GREMLIN Database
ALR1 - Alanine racemase 1
UniProt: P10725 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (353)
Sequences: 4919 (3649)
Seq/√Len: 194.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_I245_A3.6571.00
166_T202_C3.4211.00
279_G320_L2.9541.00
297_D304_R2.9341.00
252_L279_G2.8261.00
263_S268_A2.7781.00
257_L277_W2.7661.00
205_S224_G2.7441.00
187_K216_F2.7401.00
21_E243_R2.7181.00
73_I101_Y2.6841.00
259_R275_D2.6791.00
304_R345_E2.6731.00
263_S271_T2.6201.00
72_A103_V2.5351.00
249_H329_K2.5231.00
278_I308_A2.4911.00
26_M224_G2.4001.00
57_L82_A2.3601.00
257_L275_D2.3561.00
15_D18_A2.2841.00
98_A105_L2.2731.00
269_E310_R2.2521.00
13_E249_H2.2041.00
35_H62_S2.1981.00
270_Y276_T2.1871.00
136_N262_E2.1691.00
250_S281_V2.1461.00
298_I318_V2.1341.00
252_L324_Y2.1101.00
248_L283_V2.1031.00
39_V65_A2.0941.00
132_D136_N2.0851.00
258_I272_A2.0791.00
265_S312_C2.0671.00
37_M218_A2.0581.00
274_K322_Q2.0471.00
335_R340_Y2.0291.00
183_F214_G2.0191.00
361_I365_V1.9861.00
260_K275_D1.9601.00
228_L354_N1.9591.00
228_L358_A1.9451.00
181_M185_R1.9321.00
190_I200_V1.8921.00
126_H160_K1.8671.00
343_M358_A1.8621.00
289_W332_L1.8571.00
178_Y268_A1.8141.00
50_A78_K1.8051.00
25_N28_K1.7981.00
43_N363_S1.7941.00
301_K328_T1.7931.00
21_E25_N1.7551.00
20_K55_A1.7371.00
106_T165_F1.7331.00
325_P328_T1.7141.00
11_W249_H1.7081.00
170_T268_A1.7021.00
38_A225_M1.6981.00
331_T340_Y1.6761.00
140_V149_V1.6751.00
300_V318_V1.6241.00
259_R272_A1.6151.00
259_R262_E1.5981.00
255_V320_L1.5971.00
114_Q152_I1.5921.00
183_F216_F1.5911.00
184_E188_E1.5521.00
104_T162_K1.5471.00
23_V225_M1.5301.00
57_L64_L1.5291.00
290_L360_T1.5281.00
344_D354_N1.5201.00
37_M65_A1.5091.00
131_V189_L1.5051.00
102_D123_G1.5021.00
49_D74_S1.4961.00
280_T317_M1.4861.00
208_G221_F1.4791.00
300_V305_L1.4721.00
299_L341_I1.4561.00
12_A365_V1.4511.00
128_H201_H1.4461.00
170_T179_F1.4441.00
30_I34_V1.4431.00
19_I52_T1.4431.00
40_V53_A1.4331.00
281_V316_F1.4181.00
200_V217_N1.4141.00
18_A243_R1.4111.00
276_T319_E1.4031.00
299_L331_T1.3951.00
246_F333_I1.3841.00
276_T321_D1.3841.00
53_A75_L1.3821.00
314_D364_R1.3801.00
170_T173_E1.3741.00
51_E369_F1.3611.00
50_A74_S1.3611.00
281_V330_V1.3611.00
203_A214_G1.3521.00
20_K59_A1.3391.00
312_C317_M1.3281.00
30_I219_V1.3131.00
171_A206_A1.2911.00
35_H63_C1.2871.00
183_F187_K1.2771.00
16_L369_F1.2681.00
272_A276_T1.2651.00
124_S160_K1.2621.00
10_T283_V1.2461.00
203_A215_F1.2451.00
262_E272_A1.2281.00
110_V114_Q1.2251.00
180_L213_K1.2241.00
51_E54_K1.2201.00
21_E241_Q1.2161.00
47_H246_F1.2121.00
55_A59_A1.2081.00
252_L255_V1.2081.00
12_A248_L1.1951.00
37_M63_C1.1951.00
255_V326_P1.1901.00
117_A156_N1.1891.00
23_V61_A1.1881.00
64_L82_A1.1871.00
110_V152_I1.1831.00
269_E295_G1.1831.00
126_H162_K1.1771.00
180_L184_E1.1761.00
38_A61_A1.1711.00
147_Q192_P1.1711.00
142_T188_E1.1681.00
117_A152_I1.1681.00
23_V36_L1.1621.00
183_F202_C1.1621.00
178_Y263_S1.1571.00
258_I264_V1.1521.00
289_W346_I1.1441.00
278_I317_M1.1381.00
10_T250_S1.1291.00
273_E276_T1.1171.00
114_Q118_R1.1111.00
203_A207_A1.1101.00
185_R188_E1.1091.00
176_R210_R1.1031.00
77_K101_Y1.1021.00
252_L320_L1.0991.00
42_A286_A1.0941.00
333_I343_M1.0941.00
269_E294_K1.0941.00
26_M221_F1.0931.00
25_N29_H1.0931.00
320_L324_Y1.0921.00
299_L304_R1.0901.00
75_L80_L1.0891.00
19_I56_A1.0891.00
56_A225_M1.0851.00
181_M184_E1.0791.00
31_G34_V1.0771.00
27_K62_S1.0741.00
97_I101_Y1.0731.00
311_I316_F1.0731.00
11_W368_M1.0701.00
283_V332_L1.0701.00
132_D256_K1.0671.00
117_A158_R1.0651.00
251_T329_K1.0611.00
248_L365_V1.0611.00
274_K321_D1.0561.00
187_K191_A1.0511.00
96_A100_E1.0501.00
350_L357_V1.0401.00
111_E326_P1.0401.00
104_T126_H1.0381.00
289_W307_I1.0361.00
224_G242_L1.0351.00
57_L81_K1.0281.00
298_I316_F1.0271.00
73_I77_K1.0261.00
86_V103_V1.0251.00
36_L221_F1.0221.00
305_L321_D1.0191.00
297_D306_K1.0171.00
299_L340_Y1.0141.00
63_C104_T1.0001.00
141_K262_E1.0001.00
83_P104_T0.9931.00
334_G341_I0.9921.00
342_S345_E0.9830.99
130_K138_L0.9760.99
261_G272_A0.9750.99
276_T308_A0.9750.99
31_G215_F0.9740.99
96_A122_K0.9690.99
297_D349_R0.9680.99
121_K158_R0.9680.99
12_A246_F0.9670.99
16_L55_A0.9580.99
194_P200_V0.9560.99
146_V189_L0.9500.99
97_I100_E0.9480.99
179_F211_L0.9470.99
208_G219_V0.9470.99
187_K213_K0.9430.99
30_I36_L0.9430.99
212_K215_F0.9410.99
107_G127_F0.9380.99
347_A352_T0.9330.99
249_H331_T0.9320.99
107_G113_L0.9260.99
50_A54_K0.9230.99
254_H326_P0.9190.99
138_L280_T0.9120.99
223_I355_Y0.9100.99
23_V56_A0.9070.99
24_S59_A0.9060.99
281_V318_V0.9050.99
200_V216_F0.8990.99
15_D370_L0.8950.99
246_F361_I0.8890.99
170_T178_Y0.8840.99
76_R84_I0.8820.99
199_M217_N0.8770.99
250_S282_P0.8750.99
290_L350_L0.8740.99
300_V330_V0.8720.99
138_L315_Q0.8710.99
305_L318_V0.8680.99
99_A125_L0.8680.99
11_W251_T0.8670.99
168_F207_A0.8670.99
38_A56_A0.8650.99
113_L156_N0.8650.99
252_L300_V0.8630.99
60_G82_A0.8580.99
131_V146_V0.8570.99
13_E368_M0.8570.99
341_I345_E0.8530.99
142_T185_R0.8520.98
173_E176_R0.8520.98
151_A196_K0.8470.98
54_K78_K0.8460.98
48_G369_F0.8410.98
10_T365_V0.8400.98
305_L322_Q0.8390.98
20_K24_S0.8380.98
168_F202_C0.8370.98
265_S317_M0.8360.98
258_I262_E0.8340.98
102_D126_H0.8340.98
318_V330_V0.8330.98
292_K351_E0.8320.98
264_V276_T0.8320.98
170_T267_G0.8290.98
208_G215_F0.8280.98
26_M36_L0.8260.98
20_K58_D0.8240.98
293_L349_R0.8230.98
63_C218_A0.8180.98
63_C83_P0.8180.98
16_L51_E0.8180.98
277_W323_E0.8120.98
164_V190_I0.8080.98
301_K324_Y0.8040.98
264_V278_I0.8040.98
76_R102_D0.8040.98
23_V59_A0.8030.98
292_K350_L0.8030.98
228_L343_M0.8020.98
146_V150_M0.8000.98
163_G201_H0.7990.98
281_V298_I0.7960.98
172_D267_G0.7870.97
274_K319_E0.7860.97
301_K325_P0.7860.97
186_F200_V0.7860.97
113_L153_L0.7840.97
261_G275_D0.7800.97
12_A47_H0.7800.97
263_S272_A0.7790.97
128_H163_G0.7770.97
111_E114_Q0.7770.97
206_A230_P0.7750.97
136_N141_K0.7740.97
180_L211_L0.7740.97
14_I369_F0.7740.97
221_F224_G0.7720.97
303_K322_Q0.7710.97
296_T349_R0.7700.97
223_I228_L0.7690.97
52_T56_A0.7670.97
127_F159_L0.7650.97
151_A155_R0.7630.97
75_L84_I0.7610.97
264_V317_M0.7560.97
324_Y328_T0.7550.97
107_G116_A0.7550.97
12_A361_I0.7530.97
166_T216_F0.7490.97
150_M193_L0.7470.97
113_L149_V0.7460.97
223_I354_N0.7460.97
290_L357_V0.7460.97
250_S316_F0.7450.97
291_R356_E0.7440.96
52_T245_A0.7410.96
99_A119_H0.7390.96
39_V87_L0.7390.96
272_A275_D0.7350.96
253_S282_P0.7340.96
85_L128_H0.7330.96
131_V164_V0.7320.96
298_I332_L0.7320.96
35_H199_M0.7270.96
91_P94_Y0.7270.96
15_D335_R0.7190.96
209_L240_F0.7180.96
110_V145_E0.7140.96
52_T59_A0.7130.96
136_N258_I0.7130.96
169_A178_Y0.7130.96
15_D247_T0.7120.95
301_K323_E0.7120.95
65_A218_A0.7120.95
147_Q151_A0.7110.95
40_V64_L0.7100.95
16_L52_T0.7090.95
92_P115_E0.7090.95
283_V316_F0.7070.95
86_V98_A0.7070.95
53_A80_L0.7050.95
183_F203_A0.7050.95
291_R353_I0.7040.95
260_K273_E0.7040.95
25_N241_Q0.7030.95
343_M354_N0.7020.95
145_E148_N0.7010.95
43_N49_D0.6980.95
293_L350_L0.6980.95
247_T331_T0.6960.95
258_I278_I0.6940.95
56_A64_L0.6930.95
18_A21_E0.6930.95
186_F202_C0.6930.95
300_V324_Y0.6920.95
170_T176_R0.6920.95
14_I245_A0.6900.95
345_E348_G0.6890.95
316_F332_L0.6870.95
85_L104_T0.6870.95
289_W316_F0.6860.94
133_T182_Q0.6850.94
72_A101_Y0.6780.94
24_S60_G0.6770.94
148_N151_A0.6760.94
120_T125_L0.6760.94
176_R211_L0.6750.94
18_A242_L0.6740.94
229_R240_F0.6720.94
305_L320_L0.6710.94
69_L98_A0.6700.94
17_S20_K0.6690.94
50_A80_L0.6680.94
90_V105_L0.6670.94
13_E247_T0.6660.94
298_I330_V0.6660.94
13_E370_L0.6650.94
49_D286_A0.6650.94
206_A223_I0.6610.93
35_H218_A0.6590.93
94_Y97_I0.6580.93
248_L333_I0.6580.93
176_R180_L0.6550.93
333_I357_V0.6540.93
192_P195_L0.6540.93
110_V148_N0.6540.93
149_V153_L0.6530.93
243_R335_R0.6530.93
69_L72_A0.6520.93
199_M218_A0.6510.93
305_L324_Y0.6510.93
264_V308_A0.6500.93
67_A314_D0.6490.93
202_C216_F0.6490.93
27_K36_L0.6480.93
248_L361_I0.6480.93
99_A120_T0.6480.93
141_K145_E0.6460.93
9_D251_T0.6450.92
119_H122_K0.6450.92
232_A348_G0.6450.92
191_A194_P0.6440.92
89_A108_Y0.6440.92
277_W322_Q0.6420.92
108_Y254_H0.6400.92
354_N358_A0.6390.92
74_S78_K0.6380.92
254_H280_T0.6370.92
207_A211_L0.6330.92
188_E191_A0.6300.92
257_L276_T0.6300.92
277_W320_L0.6240.91
8_R68_I0.6240.91
81_K102_D0.6220.91
352_T357_V0.6200.91
290_L293_L0.6190.91
210_R231_S0.6180.91
303_K323_E0.6170.91
111_E115_E0.6160.91
73_I97_I0.6150.91
331_T341_I0.6140.91
21_E24_S0.6140.91
36_L219_V0.6130.90
63_C85_L0.6130.90
141_K256_K0.6110.90
84_I103_V0.6060.90
300_V320_L0.6060.90
74_S363_S0.6030.90
34_V219_V0.6030.90
113_L117_A0.6030.90
172_D310_R0.6010.90
65_A87_L0.5990.89
42_A364_R0.5990.89
38_A64_L0.5980.89
44_A49_D0.5980.89
153_L161_C0.5980.89
148_N152_I0.5980.89
255_V277_W0.5970.89
307_I311_I0.5970.89
344_D348_G0.5960.89
307_I318_V0.5930.89
172_D291_R0.5920.89
147_Q150_M0.5900.89
276_T322_Q0.5890.89
55_A58_D0.5890.89
61_A64_L0.5890.89
253_S315_Q0.5880.89
287_D364_R0.5880.89
264_V272_A0.5860.88
273_E306_K0.5860.88
304_R341_I0.5830.88
250_S330_V0.5820.88
53_A64_L0.5790.88
191_A195_L0.5760.88
24_S27_K0.5740.87
18_A245_A0.5700.87
297_D345_E0.5700.87
24_S28_K0.5700.87
40_V226_Y0.5690.87
183_F211_L0.5690.87
56_A59_A0.5670.87
37_M85_L0.5650.87
223_I358_A0.5650.87
112_W116_A0.5640.86
270_Y308_A0.5640.86
333_I361_I0.5620.86
331_T334_G0.5610.86
346_I357_V0.5610.86
307_I316_F0.5610.86
80_L83_P0.5600.86
118_R122_K0.5560.86
89_A105_L0.5510.85
15_D243_R0.5510.85
52_T55_A0.5510.85
189_L192_P0.5480.85
133_T185_R0.5470.85
168_F214_G0.5460.85
63_C199_M0.5440.84
19_I225_M0.5400.84
42_A314_D0.5390.84
333_I346_I0.5390.84
294_K351_E0.5340.83
221_F225_M0.5340.83
26_M208_G0.5330.83
62_S83_P0.5330.83
146_V149_V0.5310.83
56_A61_A0.5310.83
345_E349_R0.5310.83
264_V270_Y0.5310.83
140_V146_V0.5290.83
25_N243_R0.5290.83
166_T179_F0.5290.83
17_S21_E0.5290.83
229_R241_Q0.5280.83
91_P251_T0.5270.83
57_L62_S0.5260.82
260_K274_K0.5250.82
287_D314_D0.5240.82
186_F190_I0.5230.82
286_A364_R0.5230.82
96_A119_H0.5220.82
298_I305_L0.5210.82
26_M30_I0.5210.82
25_N240_F0.5210.82
188_E192_P0.5190.82
277_W324_Y0.5190.82
83_P126_H0.5160.81
280_T315_Q0.5160.81
128_H162_K0.5150.81
343_M357_V0.5150.81
73_I103_V0.5150.81
165_F312_C0.5150.81
117_A121_K0.5140.81
208_G224_G0.5140.81
44_A54_K0.5120.81
116_A125_L0.5120.81
50_A53_A0.5090.80
169_A182_Q0.5090.80
34_V215_F0.5090.80
133_T169_A0.5090.80
355_Y359_C0.5080.80
286_A314_D0.5070.80
231_S234_M0.5070.80
69_L73_I0.5060.80
90_V98_A0.5060.80
229_R344_D0.5050.80
279_G324_Y0.5050.80
62_S82_A0.5050.80
129_L140_V0.5050.80
135_M355_Y0.5040.80
153_L159_L0.5040.80
141_K259_R0.5040.80
109_S112_W0.5030.80
30_I215_F0.5020.79
152_I156_N0.5020.79
49_D78_K0.5010.79
85_L106_T0.5000.79
302_G341_I0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bd0A 2 0.9743 100 0.258 Contact Map
2vd8A 2 0.9383 100 0.262 Contact Map
3hurA 4 0.9614 100 0.27 Contact Map
3e5pA 2 0.9434 100 0.278 Contact Map
4a3qA 2 0.9126 100 0.28 Contact Map
3co8A 2 0.9357 100 0.285 Contact Map
3s46A 2 0.9383 100 0.296 Contact Map
4lusA 2 0.9614 100 0.318 Contact Map
3kw3A 2 0.9075 100 0.321 Contact Map
1vfsA 2 0.9589 100 0.321 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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