GREMLIN Database
G3P1 - Glyceraldehyde-3-phosphate dehydrogenase 1
UniProt: P09124 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (328)
Sequences: 5430 (2477)
Seq/√Len: 136.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_N222_E4.2901.00
77_E82_K3.6621.00
171_K249_N3.4101.00
162_K166_D3.1591.00
140_D143_N3.1571.00
274_G290_N3.0821.00
136_E329_Y2.7711.00
204_N283_G2.7711.00
107_A111_E2.7451.00
79_D82_K2.7131.00
251_E305_S2.6961.00
261_L294_I2.5391.00
168_F260_A2.4711.00
181_Y202_A2.4421.00
167_K263_E2.4281.00
141_A144_H2.4211.00
56_A68_N2.4111.00
4_K28_E2.3671.00
292_S311_S2.3421.00
147_I330_I2.3051.00
61_D71_T2.2911.00
105_D108_K2.2741.00
64_N71_T2.1921.00
291_S322_R2.1871.00
232_M241_L2.1531.00
102_K105_D2.1391.00
238_N286_N2.1161.00
172_R247_E2.0891.00
132_M136_E2.0261.00
250_Q256_E2.0141.00
257_V307_V1.9811.00
22_L54_L1.9231.00
180_S236_T1.9121.00
46_Q278_E1.9071.00
80_P100_F1.9011.00
51_H238_N1.8691.00
217_S224_K1.8651.00
239_V285_Y1.8621.00
28_E70_K1.8601.00
21_A29_V1.8571.00
205_I232_M1.8441.00
259_A263_E1.8421.00
40_M195_Y1.8391.00
61_D64_N1.8311.00
251_E304_G1.8131.00
161_A223_L1.8031.00
10_F45_L1.7851.00
103_R107_A1.7691.00
84_S87_K1.7411.00
18_F29_V1.7251.00
262_K277_E1.7121.00
116_K145_D1.7081.00
228_N300_M1.7001.00
81_A111_E1.6961.00
81_A108_K1.6821.00
275_Y296_A1.6761.00
248_L307_V1.6741.00
118_I327_A1.6721.00
322_R325_D1.6351.00
96_S120_S1.6341.00
18_F45_L1.6291.00
274_G288_N1.6171.00
94_V327_A1.5871.00
20_A321_N1.5861.00
18_F67_V1.5811.00
161_A170_I1.5761.00
171_K305_S1.5611.00
120_S323_V1.5551.00
128_I144_H1.5541.00
258_N299_T1.5521.00
171_K247_E1.5511.00
184_D192_H1.5301.00
49_S203_E1.5231.00
279_P297_L1.5151.00
262_K266_E1.5121.00
73_E87_K1.5001.00
43_H198_A1.4811.00
101_T119_I1.4741.00
4_K89_G1.4711.00
102_K124_N1.4661.00
168_F248_L1.4221.00
107_A110_L1.4211.00
64_N73_E1.4151.00
38_A74_V1.3971.00
49_S283_G1.3951.00
276_S285_Y1.3921.00
53_K288_N1.3821.00
123_A126_E1.3781.00
24_N328_A1.3561.00
288_N293_T1.3521.00
43_H195_Y1.3511.00
203_E237_P1.3431.00
160_F311_S1.3371.00
23_N55_D1.3211.00
218_L224_K1.3121.00
160_F292_S1.3061.00
187_I201_A1.3061.00
103_R127_D1.3021.00
94_V323_V1.3001.00
253_T256_E1.2961.00
164_L261_L1.2921.00
183_N188_L1.2891.00
128_I138_K1.2841.00
75_S88_Q1.2811.00
254_A299_T1.2761.00
96_S323_V1.2751.00
173_G227_L1.2751.00
106_A119_I1.2711.00
262_K275_Y1.2681.00
276_S280_L1.2631.00
197_R208_T1.2511.00
200_A203_E1.2431.00
31_A75_S1.2411.00
290_N293_T1.2241.00
280_L285_Y1.2241.00
247_E305_S1.2161.00
172_R303_E1.2151.00
163_V273_L1.2081.00
92_I327_A1.2061.00
165_N220_L1.1941.00
83_L88_Q1.1871.00
79_D108_K1.1841.00
277_E296_A1.1830.99
194_D197_R1.1810.99
291_S325_D1.1810.99
163_V260_A1.1760.99
54_L68_N1.1720.99
172_R305_S1.1570.99
183_N190_L1.1430.99
269_L273_L1.1360.99
164_L309_V1.1340.99
167_K260_A1.1330.99
38_A60_V1.1300.99
18_F72_I1.1270.99
186_Q190_L1.1270.99
61_D66_V1.1270.99
102_K125_E1.1240.99
283_G286_N1.1090.99
160_F261_L1.0990.99
17_V323_V1.0960.99
298_S310_I1.0960.99
167_K171_K1.0920.99
16_N51_H1.0890.99
248_L252_V1.0830.99
17_V94_V1.0720.99
289_K317_S1.0710.99
317_S321_N1.0700.99
169_G248_L1.0660.99
6_G83_L1.0660.99
17_V320_S1.0560.99
119_I123_A1.0510.99
26_E328_A1.0480.99
196_R295_D1.0460.99
319_Y323_V1.0460.99
178_V232_M1.0430.99
23_N287_G1.0430.99
168_F252_V1.0410.99
252_V256_E1.0350.99
139_Y145_D1.0340.99
66_V69_G1.0320.99
42_A58_V1.0300.99
160_F309_V1.0270.99
301_V307_V1.0230.99
104_A125_E1.0190.98
241_L310_I1.0130.98
63_N73_E1.0130.98
6_G90_V1.0120.98
50_V237_P1.0110.98
230_G310_I1.0050.98
139_Y147_I1.0040.98
37_D40_M1.0040.98
47_Y278_E1.0040.98
66_V71_T1.0020.98
259_A262_K1.0000.98
252_V301_V0.9990.98
116_K139_Y0.9950.98
45_L56_A0.9950.98
138_K222_E0.9940.98
164_L248_L0.9880.98
41_L74_V0.9880.98
103_R126_E0.9860.98
165_N249_N0.9840.98
254_A258_N0.9770.98
236_T239_V0.9760.98
83_L112_A0.9740.98
168_F257_V0.9700.98
255_E259_A0.9640.98
140_D144_H0.9610.98
92_I118_I0.9560.98
232_M310_I0.9530.98
22_L70_K0.9490.98
127_D144_H0.9480.98
265_A268_D0.9450.98
131_V150_A0.9400.97
118_I147_I0.9400.97
260_A263_E0.9340.97
289_K321_N0.9300.97
157_L175_M0.9290.97
276_S297_L0.9260.97
184_D197_R0.9220.97
301_V304_G0.9210.97
163_V269_L0.9200.97
273_L292_S0.9170.97
275_Y294_I0.9140.97
172_R306_M0.9110.97
50_V238_N0.9100.97
108_K112_A0.9080.97
130_I144_H0.9070.97
104_A107_A0.9050.97
252_V260_A0.9050.97
164_L246_A0.9030.97
90_V93_V0.8990.97
91_E115_K0.8980.97
274_G293_T0.8950.97
51_H287_G0.8860.96
73_E88_Q0.8810.96
239_V286_N0.8800.96
130_I139_Y0.8770.96
287_G317_S0.8730.96
3_V27_V0.8710.96
31_A90_V0.8700.96
252_V257_V0.8690.96
132_M326_L0.8690.96
156_C242_V0.8670.96
75_S84_S0.8550.96
132_M329_Y0.8540.96
107_A146_V0.8530.95
51_H286_N0.8480.95
41_L191_P0.8480.95
21_A324_V0.8390.95
263_E268_D0.8310.95
183_N206_I0.8270.95
192_H197_R0.8260.95
258_N294_I0.8250.95
10_F32_V0.8230.95
34_D191_P0.8230.95
263_E267_G0.8210.94
57_E68_N0.8190.94
276_S296_A0.8170.94
27_V328_A0.8140.94
46_Q53_K0.8120.94
123_A129_T0.8120.94
102_K108_K0.8050.94
92_I330_I0.8040.94
39_N60_V0.8030.94
6_G112_A0.8010.94
119_I126_E0.7980.94
200_A237_P0.7970.94
30_V90_V0.7960.94
50_V188_L0.7930.93
60_V66_V0.7880.93
118_I326_L0.7850.93
137_D268_D0.7810.93
36_T191_P0.7780.93
132_M272_I0.7770.93
50_V203_E0.7760.93
102_K107_A0.7760.93
31_A88_Q0.7740.93
129_T218_L0.7720.92
160_F294_I0.7720.92
181_Y187_I0.7680.92
43_H47_Y0.7650.92
243_D308_K0.7630.92
126_E218_L0.7630.92
92_I331_A0.7630.92
32_V65_L0.7620.92
174_M230_G0.7600.92
186_Q198_A0.7550.92
45_L54_L0.7550.92
103_R146_V0.7500.91
150_A319_Y0.7480.91
248_L301_V0.7480.91
84_S88_Q0.7480.91
99_F105_D0.7470.91
17_V324_V0.7470.91
137_D329_Y0.7430.91
35_L191_P0.7400.91
101_T105_D0.7380.91
252_V307_V0.7370.91
195_Y198_A0.7350.90
196_R298_S0.7330.90
216_V220_L0.7320.90
192_H198_A0.7290.90
108_K111_E0.7290.90
205_I310_I0.7280.90
176_T245_V0.7260.90
75_S83_L0.7250.90
50_V200_A0.7220.90
175_M242_V0.7190.90
38_A42_A0.7190.90
167_K264_A0.7170.89
78_R99_F0.7150.89
59_S66_V0.7140.89
260_A264_A0.7130.89
36_T41_L0.7120.89
31_A73_E0.7120.89
294_I297_L0.7120.89
168_F250_Q0.7110.89
130_I138_K0.7090.89
34_D99_F0.7080.89
303_E306_M0.7070.89
160_F242_V0.7040.89
230_G308_K0.7030.88
216_V227_L0.7020.88
58_V67_V0.7010.88
327_A330_I0.6990.88
266_E270_K0.6980.88
46_Q57_E0.6980.88
139_Y329_Y0.6980.88
3_V331_A0.6930.88
35_L99_F0.6930.88
35_L77_E0.6910.88
157_L161_A0.6900.88
103_R145_D0.6900.88
60_V64_N0.6900.88
49_S237_P0.6880.87
251_E303_E0.6860.87
274_G292_S0.6860.87
183_N186_Q0.6840.87
181_Y237_P0.6820.87
7_I18_F0.6810.87
42_A60_V0.6780.87
256_E259_A0.6780.87
267_G270_K0.6770.87
77_E83_L0.6770.87
35_L41_L0.6760.86
239_V242_V0.6750.86
161_A227_L0.6750.86
209_S214_K0.6720.86
263_E266_E0.6700.86
246_A307_V0.6700.86
169_G249_N0.6700.86
230_G300_M0.6690.86
35_L78_R0.6680.86
24_N321_N0.6670.86
246_A309_V0.6650.86
131_V134_V0.6650.86
15_R19_R0.6640.85
22_L68_N0.6630.85
96_S327_A0.6610.85
75_S87_K0.6590.85
262_K265_A0.6540.85
62_G66_V0.6530.85
63_N71_T0.6530.85
139_Y330_I0.6500.84
149_N320_S0.6480.84
20_A324_V0.6450.84
4_K91_E0.6440.84
261_L273_L0.6440.84
27_V92_I0.6440.84
86_G112_A0.6430.84
211_G240_S0.6420.84
55_D68_N0.6390.83
32_V74_V0.6390.83
202_A237_P0.6380.83
118_I330_I0.6380.83
119_I146_V0.6370.83
43_H280_L0.6370.83
107_A145_D0.6360.83
176_T232_M0.6300.82
3_V26_E0.6290.82
23_N56_A0.6270.82
6_G31_A0.6250.82
248_L257_V0.6250.82
57_E69_G0.6250.82
35_L76_A0.6220.82
261_L309_V0.6210.81
174_M302_M0.6200.81
43_H194_D0.6200.81
93_V114_A0.6200.81
39_N195_Y0.6170.81
104_A111_E0.6120.81
6_G88_Q0.6110.80
123_A128_I0.6100.80
130_I326_L0.6080.80
164_L244_L0.6070.80
78_R81_A0.6050.80
157_L242_V0.6040.80
178_V205_I0.6020.79
245_V306_M0.6010.79
167_K250_Q0.6000.79
35_L83_L0.5990.79
18_F22_L0.5990.79
106_A146_V0.5980.79
194_D208_T0.5960.79
5_V327_A0.5950.79
46_Q58_V0.5920.78
3_V6_G0.5920.78
45_L67_V0.5920.78
141_A145_D0.5920.78
101_T106_A0.5920.78
161_A244_L0.5920.78
110_L145_D0.5910.78
239_V280_L0.5900.78
20_A24_N0.5890.78
257_V261_L0.5870.78
85_W109_H0.5870.78
65_L72_I0.5860.78
6_G89_G0.5850.77
247_E306_M0.5850.77
173_G246_A0.5850.77
203_E286_N0.5840.77
163_V264_A0.5820.77
174_M228_N0.5820.77
132_M149_N0.5810.77
161_A220_L0.5800.77
156_C311_S0.5800.77
128_I140_D0.5780.77
3_V92_I0.5770.77
103_R108_K0.5770.77
30_V33_N0.5740.76
132_M325_D0.5740.76
195_Y279_P0.5730.76
35_L97_T0.5700.76
38_A63_N0.5700.76
205_I236_T0.5690.76
236_T285_Y0.5680.75
216_V228_N0.5680.75
144_H147_I0.5670.75
39_N43_H0.5650.75
150_A215_A0.5650.75
261_L275_Y0.5630.75
323_V327_A0.5620.75
205_I234_V0.5620.75
181_Y203_E0.5610.75
83_L109_H0.5600.74
24_N325_D0.5600.74
194_D198_A0.5590.74
246_A261_L0.5590.74
258_N296_A0.5590.74
110_L146_V0.5590.74
168_F246_A0.5570.74
91_E114_A0.5560.74
38_A64_N0.5560.74
175_M229_G0.5540.74
139_Y143_N0.5520.73
16_N317_S0.5510.73
176_T243_D0.5500.73
177_T240_S0.5500.73
262_K296_A0.5500.73
84_S112_A0.5500.73
45_L58_V0.5490.73
109_H114_A0.5490.73
88_Q112_A0.5480.73
181_Y201_A0.5470.73
91_E113_G0.5440.72
5_V27_V0.5440.72
101_T124_N0.5430.72
167_K268_D0.5410.72
184_D198_A0.5400.72
29_V33_N0.5400.72
40_M191_P0.5390.72
173_G244_L0.5390.72
32_V72_I0.5390.72
265_A274_G0.5380.71
39_N62_G0.5370.71
230_G298_S0.5350.71
278_E285_Y0.5350.71
4_K30_V0.5340.71
175_M244_L0.5320.71
255_E258_N0.5320.71
176_T308_K0.5320.71
86_G114_A0.5320.71
21_A24_N0.5320.71
161_A246_A0.5310.70
53_K278_E0.5310.70
6_G75_S0.5300.70
319_Y326_L0.5290.70
17_V21_A0.5290.70
40_M198_A0.5290.70
62_G65_L0.5290.70
20_A317_S0.5270.70
162_K268_D0.5250.70
167_K248_L0.5250.70
36_T40_M0.5230.69
302_M306_M0.5230.69
252_V305_S0.5230.69
6_G85_W0.5220.69
133_G272_I0.5200.69
326_L329_Y0.5200.69
166_D220_L0.5200.69
8_N33_N0.5190.69
136_E268_D0.5180.69
42_A65_L0.5080.67
165_N223_L0.5080.67
266_E275_Y0.5080.67
47_Y53_K0.5060.67
149_N325_D0.5050.67
188_L237_P0.5040.67
291_S320_S0.5040.67
156_C292_S0.5030.66
230_G241_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4boyA 4 0.997 100 0.199 Contact Map
3idsC 4 1 100 0.213 Contact Map
3docA 4 0.994 100 0.218 Contact Map
4lsmA 4 0.9851 100 0.22 Contact Map
1rm4O 4 0.994 100 0.221 Contact Map
2ep7A 4 0.9881 100 0.221 Contact Map
2x5jO 4 0.9761 100 0.221 Contact Map
3cpsA 4 0.991 100 0.231 Contact Map
4o59O 4 0.9851 100 0.231 Contact Map
1obfO 4 0.9851 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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