GREMLIN Database
DNAB - Replication initiation and membrane attachment protein
UniProt: P07908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (428)
Sequences: 491 (432)
Seq/√Len: 20.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_I89_I6.3981.00
93_K156_D6.2391.00
65_H108_Y5.5181.00
353_G390_V4.6321.00
244_D247_Q4.2811.00
234_I248_M4.1711.00
243_I248_M4.0041.00
212_F252_V3.9951.00
207_F248_M3.9111.00
454_E457_K3.8351.00
84_G159_R3.4681.00
65_H83_Q3.2521.00
340_I375_I3.2041.00
35_Q48_T3.0790.99
14_Y52_E2.8930.99
387_V396_L2.8830.99
381_H400_E2.7200.99
262_I267_L2.5810.98
388_K392_E2.5610.98
457_K460_M2.5100.98
316_E353_G2.5010.98
73_Q132_R2.4770.98
455_Q458_K2.3320.96
215_G249_Q2.3250.96
315_L360_Y2.2900.96
451_D455_Q2.2810.96
404_Y407_W2.2570.96
237_L267_L2.2280.95
158_T164_A2.1920.95
268_R342_E2.1920.95
93_K111_L2.1610.94
133_V141_L2.1360.94
457_K461_E2.1040.94
230_V262_I2.0640.93
209_F231_R2.0330.92
126_N130_Y2.0080.92
97_K154_A1.9990.92
343_E372_K1.9940.92
122_D126_N1.9560.91
451_D454_E1.9370.90
350_L379_A1.9140.90
425_E430_W1.9070.90
69_M79_I1.8820.89
327_I363_M1.8700.89
367_D385_K1.8480.88
69_M76_L1.8430.88
267_L361_Y1.8310.88
316_E391_R1.8040.87
133_V137_K1.7630.86
401_N404_Y1.7440.85
227_T230_V1.7360.85
397_A400_E1.7330.85
22_L110_L1.7290.84
315_L357_V1.7210.84
385_K396_L1.7150.84
207_F245_P1.7140.84
88_G165_F1.7120.84
251_V271_A1.6970.83
33_L46_Y1.6800.83
27_R50_W1.6520.82
344_I355_T1.6320.81
337_D380_S1.6320.81
107_I163_H1.6130.80
91_L113_P1.5990.79
94_V234_I1.5980.79
323_L337_D1.5880.79
95_Y386_K1.5780.78
120_F142_K1.5680.78
276_Q283_L1.5650.78
16_V49_L1.5510.77
123_G126_N1.5500.77
87_E108_Y1.5420.77
33_L120_F1.5380.77
88_G166_E1.5350.76
453_E456_K1.5210.76
381_H396_L1.5200.76
369_K381_H1.5100.75
345_M355_T1.5100.75
95_Y109_E1.5090.75
454_E458_K1.5000.75
382_W393_A1.5000.75
315_L364_L1.4990.75
263_T266_A1.4870.74
66_R69_M1.4870.74
99_S103_E1.4800.74
323_L338_L1.4790.74
93_K374_Y1.4760.74
335_K339_K1.4740.73
44_S79_I1.4600.73
331_T380_S1.4590.73
387_V458_K1.4540.72
240_L425_E1.4480.72
8_V377_K1.4430.72
323_L360_Y1.4430.72
369_K400_E1.4390.72
137_K140_Q1.4320.71
93_K109_E1.4260.71
394_M398_I1.4250.71
373_N376_Q1.4180.70
18_S53_L1.4180.70
35_Q161_F1.4170.70
94_V158_T1.4130.70
216_L226_M1.4050.70
134_G361_Y1.3910.69
328_A337_D1.3870.69
64_T92_L1.3860.69
450_Q454_E1.3840.69
85_K359_I1.3840.69
41_V78_T1.3790.68
83_Q92_L1.3720.68
332_E380_S1.3630.67
133_V383_A1.3540.67
95_Y156_D1.3540.67
48_T68_L1.3530.67
78_T138_Y1.3510.67
333_P374_Y1.3510.67
313_A317_A1.3460.66
260_D267_L1.3410.66
238_S245_P1.3380.66
83_Q108_Y1.3170.65
433_E437_A1.3140.64
70_G252_V1.3080.64
452_L455_Q1.3080.64
80_H83_Q1.3060.64
213_L226_M1.2980.63
449_P452_L1.2920.63
10_P312_I1.2920.63
97_K316_E1.2790.62
247_Q351_E1.2780.62
106_F128_F1.2620.61
207_F234_I1.2620.61
425_E432_T1.2550.61
314_L318_I1.2530.61
68_L79_I1.2520.61
351_E373_N1.2490.60
311_L360_Y1.2240.59
35_Q145_F1.2240.59
348_Q360_Y1.2230.59
72_T79_I1.2230.59
44_S198_P1.2200.59
416_K419_Q1.2130.58
328_A384_R1.2080.58
321_K325_Q1.2020.57
82_E159_R1.1980.57
107_I154_A1.1940.57
207_F249_Q1.1900.57
449_P459_M1.1870.56
288_E321_K1.1830.56
75_N78_T1.1760.56
76_L345_M1.1700.55
268_R275_Y1.1670.55
321_K338_L1.1600.55
396_L400_E1.1590.55
14_Y243_I1.1590.55
304_E309_G1.1420.53
96_M104_R1.1410.53
370_L375_I1.1370.53
354_V393_A1.1360.53
263_T359_I1.1350.53
26_D29_I1.1340.53
39_G46_Y1.1340.53
10_P69_M1.1330.53
355_T375_I1.1320.53
207_F212_F1.1300.53
85_K161_F1.1270.52
414_S419_Q1.1230.52
458_K461_E1.1170.52
456_K460_M1.1110.51
380_S384_R1.1010.51
214_A336_A1.0980.50
266_A270_A1.0940.50
48_T72_T1.0940.50
247_Q250_N1.0920.50
394_M397_A1.0890.50
362_V375_I1.0890.50
49_L68_L1.0870.50
391_R395_K1.0870.50
35_Q377_K1.0820.49
133_V242_G1.0820.49
37_L128_F1.0820.49
44_S342_E1.0780.49
418_N422_I1.0750.49
436_T439_D1.0740.49
156_D355_T1.0740.49
75_N339_K1.0720.49
352_P390_V1.0700.49
163_H389_T1.0660.48
90_G324_L1.0640.48
30_I110_L1.0620.48
405_L414_S1.0550.48
355_T381_H1.0520.47
38_I406_E1.0500.47
374_Y377_K1.0460.47
75_N249_Q1.0450.47
108_Y248_M1.0450.47
234_I417_R1.0430.47
88_G158_T1.0390.47
389_T392_E1.0390.47
411_K415_S1.0380.47
13_P62_E1.0360.46
325_Q332_E1.0330.46
212_F387_V1.0320.46
12_D106_F1.0320.46
95_Y158_T1.0290.46
357_V384_R1.0180.45
211_L246_L1.0160.45
212_F249_Q1.0110.45
55_Q60_G1.0110.45
60_G82_E1.0090.45
369_K397_A1.0070.44
315_L394_M1.0070.44
251_V351_E1.0070.44
160_P221_I1.0060.44
85_K338_L1.0040.44
434_K454_E1.0020.44
350_L357_V1.0010.44
249_Q253_M0.9950.44
343_E376_Q0.9940.44
37_L140_Q0.9930.44
158_T392_E0.9910.43
402_R415_S0.9900.43
208_D234_I0.9870.43
208_D382_W0.9780.43
331_T384_R0.9750.42
231_R235_K0.9740.42
365_K401_N0.9670.42
155_K373_N0.9650.42
386_K407_W0.9590.41
90_G141_L0.9570.41
241_Y393_A0.9550.41
453_E457_K0.9550.41
223_R344_I0.9490.41
163_H193_S0.9460.41
153_D414_S0.9410.40
53_L60_G0.9390.40
258_E263_T0.9370.40
69_M368_M0.9340.40
241_Y366_T0.9290.39
16_V424_E0.9290.39
88_G240_L0.9260.39
414_S441_E0.9240.39
401_N407_W0.9220.39
90_G161_F0.9210.39
66_R380_S0.9200.39
65_H382_W0.9160.39
208_D393_A0.9110.38
37_L342_E0.9110.38
212_F365_K0.9090.38
372_K375_I0.9080.38
387_V405_L0.9070.38
248_M286_L0.9050.38
259_R435_E0.9040.38
350_L354_V0.9030.38
28_Q80_H0.9020.38
10_P430_W0.9010.38
308_D398_I0.9000.38
361_Y366_T0.8990.38
382_W430_W0.8990.38
87_E94_V0.8970.37
128_F167_S0.8960.37
233_T248_M0.8950.37
320_P393_A0.8940.37
69_M249_Q0.8910.37
268_R272_S0.8890.37
324_L393_A0.8850.37
355_T387_V0.8850.37
114_L244_D0.8830.37
252_V392_E0.8830.37
128_F268_R0.8810.36
73_Q278_E0.8770.36
357_V394_M0.8690.36
202_I205_D0.8680.36
374_Y381_H0.8680.36
93_K392_E0.8660.36
436_T450_Q0.8650.35
368_M381_H0.8640.35
8_V12_D0.8570.35
164_A344_I0.8560.35
116_P120_F0.8510.35
429_D432_T0.8510.35
45_L79_I0.8490.35
22_L45_L0.8450.34
275_Y284_P0.8440.34
102_Q441_E0.8430.34
419_Q422_I0.8430.34
36_P46_Y0.8390.34
362_V374_Y0.8330.34
89_I165_F0.8310.33
450_Q453_E0.8280.33
133_V136_T0.8260.33
268_R331_T0.8200.33
126_N138_Y0.8180.33
387_V390_V0.8180.33
234_I433_E0.8160.33
35_Q39_G0.8150.33
367_D372_K0.8140.32
32_Q145_F0.8140.32
22_L46_Y0.8120.32
303_E309_G0.8100.32
358_L378_I0.8100.32
433_E450_Q0.8090.32
337_D370_L0.8070.32
328_A380_S0.8070.32
43_F47_M0.8050.32
377_K398_I0.8040.32
344_I375_I0.8030.32
87_E90_G0.8020.32
65_H126_N0.8010.32
455_Q460_M0.8000.32
361_Y374_Y0.8000.32
157_I377_K0.8000.32
241_Y342_E0.7980.32
95_Y374_Y0.7980.32
163_H241_Y0.7980.32
22_L50_W0.7920.31
266_A365_K0.7910.31
209_F248_M0.7870.31
49_L361_Y0.7870.31
334_S380_S0.7840.31
108_Y361_Y0.7830.31
165_F294_H0.7830.31
395_K399_E0.7820.31
20_S26_D0.7790.30
34_Y114_L0.7790.30
148_P303_E0.7780.30
219_T375_I0.7770.30
428_P431_M0.7760.30
46_Y237_L0.7750.30
44_S47_M0.7740.30
37_L114_L0.7720.30
415_S438_S0.7710.30
244_D262_I0.7690.30
35_Q132_R0.7680.30
371_S431_M0.7680.30
50_W92_L0.7660.30
85_K165_F0.7660.30
160_P210_D0.7660.30
426_K438_S0.7660.30
368_M385_K0.7650.30
72_T110_L0.7650.30
163_H374_Y0.7650.30
42_A126_N0.7640.30
56_N144_F0.7640.30
438_S454_E0.7620.30
123_G268_R0.7600.29
321_K359_I0.7590.29
221_I313_A0.7560.29
96_M142_K0.7550.29
207_F236_K0.7530.29
88_G147_H0.7520.29
106_F245_P0.7510.29
115_R435_E0.7500.29
220_M369_K0.7470.29
287_V457_K0.7450.29
90_G320_P0.7440.29
418_N421_V0.7410.28
216_L252_V0.7400.28
315_L397_A0.7390.28
299_E303_E0.7390.28
70_G108_Y0.7380.28
47_M214_A0.7370.28
92_L157_I0.7370.28
311_L327_I0.7350.28
233_T264_T0.7300.28
40_P44_S0.7300.28
105_L156_D0.7290.28
122_D242_G0.7280.28
93_K213_L0.7270.28
126_N268_R0.7240.27
414_S417_R0.7230.27
337_D381_H0.7220.27
36_P42_A0.7210.27
131_N431_M0.7210.27
35_Q400_E0.7210.27
328_A368_M0.7200.27
34_Y129_L0.7200.27
82_E92_L0.7190.27
381_H384_R0.7180.27
99_S102_Q0.7170.27
327_I347_E0.7150.27
325_Q333_P0.7140.27
157_I265_E0.7140.27
22_L167_S0.7100.27
358_L382_W0.7090.27
40_P387_V0.7080.27
287_V452_L0.7040.26
146_T273_D0.7040.26
136_T143_Q0.7040.26
71_M79_I0.7040.26
203_T263_T0.7040.26
76_L79_I0.7040.26
340_I344_I0.7010.26
19_R94_V0.7000.26
437_A442_S0.6980.26
335_K419_Q0.6970.26
37_L92_L0.6940.26
150_I263_T0.6940.26
415_S457_K0.6930.26
118_E173_W0.6910.26
337_D364_L0.6900.26
241_Y382_W0.6900.26
340_I352_P0.6890.26
118_E392_E0.6880.26
234_I419_Q0.6880.26
31_T95_Y0.6840.25
361_Y400_E0.6830.25
416_K441_E0.6830.25
279_R351_E0.6780.25
311_L323_L0.6780.25
371_S380_S0.6760.25
370_L403_Q0.6760.25
314_L360_Y0.6750.25
158_T227_T0.6740.25
207_F238_S0.6730.25
238_S337_D0.6720.25
87_E158_T0.6700.25
250_N372_K0.6700.25
218_E398_I0.6690.25
7_D269_K0.6680.25
240_L319_S0.6680.25
107_I192_T0.6670.25
387_V403_Q0.6670.25
157_I261_V0.6650.24
413_K439_D0.6650.24
272_S342_E0.6640.24
95_Y213_L0.6600.24
415_S418_N0.6600.24
74_S155_K0.6580.24
22_L141_L0.6560.24
154_A248_M0.6560.24
337_D384_R0.6560.24
87_E241_Y0.6550.24
33_L379_A0.6520.24
81_Q303_E0.6520.24
62_E131_N0.6490.24
157_I420_K0.6490.24
443_G459_M0.6450.23
256_I397_A0.6440.23
311_L328_A0.6420.23
331_T394_M0.6410.23
46_Y257_D0.6400.23
144_F378_I0.6380.23
240_L321_K0.6380.23
97_K157_I0.6350.23
435_E450_Q0.6350.23
152_E417_R0.6340.23
300_Q443_G0.6340.23
42_A143_Q0.6340.23
156_D261_V0.6320.23
66_R70_G0.6320.23
406_E461_E0.6310.23
219_T260_D0.6300.23
150_I204_E0.6280.23
304_E308_D0.6270.23
237_L262_I0.6260.23
330_G382_W0.6260.23
94_V307_L0.6250.23
441_E457_K0.6240.23
29_I378_I0.6240.23
98_E155_K0.6230.22
116_P387_V0.6200.22
89_I122_D0.6190.22
47_M244_D0.6180.22
154_A435_E0.6180.22
350_L355_T0.6170.22
30_I313_A0.6160.22
368_M372_K0.6160.22
123_G138_Y0.6150.22
387_V435_E0.6150.22
28_Q54_E0.6140.22
330_G346_F0.6140.22
151_S359_I0.6130.22
30_I269_K0.6130.22
242_G332_E0.6120.22
329_D397_A0.6110.22
65_H130_Y0.6100.22
122_D425_E0.6090.22
168_L429_D0.6090.22
30_I36_P0.6090.22
385_K399_E0.6080.22
360_Y397_A0.6060.22
84_G341_I0.6050.22
415_S424_E0.6050.22
196_Q351_E0.6050.22
202_I280_N0.6050.22
62_E82_E0.6040.22
163_H205_D0.6030.22
348_Q379_A0.6030.22
323_L327_I0.6030.22
196_Q412_T0.6020.22
46_Y85_K0.6020.22
60_G141_L0.6020.22
52_E145_F0.6010.21
315_L328_A0.6010.21
397_A423_R0.5990.21
325_Q392_E0.5980.21
8_V157_I0.5980.21
115_R451_D0.5960.21
45_L406_E0.5960.21
41_V74_S0.5950.21
247_Q361_Y0.5940.21
277_I333_P0.5940.21
8_V350_L0.5930.21
57_R88_G0.5930.21
395_K449_P0.5930.21
111_L156_D0.5900.21
12_D342_E0.5900.21
440_S443_G0.5900.21
424_E460_M0.5880.21
427_L431_M0.5880.21
23_Q142_K0.5860.21
7_D21_M0.5860.21
128_F159_R0.5860.21
155_K180_E0.5850.21
315_L337_D0.5850.21
317_A414_S0.5840.21
122_D226_M0.5820.21
35_Q427_L0.5810.21
141_L427_L0.5800.21
62_E99_S0.5790.20
363_M396_L0.5790.20
338_L384_R0.5780.20
140_Q201_T0.5770.20
16_V76_L0.5760.20
24_D159_R0.5750.20
237_L353_G0.5740.20
91_L356_N0.5740.20
337_D352_P0.5720.20
36_P86_L0.5700.20
126_N144_F0.5690.20
122_D141_L0.5680.20
255_A427_L0.5670.20
81_Q116_P0.5670.20
381_H404_Y0.5670.20
263_T420_K0.5660.20
124_M425_E0.5660.20
126_N147_H0.5650.20
29_I32_Q0.5650.20
87_E125_L0.5640.20
9_L66_R0.5630.20
314_L327_I0.5620.20
51_G212_F0.5620.20
255_A299_E0.5610.20
242_G321_K0.5600.20
82_E260_D0.5600.20
181_E261_V0.5590.20
325_Q398_I0.5590.20
451_D458_K0.5580.20
26_D212_F0.5580.20
323_L328_A0.5580.20
315_L363_M0.5570.20
401_N405_L0.5570.20
285_D293_V0.5570.20
98_E395_K0.5550.19
454_E460_M0.5550.19
358_L379_A0.5540.19
299_E304_E0.5540.19
10_P382_W0.5510.19
193_S440_S0.5500.19
452_L458_K0.5500.19
15_V30_I0.5500.19
83_Q87_E0.5490.19
39_G85_K0.5490.19
108_Y268_R0.5490.19
34_Y134_G0.5490.19
334_S337_D0.5480.19
261_V406_E0.5480.19
115_R181_E0.5470.19
315_L374_Y0.5470.19
8_V257_D0.5460.19
142_K341_I0.5450.19
160_P240_L0.5440.19
97_K153_D0.5430.19
196_Q435_E0.5430.19
90_G393_A0.5430.19
357_V400_E0.5420.19
344_I371_S0.5420.19
355_T384_R0.5410.19
85_K334_S0.5410.19
424_E449_P0.5400.19
303_E413_K0.5400.19
292_P313_A0.5400.19
124_M131_N0.5400.19
242_G249_Q0.5400.19
389_T434_K0.5390.19
34_Y46_Y0.5380.19
357_V393_A0.5380.19
332_E337_D0.5370.19
194_V202_I0.5350.19
226_M266_A0.5340.19
351_E354_V0.5330.19
271_A386_K0.5330.19
14_Y384_R0.5320.19
33_L36_P0.5320.19
125_L275_Y0.5310.18
8_V65_H0.5300.18
30_I117_N0.5280.18
87_E320_P0.5280.18
417_R457_K0.5280.18
28_Q282_Q0.5270.18
259_R266_A0.5270.18
23_Q145_F0.5250.18
14_Y67_Q0.5240.18
135_K139_Q0.5220.18
245_P305_D0.5210.18
31_T227_T0.5210.18
35_Q423_R0.5200.18
90_G241_Y0.5190.18
161_F247_Q0.5160.18
324_L370_L0.5160.18
52_E366_T0.5160.18
449_P453_E0.5150.18
80_H84_G0.5150.18
131_N167_S0.5140.18
155_K285_D0.5130.18
360_Y394_M0.5120.18
379_A398_I0.5120.18
89_I318_I0.5110.18
78_T373_N0.5110.18
282_Q306_S0.5090.18
127_V219_T0.5080.18
227_T384_R0.5080.18
13_P103_E0.5070.18
195_G199_S0.5070.18
221_I425_E0.5070.18
37_L163_H0.5070.18
231_R248_M0.5060.18
196_Q294_H0.5050.17
22_L130_Y0.5050.17
97_K388_K0.5050.17
248_M267_L0.5040.17
65_H209_F0.5040.17
438_S441_E0.5030.17
13_P102_Q0.5020.17
46_Y78_T0.5020.17
272_S283_L0.5020.17
74_S171_S0.5020.17
64_T158_T0.5020.17
106_F353_G0.5010.17
337_D348_Q0.5010.17
38_I43_F0.5000.17
253_M311_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zc2A 1 0.1589 98.8 0.904 Contact Map
2i5uA 1 0.1483 97.8 0.929 Contact Map
2v79A 4 0.2436 70.9 0.965 Contact Map
4pt7A 3 0.2564 68.4 0.965 Contact Map
2vn2A 4 0.2309 57.1 0.968 Contact Map
4ptaD 3 0.2309 54.8 0.968 Contact Map
3by6A 2 0.25 47.2 0.969 Contact Map
4kmfA 1 0.1314 46.4 0.969 Contact Map
1r1tA 2 0.2076 44.3 0.97 Contact Map
4r1hA 2 0.2267 43.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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