GREMLIN Database
GPSB - Cell cycle protein GpsB
UniProt: P0CI74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 98 (92)
Sequences: 307 (195)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_L65_A4.3781.00
21_G26_K3.7321.00
80_I84_L3.5881.00
8_L36_M3.0870.99
55_N58_L2.7970.99
5_K12_E2.7640.99
9_S12_E2.0690.93
61_Q64_E2.0170.92
90_H96_L1.9600.90
7_K36_M1.9570.90
74_N78_F1.9220.89
49_E53_Q1.8890.89
33_F45_H1.8050.86
6_V43_T1.8050.86
21_G89_K1.8040.86
47_E52_Q1.6280.80
9_S29_D1.6140.79
86_N92_F1.5720.77
64_E90_H1.5550.76
52_Q55_N1.4830.73
19_K89_K1.4690.72
90_H94_S1.4680.72
81_L85_S1.4600.72
47_E50_E1.4560.71
51_L55_N1.4250.70
63_E67_K1.3220.64
64_E68_K1.2570.60
10_A49_E1.2270.58
76_T80_I1.2220.58
23_R93_G1.2060.57
45_H55_N1.2050.57
26_K68_K1.2000.56
54_E59_K1.1800.55
56_L72_Q1.1790.55
61_Q68_K1.1710.54
11_K42_E1.1350.52
11_K54_E1.1260.51
15_E33_F1.1250.51
19_K77_N1.0870.49
86_N96_L1.0870.49
11_K15_E1.0500.46
55_N59_K1.0290.45
10_A45_H1.0070.44
17_E39_K1.0010.43
19_K93_G0.9850.42
10_A46_Q0.9730.41
39_K43_T0.9700.41
74_N96_L0.9330.39
60_K70_P0.9300.39
63_E82_K0.9160.38
76_T96_L0.9150.38
75_T95_K0.8950.37
48_I51_L0.8910.36
20_T62_L0.8750.35
19_K79_D0.8630.35
14_L94_S0.8590.34
9_S93_G0.8320.33
26_K89_K0.8210.32
57_Q72_Q0.8190.32
9_S94_S0.8150.32
6_V44_F0.8150.32
50_E54_E0.8030.31
8_L16_K0.7990.31
28_E49_E0.7960.31
9_S59_K0.7930.31
64_E70_P0.7830.30
86_N93_G0.7760.30
15_E49_E0.7700.29
14_L95_K0.7660.29
9_S73_S0.7500.28
26_K95_K0.7490.28
21_G27_Q0.7480.28
46_Q49_E0.7440.28
61_Q65_A0.7420.28
81_L92_F0.7410.28
68_K75_T0.7360.28
29_D32_K0.7330.27
48_I73_S0.7280.27
57_Q92_F0.7210.27
17_E23_R0.7130.26
22_V84_L0.7120.26
66_S70_P0.7000.26
62_L67_K0.6910.25
63_E71_V0.6870.25
46_Q50_E0.6840.25
16_K85_S0.6770.25
45_H53_Q0.6720.24
53_Q64_E0.6680.24
19_K29_D0.6580.24
38_I51_L0.6450.23
21_G47_E0.6350.23
9_S25_Y0.6280.22
11_K71_V0.6270.22
92_F95_K0.6250.22
22_V26_K0.6240.22
28_E82_K0.6140.22
28_E32_K0.6090.21
64_E72_Q0.6070.21
23_R54_E0.6050.21
14_L25_Y0.6030.21
12_E42_E0.5990.21
9_S64_E0.5940.21
19_K76_T0.5930.21
60_K67_K0.5920.21
23_R39_K0.5880.21
73_S82_K0.5860.20
23_R29_D0.5790.20
39_K46_Q0.5790.20
43_T49_E0.5740.20
79_D84_L0.5740.20
32_K82_K0.5690.20
10_A95_K0.5680.20
46_Q53_Q0.5680.20
14_L96_L0.5680.20
67_K82_K0.5680.20
63_E68_K0.5650.20
13_I58_L0.5620.19
68_K72_Q0.5610.19
16_K27_Q0.5580.19
49_E72_Q0.5520.19
29_D73_S0.5510.19
39_K75_T0.5500.19
56_L59_K0.5490.19
9_S60_K0.5470.19
57_Q82_K0.5460.19
59_K63_E0.5420.19
57_Q63_E0.5380.18
64_E67_K0.5320.18
23_R27_Q0.5310.18
45_H49_E0.5280.18
21_G75_T0.5250.18
80_I92_F0.5220.18
32_K90_H0.5170.18
15_E80_I0.5120.17
54_E93_G0.5090.17
22_V42_E0.5070.17
54_E58_L0.5070.17
51_L86_N0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wujA 2 0.5102 99.5 0.608 Contact Map
3swyA 3 0.4694 57.5 0.903 Contact Map
4y66B 1 0.9388 53.1 0.905 Contact Map
3q4fC 2 0.6224 36 0.915 Contact Map
4dznA 3 0.3265 35.8 0.915 Contact Map
3swfA 3 0.551 31.7 0.917 Contact Map
4wbdA 2 0.898 30.3 0.918 Contact Map
3wpaA 3 0 26.3 0.92 Contact Map
1sesA 2 0.949 24.7 0.921 Contact Map
3ucsA 2 0.6224 24.5 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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