GREMLIN Database
SP2AB - Anti-sigma F factor
UniProt: P10728 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (134)
Sequences: 1125 (847)
Seq/√Len: 73.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_R131_T3.1701.00
51_A55_G2.9141.00
23_V68_V2.8851.00
119_D135_T2.8521.00
27_I40_I2.8131.00
6_H67_S2.7931.00
27_I75_V2.7751.00
23_V66_I2.6811.00
51_A64_V2.6481.00
91_E94_Q2.4731.00
74_V135_T2.4631.00
59_N62_G2.3361.00
8_E63_K2.3151.00
117_M120_V2.2671.00
74_V137_H2.2491.00
117_M134_L2.1291.00
57_E84_L2.0241.00
10_S63_K1.9461.00
40_I117_M1.9201.00
43_V112_I1.8991.00
43_V117_M1.8951.00
78_T133_R1.8631.00
8_E65_Y1.8211.00
76_Y133_R1.8081.00
40_I138_L1.8061.00
47_A113_M1.8041.00
69_T76_Y1.7851.00
6_H65_Y1.7501.00
57_E100_K1.7211.00
65_Y80_R1.6421.00
67_S78_T1.6190.99
113_M132_I1.5360.99
5_M68_V1.4910.99
121_S133_R1.4810.99
117_M136_K1.4450.99
118_D136_K1.4090.99
4_E69_T1.3990.98
71_E74_V1.3930.98
65_Y82_E1.3920.98
52_I64_V1.3890.98
56_Y62_G1.3260.98
112_I115_N1.3260.98
66_I79_I1.2900.97
123_D131_T1.2650.97
9_F64_V1.2410.97
11_A56_Y1.2280.96
87_T126_P1.1820.96
93_R114_E1.1390.95
9_F66_I1.1290.94
110_F122_I1.1270.94
120_V134_L1.1230.94
11_A64_V1.1150.94
42_T116_F1.0830.93
33_T36_E1.0680.93
100_K103_L1.0610.92
11_A61_E1.0570.92
47_A79_I1.0570.92
39_E43_V1.0510.92
85_G130_T1.0460.92
43_V77_M1.0420.92
113_M134_L1.0300.91
20_R45_S1.0090.90
122_I130_T1.0080.90
73_H137_H1.0070.90
23_V40_I1.0050.90
13_S16_E1.0050.90
48_V64_V0.9970.90
110_F113_M0.9870.89
74_V82_E0.9560.88
27_I32_P0.9490.87
47_A134_L0.9390.87
106_S112_I0.9100.85
93_R122_I0.9040.85
16_E32_P0.9000.84
9_F19_A0.8900.84
90_E93_R0.8780.83
4_E63_K0.8680.82
68_V75_V0.8670.82
44_V79_I0.8640.82
16_E42_T0.8380.80
4_E57_E0.8350.80
106_S111_T0.8260.79
36_E136_K0.8240.79
24_A41_K0.8200.78
22_T66_I0.8190.78
12_L22_T0.8140.78
32_P138_L0.8140.78
39_E49_T0.8120.78
89_L95_P0.8080.77
119_D137_H0.8000.77
53_I106_S0.7980.76
20_R41_K0.7980.76
5_M23_V0.7980.76
23_V70_L0.7900.76
93_R112_I0.7810.75
47_A132_I0.7810.75
49_T52_I0.7720.74
25_S74_V0.7670.74
34_M112_I0.7640.73
83_G109_G0.7530.72
4_E67_S0.7480.72
45_S130_T0.7480.72
10_S59_N0.7480.72
83_G107_G0.7450.71
63_K82_E0.7420.71
4_E7_L0.7380.71
76_Y135_T0.7370.71
24_A34_M0.7370.71
61_E121_S0.7310.70
4_E38_T0.7270.69
85_G106_S0.7200.69
53_I123_D0.7170.68
28_A37_L0.7140.68
79_I134_L0.7080.67
18_F30_L0.7070.67
21_V25_S0.7070.67
7_L22_T0.7050.67
20_R39_E0.7020.67
122_I129_G0.6860.65
31_D37_L0.6860.65
36_E117_M0.6790.64
78_T131_T0.6780.64
67_S75_V0.6780.64
11_A59_N0.6760.64
35_D39_E0.6740.64
32_P38_T0.6740.64
10_S61_E0.6720.63
16_E45_S0.6560.62
111_T115_N0.6540.61
124_S130_T0.6510.61
43_V134_L0.6470.60
11_A116_F0.6350.59
18_F40_I0.6330.59
88_D91_E0.6320.59
5_M18_F0.6300.58
54_H81_D0.6210.57
30_L70_L0.6190.57
50_N109_G0.6190.57
103_L106_S0.6190.57
107_G129_G0.6150.57
54_H95_P0.6120.56
6_H80_R0.6100.56
78_T84_L0.6090.56
4_E65_Y0.6070.56
87_T90_E0.6060.56
45_S86_I0.6040.55
92_A97_F0.6010.55
54_H83_G0.6000.55
4_E76_Y0.5960.54
37_L41_K0.5920.54
119_D133_R0.5890.53
32_P108_M0.5850.53
5_M17_S0.5830.53
37_L115_N0.5830.53
42_T45_S0.5810.52
50_N81_D0.5800.52
88_D92_A0.5780.52
88_D127_E0.5770.52
96_L106_S0.5760.52
28_A114_E0.5740.52
89_L132_I0.5740.52
74_V119_D0.5680.51
72_D139_S0.5680.51
72_D91_E0.5660.51
73_H139_S0.5650.50
64_V139_S0.5620.50
81_D109_G0.5600.50
42_T115_N0.5590.50
80_R138_L0.5560.49
76_Y123_D0.5550.49
57_E61_E0.5530.49
57_E138_L0.5530.49
21_V112_I0.5520.49
16_E26_F0.5510.49
18_F25_S0.5490.48
92_A95_P0.5470.48
80_R102_E0.5430.48
11_A62_G0.5420.48
57_E102_E0.5410.47
16_E108_M0.5380.47
92_A124_S0.5380.47
50_N107_G0.5360.47
25_S111_T0.5360.47
81_D107_G0.5340.47
49_T96_L0.5320.46
45_S110_F0.5320.46
70_L90_E0.5280.46
61_E69_T0.5280.46
106_S116_F0.5250.46
63_K80_R0.5200.45
22_T68_V0.5200.45
53_I130_T0.5170.45
16_E19_A0.5170.45
4_E82_E0.5130.44
54_H109_G0.5080.43
92_A122_I0.5070.43
69_T74_V0.5050.43
21_V80_R0.5040.43
54_H107_G0.5010.43
48_V105_R0.5000.42
129_G132_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1th8A 2 0.9041 99.9 0.491 Contact Map
3ke6A 2 0.8356 99.8 0.55 Contact Map
4r3aA 1 0.9041 99.3 0.697 Contact Map
1i58A 2 0.9178 99.2 0.711 Contact Map
1b3qA 2 1 99.1 0.714 Contact Map
4r39A 1 0.9247 99.1 0.721 Contact Map
3zxqA 2 0.7329 99 0.724 Contact Map
3ehhA 2 0.7945 99 0.726 Contact Map
4bixA 2 0.9041 99 0.726 Contact Map
3a0rA 2 0.8904 99 0.728 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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