GREMLIN Database
SDHB - Succinate dehydrogenase iron-sulfur subunit
UniProt: P08066 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (228)
Sequences: 2605 (1080)
Seq/√Len: 71.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_R27_E4.5861.00
42_E53_E4.4201.00
124_K128_P3.8161.00
10_I96_R3.7881.00
59_T110_Q3.7031.00
9_F39_A3.6491.00
41_M60_W3.6231.00
10_I25_E3.4541.00
180_M235_L3.2541.00
10_I94_P3.1361.00
9_F43_I2.7971.00
39_A88_I2.7531.00
74_M83_S2.6551.00
129_I193_A2.6191.00
152_L231_S2.6001.00
187_N235_L2.4391.00
29_P42_E2.3771.00
24_E55_T2.3281.00
6_T29_P2.2261.00
6_T27_E2.1631.00
116_M159_G2.1191.00
28_I43_I2.1041.00
166_P215_S2.0611.00
76_I81_R2.0491.00
36_V76_I2.0351.00
131_G193_A2.0121.00
8_R94_P1.9941.00
42_E54_K1.9561.00
234_A237_R1.9441.00
181_S226_I1.9071.00
80_P164_A1.8861.00
12_T21_P1.8451.00
124_K198_E1.8431.00
73_S160_V1.8351.00
143_E147_Q1.8081.00
216_Q228_L1.7851.00
16_T19_S1.7841.00
73_S100_M1.7311.00
79_K221_S1.7311.00
10_I23_D1.7181.00
34_L42_E1.7071.00
118_D121_K1.6771.00
75_V163_E1.6511.00
81_R86_A1.6270.99
128_P195_N1.5750.99
9_F95_I1.5680.99
145_R190_P1.5510.99
23_D96_R1.5490.99
141_M190_P1.5450.99
8_R25_E1.5140.99
15_D22_Y1.4710.99
12_T98_K1.4630.99
174_F188_A1.4570.99
203_L207_G1.4510.99
130_D193_A1.4440.99
238_D241_L1.4300.99
153_S159_G1.4230.99
184_R188_A1.4070.98
30_Y39_A1.3960.98
79_K220_Q1.3830.98
129_I139_P1.3660.98
177_P231_S1.3660.98
203_L206_E1.3640.98
181_S231_S1.3620.98
187_N238_D1.3550.98
184_R238_D1.3500.98
146_R150_Y1.3320.98
75_V101_K1.3200.98
12_T23_D1.3180.98
142_P145_R1.3150.97
119_S207_G1.3050.97
30_Y88_I1.2960.97
219_V227_P1.2720.97
11_I58_V1.2690.97
180_M203_L1.2510.97
219_V229_T1.2490.97
61_D71_A1.1990.96
197_S201_E1.1720.95
43_I58_V1.1690.95
28_I39_A1.1400.94
201_E242_Q1.1240.94
195_N198_E1.1160.94
14_Q17_A1.0940.93
103_F163_E1.0830.93
19_S22_Y1.0790.92
18_D22_Y1.0630.92
28_I42_E1.0630.92
31_R34_L1.0360.91
24_E54_K1.0310.91
119_S203_L1.0260.90
160_V221_S1.0260.90
23_D98_K1.0240.90
74_M97_L1.0230.90
145_R148_W1.0220.90
68_V85_T1.0110.90
7_I93_Q1.0110.90
91_L94_P1.0090.90
104_P115_R1.0080.90
175_M179_P1.0060.90
181_S234_A1.0030.89
65_L68_V0.9980.89
44_R59_T0.9980.89
151_E154_K0.9920.89
106_V110_Q0.9890.89
197_S242_Q0.9840.88
166_P176_G0.9810.88
26_F59_T0.9770.88
25_E94_P0.9750.88
113_R116_M0.9670.88
184_R234_A0.9660.88
37_I65_L0.9510.87
124_K202_A0.9420.86
154_K226_I0.9420.86
85_T152_L0.9400.86
130_D195_N0.9350.86
219_V228_L0.9330.86
232_I235_L0.9280.85
28_I58_V0.9260.85
35_N65_L0.9110.84
9_F36_V0.9090.84
75_V80_P0.9040.84
74_M95_I0.9000.84
113_R159_G0.8960.83
71_A74_M0.8920.83
217_N221_S0.8890.83
11_I97_L0.8880.83
103_F113_R0.8880.83
18_D21_P0.8860.83
36_V39_A0.8860.83
36_V88_I0.8790.82
65_L72_C0.8790.82
81_R91_L0.8690.81
26_F55_T0.8660.81
7_I30_Y0.8530.80
146_R154_K0.8530.80
128_P198_E0.8510.80
195_N199_R0.8460.80
15_D18_D0.8400.79
201_E204_M0.8310.78
134_D139_P0.8300.78
152_L188_A0.8280.78
216_Q220_Q0.8280.78
41_M45_R0.8270.78
73_S191_T0.8190.77
80_P217_N0.8170.77
133_Y136_G0.8140.77
75_V215_S0.8080.76
214_N233_A0.8040.76
95_I197_S0.7980.76
216_Q219_V0.7970.75
181_S228_L0.7960.75
203_L235_L0.7950.75
131_G134_D0.7930.75
24_E77_N0.7910.75
71_A82_Q0.7910.75
133_Y139_P0.7900.75
112_D115_R0.7850.74
164_A221_S0.7830.74
20_T24_E0.7810.74
72_C102_T0.7780.74
172_S180_M0.7780.74
36_V86_A0.7780.74
101_K163_E0.7730.73
146_R149_A0.7720.73
7_I241_L0.7660.73
204_M239_T0.7600.72
192_G199_R0.7570.72
58_V109_L0.7540.71
14_Q18_D0.7500.71
167_N215_S0.7500.71
127_I186_F0.7490.71
123_V179_P0.7420.70
40_L60_W0.7410.70
77_N91_L0.7400.70
59_T107_R0.7390.70
149_A153_S0.7350.69
7_I95_I0.7350.69
86_A91_L0.7350.69
31_R42_E0.7300.69
60_W65_L0.7300.69
29_P53_E0.7280.69
71_A192_G0.7260.68
71_A199_R0.7250.68
16_T20_T0.7220.68
116_M153_S0.7170.67
220_Q229_T0.7170.67
90_Q136_G0.7140.67
204_M208_G0.7140.67
92_E106_V0.7130.67
185_L234_A0.7100.67
7_I88_I0.7100.67
7_I39_A0.7090.67
113_R117_F0.7080.67
80_P160_V0.7080.67
187_N200_L0.7070.66
55_T191_T0.7060.66
165_C218_C0.7040.66
116_M179_P0.7020.66
36_V97_L0.7020.66
61_D199_R0.7010.66
35_N66_E0.6990.66
18_D92_E0.6940.65
115_R119_S0.6900.65
166_P217_N0.6860.64
141_M145_R0.6820.64
134_D137_P0.6810.63
172_S235_L0.6800.63
101_K224_K0.6750.63
11_I28_I0.6750.63
119_S168_V0.6750.63
116_M178_A0.6710.62
115_R168_V0.6670.62
100_M177_P0.6630.61
202_A205_D0.6590.61
196_K238_D0.6590.61
212_C218_C0.6550.60
151_E228_L0.6540.60
233_A237_R0.6540.60
150_Y154_K0.6530.60
87_L90_Q0.6520.60
182_Q186_F0.6500.60
118_D122_K0.6490.60
103_F159_G0.6480.60
13_R24_E0.6470.60
115_R118_D0.6450.59
117_F175_M0.6420.59
43_I233_A0.6410.59
81_R117_F0.6400.59
142_P190_P0.6400.59
42_E45_R0.6400.59
188_A238_D0.6370.58
165_C212_C0.6370.58
12_T105_V0.6360.58
23_D174_F0.6360.58
131_G136_G0.6310.58
144_K195_N0.6310.58
40_L74_M0.6280.57
62_M160_V0.6230.57
172_S205_D0.6210.56
34_L39_A0.6180.56
195_N202_A0.6140.56
72_C186_F0.6130.55
138_G185_L0.6110.55
227_P230_T0.6100.55
25_E90_Q0.6090.55
226_I229_T0.6070.55
20_T104_P0.6070.55
10_I24_E0.6050.55
154_K228_L0.6040.54
20_T107_R0.6020.54
63_N178_A0.6010.54
67_E85_T0.5990.54
35_N87_L0.5980.54
19_S198_E0.5970.54
15_D19_S0.5940.53
76_I117_F0.5940.53
166_P182_Q0.5940.53
68_V72_C0.5930.53
91_L95_I0.5930.53
150_Y157_T0.5930.53
79_K122_K0.5930.53
196_K201_E0.5910.53
82_Q185_L0.5880.52
181_S235_L0.5880.52
11_I74_M0.5870.52
174_F179_P0.5840.52
125_A141_M0.5800.51
90_Q132_T0.5780.51
55_T107_R0.5770.51
14_Q21_P0.5770.51
88_I174_F0.5740.51
55_T185_L0.5720.50
20_T96_R0.5710.50
76_I95_I0.5710.50
66_E157_T0.5710.50
183_V190_P0.5700.50
138_G198_E0.5680.50
167_N170_S0.5670.50
7_I31_R0.5670.50
166_P221_S0.5650.50
44_R62_M0.5640.49
100_M159_G0.5620.49
9_F137_P0.5610.49
6_T19_S0.5610.49
34_L45_R0.5610.49
98_K221_S0.5570.49
44_R68_V0.5560.49
38_S236_N0.5550.48
39_A95_I0.5530.48
38_S61_D0.5490.48
191_T199_R0.5490.48
8_R96_R0.5480.48
162_L179_P0.5470.47
72_C213_G0.5460.47
144_K147_Q0.5450.47
64_C84_C0.5440.47
125_A183_V0.5440.47
158_C161_C0.5420.47
64_C69_C0.5410.47
173_K207_G0.5410.47
110_Q114_S0.5410.47
17_A24_E0.5410.47
211_D236_N0.5410.47
29_P93_Q0.5400.47
44_R183_V0.5390.46
69_C84_C0.5390.46
183_V203_L0.5380.46
17_A92_E0.5360.46
93_Q96_R0.5360.46
66_E182_Q0.5360.46
127_I191_T0.5360.46
73_S122_K0.5340.46
102_T151_E0.5340.46
8_R209_L0.5320.46
23_D105_V0.5310.45
77_N87_L0.5300.45
10_I107_R0.5290.45
75_V166_P0.5290.45
201_E206_E0.5280.45
67_E156_M0.5260.45
174_F214_N0.5250.45
53_E106_V0.5240.45
120_L213_G0.5220.44
131_G137_P0.5190.44
38_S183_V0.5160.44
133_Y140_R0.5150.44
66_E167_N0.5140.43
8_R93_Q0.5140.43
19_S90_Q0.5130.43
185_L191_T0.5120.43
151_E231_S0.5110.43
164_A168_V0.5100.43
129_I195_N0.5080.43
29_P54_K0.5070.43
166_P231_S0.5060.42
7_I97_L0.5030.42
77_N95_I0.5020.42
155_C161_C0.5020.42
180_M231_S0.5010.42
146_R153_S0.5010.42
183_V235_L0.5000.42
76_I83_S0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8103 100 0.404 Contact Map
2h88B 1 0.9209 100 0.455 Contact Map
1kf6B 1 0.9565 100 0.457 Contact Map
4ysxB 1 0.9644 100 0.459 Contact Map
2wdqB 1 0.913 100 0.467 Contact Map
2bs2B 1 0.9249 100 0.474 Contact Map
3c8yA 1 0.834 99.9 0.757 Contact Map
3i9v3 1 0.8103 99.9 0.765 Contact Map
1ffvA 1 0.6047 99.9 0.767 Contact Map
1t3qA 1 0.6245 99.8 0.786 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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