GREMLIN Database
GUN2 - Endoglucanase
UniProt: P10475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (420)
Sequences: 466 (401)
Seq/√Len: 19.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
340_P344_S3.6221.00
401_G405_D3.5141.00
324_F328_N3.4131.00
314_R322_G3.4121.00
400_K404_F3.1900.99
332_T336_T3.0120.99
400_K405_D2.9270.99
206_T209_Q2.7940.99
328_N332_T2.6440.98
324_F330_L2.6360.98
404_F407_D2.5470.97
366_N369_Q2.5120.97
331_G335_S2.4620.97
322_G331_G2.3970.96
184_A202_V2.3270.96
324_F332_T2.3030.95
232_A264_S2.2950.95
330_L334_D2.2860.95
332_T335_S2.2690.95
405_D409_A2.2540.95
328_N334_D2.2440.95
428_Q431_D2.2430.95
345_K349_T2.2410.95
333_K337_K2.2310.94
340_P346_D2.1810.94
428_Q432_T2.1450.93
404_F412_G2.1260.93
328_N336_T2.1050.92
406_C418_H2.0850.92
376_I389_V2.0650.92
191_I200_I2.0490.91
338_D342_T2.0310.91
339_I343_P2.0200.91
203_G208_S2.0160.91
344_S348_P1.9410.89
80_K122_L1.9360.89
297_Q301_S1.9200.88
407_D418_H1.8990.88
325_V330_L1.8790.87
164_Y198_N1.8720.87
338_D346_D1.8690.87
428_Q434_L1.8620.87
203_G207_W1.8520.86
317_D322_G1.8340.86
119_A126_V1.8330.86
316_S322_G1.8300.86
347_K351_E1.8260.86
314_R328_N1.8110.85
59_L90_V1.7990.85
366_N387_K1.7910.85
328_N331_G1.7900.85
314_R321_S1.7780.84
113_K155_L1.7660.84
79_L118_A1.7460.83
400_K406_C1.7440.83
339_I344_S1.7250.82
324_F334_D1.7180.82
100_G103_I1.7180.82
318_L321_S1.7170.82
330_L338_D1.7170.82
322_G334_D1.6970.81
334_D338_D1.6910.81
235_H238_F1.6840.81
127_I201_I1.6600.80
214_A246_A1.6590.80
346_D349_T1.6540.79
428_Q437_G1.6460.79
406_C409_A1.6420.79
343_P348_P1.6240.78
113_K156_Y1.6220.78
341_E344_S1.6150.78
341_E345_K1.6030.77
338_D348_P1.5990.77
313_W324_F1.5860.76
342_T348_P1.5720.76
426_P434_L1.5560.75
324_F335_S1.5550.75
55_K157_G1.5530.75
318_L326_R1.5500.75
322_G332_T1.5490.75
342_T346_D1.5490.75
322_G336_T1.5450.74
326_R334_D1.5300.74
429_G432_T1.5250.73
90_V289_V1.5240.73
314_R317_D1.5130.73
321_S326_R1.5050.72
401_G406_C1.5040.72
49_L199_I1.5000.72
317_D321_S1.4970.72
324_F331_G1.4970.72
180_I183_Y1.4810.71
69_W112_V1.4780.71
323_T327_E1.4770.71
321_S324_F1.4720.71
322_G325_V1.4530.70
168_N257_E1.4430.69
169_E229_H1.4430.69
168_N229_H1.4430.69
229_H257_E1.4430.69
169_E257_E1.4430.69
317_D325_V1.4340.69
420_F424_H1.4340.69
356_V360_A1.4280.68
370_I387_K1.4250.68
317_D330_L1.4170.68
322_G328_N1.4140.68
321_S335_S1.4130.67
424_H436_L1.4120.67
342_T347_K1.4100.67
321_S325_V1.3980.67
316_S332_T1.3970.67
335_S343_P1.3840.66
300_S305_P1.3810.66
319_S322_G1.3800.66
405_D412_G1.3780.65
328_N335_S1.3780.65
338_D344_S1.3780.65
330_L336_T1.3740.65
344_S350_Q1.3720.65
321_S330_L1.3720.65
318_L334_D1.3710.65
76_K121_E1.3700.65
164_Y195_D1.3690.65
406_C413_C1.3670.65
338_D341_E1.3450.64
201_I254_F1.3430.63
205_G209_Q1.3420.63
405_D408_Y1.3360.63
431_D437_G1.3320.63
318_L324_F1.3320.63
203_G209_Q1.3310.63
420_F433_Y1.3310.63
404_F410_Q1.3300.63
394_W397_A1.3070.61
331_G334_D1.2980.61
314_R318_L1.2930.60
297_Q303_L1.2870.60
328_N338_D1.2860.60
325_V328_N1.2850.60
299_S304_K1.2790.60
426_P436_L1.2760.59
21_G24_A1.2700.59
299_S302_A1.2670.59
354_I358_Y1.2630.59
433_Y440_N1.2600.58
152_M155_L1.2560.58
195_D198_N1.2500.58
317_D324_F1.2500.58
131_H192_R1.2440.57
92_R231_Y1.2380.57
185_E189_S1.2370.57
17_L20_G1.2310.57
326_R330_L1.2310.57
321_S331_G1.2280.56
324_F329_I1.2210.56
299_S307_A1.2160.56
401_G407_D1.2140.55
313_W322_G1.2100.55
330_L335_S1.2100.55
94_A149_F1.2080.55
346_D350_Q1.2030.55
313_W326_R1.1910.54
322_G330_L1.1900.54
401_G404_F1.1890.54
321_S329_I1.1810.53
325_V331_G1.1800.53
135_D138_P1.1780.53
369_Q387_K1.1780.53
227_A256_T1.1780.53
332_T340_P1.1680.53
87_G256_T1.1650.52
341_E349_T1.1630.52
20_G24_A1.1620.52
27_A30_A1.1620.52
344_S347_K1.1610.52
329_I334_D1.1520.51
93_A134_N1.1520.51
332_T338_D1.1510.51
339_I347_K1.1510.51
317_D331_G1.1490.51
149_F164_Y1.1430.51
240_R244_N1.1430.51
36_V83_R1.1410.51
92_R169_E1.1390.51
92_R168_N1.1390.51
92_R229_H1.1390.51
92_R257_E1.1390.51
188_I192_R1.1370.51
386_L394_W1.1270.50
153_S194_N1.1200.49
374_L436_L1.1190.49
93_A126_V1.1180.49
429_G434_L1.1170.49
24_A28_S1.1140.49
66_G69_W1.1090.49
325_V335_S1.1050.48
327_E330_L1.1000.48
403_N409_A1.1000.48
386_L393_Y1.0950.48
192_R223_N1.0940.48
406_C412_G1.0930.48
400_K412_G1.0910.48
16_L22_M1.0830.47
204_T208_S1.0770.47
320_A324_F1.0760.47
199_I225_M1.0750.47
336_T344_S1.0750.47
427_K430_A1.0720.46
48_Q56_A1.0690.46
280_Y284_K1.0690.46
71_G115_A1.0670.46
42_L59_L1.0620.46
387_K423_L1.0610.46
407_D412_G1.0600.46
156_Y199_I1.0590.46
378_N389_V1.0580.45
339_I346_D1.0570.45
404_F408_Y1.0570.45
333_K341_E1.0560.45
431_D434_L1.0530.45
166_I184_A1.0520.45
399_N405_D1.0510.45
340_P343_P1.0490.45
66_G129_D1.0450.45
83_R122_L1.0440.45
21_G25_S1.0400.44
298_E302_A1.0400.44
129_D196_P1.0340.44
226_Y287_S1.0340.44
401_G409_A1.0330.44
313_W321_S1.0290.44
180_I202_V1.0270.43
119_A122_L1.0220.43
166_I191_I1.0220.43
82_L124_I1.0190.43
436_L440_N1.0160.43
338_D345_K1.0090.42
359_R377_K1.0090.42
17_L22_M1.0080.42
428_Q433_Y1.0050.42
317_D334_D1.0040.42
323_T328_N0.9970.42
26_P31_G0.9960.42
313_W331_G0.9950.41
314_R330_L0.9930.41
231_Y257_E0.9920.41
169_E231_Y0.9920.41
168_N231_Y0.9920.41
435_E438_F0.9920.41
315_L326_R0.9890.41
410_Q419_K0.9890.41
44_I225_M0.9840.41
336_T343_P0.9840.41
424_H437_G0.9820.41
405_D413_C0.9810.41
362_D369_Q0.9780.40
334_D342_T0.9760.40
409_A412_G0.9760.40
44_I49_L0.9740.40
17_L23_I0.9630.40
403_N407_D0.9620.39
402_Q405_D0.9510.39
93_A112_V0.9470.39
437_G440_N0.9460.38
66_G165_E0.9430.38
325_V329_I0.9420.38
154_S157_G0.9400.38
400_K407_D0.9350.38
364_S371_R0.9330.38
313_W323_T0.9280.37
331_G336_T0.9260.37
340_P350_Q0.9250.37
336_T342_T0.9170.37
203_G206_T0.9160.37
423_L434_L0.9150.37
15_T27_A0.9150.37
389_V436_L0.9120.36
392_R407_D0.9090.36
129_D226_Y0.9090.36
323_T329_I0.9070.36
329_I332_T0.9070.36
325_V332_T0.9050.36
368_N371_R0.9020.36
318_L322_G0.8990.36
411_I415_N0.8970.36
76_K118_A0.8970.36
411_I418_H0.8970.36
232_A263_A0.8960.35
314_R323_T0.8950.35
343_P349_T0.8950.35
43_S50_V0.8870.35
313_W330_L0.8850.35
405_D410_Q0.8830.35
321_S332_T0.8810.35
258_W288_W0.8760.34
330_L333_K0.8750.34
165_E203_G0.8750.34
22_M27_A0.8740.34
65_H68_Q0.8720.34
296_K301_S0.8710.34
334_D344_S0.8680.34
131_H163_I0.8610.33
387_K437_G0.8610.33
49_L225_M0.8610.33
94_A256_T0.8540.33
317_D323_T0.8540.33
23_I29_A0.8510.33
46_G250_G0.8460.33
326_R331_G0.8410.32
316_S324_F0.8390.32
246_A250_G0.8380.32
314_R332_T0.8340.32
314_R324_F0.8320.32
342_T350_Q0.8310.32
371_R439_K0.8300.32
335_S340_P0.8290.32
377_K418_H0.8240.31
317_D336_T0.8240.31
147_E150_K0.8220.31
322_G326_R0.8190.31
318_L328_N0.8180.31
401_G413_C0.8170.31
415_N429_G0.8170.31
42_L51_N0.8160.31
97_T148_F0.8150.31
18_T21_G0.8150.31
322_G333_K0.8140.31
129_D165_E0.8130.31
149_F256_T0.8130.31
326_R332_T0.8100.31
150_K194_N0.8090.31
146_K190_V0.8080.31
367_S437_G0.8070.30
400_K403_N0.8040.30
332_T337_K0.8030.30
188_I200_I0.8000.30
424_H434_L0.7990.30
79_L241_D0.7960.30
190_V225_M0.7930.30
14_I19_M0.7900.30
65_H69_W0.7890.29
323_T331_G0.7850.29
136_G139_N0.7740.29
146_K186_E0.7730.29
315_L325_V0.7710.29
317_D332_T0.7680.28
18_T411_I0.7600.28
420_F426_P0.7600.28
65_H294_S0.7590.28
378_N381_N0.7530.28
94_A129_D0.7510.27
317_D329_I0.7500.27
404_F414_G0.7490.27
326_R329_I0.7480.27
321_S328_N0.7470.27
386_L433_Y0.7470.27
354_I368_N0.7450.27
153_S192_R0.7420.27
337_K345_K0.7410.27
374_L420_F0.7410.27
63_S256_T0.7400.27
368_N392_R0.7370.27
296_K303_L0.7360.27
133_L184_A0.7350.27
29_A384_V0.7340.27
20_G29_A0.7340.27
316_S325_V0.7330.27
358_Y368_N0.7330.27
297_Q300_S0.7310.26
308_S311_G0.7300.26
422_T429_G0.7290.26
62_I293_L0.7270.26
429_G435_E0.7270.26
326_R335_S0.7240.26
329_I333_K0.7190.26
145_A149_F0.7150.26
156_Y160_P0.7100.25
340_P345_K0.7090.25
140_Q144_K0.7080.25
391_A437_G0.7080.25
77_D381_N0.7070.25
322_G327_E0.7070.25
31_G35_P0.7060.25
315_L318_L0.7060.25
394_W398_K0.7050.25
187_V191_I0.7040.25
322_G335_S0.7020.25
14_I21_G0.7020.25
424_H440_N0.7020.25
315_L324_F0.7010.25
421_V429_G0.7010.25
362_D366_N0.6990.25
21_G29_A0.6990.25
389_V434_L0.6980.25
82_L293_L0.6980.25
410_Q413_C0.6950.25
360_A366_N0.6950.25
313_W327_E0.6910.25
369_Q394_W0.6890.24
19_M27_A0.6880.24
356_V384_V0.6870.24
112_V192_R0.6870.24
421_V424_H0.6850.24
320_A328_N0.6850.24
326_R336_T0.6850.24
315_L332_T0.6850.24
314_R326_R0.6840.24
331_G337_K0.6830.24
145_A294_S0.6830.24
324_F336_T0.6820.24
430_A434_L0.6800.24
423_L431_D0.6790.24
205_G208_S0.6790.24
46_G49_L0.6780.24
19_M26_P0.6780.24
432_T437_G0.6760.24
316_S331_G0.6750.24
366_N428_Q0.6740.24
325_V334_D0.6730.24
404_F418_H0.6700.24
131_H153_S0.6700.24
120_K159_T0.6700.24
329_I338_D0.6690.24
341_E346_D0.6670.23
386_L391_A0.6660.23
408_Y412_G0.6660.23
14_I32_T0.6650.23
349_T352_N0.6650.23
357_Q374_L0.6630.23
276_E279_K0.6630.23
314_R329_I0.6610.23
296_K300_S0.6610.23
316_S327_E0.6610.23
227_A259_G0.6590.23
195_D254_F0.6550.23
341_E348_P0.6540.23
330_L337_K0.6530.23
148_F223_N0.6520.23
66_G87_G0.6510.23
184_A196_P0.6500.23
316_S320_A0.6500.23
331_G338_D0.6500.23
153_S157_G0.6490.23
91_F390_T0.6480.23
356_V369_Q0.6470.23
320_A327_E0.6460.22
331_G343_P0.6460.22
376_I428_Q0.6460.22
400_K413_C0.6460.22
335_S341_E0.6430.22
87_G291_W0.6430.22
67_L108_V0.6420.22
334_D346_D0.6420.22
131_H291_W0.6410.22
109_K155_L0.6410.22
393_Y433_Y0.6400.22
316_S319_S0.6390.22
61_G92_R0.6350.22
166_I207_W0.6330.22
374_L392_R0.6310.22
15_T21_G0.6300.22
400_K408_Y0.6300.22
19_M29_A0.6300.22
192_R239_L0.6300.22
423_L437_G0.6290.22
393_Y407_D0.6270.22
228_L273_Q0.6270.22
296_K299_S0.6260.22
313_W335_S0.6250.22
407_D411_I0.6250.22
232_A261_S0.6230.21
430_A433_Y0.6230.21
193_K284_K0.6220.21
87_G227_A0.6220.21
358_Y377_K0.6210.21
315_L323_T0.6210.21
67_L115_A0.6190.21
16_L25_S0.6180.21
14_I23_I0.6180.21
380_G412_G0.6170.21
78_S293_L0.6160.21
431_D435_E0.6160.21
26_P29_A0.6160.21
324_F338_D0.6130.21
323_T332_T0.6120.21
76_K79_L0.6120.21
254_F287_S0.6110.21
65_H94_A0.6110.21
264_S271_L0.6080.21
395_Y407_D0.6070.21
404_F409_A0.6070.21
32_T376_I0.6070.21
22_M25_S0.6050.21
125_Y192_R0.6040.21
321_S341_E0.6030.21
82_L305_P0.6020.21
428_Q440_N0.6020.21
387_K395_Y0.6010.21
359_R375_Q0.6010.21
93_A176_W0.6000.20
35_P38_K0.6000.20
94_A165_E0.6000.20
348_P354_I0.5980.20
129_D195_D0.5970.20
94_A132_I0.5970.20
240_R248_S0.5970.20
300_S303_L0.5970.20
65_H167_A0.5960.20
301_S306_G0.5960.20
30_A390_T0.5940.20
21_G26_P0.5940.20
95_M165_E0.5930.20
318_L330_L0.5930.20
396_K406_C0.5930.20
421_V438_F0.5930.20
431_D439_K0.5920.20
323_T326_R0.5920.20
407_D431_D0.5900.20
153_S166_I0.5900.20
422_T428_Q0.5900.20
171_N179_D0.5880.20
397_A404_F0.5870.20
118_A122_L0.5820.20
360_A391_A0.5810.20
320_A326_R0.5800.20
345_K385_D0.5800.20
16_L26_P0.5790.20
131_H149_F0.5770.20
338_D377_K0.5770.20
369_Q423_L0.5770.20
423_L428_Q0.5740.19
125_Y164_Y0.5740.19
232_A260_T0.5730.19
298_E301_S0.5720.19
263_A305_P0.5700.19
149_F192_R0.5660.19
295_D306_G0.5660.19
390_T397_A0.5650.19
297_Q302_A0.5650.19
130_W256_T0.5650.19
192_R195_D0.5650.19
386_L434_L0.5620.19
25_S31_G0.5620.19
340_P348_P0.5610.19
339_I345_K0.5600.19
195_D223_N0.5590.19
388_D404_F0.5570.19
383_T397_A0.5570.19
374_L386_L0.5570.19
314_R338_D0.5560.19
117_E147_E0.5540.19
175_N179_D0.5540.19
94_A145_A0.5530.19
94_A230_F0.5510.18
153_S200_I0.5510.18
94_A273_Q0.5510.18
42_L60_K0.5500.18
338_D343_P0.5500.18
16_L21_G0.5490.18
260_T299_S0.5490.18
351_E440_N0.5480.18
105_N183_Y0.5480.18
345_K350_Q0.5450.18
429_G437_G0.5450.18
79_L115_A0.5420.18
400_K410_Q0.5410.18
388_D413_C0.5410.18
203_G277_W0.5400.18
67_L132_I0.5380.18
108_V164_Y0.5380.18
145_A192_R0.5380.18
329_I335_S0.5380.18
420_F429_G0.5370.18
131_H256_T0.5360.18
330_L340_P0.5360.18
142_K190_V0.5360.18
143_E379_N0.5350.18
20_G31_G0.5350.18
188_I195_D0.5330.18
66_G299_S0.5330.18
407_D410_Q0.5320.18
358_Y434_L0.5320.18
299_S306_G0.5320.18
387_K424_H0.5320.18
315_L319_S0.5300.18
431_D436_L0.5300.18
358_Y369_Q0.5290.18
129_D287_S0.5290.18
273_Q294_S0.5280.18
360_A370_I0.5270.18
365_M393_Y0.5260.18
377_K411_I0.5260.18
320_A323_T0.5250.18
134_N137_N0.5250.18
426_P439_K0.5250.18
302_A305_P0.5240.17
17_L24_A0.5220.17
134_N138_P0.5170.17
420_F428_Q0.5170.17
239_L243_A0.5170.17
156_Y195_D0.5160.17
392_R411_I0.5150.17
336_T348_P0.5150.17
314_R331_G0.5150.17
30_A419_K0.5140.17
357_Q368_N0.5130.17
94_A187_V0.5120.17
23_I32_T0.5120.17
297_Q307_A0.5100.17
318_L332_T0.5100.17
125_Y195_D0.5080.17
261_S264_S0.5080.17
403_N436_L0.5070.17
129_D292_N0.5070.17
48_Q197_D0.5060.17
14_I197_D0.5060.17
403_N406_C0.5060.17
129_D164_Y0.5050.17
337_K344_S0.5050.17
261_S298_E0.5050.17
341_E351_E0.5050.17
23_I26_P0.5050.17
208_S230_F0.5050.17
27_A33_K0.5040.17
420_F423_L0.5010.17
133_L242_K0.5010.17
113_K199_I0.5010.17
375_Q413_C0.5000.17
356_V392_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g01A 1 0.6293 100 0.592 Contact Map
3pztA 1 0.5932 100 0.6 Contact Map
3qhoA 1 0.5752 100 0.613 Contact Map
2cksA 1 0.5932 100 0.615 Contact Map
7a3hA 1 0.5992 100 0.624 Contact Map
2y8kA 1 0.8297 100 0.628 Contact Map
3wsuA 1 0.5731 100 0.629 Contact Map
3jugA 1 0.5671 100 0.63 Contact Map
1wkyA 1 0.8297 100 0.636 Contact Map
4v2xA 2 0.8537 100 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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