GREMLIN Database
DHSC - Succinate dehydrogenase cytochrome b558 subunit
UniProt: P08064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (198)
Sequences: 279 (181)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_L198_I4.3281.00
83_N96_F3.8060.99
68_I72_V3.5300.99
106_T110_V3.1860.98
144_F147_V3.0790.97
106_T152_T3.0260.97
91_M95_L2.8440.95
162_S165_V2.7750.94
21_V67_L2.6290.93
150_L195_L2.5880.92
27_Q49_M2.4980.91
18_V160_L2.4800.90
57_A61_F2.4740.90
190_L193_V2.3350.87
75_V104_I2.3090.87
164_A169_I2.1730.83
150_L191_S2.1130.81
27_Q31_V2.0860.80
77_I81_A2.0830.80
105_I147_V2.0170.78
127_V131_M2.0140.78
136_L142_L1.9890.77
48_F58_L1.9450.75
21_V110_V1.9440.75
160_L183_T1.8640.72
164_A179_S1.8630.72
36_A196_K1.8390.71
67_L110_V1.7990.69
39_A129_F1.7820.68
170_T179_S1.7510.67
179_S183_T1.7450.67
142_L146_I1.7330.66
107_L152_T1.7250.66
67_L186_I1.7160.65
69_Y94_W1.7080.65
11_R33_Q1.6850.64
160_L164_A1.6800.64
56_Y60_I1.6460.62
188_V197_A1.6310.61
81_A96_F1.5950.59
141_M144_F1.5210.56
96_F106_T1.5130.55
83_N97_V1.5030.55
56_Y64_F1.4980.55
127_V182_V1.4870.54
18_V26_I1.4620.53
195_L199_F1.4270.51
35_A200_A1.4030.50
146_I198_I1.3920.49
47_H50_D1.3810.48
64_F171_V1.3540.47
23_I62_I1.3350.46
121_A131_M1.3270.46
7_F11_R1.3250.46
55_R121_A1.3220.45
46_A49_M1.3220.45
31_V46_A1.3220.45
85_A97_V1.3110.45
78_A124_G1.3070.45
88_Y188_V1.3020.44
121_A127_V1.2840.43
112_W135_I1.2830.43
97_V101_V1.2760.43
47_H51_S1.2450.41
34_F55_R1.2420.41
23_I69_Y1.2180.40
119_I123_M1.1870.39
140_A147_V1.1850.38
27_Q34_F1.1650.38
69_Y114_V1.1480.37
138_S169_I1.1470.37
15_L19_I1.1430.36
103_G117_T1.1430.36
27_Q157_S1.1400.36
146_I195_L1.1360.36
197_A200_A1.1300.36
26_I198_I1.1280.36
130_D133_A1.1220.35
142_L199_F1.1120.35
58_L61_F1.1080.35
67_L190_L1.1040.35
116_E141_M1.0900.34
136_L149_V1.0850.34
115_W120_A1.0840.34
156_F186_I1.0820.34
41_A157_S1.0660.33
4_N72_V1.0650.33
85_A102_T1.0620.33
124_G131_M1.0600.33
54_F197_A1.0480.32
89_S162_S1.0260.31
16_L165_V1.0240.31
27_Q30_V1.0210.31
18_V48_F1.0110.30
16_L162_S1.0060.30
193_V197_A1.0050.30
105_I151_S0.9970.30
8_Y195_L0.9890.29
140_A144_F0.9880.29
76_Y174_R0.9860.29
105_I152_T0.9820.29
18_V164_A0.9820.29
90_Y110_V0.9610.28
5_R8_Y0.9580.28
60_I65_L0.9570.28
29_L81_A0.9570.28
146_I169_I0.9500.28
57_A185_I0.9460.28
71_A78_A0.9450.28
46_A55_R0.9410.27
130_D134_N0.9360.27
110_V189_A0.9330.27
27_Q55_R0.9310.27
191_S195_L0.9240.27
87_Q94_W0.9240.27
39_A69_Y0.9220.27
61_F64_F0.9130.26
83_N90_Y0.9110.26
16_L132_M0.9080.26
98_L119_I0.9060.26
92_R176_Q0.9030.26
75_V179_S0.8880.25
31_V49_M0.8840.25
124_G127_V0.8840.25
62_I110_V0.8770.25
33_Q88_Y0.8740.25
117_T132_M0.8720.25
94_W138_S0.8610.24
98_L154_F0.8530.24
107_L174_R0.8510.24
118_R122_Q0.8460.24
192_Y196_K0.8400.23
82_K102_T0.8320.23
105_I156_F0.8310.23
21_V25_L0.8260.23
37_R41_A0.8210.23
108_I111_S0.8180.23
107_L111_S0.8150.22
68_I164_A0.8130.22
42_F137_S0.8070.22
38_G164_A0.8050.22
96_F178_I0.7980.22
60_I156_F0.7940.22
31_V42_F0.7860.21
69_Y72_V0.7860.21
157_S186_I0.7840.21
153_I157_S0.7810.21
11_R182_V0.7750.21
56_Y108_I0.7740.21
157_S185_I0.7740.21
183_T186_I0.7740.21
25_L156_F0.7740.21
16_L35_A0.7720.21
102_T106_T0.7710.21
47_H195_L0.7690.21
119_I125_A0.7690.21
26_I152_T0.7610.21
94_W98_L0.7600.21
27_Q172_T0.7560.20
23_I60_I0.7560.20
104_I185_I0.7550.20
27_Q33_Q0.7540.20
71_A94_W0.7530.20
89_S154_F0.7520.20
78_A81_A0.7510.20
10_R13_H0.7500.20
26_I30_V0.7490.20
40_E48_F0.7450.20
22_G102_T0.7430.20
11_R123_M0.7420.20
141_M151_S0.7420.20
27_Q52_L0.7270.19
32_N93_N0.7240.19
8_Y127_V0.7170.19
56_Y175_S0.7150.19
67_L160_L0.7140.19
42_F89_S0.7100.19
166_T193_V0.7100.19
46_A171_V0.7100.19
112_W132_M0.7080.19
71_A177_R0.7050.19
120_A193_V0.7020.19
40_E124_G0.6970.18
27_Q62_I0.6960.18
65_L123_M0.6960.18
90_Y182_V0.6950.18
6_E186_I0.6890.18
46_A107_L0.6890.18
12_L186_I0.6820.18
50_D128_N0.6810.18
102_T152_T0.6750.18
101_V105_I0.6730.18
106_T156_F0.6710.18
110_V154_F0.6630.17
81_A184_L0.6620.17
78_A86_G0.6610.17
30_V34_F0.6610.17
6_E190_L0.6580.17
172_T188_V0.6560.17
44_S60_I0.6520.17
8_Y42_F0.6510.17
97_V151_S0.6490.17
181_Y186_I0.6480.17
143_G150_L0.6470.17
33_Q196_K0.6470.17
11_R107_L0.6470.17
68_I198_I0.6440.17
54_F82_K0.6440.17
22_G25_L0.6410.17
62_I94_W0.6380.17
12_L177_R0.6370.17
97_V104_I0.6370.17
72_V105_I0.6290.16
23_I27_Q0.6280.16
57_A171_V0.6280.16
9_F88_Y0.6230.16
79_F115_W0.6210.16
120_A123_M0.6190.16
102_T151_S0.6170.16
47_H149_V0.6130.16
89_S116_E0.6120.16
65_L149_V0.6090.16
55_R152_T0.6070.16
134_N153_I0.6060.16
112_W173_P0.6050.16
77_I150_L0.6050.16
47_H104_I0.6040.16
62_I172_T0.6030.16
184_L188_V0.6010.16
21_V95_L0.6000.16
120_A129_F0.5990.16
33_Q165_V0.5990.16
156_F172_T0.5990.16
89_S165_V0.5990.16
107_L147_V0.5980.16
142_L197_A0.5960.16
72_V180_T0.5910.15
86_G89_S0.5900.15
69_Y87_Q0.5860.15
65_L75_V0.5860.15
44_S188_V0.5850.15
160_L186_I0.5830.15
56_Y111_S0.5790.15
134_N192_Y0.5780.15
23_I125_A0.5760.15
189_A193_V0.5750.15
13_H17_G0.5700.15
137_S153_I0.5660.15
36_A41_A0.5660.15
96_F187_F0.5650.15
56_Y193_V0.5640.15
90_Y97_V0.5630.15
80_T188_V0.5630.15
80_T108_I0.5590.15
87_Q154_F0.5590.15
123_M190_L0.5550.14
117_T120_A0.5550.14
154_F158_N0.5510.14
7_F26_I0.5510.14
61_F186_I0.5500.14
39_A133_A0.5480.14
4_N90_Y0.5440.14
184_L198_I0.5400.14
54_F96_F0.5380.14
129_F175_S0.5360.14
43_N171_V0.5360.14
131_M192_Y0.5350.14
95_L104_I0.5340.14
141_M147_V0.5330.14
91_M96_F0.5330.14
85_A178_I0.5310.14
64_F182_V0.5300.14
132_M166_T0.5280.14
5_R181_Y0.5250.14
27_Q42_F0.5240.14
116_E165_V0.5240.14
101_V104_I0.5220.14
50_D193_V0.5220.14
21_V39_A0.5220.14
104_I170_T0.5210.14
55_R189_A0.5170.13
64_F111_S0.5140.13
43_N127_V0.5140.13
112_W141_M0.5140.13
54_F129_F0.5130.13
143_G146_I0.5130.13
6_E193_V0.5130.13
53_P163_F0.5130.13
176_Q201_F0.5100.13
16_L120_A0.5090.13
35_A165_V0.5060.13
132_M182_V0.5060.13
149_V199_F0.5050.13
146_I189_A0.5030.13
85_A123_M0.5020.13
121_A180_T0.5010.13
18_V175_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bs2C 2 0.9752 100 0.575 Contact Map
2wdqC 1 0.5743 99.5 0.832 Contact Map
2wdqD 2 0.5149 99.4 0.84 Contact Map
1zoyC 1 0.5644 99.2 0.855 Contact Map
2h88C 2 0.5693 99.2 0.855 Contact Map
4ytpC 1 0.6535 99.2 0.856 Contact Map
4ysxC 1 0.6436 98.8 0.876 Contact Map
2h88D 1 0.4208 67.8 0.954 Contact Map
4ysxD 1 0.5495 36.6 0.962 Contact Map
1kf6C 1 0.5495 29.8 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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