GREMLIN Database
P5CR1 - Pyrroline-5-carboxylate reductase 1
UniProt: P0CI77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (263)
Sequences: 5205 (3865)
Seq/√Len: 238.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_P158_L3.2001.00
91_A112_L2.7671.00
143_A228_K2.7511.00
235_E243_N2.6671.00
133_V146_T2.5291.00
228_K232_E2.4871.00
194_F223_L2.4491.00
197_L267_I2.4311.00
198_M230_L2.3971.00
257_A261_S2.2781.00
20_A75_C2.2671.00
49_T72_N2.1891.00
171_E217_S2.1421.00
121_E151_G2.0911.00
195_Y226_A2.0901.00
211_D214_L2.0391.00
163_E174_T2.0211.00
202_E216_R1.9971.00
145_A171_E1.9901.00
103_Q106_Q1.9891.00
261_S266_A1.9661.00
163_E167_G1.9571.00
224_L228_K1.9491.00
159_K174_T1.9251.00
24_A48_V1.9181.00
173_Y217_S1.8801.00
228_K231_M1.8591.00
190_G222_T1.8411.00
201_I271_I1.7881.00
138_S144_S1.7871.00
193_Y254_G1.7711.00
235_E239_I1.7411.00
259_K264_G1.7401.00
54_T58_T1.7321.00
239_I243_N1.7251.00
167_G172_V1.7091.00
147_A183_F1.7081.00
197_L263_G1.6981.00
150_L159_K1.6931.00
31_M169_M1.6931.00
261_S269_Q1.6861.00
206_E212_K1.6711.00
20_A79_M1.6231.00
155_S158_L1.6011.00
109_L162_A1.5741.00
18_K45_N1.5741.00
252_A256_Q1.5671.00
277_R280_E1.5521.00
50_N56_R1.5501.00
220_A231_M1.5441.00
148_I174_T1.5301.00
81_V107_L1.5231.00
181_D278_S1.5191.00
58_T62_L1.5021.00
239_I242_D1.4951.00
47_C67_K1.4881.00
48_V66_I1.4841.00
27_M111_V1.4811.00
260_K269_Q1.4801.00
143_A224_L1.4781.00
108_I124_L1.4761.00
245_T252_A1.4741.00
29_E56_R1.4411.00
176_Q179_Q1.4381.00
51_R90_D1.4321.00
263_G266_A1.4301.00
208_A272_K1.4211.00
92_E123_S1.4191.00
203_K212_K1.4071.00
92_E119_F1.4051.00
56_R59_E1.3991.00
156_E160_K1.3981.00
110_S120_I1.3961.00
175_I180_M1.3871.00
221_Q224_L1.3861.00
95_L124_L1.3791.00
207_E272_K1.3591.00
47_C69_A1.3521.00
199_E241_R1.3371.00
198_M223_L1.3371.00
194_F197_L1.3281.00
71_P74_L1.3211.00
257_A260_K1.3151.00
207_E268_S1.3121.00
145_A221_Q1.3081.00
116_T119_F1.3041.00
131_V162_A1.3001.00
263_G267_I1.2981.00
272_K276_K1.2891.00
203_K264_G1.2841.00
21_F28_A1.2831.00
59_E63_Q1.2821.00
189_S250_T1.2761.00
236_H239_I1.2601.00
275_A279_K1.2551.00
112_L115_I1.2311.00
21_F32_I1.2271.00
265_E269_Q1.2261.00
85_A111_V1.2241.00
185_G271_I1.2231.00
91_A115_I1.2171.00
254_G270_A1.1911.00
119_F123_S1.1891.00
199_E238_E1.1751.00
163_E172_V1.1751.00
148_I172_V1.1661.00
33_S63_Q1.1641.00
160_K164_A1.1541.00
139_S144_S1.1511.00
205_G210_L1.1461.00
28_A32_I1.1391.00
121_E153_Y1.1351.00
75_C79_M1.1301.00
175_I183_F1.1251.00
42_P45_N1.1221.00
81_V161_L1.1171.00
258_L270_A1.1141.00
143_A221_Q1.1021.00
148_I166_L1.1001.00
47_C78_D1.0981.00
21_F83_I1.0981.00
57_L68_G1.0981.00
31_M35_I1.0961.00
253_A256_Q1.0931.00
198_M219_G1.0861.00
245_T255_L1.0841.00
121_E152_K1.0751.00
117_T149_A1.0751.00
118_S122_Q1.0701.00
256_Q260_K1.0681.00
145_A173_Y1.0661.00
117_T130_V1.0591.00
102_I108_I1.0531.00
107_L158_L1.0521.00
241_R245_T1.0501.00
258_L267_I1.0461.00
148_I163_E1.0331.00
18_K47_C1.0311.00
117_T120_I1.0291.00
208_A275_A1.0281.00
73_Q97_S1.0261.00
181_D279_K1.0221.00
81_V109_L1.0191.00
84_L91_A1.0121.00
86_M112_L1.0071.00
37_R142_G1.0051.00
133_V166_L1.0021.00
187_A218_I1.0011.00
33_S64_Y1.0001.00
31_M111_V0.9991.00
186_I271_I0.9991.00
55_E58_T0.9961.00
18_K80_D0.9921.00
26_S243_N0.9901.00
74_L78_D0.9821.00
195_Y229_M0.9781.00
150_L174_T0.9761.00
29_E64_Y0.9731.00
171_E221_Q0.9721.00
183_F218_I0.9711.00
173_Y214_L0.9691.00
35_I165_L0.9651.00
154_V158_L0.9601.00
224_L231_M0.9591.00
196_Y255_L0.9561.00
183_F187_A0.9481.00
90_D94_A0.9461.00
32_I48_V0.9411.00
82_L106_Q0.9321.00
34_G169_M0.9241.00
120_I130_V0.9211.00
262_G265_E0.9211.00
149_A180_M0.9181.00
257_A273_H0.9171.00
119_F122_Q0.9151.00
115_I119_F0.9131.00
92_E96_S0.9101.00
83_I109_L0.9071.00
90_D93_N0.9041.00
182_I210_L0.8991.00
230_L237_P0.8981.00
220_A227_A0.8941.00
253_A277_R0.8910.99
73_Q77_E0.8890.99
214_L217_S0.8880.99
24_A60_L0.8870.99
76_I82_L0.8830.99
213_Q217_S0.8810.99
54_T57_L0.8810.99
196_Y259_K0.8730.99
262_G266_A0.8710.99
257_A269_Q0.8700.99
186_I205_G0.8680.99
236_H242_D0.8680.99
29_E63_Q0.8660.99
203_K206_E0.8650.99
242_D252_A0.8620.99
202_E206_E0.8590.99
58_T61_E0.8540.99
20_A49_T0.8530.99
57_L70_L0.8520.99
33_S140_M0.8500.99
131_V150_L0.8500.99
22_I94_A0.8450.99
250_T278_S0.8410.99
273_H276_K0.8390.99
50_N57_L0.8370.99
19_V35_I0.8360.99
49_T69_A0.8340.99
36_V43_K0.8310.99
91_A95_L0.8290.99
276_K280_E0.8260.99
47_C79_M0.8150.99
208_A271_I0.8130.99
125_L128_Q0.8130.99
139_S169_M0.8130.99
216_R220_A0.8080.99
145_A218_I0.8050.99
185_G275_A0.7980.99
77_E101_R0.7910.99
67_K78_D0.7900.99
200_F264_G0.7850.99
26_S246_S0.7840.99
96_S123_S0.7830.99
29_E59_E0.7820.99
80_D106_Q0.7820.99
238_E242_D0.7790.99
154_V159_K0.7640.98
157_D160_K0.7620.98
121_E127_E0.7590.98
56_R60_L0.7570.98
91_A110_S0.7560.98
96_S99_K0.7560.98
107_L162_A0.7550.98
224_L227_A0.7540.98
254_G257_A0.7530.98
253_A257_A0.7530.98
254_G274_A0.7520.98
205_G219_G0.7520.98
59_E62_L0.7510.98
207_E256_Q0.7450.98
61_E68_G0.7360.98
32_I60_L0.7330.98
92_E115_I0.7320.98
255_L259_K0.7290.98
32_I46_I0.7290.98
149_A176_Q0.7290.98
19_V41_I0.7240.98
196_Y264_G0.7220.98
111_V133_V0.7210.98
18_K78_D0.7190.98
261_S265_E0.7190.98
150_L156_E0.7170.98
184_T278_S0.7130.98
132_R177_E0.7120.98
141_I228_K0.7080.97
28_A85_A0.7070.97
83_I166_L0.7060.97
82_L108_I0.7050.97
210_L218_I0.7050.97
203_K207_E0.7040.97
181_D282_S0.7010.97
113_A250_T0.7010.97
276_K279_K0.6990.97
180_M278_S0.6960.97
187_A222_T0.6940.97
189_S274_A0.6920.97
117_T151_G0.6920.97
164_A167_G0.6920.97
145_A217_S0.6920.97
151_G154_V0.6920.97
205_G215_S0.6910.97
184_T190_G0.6900.97
212_K216_R0.6890.97
41_I45_N0.6880.97
52_S55_E0.6880.97
199_E203_K0.6860.97
93_N96_S0.6850.97
150_L154_V0.6830.97
95_L112_L0.6820.97
57_L61_E0.6810.97
20_A82_L0.6790.97
271_I274_A0.6780.97
179_Q182_I0.6770.97
161_L164_A0.6760.97
29_E33_S0.6720.97
74_L77_E0.6700.96
256_Q269_Q0.6690.96
160_K163_E0.6680.96
147_A180_M0.6650.96
143_A171_E0.6650.96
93_N97_S0.6640.96
134_M188_G0.6640.96
220_A230_L0.6590.96
238_E241_R0.6580.96
60_L64_Y0.6580.96
76_I98_L0.6570.96
131_V154_V0.6560.96
73_Q101_R0.6490.96
116_T282_S0.6430.96
117_T121_E0.6390.95
158_L161_L0.6370.95
129_P154_V0.6340.95
113_A281_I0.6330.95
129_P151_G0.6330.95
107_L131_V0.6300.95
204_T271_I0.6260.95
202_E219_G0.6210.95
72_N97_S0.6200.95
69_A75_C0.6190.95
49_T75_C0.6150.94
124_L128_Q0.6150.94
70_L74_L0.6140.94
256_Q259_K0.6140.94
50_N111_V0.6120.94
47_C75_C0.6120.94
30_G34_G0.6120.94
49_T71_P0.6080.94
182_I208_A0.6080.94
186_I201_I0.6070.94
121_E130_V0.6070.94
138_S191_P0.6060.94
190_G274_A0.6020.94
99_K125_L0.5990.94
195_Y240_L0.5920.93
32_I66_I0.5910.93
252_A255_L0.5900.93
87_K246_S0.5900.93
72_N75_C0.5880.93
202_E237_P0.5880.93
246_S250_T0.5880.93
192_A251_T0.5870.93
81_V165_L0.5870.93
20_A47_C0.5870.93
130_V151_G0.5860.93
54_T70_L0.5820.93
141_I229_M0.5810.93
272_K275_A0.5810.93
146_T169_M0.5770.92
171_E231_M0.5750.92
72_N76_I0.5740.92
182_I205_G0.5730.92
265_E268_S0.5720.92
146_T170_G0.5710.92
179_Q214_L0.5710.92
184_T189_S0.5700.92
134_M180_M0.5690.92
192_A254_G0.5660.92
76_I106_Q0.5650.91
195_Y230_L0.5580.91
198_M237_P0.5580.91
26_S87_K0.5530.91
147_A173_Y0.5530.91
180_M183_F0.5490.90
102_I124_L0.5400.90
267_I271_I0.5400.90
149_A177_E0.5400.90
48_V60_L0.5390.89
142_G169_M0.5390.89
223_L263_G0.5380.89
38_A142_G0.5350.89
190_G271_I0.5340.89
193_Y274_A0.5340.89
131_V159_K0.5330.89
31_M166_L0.5320.89
55_E59_E0.5280.88
137_T243_N0.5280.88
179_Q211_D0.5260.88
188_G250_T0.5250.88
84_L98_L0.5250.88
98_L102_I0.5240.88
193_Y222_T0.5240.88
204_T268_S0.5240.88
147_A187_A0.5230.88
94_A97_S0.5230.88
51_R57_L0.5220.88
258_L263_G0.5190.88
84_L112_L0.5190.88
136_N188_G0.5180.88
107_L129_P0.5150.87
166_L169_M0.5150.87
37_R232_E0.5140.87
24_A32_I0.5140.87
156_E159_K0.5120.87
76_I79_M0.5120.87
167_G171_E0.5110.87
175_I179_Q0.5090.87
124_L130_V0.5090.87
86_M94_A0.5080.87
22_I49_T0.5080.87
256_Q268_S0.5070.86
133_V148_I0.5050.86
79_M106_Q0.5020.86
139_S146_T0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2izzA 5 0.9293 100 0.404 Contact Map
2rcyA 5 0.8822 100 0.432 Contact Map
2ahrA 5 0.8721 100 0.439 Contact Map
1yqgA 2 0.8822 100 0.442 Contact Map
3triA 2 0.9091 100 0.457 Contact Map
3gt0A 3 0.7306 100 0.487 Contact Map
4kqwA 2 0.9461 100 0.492 Contact Map
4wjiA 2 0.8956 100 0.55 Contact Map
3fr7A 2 0.9461 100 0.565 Contact Map
2i76A 2 0.7879 100 0.609 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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