GREMLIN Database
EBRA - Multidrug resistance protein EbrA
UniProt: P0CW80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (100)
Sequences: 4246 (2985)
Seq/√Len: 298.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_G101_L3.0601.00
14_S43_L2.7131.00
50_L53_N2.5701.00
77_V84_L2.4021.00
4_G54_H2.3461.00
7_F50_L2.3391.00
21_M36_L2.3201.00
17_I40_G2.1111.00
73_T92_I2.0581.00
75_I79_W1.9811.00
12_I67_A1.9241.00
52_L60_S1.8071.00
32_K36_L1.7851.00
94_L98_G1.7771.00
55_I60_S1.7391.00
18_G40_G1.6141.00
93_L97_S1.5671.00
38_V42_S1.5361.00
17_I36_L1.4891.00
25_S34_S1.4521.00
41_Y45_F1.4431.00
86_A90_I1.4401.00
94_L97_S1.4321.00
20_A24_V1.4091.00
85_N88_G1.4071.00
20_A75_I1.3961.00
46_Y50_L1.3931.00
52_L57_L1.3791.00
28_F34_S1.3481.00
18_G41_Y1.3341.00
95_L98_G1.2971.00
92_I102_L1.2841.00
7_F47_M1.2811.00
91_G98_G1.2761.00
22_L37_V1.2761.00
25_S28_F1.2661.00
14_S40_G1.2661.00
89_L93_L1.2481.00
16_S71_L1.2461.00
24_V80_F1.2421.00
51_T60_S1.2381.00
31_W34_S1.2191.00
5_Y63_T1.1991.00
30_K33_P1.1911.00
91_G95_L1.1651.00
48_L60_S1.1571.00
83_D88_G1.1431.00
32_K35_A1.1171.00
17_I21_M1.1021.00
69_T73_T1.1011.00
84_L89_L1.0561.00
95_L99_V1.0411.00
9_T67_A1.0171.00
88_G102_L1.0161.00
87_K90_I1.0011.00
26_D30_K0.9871.00
23_K27_G0.9781.00
31_W35_A0.9771.00
84_L88_G0.9611.00
42_S46_Y0.9411.00
6_I10_I0.9351.00
74_V78_K0.9231.00
97_S101_L0.9221.00
63_T67_A0.9081.00
58_S62_A0.9051.00
4_G55_I0.9001.00
83_D86_A0.8981.00
82_E88_G0.8951.00
59_L88_G0.8941.00
4_G7_F0.8821.00
91_G94_L0.8801.00
70_V92_I0.8711.00
57_L72_T0.8631.00
10_I47_M0.8621.00
26_D29_K0.8341.00
86_A89_L0.8311.00
96_L100_V0.8311.00
94_L101_L0.8261.00
19_A72_T0.8251.00
21_M24_V0.8171.00
70_V96_L0.8161.00
9_T12_I0.8151.00
20_A80_F0.7900.99
35_A39_I0.7870.99
29_K53_N0.7810.99
16_S75_I0.7780.99
57_L80_F0.7620.99
75_I80_F0.7560.99
90_I94_L0.7530.99
65_S76_G0.7430.99
12_I44_A0.7410.99
29_K34_S0.7410.99
29_K33_P0.7400.99
69_T96_L0.7340.99
62_A65_S0.7280.99
76_G80_F0.7200.99
66_G99_V0.7040.99
35_A38_V0.6900.99
87_K91_G0.6890.99
18_G37_V0.6880.99
21_M37_V0.6780.98
76_G82_E0.6760.98
77_V83_D0.6650.98
15_E44_A0.6600.98
21_M40_G0.6490.98
13_C71_L0.6320.98
77_V89_L0.6250.97
34_S37_V0.6200.97
50_L54_H0.6190.97
13_C17_I0.6160.97
21_M25_S0.6150.97
78_K81_K0.6130.97
62_A92_I0.6120.97
41_Y65_S0.6100.97
39_I43_L0.6040.97
67_A71_L0.5970.96
8_L60_S0.5930.96
11_A47_M0.5910.96
28_F33_P0.5900.96
56_P59_L0.5900.96
20_A57_L0.5850.96
45_F52_L0.5790.96
90_I93_L0.5780.96
73_T102_L0.5730.96
11_A48_L0.5670.95
41_Y57_L0.5560.95
12_I99_V0.5540.95
36_L40_G0.5500.94
76_G88_G0.5490.94
23_K26_D0.5470.94
64_W95_L0.5470.94
27_G33_P0.5460.94
59_L62_A0.5450.94
25_S29_K0.5410.94
91_G97_S0.5400.94
82_E85_N0.5400.94
36_L39_I0.5400.94
18_G65_S0.5380.94
4_G51_T0.5360.94
58_S88_G0.5340.94
8_L55_I0.5340.94
14_S37_V0.5330.94
22_L64_W0.5250.93
45_F49_S0.5250.93
77_V82_E0.5220.93
25_S30_K0.5210.93
7_F51_T0.5090.92
70_V102_L0.5070.92
19_A41_Y0.5010.91
20_A23_K0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.9619 99.9 0.344 Contact Map
2i68A 2 0.7429 99.9 0.381 Contact Map
4gx0A 3 0.7333 3.6 0.941 Contact Map
4pypA 1 1 3.5 0.941 Contact Map
4f35D 2 0.8762 2.5 0.945 Contact Map
2ls4A 1 0.2286 2.4 0.946 Contact Map
3effK 4 0.7619 2.1 0.947 Contact Map
3rqwA 4 0.4952 1.8 0.949 Contact Map
2c9kA 1 0.3714 1.8 0.949 Contact Map
4xnjA 1 0.9905 1.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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