GREMLIN Database
XYLA - Xylose isomerase
UniProt: P0CI80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (428)
Sequences: 953 (381)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_F136_M4.8681.00
35_N38_E4.8031.00
133_K185_E4.5091.00
176_V218_F4.4051.00
38_E374_K4.1401.00
253_A271_L3.5751.00
44_T47_E3.5731.00
213_D263_Y3.5681.00
89_V132_I3.5151.00
130_G185_E3.4441.00
364_A436_A3.1520.99
181_E225_Y3.0810.99
104_F132_I3.0790.99
402_L406_E2.9800.99
41_G377_H2.9710.99
190_N236_L2.9620.99
228_E412_H2.9610.99
210_F397_T2.9280.99
21_E27_N2.8980.99
146_N183_A2.8090.98
183_A188_A2.7910.98
40_I374_K2.6970.98
95_M359_I2.6560.98
388_V434_L2.4870.96
253_A273_L2.4730.96
161_A218_F2.4690.96
96_F141_V2.4540.96
33_Y374_K2.4460.96
129_M182_T2.4360.96
46_K102_P2.4080.96
90_E135_Y2.3940.95
31_F366_M2.3860.95
20_Y23_K2.3730.95
214_N405_I2.3730.95
257_I297_L2.3620.95
39_V44_T2.3070.94
377_H381_E2.3060.94
59_F92_A2.2740.94
32_K440_Q2.2580.94
301_V331_I2.2460.94
53_I101_A2.1940.93
293_R334_N2.1530.92
97_E141_V2.1370.92
92_A96_F2.1210.91
37_Q44_T2.1080.91
53_I59_F2.1070.91
316_E435_K2.0940.91
387_D391_H2.0420.90
403_E408_R2.0410.90
59_F96_F2.0360.90
289_L301_V2.0000.89
324_T368_A1.9940.89
332_L373_L1.9450.87
103_F189_E1.9220.87
86_K127_M1.9160.87
53_I99_L1.9080.86
409_A413_T1.9080.86
410_N413_T1.8590.85
163_S396_F1.8580.85
117_T120_E1.8440.84
35_N374_K1.8420.84
209_K262_Q1.8340.84
129_M185_E1.8180.83
134_D138_N1.8160.83
146_N188_A1.7680.82
135_Y138_N1.7620.81
69_A154_P1.7440.81
82_M127_M1.7180.80
98_K359_I1.7170.80
37_Q46_K1.6970.79
115_G124_N1.6920.79
334_N337_L1.6860.78
45_L373_L1.6860.78
179_G183_A1.6850.78
257_I261_K1.6620.77
433_K437_I1.6530.77
162_T219_M1.6460.77
109_R121_T1.6290.76
210_F405_I1.6230.76
193_F222_A1.6070.75
55_Y92_A1.5970.74
29_L360_Y1.5940.74
220_H264_G1.5810.74
102_P141_V1.5670.73
246_T307_H1.5660.73
210_F214_N1.5570.73
51_F366_M1.5490.72
201_E351_S1.5390.72
90_E131_M1.5350.71
208_L291_M1.5260.71
146_N179_G1.5240.71
212_L254_A1.5230.71
275_A285_F1.5200.71
329_Y379_L1.5190.71
261_K266_D1.5140.70
192_V236_L1.5080.70
223_V268_H1.4990.70
129_M133_K1.4890.69
109_R122_N1.4780.68
226_A235_F1.4780.68
25_S32_K1.4700.68
130_G133_K1.4570.67
401_G404_I1.4560.67
390_Q397_T1.4540.67
53_I96_F1.4240.66
235_F269_F1.4220.65
242_K310_L1.4220.65
133_K137_R1.4210.65
258_A261_K1.4180.65
301_V342_L1.3900.64
256_T271_L1.3900.64
169_F396_F1.3890.64
227_K268_H1.3870.63
112_A124_N1.3640.62
416_Q420_N1.3480.61
365_G368_A1.3450.61
223_V227_K1.3450.61
257_I295_H1.3430.61
54_A362_H1.3420.61
415_E419_L1.3420.61
27_N30_A1.3380.61
212_L263_Y1.3330.60
318_P365_G1.3220.60
109_R175_Q1.3200.59
220_H224_D1.3150.59
385_F438_L1.3090.59
119_K123_Q1.3090.59
298_L337_L1.3070.59
180_L226_A1.2900.58
218_F411_F1.2770.57
289_L327_A1.2670.56
21_E25_S1.2640.56
378_K441_Y1.2620.56
384_V441_Y1.2600.56
21_E30_A1.2590.56
183_A233_G1.2540.55
208_L254_A1.2410.55
60_T88_R1.2400.55
285_F327_A1.2390.55
132_I136_M1.2320.54
114_E171_Y1.2230.54
397_T405_I1.2220.53
18_V359_I1.2100.53
69_A152_T1.2100.53
121_T171_Y1.2000.52
35_N40_I1.2000.52
403_E413_T1.1930.52
262_Q295_H1.1930.52
166_A395_S1.1920.52
162_T212_L1.1860.51
48_H52_S1.1720.50
81_G84_L1.1700.50
356_D360_Y1.1690.50
320_D323_S1.1680.50
356_D430_R1.1670.50
184_K229_I1.1560.49
97_E139_S1.1490.49
255_T291_M1.1480.49
158_H351_S1.1480.49
290_R330_E1.1450.49
50_R103_F1.1440.49
360_Y436_A1.1360.48
97_E138_N1.1360.48
333_Q386_E1.1350.48
18_V29_L1.1200.47
29_L109_R1.1150.47
334_N338_G1.1110.47
118_L418_A1.1070.46
58_T358_L1.1020.46
179_G188_A1.1010.46
276_N306_G1.0960.46
324_T372_G1.0850.45
114_E121_T1.0840.45
33_Y38_E1.0810.45
86_K128_I1.0750.44
254_A291_M1.0750.44
39_V42_G1.0710.44
234_Q339_S1.0700.44
36_P100_D1.0680.44
126_D178_K1.0680.44
86_K131_M1.0640.44
180_L235_F1.0630.44
117_T121_T1.0630.44
51_F369_F1.0610.43
53_I100_D1.0560.43
305_Q319_T1.0500.43
242_K309_L1.0480.43
114_E153_N1.0460.43
66_V71_T1.0430.42
431_Q435_K1.0400.42
286_E320_D1.0330.42
142_K189_E1.0330.42
19_V420_N1.0310.42
121_T174_A1.0250.41
333_Q380_I1.0240.41
253_A257_I1.0210.41
25_S28_P1.0210.41
332_L380_I1.0150.41
216_A220_H1.0100.40
234_Q270_K1.0100.40
258_A291_M1.0080.40
113_P124_N1.0070.40
190_N338_G1.0060.40
222_A235_F1.0060.40
165_N427_E1.0040.40
48_H373_L1.0040.40
166_A400_I1.0020.40
128_I132_I1.0010.40
146_N435_K0.9990.40
43_K48_H0.9970.40
91_A355_P0.9920.39
161_A215_L0.9890.39
58_T348_V0.9860.39
89_V131_M0.9830.39
226_A268_H0.9820.39
360_Y430_R0.9770.38
125_L182_T0.9730.38
432_E435_K0.9700.38
215_L219_M0.9670.38
131_M135_Y0.9660.38
146_N316_E0.9650.38
220_H223_V0.9550.37
404_I414_L0.9530.37
72_M348_V0.9500.37
184_K226_A0.9440.37
165_N426_N0.9430.36
236_L338_G0.9380.36
184_K232_T0.9370.36
63_G246_T0.9280.36
212_L215_L0.9280.36
40_I373_L0.9270.36
100_D140_G0.9190.35
20_Y35_N0.9140.35
236_L339_S0.9120.35
60_T81_G0.9120.35
222_A411_F0.9100.35
175_Q179_G0.9050.34
388_V433_K0.8970.34
18_V363_I0.8970.34
325_T375_V0.8950.34
271_L297_L0.8930.34
321_L368_A0.8930.34
161_A176_V0.8920.34
261_K295_H0.8910.34
33_Y440_Q0.8910.34
42_G377_H0.8900.33
64_T69_A0.8890.33
253_A288_E0.8880.33
208_L290_R0.8850.33
166_A399_G0.8840.33
14_S26_T0.8810.33
116_S120_E0.8780.33
400_I417_Y0.8740.33
207_D210_F0.8690.32
103_F142_K0.8640.32
169_F404_I0.8630.32
380_I386_E0.8600.32
14_S356_D0.8580.32
150_M172_A0.8550.32
328_M342_L0.8550.32
319_T364_A0.8530.31
285_F289_L0.8500.31
371_R375_V0.8500.31
380_I441_Y0.8490.31
105_A365_G0.8460.31
45_L332_L0.8460.31
293_R330_E0.8440.31
36_P46_K0.8430.31
166_A396_F0.8430.31
65_D198_E0.8340.30
95_M98_K0.8340.30
18_V31_F0.8330.30
207_D390_Q0.8310.30
217_R405_I0.8290.30
100_D141_V0.8270.30
342_L369_F0.8270.30
261_K297_L0.8240.30
15_A356_D0.8230.30
115_G153_N0.8230.30
82_M113_P0.8220.30
213_D262_Q0.8200.30
384_V388_V0.8190.30
255_T258_A0.8180.30
22_G25_S0.8150.29
160_A431_Q0.8120.29
44_T102_P0.8090.29
41_G380_I0.8050.29
19_V402_L0.8010.29
50_R339_S0.8000.29
150_M156_F0.7990.29
19_V267_N0.7970.29
52_S251_T0.7960.28
59_F141_V0.7960.28
24_D39_V0.7950.28
305_Q316_E0.7930.28
258_A295_H0.7930.28
213_D416_Q0.7920.28
319_T365_G0.7920.28
83_D139_S0.7910.28
214_N397_T0.7900.28
96_F101_A0.7880.28
141_V172_A0.7870.28
384_V387_D0.7840.28
43_K47_E0.7800.28
208_L294_V0.7790.28
418_A421_H0.7740.27
193_F235_F0.7690.27
74_R348_V0.7680.27
157_V426_N0.7670.27
178_K181_E0.7670.27
208_L295_H0.7660.27
54_A105_A0.7660.27
19_V24_D0.7620.27
383_R386_E0.7620.27
118_L126_D0.7620.27
378_K382_D0.7600.27
253_A292_A0.7590.27
237_I269_F0.7550.26
83_D87_M0.7540.26
202_T434_L0.7530.26
31_F342_L0.7480.26
212_L291_M0.7460.26
256_T316_E0.7450.26
26_T440_Q0.7440.26
52_S105_A0.7430.26
95_M99_L0.7420.26
32_K39_V0.7410.26
29_L356_D0.7410.26
22_G27_N0.7410.26
109_R115_G0.7400.26
400_I404_I0.7400.26
100_D139_S0.7390.26
94_E332_L0.7380.26
136_M140_G0.7380.26
115_G120_E0.7320.25
319_T368_A0.7270.25
149_N152_T0.7270.25
48_H332_L0.7250.25
105_A289_L0.7240.25
316_E432_E0.7220.25
121_T178_K0.7200.25
53_I92_A0.7190.25
148_A156_F0.7180.25
112_A131_M0.7180.25
236_L337_L0.7170.25
306_G310_L0.7140.25
189_E232_T0.7140.25
190_N337_L0.7140.25
65_D197_R0.7120.24
63_G72_M0.7100.24
183_A231_Y0.7090.24
316_E365_G0.7090.24
275_A279_T0.7060.24
215_L442_I0.7040.24
214_N217_R0.7030.24
298_L338_G0.7020.24
59_F95_M0.7020.24
96_F102_P0.6970.24
146_N191_Y0.6960.24
53_I362_H0.6960.24
202_T351_S0.6940.24
257_I291_M0.6940.24
278_A288_E0.6940.24
122_N178_K0.6930.24
167_D417_Y0.6930.24
348_V358_L0.6920.24
16_N26_T0.6920.24
40_I377_H0.6890.23
36_P44_T0.6890.23
275_A308_P0.6870.23
37_Q62_D0.6860.23
391_H427_E0.6860.23
189_E339_S0.6840.23
360_Y364_A0.6820.23
111_I128_I0.6820.23
417_Y421_H0.6810.23
310_L404_I0.6800.23
140_G410_N0.6790.23
276_N279_T0.6790.23
353_F426_N0.6780.23
41_G44_T0.6770.23
216_A262_Q0.6760.23
193_F268_H0.6740.23
324_T369_F0.6730.23
65_D68_G0.6730.23
118_L178_K0.6730.23
389_I410_N0.6720.23
26_T382_D0.6720.23
257_I396_F0.6710.23
316_E319_T0.6700.23
234_Q309_L0.6680.22
305_Q364_A0.6680.22
375_V441_Y0.6670.22
325_T332_L0.6670.22
216_A266_D0.6660.22
18_V398_E0.6650.22
111_I131_M0.6640.22
122_N185_E0.6640.22
309_L323_S0.6640.22
321_L371_R0.6640.22
256_T435_K0.6620.22
81_G112_A0.6600.22
99_L385_F0.6570.22
31_F51_F0.6560.22
225_Y410_N0.6550.22
126_D182_T0.6550.22
16_N19_V0.6550.22
201_E310_L0.6540.22
18_V27_N0.6530.22
109_R112_A0.6520.22
126_D185_E0.6520.22
26_T267_N0.6510.22
19_V46_K0.6500.22
119_K419_L0.6480.22
122_N126_D0.6470.22
83_D137_R0.6460.22
375_V442_I0.6460.22
183_A435_K0.6450.21
114_E120_E0.6450.21
50_R102_P0.6420.21
253_A291_M0.6400.21
118_L122_N0.6390.21
54_A226_A0.6380.21
355_P360_Y0.6360.21
400_I403_E0.6350.21
22_G30_A0.6340.21
386_E389_I0.6340.21
219_M223_V0.6340.21
365_G432_E0.6320.21
17_K46_K0.6310.21
45_L374_K0.6300.21
119_K420_N0.6300.21
234_Q298_L0.6300.21
301_V337_L0.6290.21
70_A154_P0.6280.21
256_T273_L0.6280.21
401_G414_L0.6270.21
297_L422_K0.6270.21
54_A60_T0.6270.21
212_L262_Q0.6260.21
20_Y361_A0.6260.21
104_F140_G0.6250.21
138_N141_V0.6240.21
27_N289_L0.6230.21
139_S282_G0.6220.21
223_V226_A0.6200.20
180_L401_G0.6200.20
26_T384_V0.6160.20
153_N171_Y0.6160.20
156_F172_A0.6150.20
95_M358_L0.6130.20
109_R116_S0.6120.20
318_P329_Y0.6120.20
221_M413_T0.6110.20
46_K140_G0.6100.20
273_L301_V0.6090.20
161_A180_L0.6090.20
122_N415_E0.6070.20
24_D416_Q0.6070.20
55_Y89_V0.6060.20
118_L213_D0.6060.20
293_R298_L0.6050.20
193_F227_K0.6040.20
39_V377_H0.6030.20
148_A176_V0.6010.20
202_T349_R0.6000.20
257_I271_L0.5990.20
114_E117_T0.5990.20
66_V77_D0.5990.20
132_I182_T0.5980.20
53_I58_T0.5970.20
332_L376_A0.5970.20
190_N234_Q0.5960.19
26_T408_R0.5950.19
112_A115_G0.5950.19
118_L182_T0.5940.19
251_T282_G0.5940.19
118_L171_Y0.5940.19
273_L289_L0.5930.19
156_F175_Q0.5930.19
39_V408_R0.5930.19
437_I440_Q0.5920.19
37_Q47_E0.5920.19
97_E140_G0.5920.19
286_E327_A0.5920.19
191_Y296_G0.5910.19
41_G332_L0.5910.19
21_E28_P0.5910.19
202_T223_V0.5890.19
158_H353_F0.5890.19
91_A327_A0.5880.19
379_L384_V0.5870.19
236_L270_K0.5870.19
360_Y433_K0.5860.19
22_G28_P0.5850.19
100_D172_A0.5850.19
17_K79_Y0.5840.19
70_A153_N0.5830.19
17_K97_E0.5820.19
15_A359_I0.5800.19
121_T182_T0.5800.19
104_F410_N0.5800.19
413_T416_Q0.5790.19
223_V269_F0.5780.19
181_E213_D0.5760.19
26_T123_Q0.5750.19
150_M245_T0.5740.19
79_Y84_L0.5740.19
326_L330_E0.5730.19
120_E124_N0.5720.19
349_R432_E0.5720.19
84_L113_P0.5720.19
14_S19_V0.5710.19
25_S30_A0.5710.19
49_L282_G0.5710.19
97_E136_M0.5700.18
41_G381_E0.5690.18
320_D326_L0.5690.18
207_D214_N0.5690.18
276_N310_L0.5680.18
18_V109_R0.5680.18
92_A141_V0.5670.18
96_F362_H0.5670.18
209_K293_R0.5660.18
37_Q127_M0.5660.18
286_E326_L0.5650.18
58_T81_G0.5640.18
36_P77_D0.5640.18
219_M327_A0.5640.18
264_G297_L0.5630.18
320_D325_T0.5620.18
386_E390_Q0.5620.18
55_Y59_F0.5610.18
125_L178_K0.5600.18
403_E409_A0.5600.18
62_D69_A0.5590.18
399_G402_L0.5590.18
266_D297_L0.5580.18
271_L422_K0.5580.18
44_T69_A0.5580.18
167_D400_I0.5580.18
396_F399_G0.5580.18
421_H424_I0.5570.18
359_I363_I0.5560.18
290_R305_Q0.5550.18
84_L87_M0.5550.18
178_K182_T0.5540.18
192_V334_N0.5530.18
132_I415_E0.5530.18
220_H263_Y0.5500.18
215_L414_L0.5500.18
214_N409_A0.5490.18
23_K32_K0.5490.18
61_A72_M0.5480.18
144_L328_M0.5470.18
242_K251_T0.5460.18
114_E155_R0.5450.18
44_T50_R0.5450.18
40_I371_R0.5450.18
77_D84_L0.5440.18
291_M295_H0.5430.17
20_Y320_D0.5430.17
144_L265_L0.5430.17
87_M382_D0.5420.17
15_A29_L0.5420.17
214_N407_G0.5410.17
384_V440_Q0.5400.17
319_T432_E0.5400.17
123_Q127_M0.5380.17
122_N156_F0.5380.17
132_I167_D0.5370.17
14_S172_A0.5360.17
396_F400_I0.5360.17
301_V308_P0.5360.17
276_N328_M0.5350.17
18_V100_D0.5350.17
17_K270_K0.5350.17
384_V437_I0.5330.17
31_F180_L0.5320.17
61_A351_S0.5320.17
150_M176_V0.5310.17
91_A98_K0.5300.17
180_L208_L0.5300.17
296_G338_G0.5300.17
117_T418_A0.5300.17
29_L41_G0.5290.17
382_D441_Y0.5280.17
162_T437_I0.5270.17
330_E334_N0.5260.17
32_K377_H0.5260.17
82_M112_A0.5250.17
157_V353_F0.5240.17
94_E98_K0.5240.17
382_D434_L0.5240.17
234_Q337_L0.5230.17
242_K353_F0.5230.17
50_R189_E0.5210.17
91_A359_I0.5200.17
179_G286_E0.5190.17
49_L342_L0.5180.17
236_L384_V0.5180.17
90_E138_N0.5180.17
306_G328_M0.5180.17
80_K127_M0.5170.17
245_T307_H0.5170.17
326_L329_Y0.5160.17
224_D227_K0.5160.17
83_D290_R0.5160.17
226_A260_L0.5150.17
202_T431_Q0.5140.16
38_E213_D0.5130.16
251_T309_L0.5130.16
70_A426_N0.5130.16
284_T417_Y0.5120.16
316_E431_Q0.5120.16
20_Y73_Q0.5100.16
58_T170_A0.5100.16
39_V46_K0.5100.16
60_T79_Y0.5090.16
399_G403_E0.5090.16
97_E391_H0.5090.16
125_L129_M0.5080.16
111_I227_K0.5080.16
60_T84_L0.5080.16
143_L186_L0.5070.16
105_A191_Y0.5070.16
103_F187_G0.5070.16
153_N175_Q0.5070.16
35_N416_Q0.5060.16
79_Y188_A0.5060.16
40_I332_L0.5040.16
39_V301_V0.5040.16
236_L334_N0.5040.16
73_Q77_D0.5030.16
390_Q398_E0.5030.16
49_L373_L0.5030.16
59_F101_A0.5020.16
123_Q381_E0.5020.16
50_R209_K0.5010.16
374_K378_K0.5000.16
82_M348_V0.5000.16
149_N310_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0cA 4 0.9798 100 0.486 Contact Map
1ximA 4 0.8539 100 0.705 Contact Map
1xlaA 4 0.8539 100 0.706 Contact Map
1muwA 4 0.8539 100 0.71 Contact Map
1bxbA 4 0.8539 100 0.726 Contact Map
3p14A 2 0.8629 100 0.735 Contact Map
3m0mA 4 0.8629 100 0.839 Contact Map
3ktcA 4 0.7371 100 0.844 Contact Map
1d8wA 4 0.8135 100 0.851 Contact Map
3cqjA 2 0.618 99.4 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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