GREMLIN Database
RL24 - 50S ribosomal protein L24
UniProt: P0CI78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 103 (100)
Sequences: 2633 (1472)
Seq/√Len: 147.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_V68_V3.1291.00
42_K58_N3.0541.00
3_V23_I2.6161.00
10_M20_Q2.4621.00
31_D64_H2.1271.00
41_V61_A2.1231.00
42_K56_I2.0851.00
22_T36_E2.0751.00
74_K99_Q1.9241.00
72_D97_S1.9061.00
82_G95_K1.8971.00
85_V90_K1.8931.00
8_K20_Q1.8431.00
94_A97_S1.7711.00
12_I69_M1.7411.00
72_D94_A1.7391.00
79_T94_A1.7271.00
84_K93_V1.7091.00
75_T97_S1.6991.00
11_V38_V1.6941.00
72_D75_T1.6491.00
32_R62_P1.5381.00
10_M78_V1.5081.00
27_F34_L1.5011.00
13_S67_N1.4841.00
16_D19_K1.4661.00
70_P81_V1.4591.00
83_Y90_K1.4141.00
82_G93_V1.4041.00
48_T52_P1.3971.00
64_H67_N1.3931.00
75_T94_A1.3701.00
27_F30_K1.3451.00
8_K22_T1.3301.00
16_D38_V1.2921.00
70_P101_L1.2871.00
33_V65_V1.2741.00
47_P54_G1.2611.00
2_H83_Y1.2511.00
19_K38_V1.2291.00
45_S57_S1.2281.00
6_G22_T1.2251.00
26_A65_V1.2131.00
71_L76_G1.2041.00
44_H56_I1.1901.00
75_T96_K1.1761.00
91_V100_V1.1661.00
40_M58_N1.1511.00
31_D65_V1.1390.99
25_A34_L1.1380.99
43_K59_Q1.1300.99
84_K100_V1.1210.99
20_Q71_L1.0830.99
48_T51_N1.0630.99
24_L36_E1.0440.99
10_M71_L1.0380.99
27_F32_R1.0240.99
20_Q76_G1.0220.99
36_E60_E1.0140.99
49_Q52_P1.0090.99
72_D79_T0.9510.98
34_L62_P0.9490.98
77_E96_K0.9460.98
86_E89_K0.8620.97
45_S59_Q0.8580.96
15_K39_N0.8560.96
85_V93_V0.8530.96
40_M60_E0.8520.96
15_K41_V0.8280.96
2_H70_P0.8170.95
32_R67_N0.8120.95
71_L78_V0.8120.95
79_T96_K0.8030.95
48_T54_G0.7940.95
71_L79_T0.7910.94
69_M80_R0.7900.94
93_V100_V0.7760.94
5_K26_A0.7740.94
65_V68_V0.7710.94
21_G35_V0.7710.94
40_M61_A0.7700.94
41_V59_Q0.7650.93
32_R64_H0.7640.93
8_K71_L0.7530.93
45_S48_T0.7470.93
2_H81_V0.7390.92
23_I33_V0.7350.92
59_Q62_P0.7270.92
13_S17_K0.6990.90
21_G37_G0.6890.89
69_M78_V0.6860.89
85_V88_G0.6790.89
2_H65_V0.6770.88
34_L59_Q0.6750.88
2_H69_M0.6680.88
72_D96_K0.6530.87
69_M81_V0.6400.86
83_Y95_K0.6340.85
18_G21_G0.6330.85
71_L94_A0.6300.85
80_R95_K0.6300.85
79_T97_S0.6230.84
6_G76_G0.6180.84
63_I67_N0.6180.84
84_K98_G0.6060.82
25_A62_P0.6050.82
3_V68_V0.6050.82
47_P51_N0.6040.82
3_V65_V0.6000.82
74_K97_S0.5950.81
87_D90_K0.5910.81
48_T53_Q0.5900.81
85_V89_K0.5880.80
73_P97_S0.5850.80
65_V83_Y0.5840.80
86_E100_V0.5800.79
16_D35_V0.5800.79
47_P58_N0.5790.79
45_S52_P0.5790.79
79_T101_L0.5690.78
84_K91_V0.5670.78
94_A101_L0.5650.78
70_P79_T0.5650.78
26_A30_K0.5550.76
57_S91_V0.5540.76
85_V91_V0.5530.76
10_M69_M0.5520.76
45_S63_I0.5510.76
3_V26_A0.5490.76
24_L60_E0.5460.75
41_V55_G0.5430.75
93_V98_G0.5420.75
41_V60_E0.5380.74
32_R61_A0.5360.74
3_V70_P0.5350.74
11_V63_I0.5350.74
5_K28_P0.5280.73
51_N57_S0.5280.73
28_P31_D0.5260.73
71_L75_T0.5250.72
47_P50_A0.5210.72
39_N62_P0.5200.72
37_G40_M0.5190.72
47_P52_P0.5180.71
13_S16_D0.5160.71
70_P97_S0.5090.70
11_V68_V0.5070.70
19_K40_M0.5050.70
5_K25_A0.5000.69
23_I26_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboW 1 1 100 0.087 Contact Map
4rb6Y 1 0.9903 100 0.112 Contact Map
2zjrR 1 0.9709 100 0.118 Contact Map
3j3wU 1 1 100 0.138 Contact Map
4tp9U 1 0.9709 100 0.138 Contact Map
3j7yV 1 0.9903 100 0.144 Contact Map
1vw4Q 1 0.9029 100 0.241 Contact Map
4a17S 1 0.7767 99.9 0.419 Contact Map
1vq8T 1 0.7767 99.9 0.421 Contact Map
4w20Y 1 0.7961 99.9 0.427 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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