GREMLIN Database
DACA - D-alanyl-D-alanine carboxypeptidase DacA
UniProt: P08750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 443 (373)
Sequences: 3993 (3188)
Seq/√Len: 165.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_D198_K3.7931.00
56_S59_A3.7841.00
120_V139_I3.0161.00
91_T117_K2.9831.00
144_A153_K2.9251.00
95_D141_E2.9081.00
77_L139_I2.7971.00
381_K402_G2.7661.00
45_M306_A2.7471.00
58_N61_K2.6791.00
255_D279_R2.6611.00
280_V306_A2.5461.00
127_T139_I2.4971.00
204_A257_L2.4911.00
90_Q142_I2.4671.00
96_D114_K2.4661.00
378_K404_D2.4641.00
157_K160_E2.4581.00
125_Q220_I2.4531.00
163_L203_L2.4041.00
62_R194_E2.4031.00
253_T275_R2.3151.00
60_D165_D2.3061.00
79_E157_K2.3041.00
119_T122_E2.2531.00
75_Y206_H2.2081.00
126_A132_A2.1611.00
274_E277_G2.1141.00
373_V407_T2.1141.00
147_E171_A2.0991.00
71_M270_T2.0891.00
255_D272_T2.0821.00
127_T136_A2.0631.00
72_M166_Y2.0551.00
335_E409_E1.9941.00
93_T117_K1.9911.00
43_A55_Y1.9841.00
87_K90_Q1.9561.00
48_A281_I1.9501.00
198_K202_V1.9371.00
149_K152_E1.9121.00
314_E317_A1.8931.00
341_V408_K1.8731.00
282_T299_T1.8681.00
62_R165_D1.8521.00
298_E301_K1.8241.00
96_D100_E1.8121.00
152_E156_A1.8071.00
369_L379_V1.7991.00
146_S149_K1.7821.00
385_E390_E1.7701.00
273_A307_F1.7671.00
72_M158_A1.7661.00
204_A270_T1.7631.00
92_Y142_I1.7551.00
378_K381_K1.7331.00
91_T119_T1.7111.00
86_V120_V1.7101.00
213_E216_E1.6881.00
144_A149_K1.6811.00
92_Y138_A1.6551.00
42_A63_L1.6511.00
163_L202_V1.6491.00
166_Y195_V1.6401.00
161_L206_H1.6381.00
42_A197_A1.6301.00
45_M280_V1.6091.00
94_P138_A1.6071.00
95_D98_V1.5921.00
68_M270_T1.5801.00
74_E127_T1.5791.00
73_T136_A1.5761.00
97_Y141_E1.5691.00
74_E128_A1.5661.00
377_T407_T1.5661.00
343_N404_D1.5611.00
167_K194_E1.5551.00
89_D121_K1.5521.00
361_K385_E1.5491.00
327_T337_E1.5381.00
86_V142_I1.5371.00
379_V407_T1.5191.00
77_L120_V1.5181.00
374_K410_N1.5131.00
129_I220_I1.4971.00
205_D281_I1.4911.00
47_E278_M1.4771.00
338_V407_T1.4771.00
156_A160_E1.4741.00
41_S286_N1.4701.00
68_M200_M1.4681.00
390_E402_G1.4661.00
262_T265_A1.4531.00
197_A285_L1.4481.00
80_A85_K1.4471.00
206_H209_T1.4461.00
175_E264_S1.4331.00
222_K234_D1.4221.00
44_I198_K1.4111.00
375_K410_N1.4081.00
383_T402_G1.3971.00
169_V176_N1.3961.00
374_K377_T1.3961.00
121_K125_Q1.3881.00
362_V405_L1.3511.00
65_I195_V1.3491.00
363_T383_T1.3391.00
251_K304_D1.3341.00
88_W124_Y1.3321.00
121_K217_T1.3221.00
126_A135_A1.3191.00
45_M282_T1.3181.00
74_E124_Y1.3161.00
200_M270_T1.3161.00
271_G299_T1.3121.00
169_V178_D1.3081.00
121_K216_E1.3021.00
94_P112_L1.2891.00
224_K234_D1.2821.00
69_T193_S1.2811.00
88_W121_K1.2791.00
64_P264_S1.2751.00
125_Q223_T1.2731.00
363_T381_K1.2661.00
44_I59_A1.2651.00
206_H210_D1.2581.00
71_M204_A1.2521.00
68_M285_L1.2461.00
64_P175_E1.2451.00
110_V126_A1.2441.00
158_A163_L1.2421.00
383_T390_E1.2391.00
125_Q129_I1.2361.00
272_T279_R1.2341.00
82_D213_E1.2321.00
153_K156_A1.2281.00
101_I137_I1.2271.00
221_A243_K1.2161.00
254_V271_G1.2141.00
81_I214_I1.2081.00
205_D209_T1.1991.00
334_K412_E1.1961.00
215_L272_T1.1901.00
75_Y157_K1.1891.00
149_K153_K1.1851.00
86_V139_I1.1851.00
75_Y210_D1.1761.00
361_K383_T1.1751.00
339_G408_K1.1691.00
274_E279_R1.1681.00
314_E347_S1.1681.00
46_I201_A1.1631.00
414_A418_V1.1631.00
59_A198_K1.1541.00
131_S258_K1.1541.00
98_V141_E1.1531.00
178_D194_E1.1511.00
287_A298_E1.1431.00
311_S352_N1.1411.00
77_L127_T1.1331.00
421_M425_G1.1241.00
169_V193_S1.1161.00
42_A58_N1.1131.00
71_M257_L1.1111.00
316_Y342_T1.1091.00
76_L80_A1.1091.00
327_T339_G1.1091.00
60_D196_S1.1001.00
157_K206_H1.0931.00
44_I53_I1.0911.00
43_A57_K1.0911.00
265_A268_C1.0881.00
300_K304_D1.0791.00
273_A303_F1.0771.00
151_V171_A1.0771.00
317_A345_A1.0730.99
97_Y148_T1.0700.99
289_G294_G1.0620.99
284_V299_T1.0530.99
251_K254_V1.0520.99
51_G205_D1.0520.99
81_I86_V1.0500.99
317_A320_D1.0480.99
328_I340_I1.0410.99
158_A203_L1.0400.99
22_C25_P1.0370.99
351_K354_E1.0360.99
151_V155_N1.0310.99
131_S259_T1.0300.99
407_T410_N1.0230.99
136_A171_A1.0200.99
77_L86_V1.0190.99
415_N418_V1.0170.99
330_V333_G1.0120.99
340_I379_V1.0080.99
343_N406_V1.0070.99
41_S63_L1.0070.99
113_R116_G1.0060.99
271_G303_F1.0040.99
62_R196_S1.0000.99
359_K385_E0.9910.99
92_Y120_V0.9910.99
99_Y114_K0.9910.99
339_G409_E0.9890.99
338_V373_V0.9870.99
254_V303_F0.9850.99
80_A153_K0.9840.99
132_A135_A0.9780.99
167_K178_D0.9770.99
312_M349_P0.9740.99
386_Y389_D0.9680.99
346_F401_A0.9670.99
94_P118_Y0.9640.99
216_E219_S0.9600.99
305_Y310_F0.9580.99
80_A143_V0.9560.99
330_V371_A0.9490.99
77_L143_V0.9450.99
318_E345_A0.9430.99
40_A287_A0.9420.99
354_E357_N0.9410.99
71_M207_L0.9360.99
338_V411_V0.9330.99
76_L143_V0.9330.99
65_I285_L0.9290.99
218_S257_L0.9280.99
143_V153_K0.9270.99
44_I56_S0.9260.98
89_D119_T0.9250.98
275_R307_F0.9240.98
333_G371_A0.9220.98
49_S312_M0.9160.98
76_L157_K0.9160.98
94_P123_L0.9130.98
200_M285_L0.9120.98
39_N298_E0.9110.98
413_K419_L0.9100.98
37_D57_K0.9100.98
208_I215_L0.9050.98
385_E388_G0.9010.98
288_K294_G0.8930.98
201_A283_V0.8920.98
251_K273_A0.8910.98
215_L279_R0.8880.98
175_E262_T0.8870.98
195_V200_M0.8860.98
47_E349_P0.8850.98
49_S347_S0.8820.98
377_T410_N0.8810.98
165_D196_S0.8800.98
128_A218_S0.8760.98
47_E312_M0.8710.98
78_L214_I0.8660.98
314_E345_A0.8650.98
312_M347_S0.8600.98
202_V205_D0.8590.98
164_T198_K0.8560.97
414_A422_R0.8550.97
81_I88_W0.8540.97
156_A159_K0.8530.97
88_W217_T0.8520.97
215_L218_S0.8510.97
155_N167_K0.8460.97
66_A265_A0.8460.97
275_R304_D0.8440.97
270_T283_V0.8420.97
44_I201_A0.8410.97
346_F403_V0.8400.97
97_Y147_E0.8370.97
112_L138_A0.8360.97
86_V92_Y0.8360.97
72_M154_M0.8340.97
109_N112_L0.8320.97
269_F299_T0.8300.97
71_M128_A0.8290.97
137_I147_E0.8280.97
108_S132_A0.8280.97
207_L257_L0.8270.97
274_E307_F0.8260.97
79_E210_D0.8230.97
44_I283_V0.8180.97
67_S258_K0.8160.97
225_F235_M0.8140.97
159_K164_T0.8130.97
284_V287_A0.8120.97
86_V90_Q0.8120.97
369_L373_V0.8060.96
82_D211_Y0.8020.96
251_K300_K0.8010.96
200_M204_A0.7990.96
305_Y309_N0.7960.96
214_I218_S0.7950.96
123_L135_A0.7910.96
294_G298_E0.7850.96
239_N269_F0.7820.96
118_Y123_L0.7820.96
49_S279_R0.7820.96
80_A86_V0.7810.96
333_G411_V0.7810.96
102_S107_L0.7800.96
93_T142_I0.7790.96
158_A168_F0.7770.96
41_S61_K0.7760.96
257_L272_T0.7750.96
79_E83_Q0.7730.95
118_Y122_E0.7710.95
321_Q339_G0.7710.95
116_G233_M0.7690.95
82_D210_D0.7690.95
373_V379_V0.7650.95
21_T25_P0.7640.95
372_P411_V0.7630.95
78_L124_Y0.7590.95
42_A285_L0.7590.95
243_K250_K0.7560.95
240_F296_F0.7560.95
282_T303_F0.7530.95
222_K236_P0.7510.95
122_E125_Q0.7500.95
271_G282_T0.7460.94
235_M238_W0.7450.94
71_M203_L0.7410.94
253_T304_D0.7400.94
54_L310_F0.7380.94
161_L203_L0.7360.94
125_Q217_T0.7340.94
74_E218_S0.7340.94
63_L285_L0.7320.94
223_T235_M0.7300.94
207_L214_I0.7270.94
342_T405_L0.7270.94
84_G87_K0.7270.94
333_G372_P0.7260.94
76_L79_E0.7250.94
239_N271_G0.7240.94
72_M76_L0.7240.94
130_Y238_W0.7230.94
382_L403_V0.7220.93
154_M158_A0.7180.93
278_M312_M0.7170.93
67_S260_G0.7170.93
376_G407_T0.7160.93
68_M268_C0.7160.93
23_L26_M0.7140.93
357_N387_T0.7120.93
110_V118_Y0.7100.93
208_I255_D0.7080.93
80_A83_Q0.7070.93
64_P176_N0.7070.93
46_I205_D0.7000.92
313_K355_E0.6980.92
224_K232_E0.6980.92
334_K418_V0.6970.92
124_Y217_T0.6960.92
72_M168_F0.6950.92
88_W91_T0.6940.92
165_D199_D0.6940.92
358_Y386_Y0.6940.92
158_A161_L0.6910.92
267_S290_N0.6890.92
56_S198_K0.6870.92
72_M163_L0.6870.92
97_Y101_I0.6840.92
204_A256_G0.6810.91
155_N168_F0.6800.91
74_E78_L0.6770.91
85_K153_K0.6760.91
79_E160_E0.6740.91
46_I202_V0.6730.91
67_S131_S0.6720.91
301_K304_D0.6720.91
208_I279_R0.6710.91
122_E223_T0.6700.91
101_I174_L0.6700.91
118_Y225_F0.6680.91
151_V166_Y0.6660.90
416_W420_T0.6600.90
101_I109_N0.6590.90
110_V130_Y0.6560.90
254_V273_A0.6560.90
278_M310_F0.6560.90
261_S267_S0.6540.90
360_A384_A0.6540.90
415_N419_L0.6520.89
92_Y123_L0.6510.89
24_A27_S0.6510.89
76_L154_M0.6480.89
172_T175_E0.6460.89
52_K349_P0.6460.89
358_Y400_L0.6440.89
123_L139_I0.6440.89
214_I257_L0.6430.89
46_I281_I0.6420.89
321_Q327_T0.6410.89
67_S259_T0.6400.89
148_T152_E0.6390.89
261_S290_N0.6380.88
332_K370_T0.6380.88
52_K389_D0.6380.88
153_K157_K0.6380.88
45_M302_M0.6360.88
40_A298_E0.6360.88
238_W261_S0.6350.88
262_T268_C0.6320.88
420_T424_I0.6300.88
359_K388_G0.6290.88
253_T273_A0.6280.88
342_T346_F0.6280.88
56_S60_D0.6250.87
95_D138_A0.6230.87
107_L134_A0.6230.87
331_D368_N0.6210.87
231_D235_M0.6210.87
418_V421_M0.6200.87
200_M268_C0.6180.87
130_Y235_M0.6160.87
78_L211_Y0.6160.87
72_M203_L0.6150.87
66_A259_T0.6130.86
155_N159_K0.6130.86
168_F200_M0.6130.86
75_Y211_Y0.6110.86
22_C26_M0.6100.86
381_K404_D0.6100.86
282_T302_M0.6090.86
76_L166_Y0.6070.86
16_L25_P0.6070.86
66_A69_T0.6060.86
350_V358_Y0.6060.86
67_S70_K0.6040.86
107_L172_T0.6020.85
240_F290_N0.6020.85
8_Q11_M0.6020.85
129_I217_T0.6000.85
251_K303_F0.5990.85
207_L218_S0.5970.85
79_E82_D0.5960.85
319_G342_T0.5960.85
138_A142_I0.5960.85
66_A260_G0.5950.85
241_M269_F0.5940.85
66_A131_S0.5930.85
18_L21_T0.5930.85
218_S256_G0.5930.85
214_I217_T0.5920.84
36_I305_Y0.5920.84
340_I405_L0.5910.84
289_G295_R0.5900.84
140_A147_E0.5880.84
360_A382_L0.5860.84
167_K193_S0.5860.84
17_T21_T0.5850.84
55_Y302_M0.5850.84
163_L199_D0.5850.84
418_V422_R0.5840.84
68_M71_M0.5840.84
69_T195_V0.5800.83
62_R195_V0.5790.83
218_S272_T0.5770.83
316_Y382_L0.5760.83
129_I223_T0.5760.83
259_T295_R0.5750.83
386_Y400_L0.5740.83
284_V302_M0.5730.83
371_A411_V0.5700.82
79_E211_Y0.5690.82
250_K300_K0.5690.82
14_V17_T0.5680.82
193_S268_C0.5660.82
38_I43_A0.5660.82
107_L111_P0.5650.82
58_N63_L0.5640.82
208_I257_L0.5620.81
47_E50_S0.5610.81
121_K213_E0.5610.81
76_L153_K0.5600.81
365_N368_N0.5600.81
315_I348_L0.5600.81
70_K133_N0.5590.81
250_K296_F0.5570.81
166_Y199_D0.5570.81
38_I298_E0.5560.81
48_A205_D0.5560.81
176_N194_E0.5550.81
143_V151_V0.5550.81
141_E147_E0.5540.80
287_A294_G0.5530.80
53_I56_S0.5520.80
323_K362_V0.5510.80
78_L218_S0.5490.80
46_I51_G0.5470.80
157_K161_L0.5470.80
102_S109_N0.5460.79
39_N294_G0.5460.79
52_K354_E0.5450.79
200_M203_L0.5450.79
128_A214_I0.5450.79
124_Y128_A0.5440.79
102_S134_A0.5440.79
97_Y137_I0.5440.79
86_V143_V0.5420.79
101_I107_L0.5420.79
118_Y126_A0.5410.79
315_I384_A0.5410.79
362_V382_L0.5410.79
65_I200_M0.5400.79
269_F284_V0.5400.79
169_V194_E0.5390.79
96_D99_Y0.5390.79
164_T202_V0.5380.78
316_Y384_A0.5380.78
313_K350_V0.5370.78
54_L280_V0.5340.78
123_L142_I0.5340.78
78_L213_E0.5330.78
278_M349_P0.5320.78
255_D274_E0.5320.78
62_R167_K0.5310.78
219_S255_D0.5300.77
75_Y203_L0.5300.77
109_N134_A0.5300.77
195_V199_D0.5290.77
175_E265_A0.5280.77
332_K423_S0.5270.77
112_L118_Y0.5260.77
65_I69_T0.5250.77
110_V235_M0.5250.77
120_V142_I0.5230.76
48_A209_T0.5230.76
251_K307_F0.5230.76
154_M168_F0.5210.76
74_E207_L0.5210.76
62_R178_D0.5210.76
168_F203_L0.5200.76
269_F282_T0.5200.76
111_P231_D0.5190.76
220_I223_T0.5180.76
53_I59_A0.5180.76
131_S262_T0.5160.76
259_T262_T0.5150.75
319_G341_V0.5140.75
97_Y100_E0.5130.75
124_Y136_A0.5130.75
137_I172_T0.5130.75
108_S259_T0.5100.75
376_G380_G0.5090.75
155_N163_L0.5090.75
11_M15_V0.5080.74
390_E401_A0.5070.74
110_V132_A0.5070.74
329_S337_E0.5060.74
44_I48_A0.5050.74
78_L217_T0.5050.74
267_S296_F0.5050.74
269_F296_F0.5050.74
15_V26_M0.5040.74
71_M78_L0.5020.74
150_F154_M0.5010.73
39_N288_K0.5010.73
330_V369_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzfA 1 0.7923 100 0.316 Contact Map
1xp4A 3 0.8284 100 0.328 Contact Map
4k91A 1 0.7743 100 0.329 Contact Map
3itaA 1 0.781 100 0.329 Contact Map
3a3jA 1 0.7698 100 0.34 Contact Map
3mfdA 1 0.7246 100 0.355 Contact Map
3hunA 1 0.7652 100 0.406 Contact Map
1tvfA 1 0.7923 100 0.445 Contact Map
4pprA 1 0.6614 100 0.531 Contact Map
4ryeA 1 0.5937 100 0.532 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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