GREMLIN Database
AK2 - Aspartokinase 2
UniProt: P08495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (391)
Sequences: 4806 (2707)
Seq/√Len: 136.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_Y130_I4.2841.00
91_D129_K4.0101.00
357_E398_A3.9461.00
140_T144_E3.8231.00
387_D390_K3.6381.00
37_V164_L3.4341.00
133_V160_L3.2301.00
161_A169_C3.1981.00
40_V78_I2.9221.00
203_L344_V2.8501.00
95_Y124_Q2.8341.00
360_A364_Q2.8251.00
27_I88_K2.7381.00
262_T310_T2.6471.00
82_S92_A2.5861.00
20_Q88_K2.5661.00
168_K227_E2.5641.00
194_G241_E2.5431.00
227_E239_L2.5411.00
22_A81_L2.5341.00
176_P233_E2.5091.00
21_N24_N2.4991.00
257_F388_M2.4581.00
337_K385_E2.4371.00
24_N88_K2.3911.00
281_T285_K2.3321.00
278_T326_A2.2681.00
27_I90_Y2.2351.00
93_V129_K2.2331.00
198_D220_K2.2271.00
317_V321_E2.1841.00
78_I134_A2.1661.00
341_V395_L2.1551.00
26_A38_V2.1511.00
11_T14_G2.1341.00
259_D389_V2.1151.00
46_S49_E2.1051.00
106_A140_T2.0701.00
51_V66_M2.0171.00
52_S56_A1.9891.00
104_T146_T1.9771.00
348_M353_G1.9731.00
51_V70_L1.9641.00
188_S397_D1.9541.00
193_E236_A1.9491.00
28_A234_T1.9111.00
86_Q91_D1.9081.00
313_A334_T1.8841.00
119_S123_D1.8221.00
71_A145_I1.8101.00
19_I81_L1.7981.00
11_T44_G1.7961.00
165_K222_Y1.7651.00
365_K390_K1.7481.00
170_D227_E1.7421.00
259_D385_E1.7371.00
27_I130_I1.7341.00
30_K35_Q1.7141.00
27_I85_L1.7131.00
118_T122_A1.7081.00
40_V81_L1.7071.00
67_D109_G1.7031.00
384_S387_D1.6981.00
160_L164_L1.6981.00
219_A226_L1.6951.00
285_K322_E1.6931.00
223_Q242_E1.6871.00
26_A85_L1.6831.00
158_V169_C1.6831.00
192_L195_I1.6741.00
390_K393_E1.6681.00
54_A66_M1.6581.00
24_N27_I1.6471.00
121_L131_V1.6301.00
310_T336_S1.6181.00
362_L391_A1.6111.00
364_Q398_A1.5951.00
37_V133_V1.5911.00
45_K209_G1.5811.00
93_V131_V1.5621.00
120_V124_Q1.5541.00
321_E324_K1.5401.00
176_P179_F1.5381.00
29_E170_D1.5351.00
173_T228_V1.5291.00
276_L304_I1.5051.00
8_F25_R1.4871.00
277_S284_A1.4851.00
368_L372_V1.4841.00
66_M70_L1.4641.00
84_A88_K1.4551.00
255_I392_V1.4401.00
51_V55_K1.4291.00
98_W145_I1.4261.00
113_I159_A1.4241.00
25_R234_T1.4161.00
23_A88_K1.4111.00
361_V398_A1.4081.00
18_K21_N1.3941.00
365_K394_S1.3821.00
30_K90_Y1.3711.00
339_A388_M1.3651.00
20_Q87_E1.3521.00
358_M381_T1.3381.00
64_R144_E1.3351.00
181_T257_F1.3341.00
34_H167_D1.3201.00
358_M395_L1.3201.00
170_D229_R1.3091.00
262_T313_A1.2981.00
21_N231_S1.2951.00
44_G48_D1.2921.00
72_T76_V1.2901.00
19_I84_A1.2861.00
24_N28_A1.2801.00
341_V392_V1.2601.00
45_K49_E1.2591.00
269_L274_T1.2531.00
4_I34_H1.2531.00
264_V316_T1.2501.00
292_I382_V1.2491.00
104_T138_G1.2441.00
54_A69_L1.2401.00
30_K130_I1.2381.00
176_P230_S1.2381.00
310_T385_E1.2361.00
39_V160_L1.2341.00
69_L79_S1.2181.00
123_D127_K1.2171.00
95_Y131_V1.2141.00
122_A126_E1.2131.00
35_Q126_E1.2121.00
286_R315_Q1.2081.00
97_G100_A1.2061.00
266_I279_I1.1981.00
14_G44_G1.1901.00
341_V391_A1.1881.00
6_Q29_E1.1841.00
361_V394_S1.1831.00
116_I120_V1.1810.99
85_L90_Y1.1790.99
317_V334_T1.1770.99
329_F332_I1.1770.99
111_A146_T1.1700.99
108_H111_A1.1700.99
91_D128_G1.1670.99
389_V393_E1.1610.99
121_L160_L1.1590.99
169_C219_A1.1590.99
3_L167_D1.1520.99
263_R370_K1.1470.99
123_D126_E1.1460.99
180_T396_H1.1450.99
23_A84_A1.1420.99
12_S231_S1.1320.99
15_S18_K1.1280.99
106_A142_D1.1270.99
185_Y392_V1.1210.99
23_A27_I1.1160.99
62_S86_Q1.1130.99
96_T101_G1.1090.99
103_R139_M1.1080.99
27_I30_K1.1070.99
29_E36_V1.1040.99
318_A322_E1.1030.99
286_R322_E1.1000.99
63_K109_G1.0980.99
337_K384_S1.0940.99
103_R141_E1.0940.99
176_P235_E1.0910.99
58_S87_E1.0800.99
181_T392_V1.0770.99
98_W139_M1.0760.99
262_T336_S1.0750.99
11_T173_T1.0690.99
102_I156_T1.0620.99
168_K239_L1.0610.99
282_T323_Y1.0590.99
25_R231_S1.0470.99
260_Q310_T1.0460.99
162_A224_V1.0440.99
282_T319_V1.0430.99
26_A130_I1.0400.99
16_V20_Q1.0390.99
52_S55_K1.0390.99
22_A26_A1.0390.99
360_A398_A1.0380.99
195_I253_R1.0340.99
348_M354_V1.0190.98
85_L132_I1.0170.98
370_K384_S1.0170.98
71_A75_Q1.0150.98
324_K329_F1.0120.98
397_D401_L1.0110.98
314_D336_S1.0030.98
11_T45_K1.0020.98
83_M86_Q0.9980.98
110_N312_D0.9960.98
267_Y331_K0.9900.98
258_E261_I0.9860.98
265_T305_S0.9830.98
194_G239_L0.9820.98
274_T368_L0.9750.98
291_D307_S0.9710.98
46_S76_V0.9680.98
211_L240_I0.9630.98
367_I391_A0.9620.98
18_K231_S0.9570.98
318_A321_E0.9540.98
105_E111_A0.9530.98
55_K66_M0.9500.98
282_T286_R0.9460.98
4_I168_K0.9450.98
20_Q84_A0.9440.98
321_E331_K0.9410.97
120_V123_D0.9380.97
26_A132_I0.9360.97
268_G330_E0.9360.97
122_A165_K0.9350.97
106_A111_A0.9330.97
82_S86_Q0.9320.97
97_G134_A0.9280.97
343_I358_M0.9230.97
175_V210_V0.9220.97
114_T141_E0.9220.97
276_L295_Q0.9210.97
288_I319_V0.9130.97
339_A385_E0.9130.97
26_A81_L0.9110.97
276_L293_I0.9090.97
279_I304_I0.9070.97
108_H140_T0.9060.97
53_L57_I0.9030.97
280_F290_V0.9020.97
78_I94_S0.9000.97
342_S380_S0.8990.97
259_D388_M0.8980.97
6_Q170_D0.8950.97
179_F189_A0.8900.96
18_K232_T0.8890.96
335_E370_K0.8870.96
288_I315_Q0.8840.96
156_T160_L0.8820.96
82_S94_S0.8820.96
124_Q129_K0.8800.96
29_E34_H0.8770.96
13_V40_V0.8770.96
353_G376_E0.8770.96
291_D340_K0.8760.96
283_L290_V0.8750.96
279_I323_Y0.8730.96
341_V383_V0.8720.96
292_I380_S0.8710.96
3_L35_Q0.8660.96
23_A81_L0.8630.96
251_I354_V0.8580.96
355_A359_F0.8560.96
67_D147_T0.8540.96
13_V77_T0.8540.96
3_L34_H0.8520.95
337_K386_N0.8500.95
309_K312_D0.8480.95
185_Y257_F0.8470.95
111_A114_T0.8420.95
397_D400_E0.8420.95
19_I43_M0.8390.95
140_T146_T0.8380.95
367_I394_S0.8370.95
349_V376_E0.8370.95
42_A47_T0.8370.95
117_D122_A0.8340.95
37_V131_V0.8340.95
37_V160_L0.8320.95
81_L132_I0.8310.95
30_K91_D0.8310.95
104_T108_H0.8310.95
186_V392_V0.8270.95
257_F392_V0.8260.95
37_V125_L0.8250.95
269_L275_T0.8210.94
3_L6_Q0.8190.94
35_Q129_K0.8150.94
11_T15_S0.8150.94
213_P218_F0.8150.94
196_S199_E0.8140.94
206_L342_S0.8130.94
21_N25_R0.8110.94
93_V124_Q0.8110.94
216_V226_L0.8110.94
367_I390_K0.8110.94
96_T134_A0.8100.94
103_R117_D0.8070.94
98_W101_G0.8050.94
35_Q128_G0.7990.94
264_V308_V0.7960.94
131_V134_A0.7930.93
211_L226_L0.7920.93
21_N232_T0.7870.93
79_S83_M0.7870.93
338_L382_V0.7860.93
338_L370_K0.7850.93
343_I379_V0.7830.93
92_A132_I0.7820.93
53_L69_L0.7780.93
68_M94_S0.7750.93
214_R217_E0.7750.93
259_D339_A0.7740.93
308_V316_T0.7730.93
81_L85_L0.7720.92
48_D150_R0.7710.92
187_K393_E0.7710.92
365_K387_D0.7660.92
96_T100_A0.7620.92
267_Y333_E0.7610.92
58_S61_P0.7610.92
101_G104_T0.7590.92
23_A85_L0.7560.92
362_L367_I0.7550.92
211_L215_A0.7510.91
361_V365_K0.7490.91
312_D315_Q0.7480.91
276_L290_V0.7460.91
292_I373_S0.7450.91
154_D174_D0.7430.91
181_T186_V0.7410.91
124_Q131_V0.7410.91
261_I309_K0.7400.91
97_G133_V0.7390.91
11_T46_S0.7390.91
280_F289_N0.7390.91
288_I316_T0.7380.91
320_L332_I0.7350.91
286_R319_V0.7350.91
279_I320_L0.7350.91
59_D314_D0.7340.90
105_E112_R0.7330.90
15_S43_M0.7320.90
194_G243_E0.7300.90
75_Q145_I0.7300.90
8_F13_V0.7300.90
264_V317_V0.7290.90
340_K380_S0.7290.90
283_L288_I0.7280.90
61_P66_M0.7280.90
8_F12_S0.7270.90
55_K311_E0.7270.90
194_G245_S0.7260.90
185_Y259_D0.7250.90
105_E108_H0.7220.90
8_F29_E0.7200.90
82_S132_I0.7190.90
353_G368_L0.7170.89
296_T305_S0.7160.89
283_L313_A0.7140.89
294_I373_S0.7140.89
179_F211_L0.7130.89
58_S62_S0.7120.89
356_A363_A0.7120.89
281_T360_A0.7040.89
97_G137_Q0.7030.88
276_L368_L0.7010.88
216_V240_I0.7000.88
254_G344_V0.6990.88
335_E338_L0.6980.88
335_E384_S0.6980.88
171_I178_V0.6970.88
196_S242_E0.6940.88
322_E326_A0.6940.88
194_G244_S0.6930.88
67_D138_G0.6910.88
162_A222_Y0.6880.87
48_D52_S0.6870.87
104_T111_A0.6860.87
115_D118_T0.6810.87
181_T255_I0.6800.87
124_Q127_K0.6800.87
173_T210_V0.6800.87
178_V238_T0.6790.87
103_R143_C0.6790.87
105_E110_N0.6790.87
302_T305_S0.6770.87
360_A363_A0.6750.86
277_S281_T0.6750.86
102_I116_I0.6750.86
320_L323_Y0.6750.86
97_G101_G0.6740.86
14_G43_M0.6740.86
63_K315_Q0.6730.86
275_T304_I0.6720.86
178_V200_M0.6710.86
274_T295_Q0.6700.86
364_Q386_N0.6700.86
7_K10_G0.6680.86
283_L306_F0.6660.86
279_I306_F0.6630.85
320_L324_K0.6620.85
296_T302_T0.6600.85
283_L316_T0.6580.85
261_I291_D0.6570.85
103_R115_D0.6550.85
180_T190_R0.6550.85
86_Q92_A0.6530.85
37_V156_T0.6520.84
75_Q96_T0.6510.84
78_I132_I0.6510.84
279_I332_I0.6470.84
91_D127_K0.6470.84
44_G209_G0.6460.84
363_A368_L0.6460.84
355_A372_V0.6460.84
8_F170_D0.6440.84
230_S233_E0.6430.84
18_K22_A0.6420.84
348_M376_E0.6420.84
262_T308_V0.6410.83
156_T218_F0.6410.83
94_S134_A0.6400.83
273_L276_L0.6390.83
217_E221_N0.6370.83
386_N390_K0.6360.83
76_V79_S0.6360.83
122_A125_L0.6310.82
280_F293_I0.6270.82
280_F291_D0.6270.82
362_L381_T0.6270.82
155_T212_H0.6260.82
390_K394_S0.6260.82
107_I110_N0.6250.82
188_S401_L0.6230.82
75_Q78_I0.6230.82
340_K382_V0.6220.82
125_L131_V0.6210.81
6_Q25_R0.6190.81
178_V210_V0.6180.81
280_F304_I0.6180.81
103_R114_T0.6170.81
212_H218_F0.6170.81
260_Q385_E0.6170.81
118_T121_L0.6160.81
229_R234_T0.6160.81
57_I83_M0.6160.81
359_F369_I0.6150.81
383_V388_M0.6130.81
14_G232_T0.6130.81
394_S398_A0.6120.81
265_T333_E0.6110.80
315_Q318_A0.6100.80
215_A218_F0.6090.80
85_L92_A0.6090.80
171_I210_V0.6080.80
28_A235_E0.6060.80
171_I209_G0.6050.80
268_G297_Q0.6050.80
313_A316_T0.6050.80
22_A231_S0.6040.80
358_M379_V0.6030.80
72_T75_Q0.6030.80
391_A394_S0.6020.79
108_H144_E0.6020.79
84_A87_E0.5990.79
264_V332_I0.5990.79
5_V166_A0.5970.79
106_A141_E0.5970.79
393_E397_D0.5940.79
190_R194_G0.5940.79
60_Q314_D0.5930.78
30_K33_G0.5920.78
305_S371_M0.5900.78
276_L372_V0.5880.78
179_F191_K0.5880.78
190_R250_L0.5880.78
384_S394_S0.5860.78
119_S122_A0.5860.78
8_F234_T0.5860.78
261_I307_S0.5860.78
46_S53_L0.5830.77
173_T231_S0.5830.77
383_V391_A0.5830.77
267_Y302_T0.5830.77
12_S210_V0.5830.77
20_Q24_N0.5810.77
99_Q124_Q0.5810.77
66_M109_G0.5800.77
278_T323_Y0.5780.77
314_D317_V0.5780.77
367_I387_D0.5760.76
211_L228_V0.5750.76
253_R256_A0.5750.76
353_G356_A0.5750.76
272_G275_T0.5740.76
17_E20_Q0.5730.76
257_F341_V0.5730.76
181_T396_H0.5720.76
202_E359_F0.5710.76
12_S171_I0.5700.76
80_L99_Q0.5700.76
215_A219_A0.5700.76
92_A130_I0.5690.76
348_M379_V0.5680.75
40_V77_T0.5680.75
219_A222_Y0.5680.75
67_D149_G0.5650.75
274_T289_N0.5650.75
14_G18_K0.5650.75
292_I307_S0.5640.75
96_T145_I0.5630.75
359_F372_V0.5630.75
177_G191_K0.5620.75
155_T215_A0.5620.75
348_M355_A0.5610.75
271_S274_T0.5610.75
368_L373_S0.5600.74
168_K229_R0.5570.74
3_L122_A0.5550.74
365_K391_A0.5530.74
13_V22_A0.5520.73
266_I332_I0.5490.73
13_V43_M0.5470.73
134_A145_I0.5470.73
336_S390_K0.5460.73
106_A114_T0.5460.73
151_G215_A0.5450.72
180_T189_A0.5420.72
241_E244_S0.5420.72
371_M382_V0.5410.72
68_M145_I0.5390.72
165_K223_Q0.5390.72
152_G174_D0.5380.71
359_F368_L0.5370.71
365_K397_D0.5370.71
181_T190_R0.5360.71
108_H146_T0.5330.71
252_V255_I0.5310.71
250_L253_R0.5310.71
278_T322_E0.5310.71
22_A29_E0.5300.70
136_F153_S0.5290.70
225_P239_L0.5290.70
67_D108_H0.5280.70
291_D354_V0.5280.70
257_F339_A0.5270.70
11_T18_K0.5260.70
159_A214_R0.5250.70
290_V303_G0.5240.70
41_S47_T0.5240.70
54_A61_P0.5240.70
357_E361_V0.5230.69
355_A376_E0.5220.69
102_I113_I0.5220.69
263_R371_M0.5210.69
75_Q98_W0.5180.69
310_T337_K0.5170.68
280_F295_Q0.5160.68
111_A147_T0.5150.68
285_K326_A0.5140.68
200_M206_L0.5140.68
22_A25_R0.5130.68
273_L368_L0.5110.68
243_E250_L0.5110.68
271_S302_T0.5100.67
36_V130_I0.5090.67
4_I170_D0.5090.67
354_V379_V0.5080.67
136_F150_R0.5080.67
47_T73_G0.5070.67
283_L319_V0.5060.67
30_K128_G0.5060.67
356_A360_A0.5050.67
271_S276_L0.5050.67
221_N250_L0.5050.67
15_S22_A0.5050.67
193_E321_E0.5040.67
376_E379_V0.5040.67
36_V161_A0.5040.67
93_V143_C0.5040.67
357_E400_E0.5030.66
170_D230_S0.5030.66
12_S173_T0.5030.66
89_G94_S0.5020.66
311_E314_D0.5020.66
260_Q311_E0.5010.66
202_E205_N0.5010.66
78_I96_T0.5010.66
69_L83_M0.5000.66
315_Q319_V0.5000.66
368_L371_M0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.9461 100 0.231 Contact Map
2cdqA 2 0.973 100 0.242 Contact Map
3ab4A 7 0.9412 100 0.243 Contact Map
3l76A 2 0.9755 100 0.249 Contact Map
3c1mA 3 0.973 100 0.26 Contact Map
3tviA 2 0.9485 100 0.277 Contact Map
4ab7A 3 0.8529 100 0.655 Contact Map
2a1fA 5 0.5515 100 0.708 Contact Map
2j4jA 5 0.5074 100 0.709 Contact Map
1ybdA 5 0.5294 100 0.709 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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