P5CR1 - BACSU - GREMLIN Contacts

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P5CR1 - Pyrroline-5-carboxylate reductase 1

UniProt:	P0CI77	Sequences: MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQNICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRIQPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKKLAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSIGAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAKRSKEISEDIEKTAAPLSGVIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (263)
Sequences:	5205 (3865)
Seq/√Len:	238.3

ECOLI - P5CR
BACSU - P5CR1 P5CR2 COMER P5CR3
SULSO - Q97ZT3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_P	158_L	3.200	1.00
91_A	112_L	2.767	1.00
143_A	228_K	2.751	1.00
235_E	243_N	2.667	1.00
133_V	146_T	2.529	1.00
228_K	232_E	2.487	1.00
194_F	223_L	2.449	1.00
197_L	267_I	2.431	1.00
198_M	230_L	2.397	1.00
257_A	261_S	2.278	1.00
20_A	75_C	2.267	1.00
49_T	72_N	2.189	1.00
171_E	217_S	2.142	1.00
121_E	151_G	2.091	1.00
195_Y	226_A	2.090	1.00
211_D	214_L	2.039	1.00
163_E	174_T	2.021	1.00
202_E	216_R	1.997	1.00
145_A	171_E	1.990	1.00
103_Q	106_Q	1.989	1.00
261_S	266_A	1.966	1.00
163_E	167_G	1.957	1.00
224_L	228_K	1.949	1.00
159_K	174_T	1.925	1.00
24_A	48_V	1.918	1.00
173_Y	217_S	1.880	1.00
228_K	231_M	1.859	1.00
190_G	222_T	1.841	1.00
201_I	271_I	1.788	1.00
138_S	144_S	1.787	1.00
193_Y	254_G	1.771	1.00
235_E	239_I	1.741	1.00
259_K	264_G	1.740	1.00
54_T	58_T	1.732	1.00
239_I	243_N	1.725	1.00
167_G	172_V	1.709	1.00
147_A	183_F	1.708	1.00
197_L	263_G	1.698	1.00
150_L	159_K	1.693	1.00
31_M	169_M	1.693	1.00
261_S	269_Q	1.686	1.00
206_E	212_K	1.671	1.00
20_A	79_M	1.623	1.00
155_S	158_L	1.601	1.00
109_L	162_A	1.574	1.00
18_K	45_N	1.574	1.00
252_A	256_Q	1.567	1.00
277_R	280_E	1.552	1.00
50_N	56_R	1.550	1.00
220_A	231_M	1.544	1.00
148_I	174_T	1.530	1.00
81_V	107_L	1.523	1.00
181_D	278_S	1.519	1.00
58_T	62_L	1.502	1.00
239_I	242_D	1.495	1.00
47_C	67_K	1.488	1.00
48_V	66_I	1.484	1.00
27_M	111_V	1.481	1.00
260_K	269_Q	1.480	1.00
143_A	224_L	1.478	1.00
108_I	124_L	1.476	1.00
245_T	252_A	1.474	1.00
29_E	56_R	1.441	1.00
176_Q	179_Q	1.438	1.00
51_R	90_D	1.432	1.00
263_G	266_A	1.430	1.00
208_A	272_K	1.421	1.00
92_E	123_S	1.419	1.00
203_K	212_K	1.407	1.00
92_E	119_F	1.405	1.00
56_R	59_E	1.399	1.00
156_E	160_K	1.398	1.00
110_S	120_I	1.396	1.00
175_I	180_M	1.387	1.00
221_Q	224_L	1.386	1.00
95_L	124_L	1.379	1.00
207_E	272_K	1.359	1.00
47_C	69_A	1.352	1.00
199_E	241_R	1.337	1.00
198_M	223_L	1.337	1.00
194_F	197_L	1.328	1.00
71_P	74_L	1.321	1.00
257_A	260_K	1.315	1.00
207_E	268_S	1.312	1.00
145_A	221_Q	1.308	1.00
116_T	119_F	1.304	1.00
131_V	162_A	1.300	1.00
263_G	267_I	1.298	1.00
272_K	276_K	1.289	1.00
203_K	264_G	1.284	1.00
21_F	28_A	1.283	1.00
59_E	63_Q	1.282	1.00
189_S	250_T	1.276	1.00
236_H	239_I	1.260	1.00
275_A	279_K	1.255	1.00
112_L	115_I	1.231	1.00
21_F	32_I	1.227	1.00
265_E	269_Q	1.226	1.00
85_A	111_V	1.224	1.00
185_G	271_I	1.223	1.00
91_A	115_I	1.217	1.00
254_G	270_A	1.191	1.00
119_F	123_S	1.189	1.00
199_E	238_E	1.175	1.00
163_E	172_V	1.175	1.00
148_I	172_V	1.166	1.00
33_S	63_Q	1.164	1.00
160_K	164_A	1.154	1.00
139_S	144_S	1.151	1.00
205_G	210_L	1.146	1.00
28_A	32_I	1.139	1.00
121_E	153_Y	1.135	1.00
75_C	79_M	1.130	1.00
175_I	183_F	1.125	1.00
42_P	45_N	1.122	1.00
81_V	161_L	1.117	1.00
258_L	270_A	1.114	1.00
143_A	221_Q	1.102	1.00
148_I	166_L	1.100	1.00
47_C	78_D	1.098	1.00
21_F	83_I	1.098	1.00
57_L	68_G	1.098	1.00
31_M	35_I	1.096	1.00
253_A	256_Q	1.093	1.00
198_M	219_G	1.086	1.00
245_T	255_L	1.084	1.00
121_E	152_K	1.075	1.00
117_T	149_A	1.075	1.00
118_S	122_Q	1.070	1.00
256_Q	260_K	1.068	1.00
145_A	173_Y	1.066	1.00
117_T	130_V	1.059	1.00
102_I	108_I	1.053	1.00
107_L	158_L	1.052	1.00
241_R	245_T	1.050	1.00
258_L	267_I	1.046	1.00
148_I	163_E	1.033	1.00
18_K	47_C	1.031	1.00
117_T	120_I	1.029	1.00
208_A	275_A	1.028	1.00
73_Q	97_S	1.026	1.00
181_D	279_K	1.022	1.00
81_V	109_L	1.019	1.00
84_L	91_A	1.012	1.00
86_M	112_L	1.007	1.00
37_R	142_G	1.005	1.00
133_V	166_L	1.002	1.00
187_A	218_I	1.001	1.00
33_S	64_Y	1.000	1.00
31_M	111_V	0.999	1.00
186_I	271_I	0.999	1.00
55_E	58_T	0.996	1.00
18_K	80_D	0.992	1.00
26_S	243_N	0.990	1.00
74_L	78_D	0.982	1.00
195_Y	229_M	0.978	1.00
150_L	174_T	0.976	1.00
29_E	64_Y	0.973	1.00
171_E	221_Q	0.972	1.00
183_F	218_I	0.971	1.00
173_Y	214_L	0.969	1.00
35_I	165_L	0.965	1.00
154_V	158_L	0.960	1.00
224_L	231_M	0.959	1.00
196_Y	255_L	0.956	1.00
183_F	187_A	0.948	1.00
90_D	94_A	0.946	1.00
32_I	48_V	0.941	1.00
82_L	106_Q	0.932	1.00
34_G	169_M	0.924	1.00
120_I	130_V	0.921	1.00
262_G	265_E	0.921	1.00
149_A	180_M	0.918	1.00
257_A	273_H	0.917	1.00
119_F	122_Q	0.915	1.00
115_I	119_F	0.913	1.00
92_E	96_S	0.910	1.00
83_I	109_L	0.907	1.00
90_D	93_N	0.904	1.00
182_I	210_L	0.899	1.00
230_L	237_P	0.898	1.00
220_A	227_A	0.894	1.00
253_A	277_R	0.891	0.99
73_Q	77_E	0.889	0.99
214_L	217_S	0.888	0.99
24_A	60_L	0.887	0.99
76_I	82_L	0.883	0.99
213_Q	217_S	0.881	0.99
54_T	57_L	0.881	0.99
196_Y	259_K	0.873	0.99
262_G	266_A	0.871	0.99
257_A	269_Q	0.870	0.99
186_I	205_G	0.868	0.99
236_H	242_D	0.868	0.99
29_E	63_Q	0.866	0.99
203_K	206_E	0.865	0.99
242_D	252_A	0.862	0.99
202_E	206_E	0.859	0.99
58_T	61_E	0.854	0.99
20_A	49_T	0.853	0.99
57_L	70_L	0.852	0.99
33_S	140_M	0.850	0.99
131_V	150_L	0.850	0.99
22_I	94_A	0.845	0.99
250_T	278_S	0.841	0.99
273_H	276_K	0.839	0.99
50_N	57_L	0.837	0.99
19_V	35_I	0.836	0.99
49_T	69_A	0.834	0.99
36_V	43_K	0.831	0.99
91_A	95_L	0.829	0.99
276_K	280_E	0.826	0.99
47_C	79_M	0.815	0.99
208_A	271_I	0.813	0.99
125_L	128_Q	0.813	0.99
139_S	169_M	0.813	0.99
216_R	220_A	0.808	0.99
145_A	218_I	0.805	0.99
185_G	275_A	0.798	0.99
77_E	101_R	0.791	0.99
67_K	78_D	0.790	0.99
200_F	264_G	0.785	0.99
26_S	246_S	0.784	0.99
96_S	123_S	0.783	0.99
29_E	59_E	0.782	0.99
80_D	106_Q	0.782	0.99
238_E	242_D	0.779	0.99
154_V	159_K	0.764	0.98
157_D	160_K	0.762	0.98
121_E	127_E	0.759	0.98
56_R	60_L	0.757	0.98
91_A	110_S	0.756	0.98
96_S	99_K	0.756	0.98
107_L	162_A	0.755	0.98
224_L	227_A	0.754	0.98
254_G	257_A	0.753	0.98
253_A	257_A	0.753	0.98
254_G	274_A	0.752	0.98
205_G	219_G	0.752	0.98
59_E	62_L	0.751	0.98
207_E	256_Q	0.745	0.98
61_E	68_G	0.736	0.98
32_I	60_L	0.733	0.98
92_E	115_I	0.732	0.98
255_L	259_K	0.729	0.98
32_I	46_I	0.729	0.98
149_A	176_Q	0.729	0.98
19_V	41_I	0.724	0.98
196_Y	264_G	0.722	0.98
111_V	133_V	0.721	0.98
18_K	78_D	0.719	0.98
261_S	265_E	0.719	0.98
150_L	156_E	0.717	0.98
184_T	278_S	0.713	0.98
132_R	177_E	0.712	0.98
141_I	228_K	0.708	0.97
28_A	85_A	0.707	0.97
83_I	166_L	0.706	0.97
82_L	108_I	0.705	0.97
210_L	218_I	0.705	0.97
203_K	207_E	0.704	0.97
181_D	282_S	0.701	0.97
113_A	250_T	0.701	0.97
276_K	279_K	0.699	0.97
180_M	278_S	0.696	0.97
187_A	222_T	0.694	0.97
189_S	274_A	0.692	0.97
117_T	151_G	0.692	0.97
164_A	167_G	0.692	0.97
145_A	217_S	0.692	0.97
151_G	154_V	0.692	0.97
205_G	215_S	0.691	0.97
184_T	190_G	0.690	0.97
212_K	216_R	0.689	0.97
41_I	45_N	0.688	0.97
52_S	55_E	0.688	0.97
199_E	203_K	0.686	0.97
93_N	96_S	0.685	0.97
150_L	154_V	0.683	0.97
95_L	112_L	0.682	0.97
57_L	61_E	0.681	0.97
20_A	82_L	0.679	0.97
271_I	274_A	0.678	0.97
179_Q	182_I	0.677	0.97
161_L	164_A	0.676	0.97
29_E	33_S	0.672	0.97
74_L	77_E	0.670	0.96
256_Q	269_Q	0.669	0.96
160_K	163_E	0.668	0.96
147_A	180_M	0.665	0.96
143_A	171_E	0.665	0.96
93_N	97_S	0.664	0.96
134_M	188_G	0.664	0.96
220_A	230_L	0.659	0.96
238_E	241_R	0.658	0.96
60_L	64_Y	0.658	0.96
76_I	98_L	0.657	0.96
131_V	154_V	0.656	0.96
73_Q	101_R	0.649	0.96
116_T	282_S	0.643	0.96
117_T	121_E	0.639	0.95
158_L	161_L	0.637	0.95
129_P	154_V	0.634	0.95
113_A	281_I	0.633	0.95
129_P	151_G	0.633	0.95
107_L	131_V	0.630	0.95
204_T	271_I	0.626	0.95
202_E	219_G	0.621	0.95
72_N	97_S	0.620	0.95
69_A	75_C	0.619	0.95
49_T	75_C	0.615	0.94
124_L	128_Q	0.615	0.94
70_L	74_L	0.614	0.94
256_Q	259_K	0.614	0.94
50_N	111_V	0.612	0.94
47_C	75_C	0.612	0.94
30_G	34_G	0.612	0.94
49_T	71_P	0.608	0.94
182_I	208_A	0.608	0.94
186_I	201_I	0.607	0.94
121_E	130_V	0.607	0.94
138_S	191_P	0.606	0.94
190_G	274_A	0.602	0.94
99_K	125_L	0.599	0.94
195_Y	240_L	0.592	0.93
32_I	66_I	0.591	0.93
252_A	255_L	0.590	0.93
87_K	246_S	0.590	0.93
72_N	75_C	0.588	0.93
202_E	237_P	0.588	0.93
246_S	250_T	0.588	0.93
192_A	251_T	0.587	0.93
81_V	165_L	0.587	0.93
20_A	47_C	0.587	0.93
130_V	151_G	0.586	0.93
54_T	70_L	0.582	0.93
141_I	229_M	0.581	0.93
272_K	275_A	0.581	0.93
146_T	169_M	0.577	0.92
171_E	231_M	0.575	0.92
72_N	76_I	0.574	0.92
182_I	205_G	0.573	0.92
265_E	268_S	0.572	0.92
146_T	170_G	0.571	0.92
179_Q	214_L	0.571	0.92
184_T	189_S	0.570	0.92
134_M	180_M	0.569	0.92
192_A	254_G	0.566	0.92
76_I	106_Q	0.565	0.91
195_Y	230_L	0.558	0.91
198_M	237_P	0.558	0.91
26_S	87_K	0.553	0.91
147_A	173_Y	0.553	0.91
180_M	183_F	0.549	0.90
102_I	124_L	0.540	0.90
267_I	271_I	0.540	0.90
149_A	177_E	0.540	0.90
48_V	60_L	0.539	0.89
142_G	169_M	0.539	0.89
223_L	263_G	0.538	0.89
38_A	142_G	0.535	0.89
190_G	271_I	0.534	0.89
193_Y	274_A	0.534	0.89
131_V	159_K	0.533	0.89
31_M	166_L	0.532	0.89
55_E	59_E	0.528	0.88
137_T	243_N	0.528	0.88
179_Q	211_D	0.526	0.88
188_G	250_T	0.525	0.88
84_L	98_L	0.525	0.88
98_L	102_I	0.524	0.88
193_Y	222_T	0.524	0.88
204_T	268_S	0.524	0.88
147_A	187_A	0.523	0.88
94_A	97_S	0.523	0.88
51_R	57_L	0.522	0.88
258_L	263_G	0.519	0.88
84_L	112_L	0.519	0.88
136_N	188_G	0.518	0.88
107_L	129_P	0.515	0.87
166_L	169_M	0.515	0.87
37_R	232_E	0.514	0.87
24_A	32_I	0.514	0.87
156_E	159_K	0.512	0.87
76_I	79_M	0.512	0.87
167_G	171_E	0.511	0.87
175_I	179_Q	0.509	0.87
124_L	130_V	0.509	0.87
86_M	94_A	0.508	0.87
22_I	49_T	0.508	0.87
256_Q	268_S	0.507	0.86
133_V	148_I	0.505	0.86
79_M	106_Q	0.502	0.86
139_S	146_T	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2izzA	5	0.9293	100	0.404	Contact Map
2rcyA	5	0.8822	100	0.432	Contact Map
2ahrA	5	0.8721	100	0.439	Contact Map
1yqgA	2	0.8822	100	0.442	Contact Map
3triA	2	0.9091	100	0.457	Contact Map
3gt0A	3	0.7306	100	0.487	Contact Map
4kqwA	2	0.9461	100	0.492	Contact Map
4wjiA	2	0.8956	100	0.55	Contact Map
3fr7A	2	0.9461	100	0.565	Contact Map
2i76A	2	0.7879	100	0.609	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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