GREMLIN Database
DBH1 - DNA-binding protein HU 1
UniProt: P08821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 92 (90)
Sequences: 4799 (2718)
Seq/√Len: 286.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R78_A3.3181.00
59_K68_E2.7551.00
35_A40_D2.6931.00
22_T26_D2.4971.00
54_E75_K2.3991.00
57_A70_E2.3671.00
61_R66_G2.2531.00
59_K70_E2.1661.00
52_V75_K2.0711.00
60_G71_I2.0501.00
8_N18_K2.0221.00
20_D23_K1.9531.00
83_K87_D1.8911.00
10_V25_V1.8451.00
61_R68_E1.8441.00
19_K23_K1.7731.00
54_E73_A1.7161.00
28_V32_I1.6251.00
36_L85_L1.5781.00
51_E80_K1.5681.00
41_K49_N1.5541.00
36_L52_V1.5251.00
55_R76_V1.4771.00
41_K51_E1.4131.00
17_S20_D1.3911.00
33_L85_L1.3711.00
10_V28_V1.3541.00
45_I82_G1.3241.00
9_A13_A1.3211.00
21_A24_A1.2771.00
6_L44_L1.2531.00
57_A73_A1.1861.00
9_A31_T1.1711.00
16_L21_A1.1661.00
74_S90_A1.1641.00
16_L24_A1.1361.00
3_K26_D1.1331.00
32_I42_I1.0951.00
13_A34_D1.0881.00
48_G79_F1.0821.00
33_L88_A1.0561.00
13_A31_T1.0481.00
34_D38_N1.0241.00
39_G75_K1.0231.00
29_F47_F1.0041.00
30_D33_L0.9981.00
9_A12_E0.9961.00
43_Q49_N0.9921.00
31_T35_A0.9841.00
29_F44_L0.9631.00
14_S21_A0.9591.00
37_K88_A0.9381.00
25_V29_F0.8951.00
27_S31_T0.8911.00
8_N12_E0.8881.00
10_V14_S0.8771.00
5_E8_N0.8771.00
1_M5_E0.8751.00
64_Q67_E0.8701.00
51_E78_A0.8611.00
16_L20_D0.8481.00
74_S86_K0.8401.00
62_N67_E0.8231.00
47_F50_F0.8211.00
28_V31_T0.8161.00
58_R76_V0.8090.99
47_F82_G0.7970.99
55_R74_S0.7950.99
34_D37_K0.7800.99
36_L77_P0.7760.99
13_A30_D0.7700.99
77_P89_V0.7680.99
2_N5_E0.7580.99
10_V24_A0.7510.99
61_R64_Q0.7450.99
84_A87_D0.7430.99
60_G69_I0.7250.99
49_N80_K0.7160.99
35_A38_N0.7070.99
62_N66_G0.6940.98
35_A42_I0.6930.98
77_P86_K0.6930.98
24_A31_T0.6910.98
11_A14_S0.6880.98
43_Q58_R0.6840.98
77_P85_L0.6760.98
31_T34_D0.6730.98
23_K27_S0.6730.98
50_F79_F0.6670.98
7_I22_T0.6670.98
4_T8_N0.6610.98
33_L37_K0.6610.98
13_A27_S0.6530.98
45_I84_A0.6520.98
57_A72_P0.6510.98
30_D34_D0.6500.98
38_N54_E0.6480.98
60_G68_E0.6410.97
22_T41_K0.6310.97
26_D30_D0.6300.97
17_S21_A0.6250.97
15_E23_K0.6240.97
55_R58_R0.6210.97
49_N82_G0.6140.97
53_R76_V0.6090.96
39_G54_E0.6080.96
29_F33_L0.5970.96
34_D54_E0.5910.96
19_K22_T0.5800.95
10_V21_A0.5760.95
27_S30_D0.5720.95
2_N45_I0.5710.95
32_I50_F0.5640.95
15_E21_A0.5590.94
32_I47_F0.5560.94
15_E20_D0.5540.94
7_I25_V0.5480.94
9_A35_A0.5480.94
3_K22_T0.5370.93
9_A38_N0.5310.93
59_K69_I0.5310.93
52_V85_L0.5300.93
38_N70_E0.5290.93
62_N65_T0.5290.93
43_Q84_A0.5270.92
20_D24_A0.5260.92
11_A18_K0.5240.92
84_A88_A0.5220.92
46_G82_G0.5120.91
10_V31_T0.5110.91
61_R69_I0.5100.91
14_S27_S0.5090.91
4_T58_R0.5070.91
21_A31_T0.5000.90
73_A80_K0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjuA 2 0.9783 100 0.149 Contact Map
2iieA 1 1 100 0.159 Contact Map
4p3vA 2 0.7826 100 0.159 Contact Map
1mulA 2 0.8261 100 0.163 Contact Map
1p71A 2 1 100 0.163 Contact Map
1b8zA 2 0.7283 100 0.164 Contact Map
1exeA 2 1 100 0.165 Contact Map
4pt4A 2 1 100 0.167 Contact Map
1owfB 1 1 100 0.168 Contact Map
1owfA 1 1 100 0.173 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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