GREMLIN Database
PTHP - Phosphocarrier protein HPr
UniProt: P08877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 88 (82)
Sequences: 2910 (1940)
Seq/√Len: 214.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_T60_E2.9181.00
65_A74_L2.7651.00
30_D68_A2.4631.00
3_Q62_T2.2911.00
6_F78_E2.2791.00
4_K78_E2.2291.00
31_A69_D2.0711.00
34_N41_T2.0661.00
29_Y76_A2.0261.00
41_T64_S2.0221.00
25_T28_K2.0181.00
36_E62_T2.0121.00
36_E64_S2.0001.00
36_E41_T1.9671.00
5_T62_T1.9031.00
78_E82_K1.8341.00
71_N75_N1.7721.00
9_T85_G1.7371.00
37_Y59_A1.7121.00
3_Q64_S1.6871.00
7_K60_E1.6301.00
30_D69_D1.6291.00
79_E84_E1.6011.00
22_L44_L1.4271.00
9_T82_K1.3661.00
25_T76_A1.3531.00
32_D66_S1.3291.00
26_A77_L1.3151.00
75_N79_E1.2851.00
22_L77_L1.2841.00
72_D76_A1.2611.00
4_K75_N1.1451.00
32_D43_N1.1071.00
29_Y73_A1.0971.00
22_L81_M1.0951.00
55_I61_I1.0841.00
11_D57_K1.0831.00
56_A59_A1.0801.00
42_V53_L1.0671.00
33_V73_A1.0561.00
36_E39_G1.0531.00
72_D75_N1.0181.00
14_I22_L1.0141.00
31_A65_A1.0001.00
22_L35_L0.9761.00
8_V55_I0.9651.00
69_D72_D0.9581.00
43_N46_S0.9220.99
21_V24_Q0.8710.99
33_V65_A0.8560.99
6_F63_I0.8440.99
26_A33_V0.8220.99
4_K82_K0.8010.98
33_V44_L0.7910.98
20_T51_M0.7880.98
21_V25_T0.7870.98
46_S49_G0.7860.98
12_S18_P0.7740.98
42_V48_M0.7680.98
76_A79_E0.7630.98
10_A80_T0.7380.97
16_A20_T0.7350.97
63_I81_M0.7300.97
26_A73_A0.7260.97
34_N64_S0.7250.97
25_T80_T0.7240.97
24_Q28_K0.7200.97
48_M52_S0.7180.97
61_I81_M0.7150.97
23_V47_I0.6990.96
19_A50_V0.6990.96
26_A45_K0.6990.96
27_S49_G0.6900.96
37_Y55_I0.6900.96
29_Y69_D0.6890.96
63_I77_L0.6850.96
21_V80_T0.6790.96
48_M51_M0.6730.95
4_K74_L0.6720.95
18_P21_V0.6620.95
22_L63_I0.6590.95
43_N48_M0.6550.95
20_T24_Q0.6530.95
63_I74_L0.6510.94
34_N43_N0.6490.94
74_L78_E0.6460.94
6_F81_M0.6440.94
42_V49_G0.6410.94
15_H80_T0.6210.93
8_V81_M0.6130.92
31_A70_E0.6130.92
27_S47_I0.6080.92
54_G59_A0.6060.92
38_N59_A0.5900.91
13_G19_A0.5820.90
19_A49_G0.5750.90
16_A47_I0.5680.89
20_T52_S0.5670.89
78_E81_M0.5610.89
16_A48_M0.5600.89
47_I51_M0.5550.88
32_D45_K0.5520.88
23_V50_V0.5480.88
6_F14_I0.5380.87
69_D73_A0.5380.87
36_E42_V0.5370.87
16_A49_G0.5370.87
47_I54_G0.5360.86
14_I55_I0.5330.86
10_A14_I0.5290.86
19_A47_I0.5280.86
6_F74_L0.5260.85
16_A54_G0.5200.85
20_T46_S0.5180.85
35_L63_I0.5140.84
43_N49_G0.5080.83
7_K57_K0.5070.83
35_L50_V0.5060.83
25_T29_Y0.5050.83
40_K50_V0.5050.83
10_A51_M0.5040.83
10_A85_G0.5020.83
65_A70_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3le1A 1 0.9886 100 0.108 Contact Map
1kklH 1 0.9773 100 0.11 Contact Map
1sphA 2 0.9773 100 0.112 Contact Map
1y51A 1 0.9773 100 0.113 Contact Map
1ptfA 1 0.9886 100 0.121 Contact Map
1pchA 1 0.9773 100 0.138 Contact Map
1ka5A 1 1 100 0.148 Contact Map
3ihsA 1 0.9318 100 0.156 Contact Map
3ccdA 2 0.9659 100 0.16 Contact Map
2jpiA 1 0.8864 73.1 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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