GREMLIN Database
DYR - Dihydrofolate reductase
UniProt: P11045 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 168 (157)
Sequences: 4698 (3566)
Seq/√Len: 284.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_L122_G3.3081.00
58_K74_T3.0801.00
36_S56_N2.8971.00
10_A117_H2.8901.00
30_Y34_I2.2961.00
136_L139_S2.2261.00
4_F108_A2.2201.00
8_M12_R2.1301.00
136_L155_L2.1231.00
79_L104_L2.1181.00
76_V85_I2.0241.00
38_H93_F2.0121.00
115_K155_L2.0111.00
9_D13_L2.0091.00
3_S112_Y2.0091.00
78_S81_D1.9131.00
111_L129_F1.8671.00
40_I59_N1.8521.00
31_F95_I1.8161.00
64_S99_Q1.7021.00
41_I92_C1.6951.00
110_R158_E1.6901.00
16_K121_E1.6691.00
99_Q102_T1.6611.00
117_H153_E1.6611.00
139_S153_E1.6391.00
137_V158_E1.6381.00
13_L125_H1.6201.00
6_F113_M1.6061.00
10_A119_E1.5941.00
77_S81_D1.5841.00
44_R48_E1.5731.00
130_D133_N1.5711.00
26_N152_Y1.5431.00
62_V100_L1.5281.00
141_Q153_E1.5241.00
144_K151_D1.5101.00
30_Y112_Y1.5041.00
30_Y156_M1.5011.00
48_E68_S1.4901.00
29_A33_K1.4821.00
110_R156_M1.4771.00
99_Q103_D1.4701.00
3_S91_E1.4571.00
9_D120_F1.4511.00
38_H91_E1.4431.00
94_V104_L1.4401.00
98_A102_T1.4361.00
39_S58_K1.4291.00
5_I93_F1.3931.00
70_F73_C1.3691.00
8_M115_K1.3541.00
60_I76_V1.3061.00
34_I112_Y1.2941.00
40_I95_I1.2901.00
47_F73_C1.2731.00
53_P59_N1.2521.00
25_P29_A1.2391.00
145_D148_N1.2031.00
20_L28_L1.1961.00
11_N119_E1.1951.00
139_S155_L1.1851.00
112_Y156_M1.1811.00
8_M113_M1.1791.00
32_K36_S1.1781.00
3_S110_R1.1661.00
65_A68_S1.1531.00
80_K107_Y1.1501.00
74_T85_I1.1491.00
59_N95_I1.1411.00
30_Y154_F1.1381.00
117_H151_D1.1251.00
50_I59_N1.1081.00
136_L157_Y1.1061.00
135_K158_E1.1031.00
62_V104_L1.1021.00
138_S156_M1.0931.00
8_M111_L1.0771.00
98_A124_R1.0621.00
6_F126_F1.0601.00
63_T75_V1.0541.00
82_V86_C1.0431.00
26_N148_N1.0361.00
91_E110_R1.0341.00
4_F104_L1.0321.00
86_C92_C1.0291.00
41_I82_V1.0251.00
81_D84_D1.0241.00
3_S93_F1.0151.00
35_T57_R1.0001.00
66_P77_S1.0001.00
142_G152_Y0.9991.00
39_S89_P0.9981.00
26_N145_D0.9731.00
23_H28_L0.9721.00
32_K55_P0.9711.00
5_I34_I0.9621.00
54_L57_R0.9571.00
63_T77_S0.9571.00
4_F126_F0.9351.00
79_L103_D0.9311.00
113_M157_Y0.9251.00
115_K157_Y0.9131.00
45_K48_E0.9081.00
12_R128_E0.9061.00
63_T68_S0.8891.00
84_D87_S0.8891.00
60_I86_C0.8841.00
46_T49_S0.8841.00
42_M50_I0.8811.00
6_F14_I0.8701.00
82_V104_L0.8541.00
18_N49_S0.8521.00
6_F111_L0.8451.00
4_F101_Y0.8441.00
25_P147_K0.8391.00
45_K99_Q0.8371.00
37_G56_N0.8331.00
68_S75_V0.8321.00
24_L116_I0.8301.00
47_F53_P0.8281.00
39_S60_I0.8281.00
118_H150_Y0.8251.00
47_F70_F0.8191.00
76_V82_V0.8181.00
12_R115_K0.8171.00
27_D154_F0.8110.99
94_V100_L0.7980.99
120_F150_Y0.7980.99
9_D119_E0.7950.99
83_L107_Y0.7930.99
61_V73_C0.7920.99
18_N45_K0.7750.99
8_M126_F0.7670.99
26_N147_K0.7580.99
145_D150_Y0.7520.99
47_F50_I0.7450.99
50_I53_P0.7390.99
10_A118_H0.7380.99
2_I92_C0.7270.99
9_D122_G0.7270.99
70_F75_V0.7260.99
34_I93_F0.7230.99
39_S59_N0.7180.99
22_W116_I0.7150.99
9_D118_H0.7140.99
115_K131_E0.7110.99
28_L32_K0.7070.99
144_K149_P0.6970.98
41_I60_I0.6970.98
53_P72_G0.6930.98
51_G59_N0.6920.98
21_P120_F0.6850.98
100_L103_D0.6790.98
38_H90_E0.6790.98
53_P70_F0.6770.98
145_D149_P0.6690.98
8_M129_F0.6640.98
25_P149_P0.6570.98
133_N159_K0.6480.98
79_L107_Y0.6480.98
63_T66_P0.6470.97
10_A115_K0.6430.97
116_I120_F0.6400.97
111_L126_F0.6390.97
20_L23_H0.6360.97
21_P122_G0.6330.97
115_K153_E0.6320.97
149_P152_Y0.6290.97
21_P101_Y0.6290.97
24_L148_N0.6280.97
53_P61_V0.6270.97
61_V70_F0.6200.97
16_K20_L0.6190.97
58_K85_I0.6090.96
144_K152_Y0.6080.96
130_D134_W0.6070.96
102_T127_P0.5990.96
62_V82_V0.5960.96
2_I108_A0.5950.96
137_V156_M0.5890.96
18_N124_R0.5890.96
30_Y138_S0.5840.95
13_L21_P0.5820.95
93_F112_Y0.5790.95
4_F105_F0.5780.95
62_V103_D0.5770.95
42_M46_T0.5760.95
18_N123_D0.5740.95
53_P73_C0.5740.95
133_N136_L0.5660.95
80_K84_D0.5640.95
142_G151_D0.5640.95
6_F127_P0.5620.94
129_F157_Y0.5610.94
105_F129_F0.5600.94
76_V81_D0.5590.94
41_I104_L0.5570.94
27_D30_Y0.5550.94
22_W120_F0.5510.94
142_G148_N0.5510.94
8_M21_P0.5500.94
26_N142_G0.5460.94
95_I101_Y0.5460.94
12_R129_F0.5450.93
112_Y154_F0.5450.93
146_E151_D0.5410.93
144_K150_Y0.5410.93
7_A22_W0.5380.93
101_Y126_F0.5370.93
142_G153_E0.5360.93
42_M95_I0.5340.93
101_Y124_R0.5330.93
39_S86_C0.5320.93
147_K150_Y0.5310.93
104_L107_Y0.5260.92
141_Q151_D0.5240.92
136_L153_E0.5230.92
47_F51_G0.5230.92
24_L145_D0.5220.92
35_T54_L0.5210.92
26_N29_A0.5190.92
32_K46_T0.5190.92
14_I122_G0.5150.91
19_D23_H0.5140.91
148_N151_D0.5100.91
122_G125_H0.5050.91
83_L86_C0.5040.91
20_L116_I0.5030.90
144_K148_N0.5030.90
65_A77_S0.5020.90
28_L49_S0.5020.90
36_S40_I0.5010.90
20_L49_S0.5010.90
38_H89_P0.5000.90
60_I85_I0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eilA 3 0.9464 100 0.283 Contact Map
3ia4A 1 0.9524 100 0.284 Contact Map
2bl9A 1 0.9405 100 0.288 Contact Map
1j3kA 1 0.9524 100 0.295 Contact Map
3irmA 4 0.994 100 0.296 Contact Map
3tq8A 1 0.9881 100 0.298 Contact Map
3rg9A 1 0.9583 100 0.302 Contact Map
2w9hA 1 0.9345 100 0.302 Contact Map
1zdrA 1 0.9524 100 0.304 Contact Map
4pssA 1 0.6726 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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