GREMLIN Database
GERAC - Spore germination protein A3
UniProt: P07870 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (356)
Sequences: 2220 (1918)
Seq/√Len: 101.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_T356_D5.0561.00
269_T358_R4.3311.00
102_K106_A4.2821.00
219_E314_K4.1141.00
37_K107_D3.8741.00
44_E138_K3.6151.00
102_K134_N3.5841.00
304_H308_T3.4121.00
99_L133_T3.2111.00
136_R139_D2.9591.00
190_H214_D2.9011.00
271_N360_N2.8631.00
300_E361_V2.7621.00
110_G209_K2.7081.00
246_Y299_V2.6861.00
266_F326_L2.6421.00
42_N72_K2.5361.00
266_F353_A2.4551.00
138_K142_N2.4371.00
304_H359_V2.4211.00
316_Q350_F2.4061.00
273_E364_R2.3981.00
211_W214_D2.3981.00
315_L350_F2.3931.00
47_Q83_S2.3741.00
270_R307_V2.3671.00
265_K354_E2.3571.00
320_K351_S2.3471.00
204_S211_W2.3361.00
45_L79_M2.2661.00
176_I186_F2.2601.00
222_N310_F2.2051.00
132_I204_S2.1901.00
265_K356_D2.1301.00
203_A220_V2.0931.00
311_I355_I2.0891.00
46_T137_T2.0681.00
105_I132_I2.0331.00
315_L324_T2.0301.00
116_N120_R1.9641.00
344_K347_D1.9581.00
100_L114_I1.9551.00
315_L323_V1.9411.00
130_V176_I1.8891.00
44_E72_K1.8891.00
267_T358_R1.8791.00
36_D137_T1.8671.00
71_T82_T1.8641.00
32_G151_S1.8511.00
258_A267_T1.8391.00
293_K296_E1.8271.00
101_S137_T1.8001.00
203_A223_I1.7991.00
42_N74_K1.7981.00
268_V326_L1.7981.00
327_G345_W1.7891.00
187_L223_I1.7361.00
35_L104_V1.7251.00
30_V90_T1.7201.00
176_I188_I1.7131.00
337_K341_I1.6781.00
38_P72_K1.6781.00
36_D101_S1.6651.00
80_M92_S1.6551.00
246_Y274_G1.6381.00
131_F191_V1.6361.00
33_I95_L1.6191.00
34_G137_T1.5891.00
81_R247_E1.5661.00
222_N303_V1.5291.00
257_T264_F1.5231.00
266_F330_V1.5211.00
263_K354_E1.5161.00
216_T219_E1.5161.00
259_Y264_F1.4921.00
44_E70_I1.4921.00
272_I361_V1.4891.00
32_G141_F1.4751.00
190_H211_W1.4621.00
269_T360_N1.4581.00
105_I206_I1.4541.00
183_D342_S1.4531.00
273_E362_I1.4521.00
311_I357_Y1.4511.00
213_R319_I1.4491.00
295_I363_V1.4441.00
205_I323_V1.4411.00
154_I191_V1.4381.00
132_I206_I1.4371.00
302_R306_T1.4331.00
255_I266_F1.4191.00
70_I138_K1.4111.00
297_K300_E1.4091.00
185_S321_A1.4041.00
100_L105_I1.4041.00
101_S104_V1.3881.00
294_S298_T1.3861.00
139_D142_N1.3851.00
302_R305_E1.3740.99
38_P44_E1.3730.99
126_R174_G1.3710.99
307_V357_Y1.3710.99
296_E300_E1.3630.99
131_F158_T1.3610.99
73_G79_M1.3590.99
300_E304_H1.3460.99
33_I118_F1.3300.99
44_E136_R1.3280.99
100_L111_M1.3170.99
228_G253_R1.3080.99
213_R321_A1.3050.99
310_F315_L1.3030.99
8_M12_T1.2870.99
74_K78_Q1.2660.99
185_S346_D1.2630.99
96_R155_Y1.2610.99
27_L91_F1.2340.99
313_E316_Q1.2240.99
316_Q345_W1.2200.99
66_T150_A1.2180.99
226_F268_V1.2170.99
345_W350_F1.2080.99
330_V337_K1.2060.99
77_H81_R1.1860.98
11_C14_L1.1750.98
226_F324_T1.1730.98
30_V92_S1.1710.98
223_I323_V1.1690.98
77_H247_E1.1610.98
38_P41_E1.1610.98
299_V361_V1.1560.98
43_L104_V1.1500.98
77_H277_S1.1460.98
119_V177_S1.1430.98
28_S49_I1.1410.98
253_R270_R1.1400.98
103_S137_T1.1390.98
260_K265_K1.1380.98
222_N315_L1.1350.98
257_T333_H1.1330.98
99_L131_F1.1290.98
73_G82_T1.1220.98
288_K291_Y1.1110.98
254_K269_T1.1080.98
95_L124_T1.1070.98
77_H117_Q1.1050.98
73_G78_Q1.1030.98
112_D209_K1.0960.97
46_T70_I1.0810.97
35_L76_V1.0800.97
274_G299_V1.0790.97
31_I50_L1.0790.97
330_V334_Y1.0780.97
133_T140_I1.0710.97
134_N192_G1.0630.97
223_I227_S1.0570.97
134_N214_D1.0570.97
292_I296_E1.0560.97
272_I303_V1.0530.97
15_L18_C1.0450.97
75_T243_L1.0400.97
226_F307_V1.0370.96
120_R367_G1.0360.96
339_K342_S1.0350.96
298_T301_K1.0350.96
275_R365_D1.0340.96
71_T83_S1.0330.96
256_K267_T1.0300.96
326_L355_I1.0300.96
105_I204_S1.0300.96
34_G136_R1.0270.96
207_K212_H1.0250.96
188_I206_I1.0230.96
46_T68_L1.0150.96
257_T334_Y1.0110.96
98_I128_S1.0110.96
48_Q150_A1.0100.96
52_P148_E1.0100.96
98_I118_F1.0060.96
194_E199_A1.0010.96
143_M193_K0.9960.96
166_R230_V0.9920.95
192_G201_N0.9890.95
94_H125_R0.9890.95
328_N331_R0.9870.95
234_V247_E0.9870.95
184_D325_G0.9780.95
216_T220_V0.9720.95
25_E126_R0.9720.95
259_Y334_Y0.9700.95
101_S133_T0.9690.95
257_T266_F0.9660.95
89_P123_G0.9650.95
192_G199_A0.9590.95
111_M176_I0.9530.94
131_F189_P0.9450.94
219_E309_S0.9440.94
105_I110_G0.9400.94
346_D350_F0.9370.94
256_K269_T0.9240.93
285_D288_K0.9200.93
48_Q66_T0.9170.93
316_Q351_S0.9160.93
328_N332_I0.9140.93
102_K214_D0.9120.93
330_V338_W0.9100.93
74_K243_L0.9040.93
244_F295_I0.9030.93
308_T357_Y0.8990.92
313_E317_K0.8980.92
34_G46_T0.8940.92
103_S106_A0.8930.92
329_E332_I0.8920.92
215_L219_E0.8850.92
205_I319_I0.8820.92
121_D277_S0.8800.92
301_K304_H0.8800.92
98_I130_V0.8770.91
308_T313_E0.8770.91
255_I268_V0.8750.91
207_K321_A0.8740.91
301_K305_E0.8730.91
297_K301_K0.8710.91
212_H321_A0.8710.91
22_E27_L0.8640.91
35_L45_L0.8550.90
270_R359_V0.8490.90
71_T79_M0.8470.90
225_L230_V0.8460.90
226_F253_R0.8460.90
304_H357_Y0.8420.90
176_I206_I0.8400.90
185_S350_F0.8390.90
176_I180_L0.8370.89
105_I211_W0.8360.89
111_M237_L0.8350.89
235_I306_T0.8350.89
110_G206_I0.8340.89
12_T16_S0.8320.89
37_K41_E0.8310.89
264_F353_A0.8250.89
279_D284_E0.8180.88
133_T137_T0.8180.88
86_K199_A0.8160.88
337_K340_K0.8150.88
75_T278_E0.8140.88
293_K297_K0.8020.87
222_N225_L0.8010.87
33_I47_Q0.7990.87
28_S147_G0.7950.87
335_P338_W0.7950.87
334_Y337_K0.7930.87
33_I98_I0.7930.87
71_T86_K0.7890.86
257_T329_E0.7870.86
140_I191_V0.7870.86
303_V307_V0.7840.86
182_S328_N0.7840.86
284_E291_Y0.7820.86
329_E333_H0.7760.86
345_W351_S0.7760.86
100_L132_I0.7750.86
206_I211_W0.7700.85
222_N307_V0.7700.85
101_S132_I0.7680.85
77_H121_D0.7670.85
305_E309_S0.7630.85
132_I211_W0.7600.84
34_G101_S0.7580.84
97_L131_F0.7550.84
258_A265_K0.7540.84
69_S83_S0.7530.84
311_I316_Q0.7470.83
273_E365_D0.7460.83
291_Y294_S0.7400.83
48_Q125_R0.7400.83
260_K290_S0.7400.83
38_P42_N0.7400.83
77_H278_E0.7360.82
106_A206_I0.7350.82
247_E277_S0.7350.82
187_L323_V0.7340.82
129_Y155_Y0.7330.82
303_V361_V0.7320.82
21_S29_L0.7300.82
23_N88_K0.7300.82
174_G178_E0.7280.82
95_L128_S0.7270.82
205_I215_L0.7240.81
225_L272_I0.7220.81
166_R221_Q0.7150.81
179_H184_D0.7130.80
259_Y337_K0.7130.80
137_T141_F0.7120.80
172_T175_E0.7110.80
78_Q236_D0.7090.80
222_N306_T0.7080.80
32_G48_Q0.7070.80
32_G97_L0.7060.80
29_L91_F0.7050.80
157_L200_I0.7050.80
92_S98_I0.7040.80
84_A122_N0.6990.79
37_K103_S0.6970.79
47_Q92_S0.6960.79
186_F325_G0.6960.79
30_V83_S0.6950.79
118_F173_L0.6920.78
152_N156_D0.6910.78
23_N94_H0.6880.78
335_P339_K0.6870.78
4_R15_L0.6860.78
101_S211_W0.6860.78
246_Y363_V0.6850.78
153_V157_L0.6840.78
134_N190_H0.6800.77
310_F314_K0.6790.77
7_C10_I0.6780.77
75_T236_D0.6780.77
130_V188_I0.6770.77
34_G138_K0.6740.77
46_T103_S0.6740.77
7_C14_L0.6730.76
111_M209_K0.6700.76
315_L319_I0.6680.76
272_I298_T0.6680.76
88_K148_E0.6670.76
111_M206_I0.6620.75
271_N362_I0.6620.75
185_S323_V0.6570.75
224_S229_T0.6550.75
35_L98_I0.6550.75
51_V54_I0.6540.74
102_K190_H0.6530.74
190_H204_S0.6530.74
50_L149_P0.6530.74
100_L115_I0.6530.74
46_T133_T0.6520.74
320_K347_D0.6520.74
16_S20_D0.6510.74
257_T326_L0.6490.74
26_E156_D0.6480.74
177_S369_K0.6470.74
264_F330_V0.6460.74
33_I45_L0.6460.74
225_L303_V0.6430.73
48_Q68_L0.6410.73
140_I193_K0.6410.73
133_T202_G0.6410.73
14_L297_K0.6400.73
47_Q80_M0.6390.73
244_F279_D0.6380.73
82_T85_L0.6350.72
248_V274_G0.6350.72
135_G202_G0.6340.72
35_L43_L0.6340.72
311_I324_T0.6330.72
279_D282_P0.6330.72
16_S19_W0.6320.72
187_L203_A0.6290.72
207_K346_D0.6280.71
323_V350_F0.6280.71
215_L314_K0.6270.71
255_I353_A0.6260.71
4_R12_T0.6260.71
276_L286_S0.6210.71
24_I65_P0.6160.70
5_I298_T0.6160.70
6_L262_G0.6160.70
274_G361_V0.6140.70
52_P60_G0.6120.69
175_E179_H0.6120.69
221_Q225_L0.6120.69
152_N155_Y0.6110.69
224_S228_G0.6110.69
104_V114_I0.6090.69
263_K352_N0.6080.69
212_H319_I0.6060.69
289_D293_K0.6040.68
343_R347_D0.6030.68
46_T138_K0.6020.68
101_S136_R0.6020.68
25_E153_V0.6010.68
37_K43_L0.6010.68
12_T45_L0.5990.68
215_L223_I0.5970.68
113_A299_V0.5970.68
201_N217_P0.5950.67
29_L66_T0.5950.67
143_M198_L0.5950.67
237_L299_V0.5950.67
81_R84_A0.5940.67
49_I69_S0.5940.67
8_M11_C0.5930.67
248_V251_S0.5930.67
81_R121_D0.5930.67
326_L350_F0.5930.67
106_A290_S0.5920.67
223_I310_F0.5920.67
77_H122_N0.5910.67
91_F96_R0.5900.67
171_V179_H0.5900.67
221_Q324_T0.5900.67
75_T245_S0.5890.67
205_I321_A0.5890.67
24_I158_T0.5880.66
307_V310_F0.5870.66
85_L217_P0.5860.66
88_K332_I0.5860.66
218_I306_T0.5850.66
72_K76_V0.5850.66
43_L114_I0.5840.66
173_L176_I0.5840.66
83_S181_T0.5840.66
12_T308_T0.5810.65
31_I174_G0.5790.65
131_F154_I0.5790.65
102_K135_G0.5760.65
13_L106_A0.5760.65
5_I9_F0.5750.65
284_E287_F0.5740.65
93_Q186_F0.5740.65
255_I329_E0.5740.65
34_G48_Q0.5740.65
18_C120_R0.5730.64
32_G152_N0.5720.64
106_A211_W0.5720.64
310_F323_V0.5710.64
132_I188_I0.5710.64
134_N211_W0.5710.64
105_I111_M0.5700.64
106_A214_D0.5690.64
349_Y353_A0.5690.64
4_R8_M0.5680.64
185_S325_G0.5670.64
247_E275_R0.5670.64
261_D271_N0.5670.64
9_F297_K0.5650.63
87_H145_D0.5650.63
316_Q353_A0.5650.63
189_P200_I0.5640.63
128_S174_G0.5620.63
175_E218_I0.5610.63
41_E313_E0.5610.63
162_K170_P0.5610.63
19_W338_W0.5590.63
25_E51_V0.5580.62
221_Q306_T0.5580.62
184_D328_N0.5580.62
20_D26_E0.5570.62
148_E156_D0.5570.62
225_L235_I0.5540.62
158_T189_P0.5540.62
116_N278_E0.5530.62
121_D247_E0.5520.62
274_G296_E0.5520.62
68_L150_A0.5510.61
269_T272_I0.5510.61
65_P150_A0.5500.61
6_L14_L0.5500.61
358_R361_V0.5500.61
168_M189_P0.5480.61
12_T309_S0.5480.61
186_F327_G0.5470.61
179_H237_L0.5460.61
112_D150_A0.5460.61
12_T15_L0.5450.61
27_L93_Q0.5450.61
46_T101_S0.5450.61
256_K297_K0.5450.61
257_T335_P0.5450.61
99_L137_T0.5440.60
24_I88_K0.5440.60
38_P103_S0.5430.60
225_L306_T0.5420.60
48_Q141_F0.5420.60
43_L268_V0.5410.60
305_E308_T0.5390.60
97_L154_I0.5380.60
22_E75_T0.5380.60
34_G142_N0.5380.60
350_F353_A0.5380.60
264_F341_I0.5370.59
230_V251_S0.5370.59
84_A145_D0.5350.59
49_I147_G0.5350.59
30_V47_Q0.5350.59
35_L100_L0.5350.59
31_I200_I0.5320.59
238_K242_H0.5300.58
258_A358_R0.5300.58
42_N305_E0.5280.58
85_L167_T0.5280.58
115_I218_I0.5270.58
10_I14_L0.5270.58
282_P286_S0.5250.58
46_T141_F0.5250.58
19_W213_R0.5250.58
58_K202_G0.5240.58
215_L310_F0.5230.57
151_S158_T0.5220.57
162_K220_V0.5220.57
299_V363_V0.5220.57
194_E197_K0.5210.57
84_A90_T0.5200.57
244_F274_G0.5190.57
34_G99_L0.5190.57
134_N216_T0.5190.57
254_K261_D0.5180.57
330_V335_P0.5180.57
5_I14_L0.5160.56
230_V233_G0.5160.56
205_I315_L0.5160.56
33_I80_M0.5150.56
97_L151_S0.5150.56
167_T221_Q0.5140.56
274_G363_V0.5140.56
341_I349_Y0.5140.56
260_K263_K0.5140.56
115_I130_V0.5100.56
48_Q151_S0.5080.55
307_V359_V0.5080.55
41_E360_N0.5080.55
175_E350_F0.5060.55
29_L173_L0.5060.55
264_F337_K0.5040.55
86_K197_K0.5040.55
216_T269_T0.5040.55
47_Q124_T0.5040.55
48_Q94_H0.5040.55
50_L153_V0.5010.54
87_H157_L0.5000.54
84_A89_P0.5000.54
35_L79_M0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n54B 5 0.8284 100 0.166 Contact Map
3zbiC 1 0.0724 47.5 0.956 Contact Map
3utkA 1 0.2172 45.6 0.957 Contact Map
3j6da 3 0.3566 18.2 0.965 Contact Map
4fybB 1 0.378 13.4 0.967 Contact Map
4pj0U 1 0.2306 12 0.967 Contact Map
2pptA 2 0.3968 10.2 0.968 Contact Map
1v98A 2 0.244 7.1 0.971 Contact Map
2v25A 1 0.563 6.9 0.971 Contact Map
2jnaA 2 0.2386 6 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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