GREMLIN Database
TYSY2 - Thymidylate synthase 2
UniProt: P11044 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (262)
Sequences: 3020 (1324)
Seq/√Len: 81.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_V170_V3.7561.00
225_R254_P3.6961.00
10_H14_H3.5801.00
63_L112_I3.2461.00
10_H32_Y3.0381.00
238_S241_N2.9611.00
225_R253_D2.8411.00
17_K27_I2.8211.00
118_D128_L2.7401.00
208_I216_V2.5991.00
117_E121_T2.5871.00
51_H54_S2.5271.00
203_F206_V2.5061.00
9_R13_E2.4701.00
161_C185_T2.4351.00
115_L128_L2.4331.00
218_L221_E2.4211.00
78_R81_N2.4081.00
186_M196_P2.3131.00
10_H29_T2.2851.00
52_F56_A2.2001.00
231_R250_E2.1761.00
231_R248_I2.1561.00
70_R74_E2.0931.00
116_I188_I2.0781.00
17_K210_Q2.0571.00
186_M230_L2.0161.00
69_V73_Q2.0121.00
99_R110_D2.0061.00
225_R255_H1.9971.00
67_T96_S1.9541.00
27_I213_I1.9491.00
12_L217_N1.9471.00
116_I239_I1.9031.00
191_V242_F1.8981.00
233_A246_D1.8951.00
19_G124_N1.8451.00
37_N40_E1.8051.00
168_A174_V1.8011.00
20_D25_G1.7991.00
57_H75_N1.7611.00
18_K124_N1.7421.00
119_I192_T1.7201.00
50_L55_I1.6971.00
103_G107_E1.6851.00
35_R198_E1.6841.00
96_S102_R1.6841.00
57_H71_Y1.6651.00
229_Q251_D1.6571.00
56_A247_F1.6561.00
232_F247_F1.6101.00
71_Y75_N1.5340.99
8_C216_V1.5300.99
27_I210_Q1.5250.99
236_V242_F1.5230.99
73_Q78_R1.4960.99
16_E156_D1.4810.99
57_H77_V1.4790.99
44_M50_L1.4770.99
130_V150_F1.4660.99
73_Q81_N1.4660.99
39_R158_K1.4640.99
233_A248_I1.4410.99
158_K195_E1.4380.99
16_E155_S1.4350.99
8_C170_V1.4280.99
28_S153_Y1.4200.99
29_T32_Y1.4190.99
223_D255_H1.4120.99
116_I192_T1.4020.99
152_F188_I1.3920.99
170_V206_V1.3890.99
17_K213_I1.3870.99
53_K76_G1.3830.99
157_G194_L1.3740.99
201_H206_V1.3670.99
119_I128_L1.3620.99
100_S108_T1.3580.99
230_L247_F1.3420.99
118_D122_N1.3200.98
229_Q250_E1.3170.98
102_R108_T1.3140.98
115_L118_D1.3080.98
163_L199_F1.2930.98
191_V236_V1.2870.98
114_R118_D1.2840.98
115_L188_I1.2830.98
113_S117_E1.2750.98
57_H244_F1.2690.98
230_L249_I1.2620.98
24_T263_S1.2590.98
186_M249_I1.2320.98
52_F249_I1.2280.98
138_I144_P1.2270.97
44_M249_I1.2230.97
113_S240_F1.1740.97
96_S108_T1.1740.97
131_S135_V1.1700.97
234_R237_D1.1660.97
83_W262_V1.1640.97
33_Q202_T1.1610.96
137_E140_K1.1570.96
216_V260_G1.1330.96
171_F260_G1.1120.96
214_E217_N1.1070.95
168_A203_F1.1030.95
190_H234_R1.0970.95
12_L213_I1.0940.95
213_I217_N1.0920.95
153_Y160_S1.0890.95
208_I260_G1.0870.95
152_F161_C1.0780.95
96_S137_E1.0740.95
66_D71_Y1.0720.95
114_R117_E1.0640.94
32_Y170_V1.0640.94
162_Q202_T1.0610.94
7_F170_V1.0570.94
226_P253_D1.0520.94
12_L208_I1.0370.93
5_K224_V1.0370.93
115_L152_F1.0320.93
103_G109_I1.0180.93
170_V174_V1.0150.93
154_V194_L1.0140.93
253_D256_P1.0010.92
114_R139_D0.9960.92
165_Q168_A0.9910.92
119_I188_I0.9800.91
168_A201_H0.9720.91
101_W135_V0.9710.91
171_F215_Q0.9710.91
171_F216_V0.9700.91
187_I191_V0.9670.91
47_T219_Q0.9660.91
164_Y204_G0.9660.91
14_H29_T0.9620.91
8_C208_I0.9550.90
257_H262_V0.9520.90
118_D125_S0.9490.90
70_R73_Q0.9480.90
119_I194_L0.9450.90
115_L130_V0.9390.90
97_Q134_N0.9220.89
57_H243_A0.9220.89
73_Q84_A0.9190.89
102_R107_E0.9170.88
190_H233_A0.9150.88
20_D24_T0.9150.88
160_S198_E0.9140.88
39_R197_G0.9140.88
215_Q260_G0.9130.88
103_G136_G0.9110.88
214_E218_L0.9100.88
50_L257_H0.9100.88
211_N263_S0.9020.88
84_A87_N0.8990.87
118_D121_T0.8960.87
25_G210_Q0.8950.87
174_V203_F0.8940.87
186_M247_F0.8940.87
232_F242_F0.8910.87
14_H32_Y0.8860.87
49_K257_H0.8780.86
149_L164_Y0.8770.86
218_L257_H0.8740.86
35_R200_I0.8730.86
238_S242_F0.8710.86
104_A136_G0.8700.86
71_Y74_E0.8700.86
39_R195_E0.8670.85
187_I247_F0.8670.85
56_A249_I0.8650.85
191_V238_S0.8600.85
96_S100_S0.8570.85
7_F32_Y0.8570.85
49_K254_P0.8480.84
12_L27_I0.8460.84
155_S160_S0.8450.84
5_K219_Q0.8430.84
210_Q263_S0.8400.84
56_A183_L0.8350.83
9_R217_N0.8320.83
101_W109_I0.8300.83
6_D9_R0.8280.83
233_A237_D0.8260.83
97_Q141_M0.8250.83
92_P96_S0.8240.82
8_C260_G0.8220.82
18_K28_S0.8180.82
182_A199_F0.8170.82
151_Q204_G0.8080.81
210_Q213_I0.8060.81
237_D242_F0.8060.81
73_Q87_N0.8060.81
157_G195_E0.8040.81
102_R137_E0.8010.81
187_I242_F0.8010.81
73_Q85_D0.7970.80
44_M179_A0.7920.80
131_S148_C0.7870.79
73_Q76_G0.7800.79
54_S57_H0.7800.79
233_A236_V0.7790.79
103_G108_T0.7780.79
236_V243_A0.7760.79
38_L185_T0.7760.79
163_L201_H0.7730.78
64_K243_A0.7720.78
148_C164_Y0.7660.78
162_Q204_G0.7480.76
124_N157_G0.7450.76
59_L180_S0.7380.75
135_V141_M0.7350.75
52_F230_L0.7350.75
121_T128_L0.7340.75
104_A107_E0.7320.74
61_W72_L0.7320.74
233_A242_F0.7300.74
62_F180_S0.7290.74
156_D194_L0.7270.74
104_A108_T0.7250.74
26_T126_R0.7210.73
90_L93_V0.7200.73
51_H78_R0.7170.73
181_Y199_F0.7160.73
231_R234_R0.7140.73
188_I192_T0.7130.72
148_C163_L0.7120.72
56_A244_F0.7110.72
112_I130_V0.7070.72
45_L254_P0.7060.72
56_A230_L0.7050.72
3_Q6_D0.7030.71
164_Y202_T0.7020.71
196_P230_L0.7020.71
193_G235_K0.6990.71
225_R256_P0.6970.71
141_M145_P0.6950.70
6_D10_H0.6940.70
150_F181_Y0.6940.70
20_D210_Q0.6930.70
137_E141_M0.6930.70
156_D195_E0.6920.70
211_N261_A0.6840.69
158_K197_G0.6820.69
51_H76_G0.6810.69
136_G139_D0.6800.69
144_P148_C0.6780.69
223_D226_P0.6750.68
101_W136_G0.6740.68
60_L247_F0.6690.68
128_L192_T0.6680.67
9_R221_E0.6670.67
41_G227_L0.6660.67
234_R242_F0.6620.67
174_V199_F0.6620.67
187_I236_V0.6600.67
69_V84_A0.6590.66
98_W132_A0.6580.66
28_S205_D0.6570.66
69_V75_N0.6550.66
187_I190_H0.6540.66
129_I133_W0.6530.66
27_I217_N0.6530.66
7_F34_M0.6520.66
225_R251_D0.6490.65
18_K153_Y0.6470.65
45_L50_L0.6460.65
174_V201_H0.6410.64
32_Y206_V0.6410.64
77_V244_F0.6400.64
135_V138_I0.6400.64
75_N243_A0.6360.64
233_A245_E0.6350.64
97_Q137_E0.6340.63
195_E198_E0.6320.63
57_H64_K0.6320.63
208_I213_I0.6310.63
5_K220_L0.6300.63
165_Q174_V0.6280.63
78_R261_A0.6280.63
112_I188_I0.6270.63
53_K57_H0.6260.62
120_K192_T0.6240.62
19_G27_I0.6230.62
190_H236_V0.6220.62
190_H242_F0.6210.62
5_K45_L0.6210.62
138_I141_M0.6190.62
5_K227_L0.6190.62
64_K71_Y0.6180.61
165_Q201_H0.6180.61
37_N198_E0.6180.61
33_Q200_I0.6180.61
104_A137_E0.6170.61
168_A206_V0.6170.61
254_P257_H0.6040.60
85_D89_E0.6030.60
92_P97_Q0.6020.59
69_V83_W0.6020.59
183_L230_L0.6010.59
50_L254_P0.6000.59
5_K9_R0.6000.59
171_F212_H0.6000.59
235_K242_F0.5960.59
37_N41_G0.5960.59
193_G237_D0.5940.58
75_N244_F0.5940.58
51_H244_F0.5940.58
235_K246_D0.5930.58
54_S77_V0.5920.58
234_R247_F0.5910.58
33_Q162_Q0.5910.58
134_N141_M0.5910.58
163_L168_A0.5900.58
56_A60_L0.5900.58
7_F36_F0.5890.58
114_R138_I0.5870.58
251_D254_P0.5850.57
69_V85_D0.5840.57
39_R196_P0.5830.57
9_R12_L0.5800.57
234_R248_I0.5790.57
109_I136_G0.5790.57
13_E217_N0.5760.56
185_T192_T0.5760.56
127_R143_L0.5730.56
217_N221_E0.5720.56
100_S105_D0.5720.56
34_M203_F0.5710.55
178_I181_Y0.5710.55
69_V93_V0.5710.55
172_L219_Q0.5670.55
78_R263_S0.5670.55
187_I232_F0.5660.55
155_S158_K0.5660.55
102_R136_G0.5650.55
82_E262_V0.5610.54
69_V81_N0.5580.54
32_Y36_F0.5580.54
112_I239_I0.5580.54
191_V234_R0.5570.54
42_F179_A0.5550.53
41_G186_M0.5530.53
190_H235_K0.5520.53
158_K198_E0.5510.53
79_I176_F0.5500.53
108_T136_G0.5480.52
36_F178_I0.5480.52
132_A141_M0.5470.52
18_K160_S0.5470.52
125_S128_L0.5460.52
234_R246_D0.5460.52
51_H75_N0.5450.52
73_Q86_E0.5450.52
122_N125_S0.5410.52
115_L150_F0.5410.52
27_I208_I0.5400.51
160_S197_G0.5380.51
150_F161_C0.5370.51
189_A194_L0.5330.51
185_T188_I0.5310.50
96_S104_A0.5310.50
13_E16_E0.5300.50
91_G97_Q0.5290.50
20_D26_T0.5250.49
27_I216_V0.5230.49
237_D241_N0.5230.49
66_D89_E0.5220.49
3_Q227_L0.5210.49
166_R169_D0.5190.49
160_S200_I0.5170.48
10_H13_E0.5170.48
18_K155_S0.5160.48
51_H57_H0.5160.48
38_L182_A0.5160.48
54_S73_Q0.5140.48
22_T26_T0.5130.48
122_N144_P0.5120.48
109_I114_R0.5120.48
231_R243_A0.5120.48
52_F186_M0.5100.48
92_P140_K0.5100.48
4_Y8_C0.5100.48
13_E223_D0.5070.47
54_S76_G0.5060.47
45_L144_P0.5040.47
48_K176_F0.5040.47
124_N156_D0.5030.47
67_T102_R0.5010.46
92_P141_M0.5000.46
8_C171_F0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v8hA 2 0.9659 100 -0.032 Contact Map
3uwlA 2 1 100 -0.031 Contact Map
3nrrA 2 1 100 -0.028 Contact Map
1hw4A 2 0.9508 100 -0.025 Contact Map
4iqbA 2 0.9848 100 -0.024 Contact Map
3hj3A 2 1 100 -0.024 Contact Map
4g9uA 2 0.9886 100 -0.024 Contact Map
4eilA 3 1 100 -0.022 Contact Map
3irmA 4 1 100 -0.02 Contact Map
3ix6A 2 0.9356 100 -0.02 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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