ACON - BACSU - GREMLIN Contacts

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ACON - Aconitate hydratase

UniProt:	P09339	Sequences: MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSKLPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVPAVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERNAERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLALKVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYLRLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLIPLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSCTNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELGFNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLASPPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRKEYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVGKFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANIRIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAAKGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDETVRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	909 (873)
Sequences:	2111 (860)
Seq/√Len:	29.1

ECOLI - ACON1 YBHJ
BACSU - ACON
HALSA - Q9HMF1
SULSO - Q97Z42

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
590_V	596_N	5.625	1.00
682_G	766_I	5.015	1.00
295_F	370_V	4.994	1.00
285_K	369_D	4.782	1.00
326_V	351_C	4.672	1.00
467_K	503_Y	4.609	1.00
501_L	505_K	4.515	1.00
757_Y	776_D	4.450	1.00
492_T	514_Y	4.403	1.00
757_Y	760_T	4.367	1.00
335_R	341_P	4.239	1.00
801_T	827_V	4.192	1.00
329_E	332_N	4.098	1.00
260_K	372_E	3.978	1.00
265_L	274_L	3.961	1.00
348_E	352_R	3.844	1.00
467_K	471_E	3.727	1.00
505_K	510_N	3.715	1.00
786_K	812_E	3.685	1.00
591_G	595_Q	3.619	1.00
468_K	608_E	3.599	1.00
747_A	750_T	3.575	1.00
532_E	536_K	3.534	1.00
231_L	321_C	3.364	1.00
470_V	503_Y	3.334	1.00
869_N	875_T	3.310	1.00
266_P	269_T	3.310	1.00
865_V	879_A	3.299	1.00
485_A	517_T	3.251	1.00
729_H	733_M	3.049	1.00
143_A	527_S	3.037	1.00
94_I	187_V	3.031	1.00
472_L	591_G	2.970	1.00
281_V	371_V	2.902	1.00
257_I	369_D	2.902	1.00
468_K	471_E	2.899	1.00
210_T	346_V	2.892	1.00
677_G	850_E	2.884	1.00
863_V	879_A	2.866	1.00
471_E	503_Y	2.785	1.00
833_K	862_L	2.746	1.00
680_V	849_I	2.740	1.00
867_A	877_F	2.677	1.00
155_L	158_E	2.669	1.00
750_T	763_V	2.668	1.00
17_K	33_A	2.657	1.00
757_Y	772_K	2.656	1.00
503_Y	506_E	2.631	1.00
67_K	71_E	2.611	1.00
382_L	397_M	2.597	0.99
542_T	579_V	2.571	0.99
755_T	769_A	2.569	0.99
35_E	43_S	2.565	0.99
784_A	811_A	2.556	0.99
865_V	877_F	2.554	0.99
787_D	790_M	2.548	0.99
116_A	658_N	2.543	0.99
531_E	558_L	2.541	0.99
131_D	178_Q	2.525	0.99
850_E	868_I	2.479	0.99
745_Q	838_A	2.452	0.99
762_E	772_K	2.438	0.99
578_T	581_I	2.427	0.99
257_I	368_T	2.396	0.99
379_E	395_S	2.395	0.99
257_I	285_K	2.384	0.99
35_E	41_K	2.342	0.99
628_T	631_D	2.340	0.99
300_A	358_Y	2.298	0.99
112_K	658_N	2.281	0.99
397_M	579_V	2.278	0.99
142_K	151_V	2.264	0.99
165_K	650_D	2.250	0.98
676_K	850_E	2.245	0.98
393_P	396_A	2.239	0.98
833_K	836_E	2.227	0.98
281_V	373_I	2.224	0.98
582_N	585_T	2.212	0.98
280_Q	284_E	2.210	0.98
812_E	837_N	2.202	0.98
446_A	517_T	2.196	0.98
140_V	483_S	2.172	0.98
44_K	366_Q	2.172	0.98
153_M	183_A	2.145	0.98
400_T	563_Y	2.137	0.98
470_V	506_E	2.129	0.98
862_L	878_E	2.125	0.98
767_Y	771_M	2.108	0.98
461_G	609_I	2.076	0.97
461_G	568_P	2.053	0.97
396_A	399_E	2.053	0.97
699_I	703_T	2.052	0.97
745_Q	839_D	2.045	0.97
607_D	611_A	2.039	0.97
196_A	230_V	2.029	0.97
684_F	742_I	2.012	0.97
610_N	613_V	2.009	0.97
808_T	851_V	2.001	0.97
657_Q	730_E	1.999	0.97
781_V	849_I	1.998	0.97
535_A	558_L	1.995	0.97
715_S	718_D	1.989	0.97
196_A	225_I	1.976	0.97
184_T	629_V	1.975	0.97
151_V	154_D	1.963	0.96
485_A	512_V	1.959	0.96
314_A	317_Y	1.958	0.96
465_V	468_K	1.954	0.96
852_D	866_R	1.951	0.96
748_P	754_F	1.946	0.96
683_K	745_Q	1.937	0.96
149_L	511_L	1.935	0.96
864_T	876_T	1.923	0.96
157_F	633_N	1.919	0.96
280_Q	391_L	1.918	0.96
379_E	393_P	1.913	0.96
314_A	322_G	1.911	0.96
172_K	643_D	1.908	0.96
17_K	30_S	1.907	0.96
867_A	875_T	1.904	0.96
259_A	281_V	1.901	0.96
68_E	71_E	1.887	0.95
496_V	501_L	1.877	0.95
764_T	769_A	1.872	0.95
317_Y	322_G	1.870	0.95
304_L	329_E	1.865	0.95
28_Y	353_S	1.861	0.95
760_T	772_K	1.855	0.95
374_D	377_Q	1.851	0.95
468_K	472_L	1.844	0.95
33_A	36_D	1.842	0.95
398_Q	586_D	1.824	0.95
382_L	565_A	1.817	0.94
764_T	772_K	1.817	0.94
199_V	210_T	1.816	0.94
783_L	849_I	1.812	0.94
277_K	381_N	1.796	0.94
700_G	706_G	1.779	0.94
658_N	663_E	1.776	0.94
680_V	683_K	1.765	0.93
721_S	724_S	1.763	0.93
894_H	903_R	1.758	0.93
634_K	638_E	1.757	0.93
22_N	342_E	1.750	0.93
722_Y	738_A	1.739	0.93
512_V	517_T	1.733	0.93
837_N	840_T	1.726	0.93
260_K	364_D	1.723	0.93
460_I	612_L	1.723	0.93
866_R	876_T	1.720	0.93
147_D	151_V	1.710	0.92
465_V	572_A	1.704	0.92
21_T	24_K	1.699	0.92
683_K	838_A	1.690	0.92
846_K	870_E	1.676	0.92
864_T	878_E	1.674	0.92
675_L	678_L	1.673	0.91
319_A	322_G	1.659	0.91
397_M	573_Y	1.652	0.91
493_G	625_E	1.652	0.91
679_R	778_T	1.648	0.91
76_W	368_T	1.647	0.91
772_K	775_E	1.646	0.91
465_V	472_L	1.646	0.91
459_L	484_L	1.643	0.91
424_E	438_K	1.641	0.91
328_E	332_N	1.641	0.91
736_T	800_G	1.631	0.90
850_E	866_R	1.622	0.90
502_P	505_K	1.616	0.90
760_T	776_D	1.616	0.90
140_V	446_A	1.612	0.90
472_L	597_V	1.611	0.90
747_A	756_T	1.611	0.90
733_M	771_M	1.606	0.90
707_K	711_E	1.595	0.89
149_L	153_M	1.595	0.89
743_K	751_E	1.591	0.89
783_L	838_A	1.589	0.89
29_Y	209_V	1.588	0.89
71_E	75_K	1.585	0.89
730_E	733_M	1.578	0.89
844_T	869_N	1.568	0.89
20_T	23_G	1.566	0.88
764_T	768_D	1.563	0.88
260_K	295_F	1.536	0.87
468_K	605_S	1.533	0.87
772_K	776_D	1.533	0.87
398_Q	582_N	1.530	0.87
631_D	637_N	1.529	0.87
381_N	391_L	1.529	0.87
747_A	763_V	1.527	0.87
757_Y	764_T	1.519	0.87
21_T	26_Y	1.518	0.87
389_Q	687_S	1.518	0.87
590_V	594_G	1.515	0.87
883_F	892_Y	1.513	0.87
472_L	595_Q	1.511	0.87
534_V	556_H	1.508	0.87
868_I	874_V	1.502	0.86
22_N	345_D	1.501	0.86
402_K	580_N	1.501	0.86
267_N	606_M	1.498	0.86
639_I	642_T	1.496	0.86
520_I	696_A	1.493	0.86
387_R	390_D	1.493	0.86
125_N	176_N	1.487	0.86
60_V	70_V	1.485	0.86
323_F	326_V	1.481	0.85
373_I	377_Q	1.474	0.85
114_M	119_G	1.471	0.85
869_N	873_N	1.467	0.85
201_A	210_T	1.465	0.85
341_P	345_D	1.460	0.85
445_A	509_F	1.458	0.85
633_N	637_N	1.457	0.85
425_I	537_N	1.447	0.84
131_D	197_S	1.447	0.84
509_F	574_A	1.445	0.84
96_Q	723_G	1.444	0.84
674_P	852_D	1.439	0.84
703_T	722_Y	1.436	0.84
17_K	28_Y	1.435	0.84
168_S	641_T	1.434	0.84
328_E	348_E	1.432	0.83
756_T	846_K	1.432	0.83
757_Y	778_T	1.427	0.83
299_I	358_Y	1.420	0.83
465_V	605_S	1.407	0.82
166_F	170_A	1.402	0.82
828_L	892_Y	1.399	0.82
493_G	624_K	1.397	0.82
197_S	200_H	1.396	0.82
783_L	832_F	1.385	0.81
255_E	369_D	1.383	0.81
611_A	615_Q	1.382	0.81
754_F	765_S	1.381	0.81
831_Q	880_V	1.374	0.81
122_D	645_A	1.374	0.81
373_I	378_I	1.372	0.81
331_L	344_I	1.360	0.80
617_V	622_F	1.355	0.80
534_V	541_I	1.345	0.79
783_L	867_A	1.337	0.79
498_S	501_L	1.333	0.79
750_T	754_F	1.331	0.79
197_S	343_H	1.327	0.78
833_K	878_E	1.324	0.78
441_A	580_N	1.323	0.78
116_A	664_E	1.318	0.78
681_V	806_I	1.317	0.78
684_F	766_I	1.314	0.78
150_A	154_D	1.314	0.78
683_K	839_D	1.312	0.78
351_C	357_F	1.308	0.77
20_T	25_T	1.306	0.77
198_V	334_L	1.305	0.77
443_A	559_V	1.298	0.77
540_L	561_G	1.296	0.77
538_D	560_K	1.295	0.77
460_I	613_V	1.291	0.76
444_I	559_V	1.288	0.76
498_S	612_L	1.286	0.76
260_K	297_P	1.284	0.76
710_Q	716_P	1.277	0.76
770_C	774_K	1.277	0.76
497_N	618_T	1.276	0.76
581_I	587_P	1.267	0.75
575_L	602_I	1.266	0.75
533_A	537_N	1.261	0.75
141_D	159_R	1.260	0.75
426_K	434_E	1.257	0.74
390_D	687_S	1.256	0.74
467_K	470_V	1.254	0.74
683_K	783_L	1.251	0.74
28_Y	210_T	1.251	0.74
142_K	148_A	1.250	0.74
56_V	70_V	1.245	0.74
501_L	511_L	1.244	0.74
96_Q	736_T	1.242	0.74
81_L	255_E	1.239	0.73
782_V	806_I	1.239	0.73
470_V	502_P	1.239	0.73
746_I	758_W	1.238	0.73
620_E	624_K	1.236	0.73
30_S	354_N	1.233	0.73
16_R	27_H	1.233	0.73
124_I	905_K	1.231	0.73
311_A	322_G	1.231	0.73
349_A	353_S	1.230	0.73
894_H	900_M	1.230	0.73
890_D	893_R	1.220	0.72
21_T	349_A	1.216	0.72
153_M	157_F	1.215	0.72
493_G	496_V	1.211	0.72
683_K	746_I	1.208	0.71
679_R	848_V	1.208	0.71
267_N	607_D	1.207	0.71
701_K	706_G	1.206	0.71
669_P	894_H	1.204	0.71
707_K	765_S	1.203	0.71
404_Q	563_Y	1.198	0.71
140_V	512_V	1.198	0.71
445_A	574_A	1.197	0.71
401_F	563_Y	1.196	0.71
424_E	436_V	1.194	0.71
528_P	532_E	1.187	0.70
420_E	423_K	1.184	0.70
755_T	766_I	1.183	0.70
389_Q	790_M	1.178	0.70
836_E	840_T	1.177	0.69
862_L	880_V	1.177	0.69
745_Q	837_N	1.175	0.69
64_V	89_K	1.168	0.69
161_A	165_K	1.168	0.69
489_K	625_E	1.168	0.69
150_A	635_R	1.165	0.69
305_A	336_L	1.161	0.68
743_K	749_G	1.160	0.68
674_P	853_V	1.160	0.68
459_L	543_S	1.157	0.68
435_T	530_I	1.152	0.68
142_K	145_T	1.152	0.68
790_M	801_T	1.150	0.68
47_Y	367_F	1.150	0.68
842_G	869_N	1.147	0.67
392_I	404_Q	1.143	0.67
502_P	506_E	1.139	0.67
24_K	342_E	1.138	0.67
476_V	482_T	1.134	0.67
581_I	586_D	1.133	0.66
771_M	774_K	1.131	0.66
578_T	586_D	1.125	0.66
619_P	623_R	1.124	0.66
314_A	319_A	1.124	0.66
674_P	854_D	1.117	0.65
848_V	868_I	1.114	0.65
264_K	301_E	1.112	0.65
700_G	703_T	1.108	0.65
708_Y	730_E	1.106	0.65
831_Q	882_R	1.105	0.64
591_G	597_V	1.105	0.64
98_F	101_V	1.103	0.64
425_I	533_A	1.101	0.64
444_I	523_S	1.096	0.64
201_A	346_V	1.088	0.63
98_F	736_T	1.087	0.63
340_D	343_H	1.087	0.63
192_L	308_A	1.083	0.63
95_L	187_V	1.082	0.63
285_K	370_V	1.080	0.63
18_T	25_T	1.080	0.63
112_K	646_L	1.077	0.62
590_V	595_Q	1.075	0.62
684_F	688_V	1.072	0.62
575_L	588_I	1.070	0.62
87_P	250_Y	1.070	0.62
266_P	379_E	1.066	0.62
866_R	874_V	1.066	0.62
531_E	535_A	1.064	0.61
442_I	544_V	1.062	0.61
836_E	878_E	1.059	0.61
759_P	764_T	1.058	0.61
398_Q	580_N	1.057	0.61
883_F	889_I	1.056	0.61
345_D	349_A	1.056	0.61
294_F	609_I	1.052	0.61
121_P	831_Q	1.050	0.60
69_H	84_I	1.048	0.60
505_K	511_L	1.047	0.60
476_V	507_L	1.046	0.60
255_E	368_T	1.046	0.60
427_F	435_T	1.045	0.60
747_A	754_F	1.044	0.60
400_T	404_Q	1.043	0.60
389_Q	721_S	1.043	0.60
30_S	353_S	1.043	0.60
658_N	661_F	1.039	0.60
311_A	319_A	1.036	0.59
114_M	905_K	1.036	0.59
73_L	253_V	1.036	0.59
467_K	502_P	1.035	0.59
335_R	348_E	1.031	0.59
801_T	804_L	1.029	0.59
680_V	783_L	1.029	0.59
317_Y	323_F	1.028	0.59
343_H	346_V	1.028	0.59
61_D	65_I	1.027	0.59
99_T	520_I	1.023	0.58
765_S	768_D	1.022	0.58
701_K	710_Q	1.022	0.58
470_V	507_L	1.021	0.58
223_T	322_G	1.020	0.58
634_K	637_N	1.018	0.58
178_Q	630_F	1.016	0.58
699_I	754_F	1.014	0.58
192_L	225_I	1.014	0.58
702_D	706_G	1.013	0.58
426_K	436_V	1.008	0.57
334_L	347_V	1.007	0.57
98_F	723_G	1.005	0.57
47_Y	362_A	1.005	0.57
701_K	716_P	1.005	0.57
31_L	42_V	1.003	0.57
471_E	502_P	1.001	0.57
573_Y	578_T	1.001	0.57
227_G	311_A	0.998	0.56
262_V	372_E	0.996	0.56
50_K	355_G	0.995	0.56
359_T	362_A	0.994	0.56
19_F	349_A	0.993	0.56
707_K	710_Q	0.993	0.56
810_I	879_A	0.993	0.56
382_L	392_I	0.992	0.56
142_K	147_D	0.991	0.56
55_S	479_Y	0.988	0.56
259_A	373_I	0.988	0.56
27_H	209_V	0.985	0.55
59_Q	89_K	0.984	0.55
760_T	778_T	0.982	0.55
382_L	579_V	0.982	0.55
251_F	885_S	0.977	0.55
154_D	635_R	0.976	0.55
257_I	311_A	0.975	0.55
844_T	870_E	0.974	0.55
397_M	563_Y	0.973	0.55
26_Y	210_T	0.972	0.54
140_V	517_T	0.971	0.54
107_L	174_F	0.970	0.54
475_K	575_L	0.969	0.54
275_A	632_D	0.969	0.54
708_Y	729_H	0.967	0.54
759_P	772_K	0.967	0.54
228_I	304_L	0.963	0.54
572_A	599_F	0.960	0.54
314_A	790_M	0.956	0.53
443_A	541_I	0.954	0.53
802_N	807_R	0.954	0.53
151_V	155_L	0.953	0.53
401_F	561_G	0.952	0.53
742_I	751_E	0.950	0.53
77_G	80_E	0.948	0.53
311_A	314_A	0.947	0.53
140_V	513_G	0.942	0.52
666_S	670_G	0.941	0.52
265_L	378_I	0.941	0.52
468_K	602_I	0.940	0.52
831_Q	884_D	0.938	0.52
266_P	376_S	0.936	0.52
278_V	373_I	0.936	0.52
52_L	90_P	0.935	0.52
584_K	600_N	0.934	0.52
835_G	840_T	0.932	0.51
682_G	742_I	0.931	0.51
849_I	877_F	0.927	0.51
632_D	637_N	0.926	0.51
428_K	434_E	0.926	0.51
77_G	82_K	0.924	0.51
93_V	216_V	0.921	0.51
117_V	903_R	0.921	0.51
836_E	877_F	0.920	0.50
476_V	479_Y	0.919	0.50
56_V	60_V	0.918	0.50
112_K	116_A	0.918	0.50
501_L	510_N	0.914	0.50
644_E	648_K	0.912	0.50
114_M	124_I	0.911	0.50
860_R	880_V	0.907	0.49
610_N	614_K	0.906	0.49
170_A	275_A	0.906	0.49
804_L	827_V	0.904	0.49
657_Q	728_N	0.902	0.49
326_V	357_F	0.902	0.49
465_V	587_P	0.901	0.49
109_S	659_P	0.897	0.49
51_V	228_I	0.895	0.48
55_S	214_T	0.894	0.48
540_L	560_K	0.894	0.48
781_V	808_T	0.893	0.48
703_T	754_F	0.891	0.48
506_E	510_N	0.890	0.48
497_N	621_L	0.888	0.48
259_A	378_I	0.886	0.48
63_F	890_D	0.886	0.48
55_S	632_D	0.886	0.48
56_V	65_I	0.886	0.48
472_L	592_K	0.881	0.47
277_K	280_Q	0.881	0.47
642_T	648_K	0.879	0.47
842_G	867_A	0.879	0.47
357_F	479_Y	0.876	0.47
397_M	542_T	0.876	0.47
665_M	903_R	0.875	0.47
116_A	663_E	0.874	0.47
379_E	396_A	0.873	0.47
651_N	657_Q	0.871	0.47
34_L	887_V	0.870	0.47
311_A	323_F	0.869	0.46
91_S	200_H	0.868	0.46
302_L	306_D	0.865	0.46
755_T	764_T	0.864	0.46
114_M	123_K	0.863	0.46
576_A	581_I	0.863	0.46
99_T	696_A	0.862	0.46
335_R	344_I	0.859	0.46
249_S	461_G	0.858	0.46
578_T	583_L	0.858	0.46
833_K	880_V	0.857	0.46
743_K	748_P	0.857	0.46
15_A	30_S	0.856	0.45
592_K	595_Q	0.854	0.45
359_T	363_E	0.853	0.45
149_L	184_T	0.853	0.45
654_T	712_K	0.853	0.45
742_I	765_S	0.851	0.45
332_N	335_R	0.850	0.45
661_F	664_E	0.849	0.45
474_L	589_G	0.849	0.45
760_T	827_V	0.848	0.45
883_F	888_E	0.847	0.45
345_D	348_E	0.847	0.45
60_V	67_K	0.846	0.45
157_F	563_Y	0.846	0.45
30_S	34_L	0.845	0.45
311_A	555_I	0.842	0.44
16_R	29_Y	0.842	0.44
613_V	616_T	0.838	0.44
96_Q	187_V	0.837	0.44
749_G	754_F	0.833	0.44
748_P	763_V	0.832	0.44
467_K	506_E	0.832	0.44
99_T	105_V	0.831	0.44
285_K	371_V	0.830	0.43
104_V	177_Y	0.829	0.43
812_E	839_D	0.829	0.43
498_S	616_T	0.829	0.43
367_F	893_R	0.829	0.43
669_P	903_R	0.827	0.43
737_F	801_T	0.827	0.43
465_V	599_F	0.827	0.43
300_A	328_E	0.827	0.43
290_K	369_D	0.827	0.43
48_S	51_V	0.826	0.43
783_L	810_I	0.825	0.43
842_G	875_T	0.823	0.43
101_V	520_I	0.823	0.43
145_T	148_A	0.823	0.43
657_Q	729_H	0.822	0.43
259_A	294_F	0.821	0.43
65_I	478_N	0.821	0.43
216_V	249_S	0.820	0.43
756_T	763_V	0.820	0.43
98_F	696_A	0.819	0.43
781_V	801_T	0.816	0.42
261_L	278_V	0.816	0.42
170_A	251_F	0.815	0.42
331_L	357_F	0.815	0.42
679_R	780_L	0.812	0.42
605_S	608_E	0.812	0.42
465_V	502_P	0.811	0.42
141_D	155_L	0.807	0.42
405_L	439_T	0.804	0.41
527_S	530_I	0.804	0.41
351_C	367_F	0.804	0.41
78_T	82_K	0.803	0.41
392_I	563_Y	0.802	0.41
859_P	889_I	0.799	0.41
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683_K	843_L	0.792	0.41
582_N	586_D	0.792	0.41
853_V	856_T	0.792	0.41
62_G	66_K	0.790	0.40
49_I	73_L	0.790	0.40
592_K	596_N	0.789	0.40
586_D	591_G	0.789	0.40
225_I	322_G	0.789	0.40
166_F	639_I	0.789	0.40
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652_D	713_G	0.784	0.40
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120_D	123_K	0.784	0.40
158_E	717_R	0.783	0.40
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492_T	501_L	0.783	0.40
36_D	43_S	0.783	0.40
231_L	351_C	0.782	0.40
781_V	810_I	0.780	0.40
858_R	861_D	0.779	0.40
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742_I	746_I	0.779	0.40
336_L	617_V	0.777	0.39
670_G	782_V	0.776	0.39
529_E	533_A	0.775	0.39
277_K	373_I	0.775	0.39
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687_S	790_M	0.772	0.39
849_I	865_V	0.771	0.39
229_G	307_R	0.771	0.39
19_F	353_S	0.771	0.39
762_E	775_E	0.771	0.39
225_I	311_A	0.771	0.39
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294_F	322_G	0.769	0.39
259_A	370_V	0.768	0.39
104_V	461_G	0.768	0.39
807_R	850_E	0.768	0.39
463_G	484_L	0.767	0.39
323_F	365_P	0.767	0.39
223_T	232_G	0.767	0.39
696_A	793_S	0.765	0.39
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180_V	630_F	0.763	0.38
19_F	28_Y	0.763	0.38
231_L	299_I	0.763	0.38
846_K	869_N	0.762	0.38
342_E	345_D	0.759	0.38
836_E	867_A	0.758	0.38
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399_E	403_K	0.757	0.38
501_L	867_A	0.757	0.38
214_T	321_C	0.757	0.38
675_L	851_V	0.756	0.38
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831_Q	834_Q	0.755	0.38
851_V	879_A	0.754	0.38
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514_Y	724_S	0.754	0.38
758_W	764_T	0.754	0.38
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178_Q	197_S	0.754	0.38
849_I	867_A	0.753	0.38
810_I	865_V	0.752	0.38
867_A	879_A	0.751	0.37
72_N	253_V	0.750	0.37
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98_F	662_F	0.747	0.37
889_I	902_L	0.747	0.37
441_A	508_G	0.747	0.37
768_D	771_M	0.746	0.37
541_I	556_H	0.745	0.37
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200_H	211_Y	0.743	0.37
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180_V	632_D	0.742	0.37
157_F	635_R	0.741	0.37
304_L	308_A	0.741	0.37
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885_S	888_E	0.740	0.37
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28_Y	209_V	0.739	0.37
299_I	324_F	0.739	0.37
531_E	556_H	0.739	0.37
398_Q	402_K	0.737	0.36
231_L	553_G	0.736	0.36
443_A	530_I	0.736	0.36
279_T	811_A	0.736	0.36
139_Q	721_S	0.735	0.36
678_L	779_G	0.734	0.36
309_T	458_V	0.733	0.36
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101_V	105_V	0.733	0.36
459_L	647_Y	0.733	0.36
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890_D	902_L	0.731	0.36
128_I	578_T	0.730	0.36
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19_F	26_Y	0.729	0.36
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568_P	609_I	0.729	0.36
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553_G	565_A	0.727	0.36
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844_T	875_T	0.724	0.36
687_S	787_D	0.723	0.35
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668_E	894_H	0.719	0.35
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578_T	588_I	0.716	0.35
520_I	793_S	0.716	0.35
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187_V	197_S	0.715	0.35
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588_I	596_N	0.714	0.35
745_Q	783_L	0.713	0.35
754_F	764_T	0.712	0.35
560_K	827_V	0.711	0.35
783_L	877_F	0.709	0.34
116_A	661_F	0.709	0.34
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252_P	885_S	0.708	0.34
65_I	69_H	0.707	0.34
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261_L	302_L	0.703	0.34
677_G	848_V	0.701	0.34
167_L	520_I	0.701	0.34
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267_N	605_S	0.696	0.34
64_V	887_V	0.696	0.34
157_F	637_N	0.696	0.34
680_V	838_A	0.696	0.34
530_I	558_L	0.695	0.33
223_T	311_A	0.695	0.33
491_V	494_Y	0.695	0.33
719_F	736_T	0.695	0.33
187_V	196_A	0.693	0.33
257_I	322_G	0.691	0.33
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99_T	522_N	0.690	0.33
61_D	66_K	0.689	0.33
143_A	530_I	0.689	0.33
225_I	232_G	0.688	0.33
467_K	621_L	0.688	0.33
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124_I	176_N	0.687	0.33
367_F	814_F	0.687	0.33
885_S	905_K	0.685	0.33
33_A	214_T	0.685	0.33
613_V	617_V	0.684	0.33
757_Y	762_E	0.683	0.33
155_L	717_R	0.682	0.33
470_V	476_V	0.681	0.33
542_T	814_F	0.680	0.32
541_I	558_L	0.680	0.32
679_R	758_W	0.678	0.32
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746_I	869_N	0.673	0.32
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647_Y	656_I	0.670	0.32
139_Q	243_G	0.669	0.32
470_V	475_K	0.669	0.32
196_A	311_A	0.668	0.32
783_L	869_N	0.668	0.32
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485_A	708_Y	0.665	0.31
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297_P	361_D	0.664	0.31
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279_T	375_L	0.657	0.31
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251_F	275_A	0.655	0.31
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484_L	501_L	0.652	0.31
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264_K	668_E	0.651	0.30
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192_L	319_A	0.650	0.30
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358_Y	365_P	0.649	0.30
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767_Y	770_C	0.639	0.30
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389_Q	724_S	0.639	0.30
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354_N	391_L	0.638	0.30
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617_V	621_L	0.634	0.29
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555_I	650_D	0.629	0.29
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621_L	767_Y	0.620	0.28
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148_A	642_T	0.616	0.28
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37_S	71_E	0.612	0.28
143_A	782_V	0.612	0.28
281_V	378_I	0.612	0.28
214_T	894_H	0.610	0.28
196_A	902_L	0.610	0.28
170_A	885_S	0.609	0.28
297_P	362_A	0.609	0.28
391_L	439_T	0.608	0.28
259_A	280_Q	0.608	0.28
357_F	363_E	0.607	0.28
259_A	477_P	0.606	0.28
499_G	503_Y	0.606	0.28
438_K	441_A	0.606	0.28
153_M	184_T	0.606	0.28
431_N	435_T	0.605	0.28
572_A	588_I	0.605	0.28
131_D	859_P	0.605	0.28
422_N	467_K	0.605	0.28
83_D	112_K	0.605	0.28
174_F	179_A	0.605	0.28
261_L	294_F	0.605	0.28
351_C	356_L	0.605	0.28
149_L	157_F	0.604	0.27
348_E	357_F	0.604	0.27
319_A	659_P	0.604	0.27
50_K	354_N	0.604	0.27
555_I	688_V	0.603	0.27
166_F	249_S	0.603	0.27
94_I	149_L	0.603	0.27
80_E	83_D	0.603	0.27
682_G	753_G	0.603	0.27
680_V	746_I	0.603	0.27
259_A	295_F	0.602	0.27
128_I	887_V	0.602	0.27
51_V	801_T	0.601	0.27
632_D	639_I	0.600	0.27
55_S	87_P	0.600	0.27
745_Q	827_V	0.600	0.27
148_A	638_E	0.599	0.27
698_A	724_S	0.599	0.27
297_P	563_Y	0.599	0.27
131_D	323_F	0.598	0.27
754_F	763_V	0.598	0.27
251_F	632_D	0.596	0.27
16_R	363_E	0.596	0.27
31_L	34_L	0.596	0.27
437_M	443_A	0.595	0.27
156_E	223_T	0.594	0.27
94_I	231_L	0.594	0.27
528_P	624_K	0.593	0.27
86_V	700_G	0.593	0.27
540_L	729_H	0.593	0.27
48_S	321_C	0.593	0.27
120_D	608_E	0.593	0.27
146_E	673_E	0.592	0.27
225_I	229_G	0.592	0.27
459_L	612_L	0.592	0.27
280_Q	381_N	0.592	0.27
225_I	858_R	0.591	0.27
830_L	879_A	0.591	0.27
161_A	640_E	0.590	0.27
838_A	842_G	0.590	0.27
28_Y	33_A	0.590	0.27
201_A	343_H	0.589	0.27
512_V	523_S	0.589	0.27
99_T	793_S	0.589	0.27
170_A	439_T	0.589	0.27
683_K	842_G	0.589	0.27
250_Y	900_M	0.589	0.27
101_V	696_A	0.588	0.26
459_L	495_L	0.588	0.26
400_T	609_I	0.588	0.26
87_P	128_I	0.588	0.26
525_P	530_I	0.588	0.26
257_I	672_V	0.587	0.26
76_W	649_W	0.586	0.26
260_K	370_V	0.586	0.26
65_I	442_I	0.586	0.26
392_I	651_N	0.585	0.26
331_L	335_R	0.585	0.26
783_L	837_N	0.585	0.26
85_D	110_L	0.585	0.26
684_F	783_L	0.585	0.26
164_Y	171_K	0.583	0.26
629_V	733_M	0.583	0.26
281_V	285_K	0.583	0.26
28_Y	32_K	0.583	0.26
680_V	846_K	0.583	0.26
86_V	885_S	0.582	0.26
73_L	77_G	0.581	0.26
711_E	850_E	0.581	0.26
122_D	175_N	0.581	0.26
639_I	843_L	0.581	0.26
317_Y	505_K	0.580	0.26
365_P	553_G	0.580	0.26
307_R	327_D	0.580	0.26
506_E	592_K	0.580	0.26
586_D	823_V	0.580	0.26
130_V	556_H	0.580	0.26
305_A	553_G	0.579	0.26
379_E	669_P	0.579	0.26
166_F	553_G	0.579	0.26
304_L	629_V	0.579	0.26
311_A	321_C	0.579	0.26
115_A	467_K	0.579	0.26
783_L	814_F	0.578	0.26
584_K	778_T	0.578	0.26
520_I	891_Y	0.578	0.26
862_L	867_A	0.576	0.26
699_I	766_I	0.576	0.26
297_P	365_P	0.576	0.26
285_K	688_V	0.576	0.26
225_I	230_V	0.576	0.26
820_S	824_F	0.576	0.26
661_F	899_Q	0.576	0.26
389_Q	514_Y	0.575	0.26
833_K	879_A	0.575	0.26
298_G	824_F	0.575	0.26
501_L	865_V	0.575	0.26
168_S	640_E	0.574	0.26
618_T	621_L	0.574	0.26
556_H	563_Y	0.572	0.26
857_V	889_I	0.571	0.25
760_T	768_D	0.571	0.25
139_Q	650_D	0.571	0.25
272_T	452_N	0.571	0.25
884_D	892_Y	0.570	0.25
631_D	688_V	0.570	0.25
98_F	187_V	0.570	0.25
783_L	840_T	0.570	0.25
164_Y	184_T	0.570	0.25
95_L	674_P	0.569	0.25
184_T	630_F	0.569	0.25
588_I	602_I	0.569	0.25
51_V	593_D	0.569	0.25
733_M	742_I	0.568	0.25
115_A	120_D	0.568	0.25
65_I	477_P	0.568	0.25
852_D	864_T	0.568	0.25
18_T	402_K	0.568	0.25
63_F	887_V	0.568	0.25
446_A	699_I	0.568	0.25
103_A	243_G	0.566	0.25
346_V	367_F	0.565	0.25
123_K	905_K	0.565	0.25
33_A	37_S	0.565	0.25
76_W	759_P	0.565	0.25
676_K	807_R	0.564	0.25
565_A	740_I	0.564	0.25
29_Y	57_L	0.564	0.25
262_V	378_I	0.564	0.25
99_T	723_G	0.563	0.25
127_E	901_V	0.563	0.25
164_Y	790_M	0.563	0.25
70_V	531_E	0.563	0.25
269_T	395_S	0.563	0.25
153_M	742_I	0.562	0.25
723_G	736_T	0.562	0.25
446_A	556_H	0.562	0.25
55_S	647_Y	0.562	0.25
497_N	615_Q	0.562	0.25
650_D	657_Q	0.562	0.25
891_Y	900_M	0.561	0.25
101_V	138_V	0.560	0.25
707_K	768_D	0.560	0.25
758_W	844_T	0.560	0.25
664_E	903_R	0.560	0.25
328_E	585_T	0.559	0.25
573_Y	881_V	0.559	0.25
836_E	842_G	0.559	0.25
158_E	406_V	0.559	0.25
183_A	857_V	0.558	0.25
15_A	74_A	0.558	0.25
322_G	790_M	0.558	0.25
332_N	352_R	0.558	0.25
153_M	485_A	0.557	0.25
64_V	88_F	0.557	0.25
330_A	729_H	0.557	0.25
588_I	591_G	0.557	0.25
492_T	511_L	0.557	0.25
832_F	837_N	0.557	0.25
112_K	661_F	0.556	0.25
681_V	684_F	0.556	0.25
117_V	667_V	0.556	0.25
151_V	367_F	0.555	0.25
187_V	200_H	0.554	0.24
241_E	697_G	0.552	0.24
225_I	613_V	0.552	0.24
336_L	343_H	0.552	0.24
170_A	173_A	0.551	0.24
183_A	557_P	0.551	0.24
166_F	461_G	0.551	0.24
286_G	728_N	0.550	0.24
472_L	589_G	0.549	0.24
57_L	214_T	0.549	0.24
272_T	453_T	0.549	0.24
376_S	764_T	0.549	0.24
433_E	782_V	0.549	0.24
530_I	780_L	0.549	0.24
183_A	639_I	0.548	0.24
518_T	523_S	0.547	0.24
383_S	391_L	0.547	0.24
259_A	322_G	0.546	0.24
150_A	881_V	0.546	0.24
127_E	675_L	0.546	0.24
696_A	735_G	0.546	0.24
281_V	602_I	0.546	0.24
489_K	624_K	0.546	0.24
105_V	727_G	0.545	0.24
27_H	906_M	0.545	0.24
192_L	859_P	0.545	0.24
323_F	881_V	0.545	0.24
94_I	196_A	0.545	0.24
124_I	642_T	0.545	0.24
705_A	709_L	0.544	0.24
57_L	60_V	0.544	0.24
326_V	338_G	0.543	0.24
216_V	457_Y	0.543	0.24
291_F	321_C	0.543	0.24
383_S	442_I	0.543	0.24
398_Q	585_T	0.543	0.24
402_K	467_K	0.543	0.24
119_G	123_K	0.543	0.24
444_I	485_A	0.542	0.24
247_Q	887_V	0.542	0.24
758_W	762_E	0.541	0.24
812_E	838_A	0.541	0.24
625_E	629_V	0.541	0.24
885_S	900_M	0.541	0.24
216_V	298_G	0.540	0.24
465_V	851_V	0.540	0.24
836_E	841_L	0.540	0.24
131_D	183_A	0.540	0.24
137_S	720_N	0.540	0.24
501_L	877_F	0.540	0.24
444_I	518_T	0.540	0.24
117_V	894_H	0.539	0.24
113_A	742_I	0.539	0.24
143_A	311_A	0.539	0.24
23_G	639_I	0.539	0.24
672_V	854_D	0.539	0.24
26_Y	184_T	0.538	0.24
743_K	747_A	0.538	0.24
140_V	784_A	0.538	0.24
96_Q	101_V	0.537	0.23
832_F	835_G	0.537	0.23
743_K	750_T	0.537	0.23
294_F	568_P	0.537	0.23
682_G	783_L	0.537	0.23
230_V	446_A	0.536	0.23
344_I	536_K	0.536	0.23
480_V	525_P	0.536	0.23
49_I	382_L	0.536	0.23
629_V	729_H	0.536	0.23
96_Q	133_V	0.535	0.23
134_I	598_Y	0.535	0.23
625_E	628_T	0.535	0.23
843_L	870_E	0.535	0.23
214_T	517_T	0.535	0.23
512_V	543_S	0.535	0.23
520_I	724_S	0.534	0.23
278_V	294_F	0.534	0.23
520_I	720_N	0.534	0.23
700_G	754_F	0.533	0.23
68_E	543_S	0.533	0.23
599_F	681_V	0.533	0.23
737_F	782_V	0.533	0.23
51_V	302_L	0.533	0.23
542_T	556_H	0.533	0.23
168_S	367_F	0.532	0.23
807_R	854_D	0.532	0.23
30_S	33_A	0.532	0.23
51_V	858_R	0.532	0.23
112_K	579_V	0.532	0.23
288_V	320_T	0.532	0.23
104_V	166_F	0.531	0.23
563_Y	579_V	0.531	0.23
278_V	513_G	0.530	0.23
178_Q	231_L	0.530	0.23
50_K	356_L	0.530	0.23
215_L	225_I	0.530	0.23
223_T	321_C	0.530	0.23
441_A	578_T	0.529	0.23
708_Y	767_Y	0.528	0.23
137_S	520_I	0.527	0.23
15_A	33_A	0.527	0.23
434_E	761_G	0.527	0.23
285_K	295_F	0.527	0.23
98_F	719_F	0.526	0.23
259_A	279_T	0.526	0.23
225_I	337_T	0.526	0.23
179_A	330_A	0.526	0.23
82_K	187_V	0.525	0.23
123_K	175_N	0.525	0.23
172_K	257_I	0.525	0.23
759_P	776_D	0.525	0.23
295_F	372_E	0.525	0.23
565_A	573_Y	0.524	0.23
98_F	520_I	0.524	0.23
832_F	849_I	0.524	0.23
311_A	765_S	0.523	0.23
859_P	881_V	0.523	0.23
386_K	747_A	0.522	0.23
383_S	886_E	0.522	0.23
170_A	310_I	0.521	0.23
286_G	786_K	0.521	0.23
630_F	729_H	0.521	0.23
24_K	422_N	0.521	0.23
581_I	596_N	0.521	0.23
714_V	851_V	0.520	0.23
297_P	561_G	0.520	0.23
130_V	322_G	0.520	0.23
381_N	588_I	0.520	0.23
275_A	633_N	0.519	0.22
680_V	781_V	0.519	0.22
472_L	600_N	0.519	0.22
270_T	568_P	0.519	0.22
86_V	303_P	0.518	0.22
50_K	553_G	0.518	0.22
770_C	804_L	0.518	0.22
21_T	345_D	0.518	0.22
94_I	560_K	0.517	0.22
174_F	780_L	0.517	0.22
122_D	383_S	0.517	0.22
760_T	764_T	0.517	0.22
665_M	669_P	0.517	0.22
317_Y	321_C	0.517	0.22
141_D	444_I	0.517	0.22
243_G	887_V	0.516	0.22
858_R	862_L	0.516	0.22
543_S	836_E	0.516	0.22
782_V	790_M	0.516	0.22
732_M	796_W	0.516	0.22
706_G	780_L	0.515	0.22
201_A	575_L	0.515	0.22
211_Y	827_V	0.515	0.22
141_D	242_A	0.515	0.22
677_G	866_R	0.515	0.22
168_S	279_T	0.514	0.22
49_I	256_V	0.514	0.22
21_T	25_T	0.514	0.22
781_V	833_K	0.514	0.22
886_E	890_D	0.513	0.22
581_I	584_K	0.513	0.22
579_V	657_Q	0.513	0.22
522_N	723_G	0.512	0.22
622_F	722_Y	0.512	0.22
139_Q	790_M	0.512	0.22
68_E	72_N	0.512	0.22
357_F	476_V	0.512	0.22
531_E	534_V	0.511	0.22
168_S	853_V	0.511	0.22
668_E	673_E	0.511	0.22
91_S	348_E	0.511	0.22
309_T	491_V	0.511	0.22
647_Y	650_D	0.511	0.22
432_G	435_T	0.511	0.22
154_D	353_S	0.511	0.22
468_K	611_A	0.511	0.22
652_D	712_K	0.510	0.22
85_D	825_M	0.510	0.22
231_L	305_A	0.510	0.22
357_F	477_P	0.510	0.22
335_R	543_S	0.510	0.22
405_L	540_L	0.510	0.22
483_S	518_T	0.509	0.22
279_T	556_H	0.509	0.22
82_K	859_P	0.509	0.22
532_E	595_Q	0.509	0.22
51_V	116_A	0.509	0.22
68_E	264_K	0.509	0.22
538_D	541_I	0.509	0.22
756_T	761_G	0.509	0.22
614_K	620_E	0.507	0.22
189_Q	245_L	0.507	0.22
375_L	707_K	0.507	0.22
467_K	597_V	0.507	0.22
24_K	356_L	0.507	0.22
94_I	225_I	0.507	0.22
93_V	275_A	0.506	0.22
590_V	598_Y	0.506	0.22
477_P	480_V	0.506	0.22
525_P	751_E	0.506	0.22
43_S	366_Q	0.505	0.22
23_G	506_E	0.505	0.22
91_S	260_K	0.505	0.22
303_P	609_I	0.505	0.22
48_S	86_V	0.505	0.22
250_Y	459_L	0.504	0.22
540_L	688_V	0.504	0.22
153_M	164_Y	0.504	0.22
624_K	634_K	0.504	0.22
304_L	332_N	0.504	0.22
114_M	906_M	0.504	0.22
184_T	517_T	0.504	0.22
114_M	513_G	0.504	0.22
125_N	134_I	0.503	0.22
447_I	453_T	0.503	0.22
279_T	356_L	0.503	0.22
323_F	859_P	0.503	0.22
110_L	885_S	0.503	0.22
73_L	199_V	0.502	0.22
832_F	838_A	0.502	0.22
55_S	95_L	0.502	0.22
206_G	842_G	0.502	0.22
445_A	570_V	0.502	0.22
51_V	407_S	0.502	0.22
574_A	721_S	0.501	0.22
581_I	722_Y	0.501	0.22
674_P	787_D	0.501	0.22
861_D	889_I	0.501	0.22
662_F	723_G	0.501	0.22
531_E	561_G	0.500	0.21
326_V	380_A	0.500	0.21
522_N	696_A	0.500	0.21
698_A	782_V	0.500	0.21
497_N	656_I	0.500	0.21
175_N	648_K	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2b3yA	1	0.9736	100	0.297	Contact Map
1c96A	1	0.8108	100	0.524	Contact Map
4kp2A	2	0.4587	100	0.716	Contact Map
4kp1A	1	0.4554	100	0.721	Contact Map
1l5jA	1	0.5644	100	0.742	Contact Map
3vbaA	2	0.1848	100	0.914	Contact Map
2pkpA	2	0.1804	100	0.915	Contact Map
1v7lA	6	0.1782	100	0.918	Contact Map
2hcuA	1	0.1892	100	0.92	Contact Map
3q3wA	1	0.1947	100	0.926	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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