
87_R144_E0.8630.12
55_A141_K0.8560.12
119_E124_T0.8520.12
140_G153_R0.8510.12
131_G139_F0.8500.12
112_E183_K0.8490.12
68_K71_V0.8440.12
159_D178_V0.8440.12
6_P152_I0.8420.12
65_E125_R0.8390.12
57_Q114_F0.8370.12
42_Y167_S0.8310.12
121_F175_F0.8290.12
39_L63_I0.8270.12
111_T179_N0.8250.12
23_L151_M0.8210.11
121_F167_S0.8200.11
136_Y171_I0.8140.11
43_D116_S0.8120.11
158_D170_N0.8100.11
108_E153_R0.8040.11
112_E116_S0.8010.11
62_S86_E0.7970.11
19_K129_F0.7960.11
43_D113_V0.7950.11
10_V177_S0.7910.11
65_E150_C0.7910.11
116_S166_T0.7900.11
7_P155_I0.7850.11
19_K146_A0.7830.11
69_F163_I0.7830.11
117_L148_M0.7790.11
133_Q173_N0.7700.11
10_V149_M0.7680.11
176_E179_N0.7660.11
118_L123_P0.7640.11
95_R185_K0.7520.11
86_E167_S0.7490.11
148_M184_K0.7490.11
62_S135_L0.7470.11
122_D145_V0.7460.11
119_E180_G0.7430.11
19_K66_I0.7430.11
145_V184_K0.7430.11
178_V185_K0.7420.11
95_R111_T0.7410.11
62_S93_S0.7350.10
112_E172_D0.7320.10
5_E137_H0.7260.10
12_E20_M0.7220.10
149_M164_F0.7220.10
42_Y59_N0.7190.10
77_A104_V0.7180.10
45_N54_I0.7170.10
33_K58_L0.7170.10
114_F169_T0.7170.10
12_E17_T0.7170.10
19_K168_L0.7100.10
167_S175_F0.7100.10
5_E43_D0.7090.10
14_L31_I0.7080.10
169_T179_N0.6830.10
78_F90_L0.6800.10
88_G122_D0.6790.10
120_E168_L0.6760.10
86_E112_E0.6730.10
15_V153_R0.6690.10
60_G93_S0.6670.10
150_C180_G0.6660.10
30_S115_W0.6620.10
124_T171_I0.6590.10
106_L173_N0.6590.10
124_T183_K0.6570.10
89_Y178_V0.6570.10
16_F115_W0.6540.10
66_I155_I0.6510.10
57_Q83_K0.6510.10
37_Q132_S0.6510.10
20_M130_K0.6510.10
174_D185_K0.6450.09
13_A168_L0.6440.09
55_A104_V0.6420.09
43_D167_S0.6400.09
151_M168_L0.6390.09
115_W138_L0.6370.09
42_Y120_E0.6340.09
109_E112_E0.6330.09
41_P131_G0.6240.09
129_F135_L0.6230.09
17_T99_K0.6180.09
162_E172_D0.6120.09
114_F184_K0.6110.09
37_Q108_E0.6090.09
122_D130_K0.6090.09
121_F128_V0.6090.09
105_Q178_V0.6070.09
46_I71_V0.6060.09
54_I87_R0.6010.09
116_S119_E0.6000.09
113_V148_M0.5960.09
78_F93_S0.5950.09
90_L142_F0.5930.09
129_F177_S0.5870.09
89_Y171_I0.5840.09
124_T169_T0.5810.09
26_A83_K0.5790.09
45_N81_S0.5780.09
179_N183_K0.5780.09
59_N96_L0.5770.09
60_G142_F0.5770.09
14_L109_E0.5750.09
44_L93_S0.5740.09
5_E168_L0.5710.09
89_Y174_D0.5710.09
13_A135_L0.5690.09
77_A140_G0.5670.09
53_W92_F0.5670.09
126_N135_L0.5610.09
116_S137_H0.5600.09
81_S92_F0.5570.09
40_K88_G0.5520.09
66_I141_K0.5500.09
6_P173_N0.5490.09
8_Y152_I0.5480.09
55_A95_R0.5440.08
31_I91_R0.5440.08
129_F182_L0.5380.08
116_S169_T0.5360.08
19_K109_E0.5350.08
91_R109_E0.5330.08
10_V153_R0.5310.08
65_E136_Y0.5290.08
117_L154_H0.5280.08
69_F167_S0.5230.08
142_F164_F0.5220.08
21_A74_V0.5210.08
54_I163_I0.5210.08
162_E173_N0.5210.08
35_W52_L0.5200.08
36_Q53_W0.5190.08
155_I169_T0.5170.08
113_V145_V0.5110.08
91_R116_S0.5090.08
105_Q181_K0.5080.08
65_E160_F0.5070.08
22_Q163_I0.5060.08
78_F156_Y0.5030.08
53_W134_P0.5020.08
59_N122_D0.5020.08
6_P137_H0.5010.08
47_N98_D0.5000.08
47_N102_T0.5000.08
47_N75_S0.5000.08
98_D102_T0.5000.08
75_S102_T0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fxaA 4 0.8966 100 0.701 Contact Map
2rdpA 2 0.6897 99.2 0.876 Contact Map
2a61A 2 0.6995 99.2 0.877 Contact Map
1s3jA 2 0.7094 99.1 0.879 Contact Map
1z91A 2 0.6749 99.1 0.879 Contact Map
3broA 2 0.6798 99.1 0.88 Contact Map
3g3zA 2 0.6995 99.1 0.88 Contact Map
3cjnA 2 0.7192 99.1 0.88 Contact Map
4rguA 4 0.7094 99.1 0.881 Contact Map
3e6mA 2 0.7389 99.1 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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