GREMLIN Database
EBRB - Multidrug resistance protein EbrB
UniProt: P0CW82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 117 (103)
Sequences: 4648 (3227)
Seq/√Len: 317.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_G100_V2.8101.00
13_S42_S2.6421.00
49_F52_K2.4821.00
20_M35_G2.2941.00
76_F83_I2.2891.00
6_Y49_F2.2551.00
3_G53_T2.2071.00
16_F39_G2.0741.00
74_V78_L1.9861.00
72_A91_L1.8841.00
11_I66_V1.8581.00
51_L59_A1.7151.00
93_L97_G1.6671.00
54_I59_A1.6591.00
17_G39_G1.5981.00
45_T49_F1.5561.00
31_W35_G1.5421.00
92_T96_A1.5221.00
40_F44_F1.5161.00
37_I41_L1.4771.00
85_L89_F1.4761.00
51_L56_L1.4691.00
27_F33_I1.4621.00
19_T23_L1.4511.00
93_L96_A1.4301.00
16_F35_G1.4111.00
29_Q32_P1.4071.00
21_L36_V1.4011.00
19_T74_V1.3791.00
15_V70_L1.3621.00
24_S33_I1.3451.00
17_G40_F1.3381.00
24_S27_F1.3321.00
6_Y46_F1.3131.00
50_S59_A1.3111.00
23_L79_F1.2751.00
99_V103_Q1.2641.00
90_G104_S1.2601.00
90_G97_G1.2561.00
13_S39_G1.2441.00
88_V92_T1.2391.00
94_V97_G1.2211.00
30_A33_I1.2111.00
84_S87_G1.1941.00
86_K104_S1.1591.00
94_V98_V1.1441.00
41_L45_T1.1201.00
91_L101_L1.1161.00
87_G101_L1.1151.00
16_F20_M1.1031.00
82_T87_G1.0821.00
68_T72_A1.0801.00
86_K89_F1.0731.00
47_L59_A1.0671.00
31_W34_A1.0611.00
83_I88_V1.0261.00
90_G94_V1.0221.00
25_E29_Q1.0091.00
75_G81_E1.0081.00
68_T95_I0.9951.00
81_E87_G0.9921.00
4_L62_T0.9861.00
8_A66_V0.9411.00
5_L9_L0.9291.00
22_K26_G0.9031.00
3_G6_Y0.9021.00
20_M23_L0.8951.00
34_A38_V0.8951.00
73_I77_L0.8901.00
83_I87_G0.8831.00
57_S61_A0.8791.00
85_L88_V0.8781.00
8_A11_I0.8761.00
25_E28_T0.8751.00
69_A91_L0.8711.00
30_A34_A0.8651.00
9_L46_F0.8641.00
58_S87_G0.8511.00
90_G93_L0.8361.00
62_T66_V0.8281.00
96_A100_V0.8091.00
61_A64_S0.8071.00
74_V79_F0.8061.00
11_I43_A0.8031.00
28_T52_K0.7901.00
56_L71_T0.7881.00
20_M39_G0.7851.00
3_G54_I0.7811.00
102_N105_K0.7771.00
28_T33_I0.7670.99
10_A46_F0.7670.99
18_S71_T0.7590.99
65_G98_V0.7550.99
15_V74_V0.7540.99
82_T85_L0.7430.99
28_T32_P0.7380.99
33_I36_V0.7370.99
55_D58_S0.7310.99
69_A95_I0.7160.99
76_F88_V0.7110.99
19_T79_F0.7090.99
20_M36_V0.7020.99
75_G79_F0.6990.99
86_K90_G0.6930.99
95_I99_V0.6860.99
21_L63_W0.6860.99
77_L80_G0.6810.99
12_V70_L0.6800.99
40_F64_S0.6790.99
93_L100_V0.6650.99
100_V104_S0.6560.98
27_F32_P0.6560.98
49_F53_T0.6550.98
56_L79_F0.6540.98
89_F93_L0.6530.98
38_V42_S0.6520.98
14_E43_A0.6510.98
19_T75_G0.6430.98
20_M24_S0.6400.98
40_F56_L0.6390.98
7_L50_S0.6370.98
35_G39_G0.6330.98
24_S29_Q0.6290.98
6_Y50_S0.6230.98
12_V16_F0.6230.98
66_V70_L0.6230.98
65_G68_T0.6160.98
64_S71_T0.6100.97
58_S61_A0.6090.97
3_G50_S0.6060.97
18_S40_F0.6040.97
24_S28_T0.6030.97
81_E84_S0.5970.97
61_A91_L0.5960.97
10_A47_L0.5770.96
64_S75_G0.5710.96
21_L44_F0.5660.96
17_G36_V0.5570.96
7_L59_A0.5370.95
39_G43_A0.5330.95
34_A37_I0.5320.94
44_F51_L0.5310.94
24_S36_V0.5280.94
61_A101_L0.5270.94
20_M37_I0.5210.94
28_T82_T0.5210.94
19_T22_K0.5200.94
70_L74_V0.5190.94
11_I98_V0.5190.94
27_F30_A0.5110.93
22_K25_E0.5070.93
50_S53_T0.5070.93
75_G87_G0.5050.93
76_F82_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.8718 99.9 0.373 Contact Map
2i68A 2 0.6667 99.9 0.39 Contact Map
4gx0A 3 0.7692 7.3 0.938 Contact Map
4ikvA 1 0.9231 7.3 0.938 Contact Map
4xnjA 1 0.9145 6.7 0.939 Contact Map
4qtnA 3 0.9145 6.2 0.94 Contact Map
1pw4A 1 0.9829 6.1 0.94 Contact Map
3effK 4 0.7863 6 0.94 Contact Map
4nv5A 1 0.9487 5.2 0.942 Contact Map
2cfqA 1 0.9744 4.8 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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