GREMLIN Database
GNTR - Gluconate operon transcriptional repressor
UniProt: P10585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (205)
Sequences: 23427 (17318)
Seq/√Len: 1209.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_S202_K3.8441.00
104_E210_I3.3311.00
205_D208_L2.9541.00
126_K195_E2.8191.00
30_R35_L2.7301.00
37_E40_T2.7191.00
30_R50_E2.4201.00
97_L101_F2.3191.00
90_E155_S2.2811.00
44_E55_R2.2341.00
117_D147_T2.2071.00
96_L218_D2.1071.00
24_A64_I2.0731.00
72_R81_I2.0261.00
28_R68_E1.9791.00
23_V53_V1.9621.00
108_K206_R1.9531.00
93_D105_R1.9391.00
73_L78_A1.8201.00
115_V202_K1.8091.00
200_A208_L1.8041.00
150_R158_Q1.7981.00
23_V51_F1.7921.00
114_L153_D1.7871.00
111_I114_L1.7671.00
147_T150_R1.7211.00
26_E30_R1.6571.00
133_D136_E1.6521.00
122_L198_I1.6441.00
193_N219_D1.6281.00
100_T214_H1.6081.00
17_A25_Y1.6001.00
104_E206_R1.5981.00
208_L212_S1.5901.00
94_V160_I1.5811.00
29_M33_S1.5651.00
100_T210_I1.5631.00
210_I214_H1.5601.00
145_H194_H1.5581.00
101_F104_E1.5251.00
196_L212_S1.4631.00
199_Q203_T1.4341.00
146_E162_N1.4311.00
103_F209_M1.4121.00
121_I140_Q1.4091.00
124_M140_Q1.4061.00
24_A68_E1.4061.00
159_M163_N1.4021.00
149_I161_W1.3991.00
119_S198_I1.3831.00
96_L214_H1.3801.00
114_L151_A1.3791.00
126_K191_L1.3711.00
156_Y167_V1.3671.00
203_T208_L1.3491.00
45_N49_A1.3381.00
96_L221_Q1.3351.00
90_E156_Y1.3301.00
195_E199_Q1.3241.00
124_M143_L1.2831.00
119_S123_E1.2781.00
110_D115_V1.2661.00
206_R210_I1.2631.00
120_K124_M1.2471.00
46_T50_E1.2381.00
121_I147_T1.2241.00
211_Q215_Q1.2211.00
41_I79_V1.2111.00
22_R26_E1.2081.00
43_S46_T1.1991.00
47_I58_V1.1971.00
95_R99_E1.1971.00
96_L100_T1.1971.00
193_N216_N1.1961.00
122_L195_E1.1951.00
208_L211_Q1.1931.00
26_E29_M1.1881.00
30_R51_F1.1851.00
89_A225_E1.1601.00
146_E150_R1.1501.00
100_T104_E1.1461.00
26_E51_F1.1441.00
66_A73_L1.1431.00
143_L147_T1.1391.00
136_E139_F1.1301.00
90_E154_H1.1281.00
89_A221_Q1.1261.00
104_E207_A1.1241.00
110_D204_K1.1181.00
214_H218_D1.1121.00
110_D114_L1.1101.00
199_Q202_K1.1101.00
110_D151_A1.1091.00
148_I201_I1.1051.00
141_D145_H1.1011.00
103_F107_V1.0971.00
115_V198_I1.0951.00
103_F213_L1.0891.00
198_I202_K1.0701.00
93_D154_H1.0651.00
102_V149_I1.0581.00
147_T151_A1.0511.00
117_D150_R1.0411.00
36_I80_V1.0401.00
119_S195_E1.0381.00
121_I143_L1.0321.00
122_L125_M1.0281.00
194_H216_N1.0231.00
123_E126_K1.0111.00
115_V204_K1.0101.00
152_I158_Q1.0011.00
17_A22_R0.9951.00
122_L126_K0.9931.00
107_V206_R0.9911.00
145_H216_N0.9891.00
221_Q225_E0.9881.00
160_I163_N0.9861.00
117_D120_K0.9851.00
140_Q143_L0.9791.00
66_A71_I0.9791.00
200_A205_D0.9721.00
99_E145_H0.9711.00
196_L215_Q0.9671.00
20_G64_I0.9611.00
196_L208_L0.9551.00
60_E63_K0.9551.00
62_L78_A0.9541.00
192_D196_L0.9531.00
101_F210_I0.9521.00
41_I77_G0.9491.00
144_F198_I0.9481.00
30_R36_I0.9411.00
116_K120_K0.9411.00
117_D121_I0.9361.00
72_R79_V0.9341.00
197_Y213_L0.9341.00
105_R109_I0.9331.00
31_I80_V0.9281.00
107_V201_I0.9271.00
139_F143_L0.9221.00
44_E59_R0.9161.00
87_K156_Y0.9151.00
71_I78_A0.9051.00
196_L199_Q0.8931.00
158_Q162_N0.8871.00
24_A28_R0.8831.00
207_A211_Q0.8801.00
95_R217_F0.8731.00
94_V156_Y0.8691.00
19_T22_R0.8651.00
64_I67_S0.8641.00
126_K130_K0.8641.00
84_T87_K0.8591.00
141_D194_H0.8591.00
207_A210_I0.8591.00
101_F105_R0.8581.00
119_S199_Q0.8541.00
121_I124_M0.8501.00
115_V119_S0.8491.00
46_T49_A0.8471.00
54_S57_P0.8441.00
28_R70_I0.8421.00
109_I153_D0.8421.00
112_E116_K0.8411.00
191_L195_E0.8401.00
48_A58_V0.8341.00
76_M79_V0.8331.00
63_K66_A0.8331.00
110_D201_I0.8301.00
86_K153_D0.8281.00
107_V204_K0.8171.00
53_V58_V0.8081.00
123_E127_V0.8071.00
28_R32_V0.8051.00
118_L198_I0.8041.00
47_I62_L0.8031.00
197_Y212_S0.8011.00
124_M127_V0.8011.00
123_E195_E0.8001.00
21_V64_I0.7951.00
128_S136_E0.7951.00
196_L200_A0.7871.00
112_E204_K0.7861.00
156_Y160_I0.7841.00
19_T57_P0.7831.00
118_L147_T0.7821.00
114_L117_D0.7781.00
93_D221_Q0.7771.00
106_L151_A0.7761.00
20_G24_A0.7731.00
125_M137_F0.7691.00
107_V209_M0.7681.00
188_T192_D0.7681.00
62_L71_I0.7661.00
127_V131_Y0.7641.00
218_D222_D0.7561.00
200_A212_S0.7541.00
86_K90_E0.7541.00
156_Y159_M0.7501.00
18_S21_V0.7501.00
105_R108_K0.7441.00
146_E165_K0.7331.00
124_M136_E0.7301.00
105_R154_H0.7291.00
63_K73_L0.7291.00
212_S215_Q0.7271.00
94_V157_I0.7191.00
117_D143_L0.7181.00
211_Q214_H0.7131.00
116_K202_K0.7131.00
104_E108_K0.7101.00
93_D109_I0.7061.00
92_Y220_V0.7061.00
116_K119_S0.7011.00
122_L191_L0.6961.00
136_E140_Q0.6911.00
35_L50_E0.6901.00
197_Y209_M0.6871.00
115_V201_I0.6851.00
57_P61_A0.6831.00
142_V169_E0.6801.00
94_V102_V0.6781.00
146_E158_Q0.6751.00
114_L150_R0.6671.00
64_I68_E0.6631.00
17_A21_V0.6591.00
215_Q219_D0.6541.00
20_G60_E0.6521.00
218_D221_Q0.6501.00
75_R78_A0.6481.00
120_K123_E0.6471.00
219_D223_K0.6451.00
103_F206_R0.6451.00
197_Y216_N0.6441.00
94_V98_L0.6431.00
106_L110_D0.6421.00
142_V165_K0.6421.00
114_L147_T0.6421.00
143_L146_E0.6391.00
87_K155_S0.6381.00
99_E194_H0.6371.00
106_L152_I0.6371.00
124_M128_S0.6261.00
193_N196_L0.6231.00
96_L217_F0.6231.00
93_D101_F0.6221.00
128_S140_Q0.6131.00
97_L157_I0.6111.00
36_I40_T0.6091.00
137_F190_I0.6081.00
102_V152_I0.6051.00
100_T213_L0.5991.00
102_V157_I0.5981.00
30_R34_G0.5981.00
39_G82_G0.5941.00
74_E77_G0.5901.00
113_P117_D0.5831.00
100_T206_R0.5801.00
97_L100_T0.5781.00
127_V130_K0.5751.00
222_D225_E0.5741.00
128_S132_E0.5701.00
85_E89_A0.5671.00
125_M191_L0.5661.00
16_K22_R0.5651.00
106_L148_I0.5631.00
118_L151_A0.5621.00
45_N48_A0.5611.00
104_E214_H0.5601.00
98_L161_W0.5591.00
51_F58_V0.5571.00
159_M167_V0.5571.00
49_A52_S0.5541.00
38_S82_G0.5531.00
112_E202_K0.5481.00
128_S133_D0.5481.00
185_E188_T0.5441.00
21_V25_Y0.5431.00
42_L71_I0.5421.00
79_V82_G0.5381.00
118_L122_L0.5371.00
149_I165_K0.5361.00
126_K192_D0.5341.00
186_D189_R0.5321.00
32_V70_I0.5301.00
130_K188_T0.5301.00
63_K67_S0.5221.00
103_F148_I0.5211.00
87_K90_E0.5201.00
94_V97_L0.5201.00
105_R152_I0.5191.00
192_D195_E0.5191.00
197_Y200_A0.5151.00
209_M213_L0.5131.00
36_I42_L0.5121.00
159_M162_N0.5121.00
101_F157_I0.5121.00
186_D223_K0.5111.00
45_N55_R0.5111.00
27_L47_I0.5111.00
215_Q218_D0.5091.00
81_I170_S0.5091.00
44_E78_A0.5091.00
99_E217_F0.5091.00
139_F169_E0.5081.00
107_V210_I0.5051.00
135_D173_L0.5041.00
88_I171_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sxyA 2 0.8189 100 0.205 Contact Map
3ihuA 1 0.8354 100 0.207 Contact Map
2hs5A 1 0.8477 100 0.213 Contact Map
3c7jA 4 0.9383 100 0.213 Contact Map
4p9fA 1 0.8642 100 0.219 Contact Map
4p96A 2 0.9177 100 0.241 Contact Map
2di3A 2 0.8642 100 0.257 Contact Map
1hw1A 2 0.8436 100 0.268 Contact Map
3ic7A 2 0.4486 99.8 0.587 Contact Map
3by6A 2 0.5021 99.8 0.591 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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