GREMLIN Database
TYSY1 - Thymidylate synthase 1
UniProt: P0CI79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (262)
Sequences: 2940 (1311)
Seq/√Len: 81.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_I185_M3.8491.00
240_F269_H3.6931.00
14_D18_N3.6151.00
76_W127_V3.3981.00
253_D256_D3.0541.00
14_D46_K2.9951.00
21_S41_L2.8871.00
240_F268_K2.8331.00
133_Q143_H2.7481.00
223_V231_L2.6561.00
132_H136_N2.5681.00
218_I221_C2.5451.00
64_A67_T2.5291.00
233_I236_E2.5051.00
92_H95_D2.5021.00
13_K17_N2.4871.00
176_L200_Q2.4571.00
130_L143_H2.4131.00
14_D43_V2.3241.00
201_R211_L2.2831.00
65_W69_I2.2491.00
246_W263_K2.1541.00
84_N88_M2.1151.00
21_S225_T2.1061.00
201_R245_L2.0751.00
83_V87_N2.0751.00
246_W265_I2.0731.00
131_L203_I2.0521.00
240_F270_G2.0351.00
41_L228_I1.9861.00
80_S110_F1.9781.00
16_I232_K1.9441.00
131_L254_F1.9181.00
206_V257_F1.9141.00
113_G125_D1.8911.00
34_D39_H1.8681.00
51_D54_E1.8271.00
33_S139_S1.8121.00
183_N189_N1.8111.00
32_D139_S1.7941.00
248_N261_D1.7901.00
69_I262_F1.7281.00
70_K89_M1.7151.00
110_F117_R1.7041.00
63_V68_A1.6891.00
134_L207_T1.6881.00
49_R213_E1.6741.00
53_S173_K1.6441.00
70_K85_D1.6301.00
247_I262_F1.6131.00
244_E266_N1.6041.00
85_D89_M1.5961.00
87_N92_H1.5931.00
41_L225_T1.5921.00
70_K91_V1.5701.00
116_N121_G1.5601.00
114_K123_K1.5350.99
12_I231_L1.5250.99
87_N95_D1.5210.99
57_I63_V1.4990.99
118_S122_E1.4960.99
251_V257_F1.4950.99
145_T165_T1.4520.99
216_F221_C1.4410.99
21_S228_I1.4250.99
12_I185_M1.4220.99
20_I171_H1.4190.99
238_E270_G1.4180.99
173_K210_E1.4150.99
248_N263_K1.4130.99
131_L207_T1.3980.99
43_V46_K1.3850.99
185_M221_C1.3840.99
42_S168_Y1.3830.99
134_L143_H1.3800.99
66_K90_G1.3770.99
130_L203_I1.3410.99
133_Q137_N1.3380.99
20_I170_K1.3150.98
178_V214_Y1.3100.98
172_G209_Y1.2980.98
167_W203_I1.2930.98
206_V251_V1.2920.98
153_L159_T1.2870.98
130_L133_Q1.2670.98
57_I264_L1.2640.98
245_L262_F1.2570.98
244_E265_I1.2550.98
129_Y133_Q1.2410.98
70_K259_I1.2370.98
38_A278_A1.2350.98
245_L264_L1.2340.98
6_K10_S1.2330.97
128_D132_H1.2290.97
201_R264_L1.2170.97
152_E155_A1.2050.97
249_P252_K1.1960.97
97_W277_V1.1760.97
65_W264_L1.1680.97
21_S33_S1.1650.96
231_L275_F1.1470.96
183_N218_I1.1330.96
146_M150_P1.1310.96
47_Q217_N1.1300.96
110_F123_K1.1300.96
110_F152_E1.1210.96
223_V275_F1.1170.95
229_D232_K1.1170.95
128_D255_Y1.1160.95
228_I232_K1.1150.95
186_A275_F1.1090.95
46_K185_M1.1040.95
167_W176_L1.0970.95
168_Y175_H1.0850.95
9_N239_Q1.0770.95
16_I228_I1.0580.94
130_L167_W1.0520.94
241_E268_K1.0490.94
11_I185_M1.0420.93
79_K85_D1.0390.93
16_I223_V1.0390.93
117_R122_E1.0390.93
226_R278_A1.0330.93
129_Y132_H1.0280.93
177_E217_N1.0220.93
118_S124_V1.0130.92
129_Y154_D1.0080.92
180_A183_N0.9980.92
272_K277_V0.9930.92
183_N216_F0.9930.92
202_M206_V0.9920.92
185_M189_N0.9910.92
186_A231_L0.9850.91
268_K271_D0.9830.91
117_R123_K0.9740.91
12_I223_V0.9730.91
134_L203_I0.9620.90
169_V209_Y0.9610.90
186_A230_N0.9570.90
84_N87_N0.9440.90
205_Q249_P0.9430.90
63_V272_K0.9430.90
49_R215_I0.9410.89
111_Q149_N0.9380.89
130_L145_T0.9370.89
60_T234_Q0.9360.89
18_N43_V0.9290.89
34_D38_A0.9260.89
201_R262_F0.9200.88
179_R219_G0.9200.88
70_K258_T0.9140.88
39_H225_T0.9140.88
189_N218_I0.9130.88
62_K272_K0.9120.88
230_N275_F0.9110.88
134_L209_Y0.9040.87
205_Q248_N0.9040.87
119_L123_K0.8970.87
53_S212_G0.8930.87
175_H213_E0.8920.87
110_F114_K0.8860.86
53_S210_E0.8740.86
11_I46_K0.8730.86
9_N234_Q0.8680.85
133_Q136_N0.8660.85
6_K242_A0.8630.85
170_K175_H0.8630.85
202_M262_F0.8600.85
69_I264_L0.8600.85
18_N46_K0.8570.85
13_K232_K0.8510.84
172_G210_E0.8500.84
233_I272_K0.8500.84
85_D88_M0.8470.84
87_N90_G0.8460.84
69_I198_V0.8440.84
65_W245_L0.8440.84
225_T228_I0.8400.83
229_D233_I0.8400.83
247_I257_F0.8360.83
133_Q140_S0.8360.83
114_K117_R0.8360.83
252_K257_F0.8340.83
225_T278_A0.8320.83
87_N101_D0.8320.83
164_E179_R0.8270.82
106_H110_F0.8230.82
62_K269_H0.8210.82
118_S123_K0.8180.82
248_N251_V0.8130.81
146_M163_Y0.8090.81
253_D257_F0.8070.81
10_S13_K0.8060.81
206_V253_D0.8010.80
111_Q156_M0.8000.80
12_I275_F0.7950.80
173_K212_G0.7820.79
32_D42_S0.7800.79
16_I41_L0.7760.78
77_Q258_T0.7750.78
118_S151_D0.7750.78
197_N214_Y0.7690.78
177_E219_G0.7690.78
248_N252_K0.7690.78
57_I194_F0.7680.77
67_T70_K0.7680.77
52_N200_Q0.7680.77
119_L151_D0.7620.77
163_Y179_R0.7570.76
139_S172_G0.7570.76
150_P156_M0.7540.76
136_N143_H0.7520.76
116_N123_K0.7430.75
75_I195_Q0.7400.75
208_G250_E0.7400.75
178_V216_F0.7380.75
10_S14_D0.7370.74
166_Q219_G0.7350.74
34_D225_T0.7330.74
64_A92_H0.7330.74
116_N120_N0.7320.74
156_M160_P0.7320.74
69_I259_I0.7300.74
116_N119_L0.7270.73
58_L269_H0.7230.73
238_E241_E0.7210.73
159_T163_Y0.7190.73
202_M257_F0.7190.73
251_V258_T0.7190.73
203_I207_T0.7120.72
74_W86_L0.7110.72
6_K13_K0.7080.71
72_L195_Q0.7000.71
152_E156_M0.6990.71
248_N257_F0.6980.70
104_I107_A0.6960.70
32_D168_Y0.6950.70
83_V89_M0.6890.69
163_Y178_V0.6840.69
179_R217_N0.6770.68
151_D154_D0.6760.68
240_F271_D0.6710.67
11_I48_M0.6700.67
202_M205_Q0.6690.67
64_A90_G0.6690.67
7_Q10_S0.6680.67
143_H207_T0.6660.67
189_N216_F0.6660.67
144_I148_W0.6640.67
70_K77_Q0.6630.66
69_I245_L0.6630.66
211_L245_L0.6620.66
73_L262_F0.6620.66
79_K82_D0.6620.66
202_M251_V0.6610.66
205_Q257_F0.6590.66
150_P153_L0.6580.66
189_N214_Y0.6570.66
249_P257_F0.6560.66
20_I32_D0.6560.66
165_T196_Y0.6530.65
208_G252_K0.6530.65
117_R152_E0.6530.65
111_Q152_E0.6510.65
99_Q103_T0.6510.65
7_Q242_A0.6490.65
127_V145_T0.6470.65
210_E213_E0.6470.65
153_L156_M0.6440.64
180_A189_N0.6430.64
46_K221_C0.6420.64
51_D213_E0.6390.64
223_V228_I0.6350.63
41_L232_K0.6350.63
250_E257_F0.6340.63
135_K207_T0.6320.63
91_V259_I0.6320.63
53_S211_L0.6310.63
89_M259_I0.6310.63
92_H276_E0.6300.63
9_N235_M0.6290.62
112_L147_L0.6250.62
40_T141_R0.6250.62
33_S41_L0.6240.62
66_K70_K0.6220.62
180_A216_F0.6220.62
13_K236_E0.6210.61
198_V245_L0.6180.61
196_Y214_Y0.6160.61
9_N242_A0.6150.61
183_N221_C0.6130.60
83_V97_W0.6100.60
200_Q203_I0.6100.60
82_D85_D0.6090.60
205_Q251_V0.6090.60
67_T91_V0.6070.60
129_Y153_L0.6060.60
63_V269_H0.6060.60
77_Q85_D0.6050.59
246_W249_P0.6040.59
178_V183_N0.6030.59
124_V151_D0.5980.59
38_A226_R0.5980.59
42_S220_D0.5960.58
110_F119_L0.5950.58
118_S121_G0.5930.58
9_N58_L0.5930.58
149_N156_M0.5930.58
11_I50_F0.5920.58
83_V107_A0.5910.58
17_N232_K0.5910.58
47_Q177_E0.5900.58
64_A259_I0.5900.58
58_L63_V0.5900.58
48_M218_I0.5880.57
47_Q215_I0.5820.57
127_V254_F0.5820.57
248_N260_D0.5780.56
232_K236_E0.5770.56
106_H111_Q0.5750.56
172_G212_G0.5730.55
46_K50_F0.5720.55
170_K173_K0.5710.55
206_V249_P0.5700.55
17_N20_I0.5690.55
142_R158_L0.5630.54
89_M258_T0.5630.54
226_R276_E0.5610.54
65_W201_R0.5610.54
175_H215_I0.5590.54
67_T87_N0.5570.53
9_N13_K0.5560.53
127_V203_I0.5550.53
186_A227_H0.5540.53
117_R121_G0.5540.53
69_I73_L0.5510.52
92_H278_A0.5500.52
83_V95_D0.5490.52
193_V196_Y0.5490.52
269_H272_K0.5470.52
13_K16_I0.5430.51
137_N159_T0.5430.51
41_L223_V0.5380.51
87_N100_E0.5380.51
105_G111_Q0.5380.51
252_K256_D0.5380.51
96_Q277_V0.5370.51
134_L169_V0.5360.51
87_N107_A0.5350.50
98_K101_D0.5350.50
205_Q250_E0.5340.50
200_Q207_T0.5340.50
79_K103_T0.5340.50
6_K9_N0.5340.50
64_A89_M0.5310.50
249_P263_K0.5310.50
137_N140_S0.5310.50
85_D96_Q0.5270.49
55_V194_F0.5260.49
147_L156_M0.5240.49
50_F216_F0.5230.49
50_F193_V0.5210.49
34_D40_T0.5190.48
175_H212_G0.5190.48
249_P261_D0.5190.48
35_G158_L0.5190.48
266_N269_H0.5180.48
123_K151_D0.5180.48
38_A225_T0.5180.48
249_P262_F0.5170.48
106_H156_M0.5170.48
32_D175_H0.5140.48
67_T90_G0.5140.48
173_K213_E0.5130.48
130_L165_T0.5120.47
202_M247_I0.5110.47
97_W102_G0.5100.47
9_N16_I0.5100.47
93_I191_F0.5090.47
58_L159_T0.5070.47
111_Q126_Q0.5070.47
117_R120_N0.5060.47
110_F153_L0.5050.47
173_K211_L0.5050.47
52_N197_N0.5050.47
38_A276_E0.5040.46
131_L134_L0.5040.46
108_Y184_D0.5030.46
64_A70_K0.5030.46
15_I43_V0.5020.46
187_L234_Q0.5010.46
58_L242_A0.5000.46
143_H153_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bkpA 2 0.9964 100 0.021 Contact Map
4iqbA 2 0.9462 100 0.024 Contact Map
3v8hA 2 0.914 100 0.025 Contact Map
3nrrA 2 0.9606 100 0.026 Contact Map
4g9uA 2 0.9498 100 0.028 Contact Map
1hw4A 2 0.914 100 0.028 Contact Map
3uwlA 2 0.9462 100 0.029 Contact Map
3qg2A 2 0.9606 100 0.029 Contact Map
1j3kC 2 0.9606 100 0.029 Contact Map
3irmA 4 0.9606 100 0.029 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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