GREMLIN Database
SP2AA - Anti-sigma F factor antagonist
UniProt: P10727 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 117 (105)
Sequences: 2541 (1977)
Seq/√Len: 192.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_S108_Q3.1301.00
19_T52_D2.4951.00
81_C106_E2.4101.00
92_D97_F2.3961.00
51_E82_A2.3051.00
71_I76_G2.2301.00
50_L53_L2.1781.00
49_N106_E2.1551.00
104_Q108_Q2.0621.00
61_L94_S2.0441.00
64_I100_I1.9981.00
22_L53_L1.9931.00
88_K92_D1.9631.00
8_N17_R1.9601.00
83_I91_F1.8991.00
48_L64_I1.8791.00
31_K57_D1.8431.00
77_E101_R1.8431.00
45_H77_E1.8021.00
34_V67_R1.7111.00
35_T70_Q1.7041.00
79_V103_E1.6821.00
62_G66_G1.6761.00
33_K36_Q1.5971.00
62_G65_L1.5701.00
18_L30_L1.4761.00
31_K62_G1.4481.00
9_V43_I1.4271.00
27_A63_V1.3621.00
47_V109_A1.3541.00
79_V101_R1.3521.00
12_S45_H1.3491.00
68_Y100_I1.3051.00
23_D26_T1.2821.00
47_V81_C1.2821.00
39_E70_Q1.2791.00
21_E89_R1.2741.00
35_T39_E1.2461.00
31_K66_G1.2321.00
41_D44_R1.1931.00
23_D95_G1.1791.00
17_R49_N1.1731.00
80_V100_I1.1581.00
9_V12_S1.1371.00
45_H76_G1.1261.00
17_R52_D1.1251.00
90_L94_S1.1161.00
36_Q40_K1.0991.00
24_H57_D1.0821.00
57_D62_G1.0621.00
88_K104_Q1.0601.00
24_H61_L1.0171.00
88_K97_F1.0151.00
6_D17_R0.9941.00
49_N82_A0.9760.99
41_D76_G0.9710.99
96_L100_I0.9670.99
56_M62_G0.9620.99
30_L63_V0.9610.99
57_D90_L0.9470.99
61_L90_L0.9360.99
65_L68_Y0.9360.99
24_H56_M0.9260.99
32_Q36_Q0.9240.99
34_V48_L0.9170.99
47_V110_L0.9160.99
68_Y72_K0.9150.99
56_M90_L0.9020.99
107_Q111_L0.8950.99
55_F96_L0.8870.99
62_G96_L0.8830.99
83_I102_F0.8810.99
35_T67_R0.8720.99
65_L96_L0.8380.98
38_L41_D0.8370.98
13_V47_V0.8310.98
106_E110_L0.8300.98
22_L30_L0.8240.98
21_E54_S0.8210.98
83_I88_K0.8190.98
103_E108_Q0.8190.98
23_D55_F0.8180.98
17_R106_E0.8130.98
56_M87_V0.8130.98
21_E95_G0.8120.98
62_G95_G0.7940.98
29_T32_Q0.7940.98
62_G69_K0.7630.97
47_V79_V0.7590.97
10_K107_Q0.7470.96
37_S40_K0.7340.96
26_T60_G0.7310.96
22_L56_M0.7160.96
80_V83_I0.7130.95
24_H91_F0.7130.95
57_D96_L0.7110.95
16_I53_L0.7090.95
57_D93_M0.7050.95
80_V91_F0.7030.95
91_F100_I0.7020.95
103_E109_A0.7010.95
16_I34_V0.6920.95
7_M33_K0.6890.95
48_L67_R0.6760.94
17_R51_E0.6760.94
13_V110_L0.6740.94
63_V66_G0.6690.94
48_L78_M0.6610.93
51_E83_I0.6600.93
72_K77_E0.6570.93
89_R95_G0.6530.93
88_K102_F0.6520.93
21_E57_D0.6360.92
28_E32_Q0.6290.91
20_G53_L0.6220.91
20_G95_G0.6150.90
90_L96_L0.6140.90
84_S87_V0.6120.90
38_L70_Q0.6080.90
108_Q111_L0.6050.90
65_L69_K0.5980.89
44_R76_G0.5980.89
68_Y96_L0.5970.89
24_H95_G0.5970.89
69_K96_L0.5960.89
59_S96_L0.5950.89
63_V67_R0.5880.88
41_D74_I0.5760.87
46_I67_R0.5690.87
30_L53_L0.5670.87
79_V109_A0.5670.87
52_D111_L0.5670.87
16_I67_R0.5660.86
57_D60_G0.5650.86
23_D89_R0.5630.86
62_G90_L0.5610.86
14_L46_I0.5530.85
9_V15_C0.5390.84
46_I78_M0.5360.83
94_S97_F0.5350.83
50_L78_M0.5330.83
64_I94_S0.5320.83
55_F67_R0.5300.83
35_T66_G0.5300.83
97_F102_F0.5290.83
36_Q39_E0.5270.82
44_R75_G0.5260.82
107_Q110_L0.5260.82
86_A93_M0.5250.82
50_L87_V0.5230.82
50_L64_I0.5230.82
25_H28_E0.5230.82
12_S43_I0.5220.82
54_S84_S0.5190.81
68_Y94_S0.5110.80
15_C47_V0.5060.80
7_M37_S0.5060.80
30_L93_M0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xs5A 1 0.9573 99.9 0.317 Contact Map
3zxnA 1 0.9829 99.9 0.32 Contact Map
1th8B 1 0.9829 99.9 0.323 Contact Map
4qtpA 2 0.9658 99.9 0.339 Contact Map
1sboA 1 0.9231 99.9 0.344 Contact Map
1h4xA 1 0.9487 99.9 0.354 Contact Map
3t6oA 5 0.9829 99.9 0.355 Contact Map
2ka5A 1 0.9829 99.9 0.364 Contact Map
4hylA 2 0.9573 99.9 0.366 Contact Map
3ny7A 1 0.9402 99.8 0.375 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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