GERAC - BACSU - GREMLIN Contacts

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GERAC - Spore germination protein A3

UniProt:	P07870	Sequences: MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLELTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSKSVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTENNKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPIEVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRLSEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHYPQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (356)
Sequences:	2220 (1918)
Seq/√Len:	101.6

BACSU - GERAC YNDF GERBC GERKC YFKR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
267_T	356_D	5.056	1.00
269_T	358_R	4.331	1.00
102_K	106_A	4.282	1.00
219_E	314_K	4.114	1.00
37_K	107_D	3.874	1.00
44_E	138_K	3.615	1.00
102_K	134_N	3.584	1.00
304_H	308_T	3.412	1.00
99_L	133_T	3.211	1.00
136_R	139_D	2.959	1.00
190_H	214_D	2.901	1.00
271_N	360_N	2.863	1.00
300_E	361_V	2.762	1.00
110_G	209_K	2.708	1.00
246_Y	299_V	2.686	1.00
266_F	326_L	2.642	1.00
42_N	72_K	2.536	1.00
266_F	353_A	2.455	1.00
138_K	142_N	2.437	1.00
304_H	359_V	2.421	1.00
316_Q	350_F	2.406	1.00
273_E	364_R	2.398	1.00
211_W	214_D	2.398	1.00
315_L	350_F	2.393	1.00
47_Q	83_S	2.374	1.00
270_R	307_V	2.367	1.00
265_K	354_E	2.357	1.00
320_K	351_S	2.347	1.00
204_S	211_W	2.336	1.00
45_L	79_M	2.266	1.00
176_I	186_F	2.260	1.00
222_N	310_F	2.205	1.00
132_I	204_S	2.190	1.00
265_K	356_D	2.130	1.00
203_A	220_V	2.093	1.00
311_I	355_I	2.089	1.00
46_T	137_T	2.068	1.00
105_I	132_I	2.033	1.00
315_L	324_T	2.030	1.00
116_N	120_R	1.964	1.00
344_K	347_D	1.958	1.00
100_L	114_I	1.955	1.00
315_L	323_V	1.941	1.00
130_V	176_I	1.889	1.00
44_E	72_K	1.889	1.00
267_T	358_R	1.879	1.00
36_D	137_T	1.867	1.00
71_T	82_T	1.864	1.00
32_G	151_S	1.851	1.00
258_A	267_T	1.839	1.00
293_K	296_E	1.827	1.00
101_S	137_T	1.800	1.00
203_A	223_I	1.799	1.00
42_N	74_K	1.798	1.00
268_V	326_L	1.798	1.00
327_G	345_W	1.789	1.00
187_L	223_I	1.736	1.00
35_L	104_V	1.725	1.00
30_V	90_T	1.720	1.00
176_I	188_I	1.713	1.00
337_K	341_I	1.678	1.00
38_P	72_K	1.678	1.00
36_D	101_S	1.665	1.00
80_M	92_S	1.655	1.00
246_Y	274_G	1.638	1.00
131_F	191_V	1.636	1.00
33_I	95_L	1.619	1.00
34_G	137_T	1.589	1.00
81_R	247_E	1.566	1.00
222_N	303_V	1.529	1.00
257_T	264_F	1.523	1.00
266_F	330_V	1.521	1.00
263_K	354_E	1.516	1.00
216_T	219_E	1.516	1.00
259_Y	264_F	1.492	1.00
44_E	70_I	1.492	1.00
272_I	361_V	1.489	1.00
32_G	141_F	1.475	1.00
190_H	211_W	1.462	1.00
269_T	360_N	1.458	1.00
105_I	206_I	1.454	1.00
183_D	342_S	1.453	1.00
273_E	362_I	1.452	1.00
311_I	357_Y	1.451	1.00
213_R	319_I	1.449	1.00
295_I	363_V	1.444	1.00
205_I	323_V	1.441	1.00
154_I	191_V	1.438	1.00
132_I	206_I	1.437	1.00
302_R	306_T	1.433	1.00
255_I	266_F	1.419	1.00
70_I	138_K	1.411	1.00
297_K	300_E	1.409	1.00
185_S	321_A	1.404	1.00
100_L	105_I	1.404	1.00
101_S	104_V	1.388	1.00
294_S	298_T	1.386	1.00
139_D	142_N	1.385	1.00
302_R	305_E	1.374	0.99
38_P	44_E	1.373	0.99
126_R	174_G	1.371	0.99
307_V	357_Y	1.371	0.99
296_E	300_E	1.363	0.99
131_F	158_T	1.361	0.99
73_G	79_M	1.359	0.99
300_E	304_H	1.346	0.99
33_I	118_F	1.330	0.99
44_E	136_R	1.328	0.99
100_L	111_M	1.317	0.99
228_G	253_R	1.308	0.99
213_R	321_A	1.305	0.99
310_F	315_L	1.303	0.99
8_M	12_T	1.287	0.99
74_K	78_Q	1.266	0.99
185_S	346_D	1.263	0.99
96_R	155_Y	1.261	0.99
27_L	91_F	1.234	0.99
313_E	316_Q	1.224	0.99
316_Q	345_W	1.220	0.99
66_T	150_A	1.218	0.99
226_F	268_V	1.217	0.99
345_W	350_F	1.208	0.99
330_V	337_K	1.206	0.99
77_H	81_R	1.186	0.98
11_C	14_L	1.175	0.98
226_F	324_T	1.173	0.98
30_V	92_S	1.171	0.98
223_I	323_V	1.169	0.98
77_H	247_E	1.161	0.98
38_P	41_E	1.161	0.98
299_V	361_V	1.156	0.98
43_L	104_V	1.150	0.98
77_H	277_S	1.146	0.98
119_V	177_S	1.143	0.98
28_S	49_I	1.141	0.98
253_R	270_R	1.140	0.98
103_S	137_T	1.139	0.98
260_K	265_K	1.138	0.98
222_N	315_L	1.135	0.98
257_T	333_H	1.133	0.98
99_L	131_F	1.129	0.98
73_G	82_T	1.122	0.98
288_K	291_Y	1.111	0.98
254_K	269_T	1.108	0.98
95_L	124_T	1.107	0.98
77_H	117_Q	1.105	0.98
73_G	78_Q	1.103	0.98
112_D	209_K	1.096	0.97
46_T	70_I	1.081	0.97
35_L	76_V	1.080	0.97
274_G	299_V	1.079	0.97
31_I	50_L	1.079	0.97
330_V	334_Y	1.078	0.97
133_T	140_I	1.071	0.97
134_N	192_G	1.063	0.97
223_I	227_S	1.057	0.97
134_N	214_D	1.057	0.97
292_I	296_E	1.056	0.97
272_I	303_V	1.053	0.97
15_L	18_C	1.045	0.97
75_T	243_L	1.040	0.97
226_F	307_V	1.037	0.96
120_R	367_G	1.036	0.96
339_K	342_S	1.035	0.96
298_T	301_K	1.035	0.96
275_R	365_D	1.034	0.96
71_T	83_S	1.033	0.96
256_K	267_T	1.030	0.96
326_L	355_I	1.030	0.96
105_I	204_S	1.030	0.96
34_G	136_R	1.027	0.96
207_K	212_H	1.025	0.96
188_I	206_I	1.023	0.96
46_T	68_L	1.015	0.96
257_T	334_Y	1.011	0.96
98_I	128_S	1.011	0.96
48_Q	150_A	1.010	0.96
52_P	148_E	1.010	0.96
98_I	118_F	1.006	0.96
194_E	199_A	1.001	0.96
143_M	193_K	0.996	0.96
166_R	230_V	0.992	0.95
192_G	201_N	0.989	0.95
94_H	125_R	0.989	0.95
328_N	331_R	0.987	0.95
234_V	247_E	0.987	0.95
184_D	325_G	0.978	0.95
216_T	220_V	0.972	0.95
25_E	126_R	0.972	0.95
259_Y	334_Y	0.970	0.95
101_S	133_T	0.969	0.95
257_T	266_F	0.966	0.95
89_P	123_G	0.965	0.95
192_G	199_A	0.959	0.95
111_M	176_I	0.953	0.94
131_F	189_P	0.945	0.94
219_E	309_S	0.944	0.94
105_I	110_G	0.940	0.94
346_D	350_F	0.937	0.94
256_K	269_T	0.924	0.93
285_D	288_K	0.920	0.93
48_Q	66_T	0.917	0.93
316_Q	351_S	0.916	0.93
328_N	332_I	0.914	0.93
102_K	214_D	0.912	0.93
330_V	338_W	0.910	0.93
74_K	243_L	0.904	0.93
244_F	295_I	0.903	0.93
308_T	357_Y	0.899	0.92
313_E	317_K	0.898	0.92
34_G	46_T	0.894	0.92
103_S	106_A	0.893	0.92
329_E	332_I	0.892	0.92
215_L	219_E	0.885	0.92
205_I	319_I	0.882	0.92
121_D	277_S	0.880	0.92
301_K	304_H	0.880	0.92
98_I	130_V	0.877	0.91
308_T	313_E	0.877	0.91
255_I	268_V	0.875	0.91
207_K	321_A	0.874	0.91
301_K	305_E	0.873	0.91
297_K	301_K	0.871	0.91
212_H	321_A	0.871	0.91
22_E	27_L	0.864	0.91
35_L	45_L	0.855	0.90
270_R	359_V	0.849	0.90
71_T	79_M	0.847	0.90
225_L	230_V	0.846	0.90
226_F	253_R	0.846	0.90
304_H	357_Y	0.842	0.90
176_I	206_I	0.840	0.90
185_S	350_F	0.839	0.90
176_I	180_L	0.837	0.89
105_I	211_W	0.836	0.89
111_M	237_L	0.835	0.89
235_I	306_T	0.835	0.89
110_G	206_I	0.834	0.89
12_T	16_S	0.832	0.89
37_K	41_E	0.831	0.89
264_F	353_A	0.825	0.89
279_D	284_E	0.818	0.88
133_T	137_T	0.818	0.88
86_K	199_A	0.816	0.88
337_K	340_K	0.815	0.88
75_T	278_E	0.814	0.88
293_K	297_K	0.802	0.87
222_N	225_L	0.801	0.87
33_I	47_Q	0.799	0.87
28_S	147_G	0.795	0.87
335_P	338_W	0.795	0.87
334_Y	337_K	0.793	0.87
33_I	98_I	0.793	0.87
71_T	86_K	0.789	0.86
257_T	329_E	0.787	0.86
140_I	191_V	0.787	0.86
303_V	307_V	0.784	0.86
182_S	328_N	0.784	0.86
284_E	291_Y	0.782	0.86
329_E	333_H	0.776	0.86
345_W	351_S	0.776	0.86
100_L	132_I	0.775	0.86
206_I	211_W	0.770	0.85
222_N	307_V	0.770	0.85
101_S	132_I	0.768	0.85
77_H	121_D	0.767	0.85
305_E	309_S	0.763	0.85
132_I	211_W	0.760	0.84
34_G	101_S	0.758	0.84
97_L	131_F	0.755	0.84
258_A	265_K	0.754	0.84
69_S	83_S	0.753	0.84
311_I	316_Q	0.747	0.83
273_E	365_D	0.746	0.83
291_Y	294_S	0.740	0.83
48_Q	125_R	0.740	0.83
260_K	290_S	0.740	0.83
38_P	42_N	0.740	0.83
77_H	278_E	0.736	0.82
106_A	206_I	0.735	0.82
247_E	277_S	0.735	0.82
187_L	323_V	0.734	0.82
129_Y	155_Y	0.733	0.82
303_V	361_V	0.732	0.82
21_S	29_L	0.730	0.82
23_N	88_K	0.730	0.82
174_G	178_E	0.728	0.82
95_L	128_S	0.727	0.82
205_I	215_L	0.724	0.81
225_L	272_I	0.722	0.81
166_R	221_Q	0.715	0.81
179_H	184_D	0.713	0.80
259_Y	337_K	0.713	0.80
137_T	141_F	0.712	0.80
172_T	175_E	0.711	0.80
78_Q	236_D	0.709	0.80
222_N	306_T	0.708	0.80
32_G	48_Q	0.707	0.80
32_G	97_L	0.706	0.80
29_L	91_F	0.705	0.80
157_L	200_I	0.705	0.80
92_S	98_I	0.704	0.80
84_A	122_N	0.699	0.79
37_K	103_S	0.697	0.79
47_Q	92_S	0.696	0.79
186_F	325_G	0.696	0.79
30_V	83_S	0.695	0.79
118_F	173_L	0.692	0.78
152_N	156_D	0.691	0.78
23_N	94_H	0.688	0.78
335_P	339_K	0.687	0.78
4_R	15_L	0.686	0.78
101_S	211_W	0.686	0.78
246_Y	363_V	0.685	0.78
153_V	157_L	0.684	0.78
134_N	190_H	0.680	0.77
310_F	314_K	0.679	0.77
7_C	10_I	0.678	0.77
75_T	236_D	0.678	0.77
130_V	188_I	0.677	0.77
34_G	138_K	0.674	0.77
46_T	103_S	0.674	0.77
7_C	14_L	0.673	0.76
111_M	209_K	0.670	0.76
315_L	319_I	0.668	0.76
272_I	298_T	0.668	0.76
88_K	148_E	0.667	0.76
111_M	206_I	0.662	0.75
271_N	362_I	0.662	0.75
185_S	323_V	0.657	0.75
224_S	229_T	0.655	0.75
35_L	98_I	0.655	0.75
51_V	54_I	0.654	0.74
102_K	190_H	0.653	0.74
190_H	204_S	0.653	0.74
50_L	149_P	0.653	0.74
100_L	115_I	0.653	0.74
46_T	133_T	0.652	0.74
320_K	347_D	0.652	0.74
16_S	20_D	0.651	0.74
257_T	326_L	0.649	0.74
26_E	156_D	0.648	0.74
177_S	369_K	0.647	0.74
264_F	330_V	0.646	0.74
33_I	45_L	0.646	0.74
225_L	303_V	0.643	0.73
48_Q	68_L	0.641	0.73
140_I	193_K	0.641	0.73
133_T	202_G	0.641	0.73
14_L	297_K	0.640	0.73
47_Q	80_M	0.639	0.73
244_F	279_D	0.638	0.73
82_T	85_L	0.635	0.72
248_V	274_G	0.635	0.72
135_G	202_G	0.634	0.72
35_L	43_L	0.634	0.72
311_I	324_T	0.633	0.72
279_D	282_P	0.633	0.72
16_S	19_W	0.632	0.72
187_L	203_A	0.629	0.72
207_K	346_D	0.628	0.71
323_V	350_F	0.628	0.71
215_L	314_K	0.627	0.71
255_I	353_A	0.626	0.71
4_R	12_T	0.626	0.71
276_L	286_S	0.621	0.71
24_I	65_P	0.616	0.70
5_I	298_T	0.616	0.70
6_L	262_G	0.616	0.70
274_G	361_V	0.614	0.70
52_P	60_G	0.612	0.69
175_E	179_H	0.612	0.69
221_Q	225_L	0.612	0.69
152_N	155_Y	0.611	0.69
224_S	228_G	0.611	0.69
104_V	114_I	0.609	0.69
263_K	352_N	0.608	0.69
212_H	319_I	0.606	0.69
289_D	293_K	0.604	0.68
343_R	347_D	0.603	0.68
46_T	138_K	0.602	0.68
101_S	136_R	0.602	0.68
25_E	153_V	0.601	0.68
37_K	43_L	0.601	0.68
12_T	45_L	0.599	0.68
215_L	223_I	0.597	0.68
113_A	299_V	0.597	0.68
201_N	217_P	0.595	0.67
29_L	66_T	0.595	0.67
143_M	198_L	0.595	0.67
237_L	299_V	0.595	0.67
81_R	84_A	0.594	0.67
49_I	69_S	0.594	0.67
8_M	11_C	0.593	0.67
248_V	251_S	0.593	0.67
81_R	121_D	0.593	0.67
326_L	350_F	0.593	0.67
106_A	290_S	0.592	0.67
223_I	310_F	0.592	0.67
77_H	122_N	0.591	0.67
91_F	96_R	0.590	0.67
171_V	179_H	0.590	0.67
221_Q	324_T	0.590	0.67
75_T	245_S	0.589	0.67
205_I	321_A	0.589	0.67
24_I	158_T	0.588	0.66
307_V	310_F	0.587	0.66
85_L	217_P	0.586	0.66
88_K	332_I	0.586	0.66
218_I	306_T	0.585	0.66
72_K	76_V	0.585	0.66
43_L	114_I	0.584	0.66
173_L	176_I	0.584	0.66
83_S	181_T	0.584	0.66
12_T	308_T	0.581	0.65
31_I	174_G	0.579	0.65
131_F	154_I	0.579	0.65
102_K	135_G	0.576	0.65
13_L	106_A	0.576	0.65
5_I	9_F	0.575	0.65
284_E	287_F	0.574	0.65
93_Q	186_F	0.574	0.65
255_I	329_E	0.574	0.65
34_G	48_Q	0.574	0.65
18_C	120_R	0.573	0.64
32_G	152_N	0.572	0.64
106_A	211_W	0.572	0.64
310_F	323_V	0.571	0.64
132_I	188_I	0.571	0.64
134_N	211_W	0.571	0.64
105_I	111_M	0.570	0.64
106_A	214_D	0.569	0.64
349_Y	353_A	0.569	0.64
4_R	8_M	0.568	0.64
185_S	325_G	0.567	0.64
247_E	275_R	0.567	0.64
261_D	271_N	0.567	0.64
9_F	297_K	0.565	0.63
87_H	145_D	0.565	0.63
316_Q	353_A	0.565	0.63
189_P	200_I	0.564	0.63
128_S	174_G	0.562	0.63
175_E	218_I	0.561	0.63
41_E	313_E	0.561	0.63
162_K	170_P	0.561	0.63
19_W	338_W	0.559	0.63
25_E	51_V	0.558	0.62
221_Q	306_T	0.558	0.62
184_D	328_N	0.558	0.62
20_D	26_E	0.557	0.62
148_E	156_D	0.557	0.62
225_L	235_I	0.554	0.62
158_T	189_P	0.554	0.62
116_N	278_E	0.553	0.62
121_D	247_E	0.552	0.62
274_G	296_E	0.552	0.62
68_L	150_A	0.551	0.61
269_T	272_I	0.551	0.61
65_P	150_A	0.550	0.61
6_L	14_L	0.550	0.61
358_R	361_V	0.550	0.61
168_M	189_P	0.548	0.61
12_T	309_S	0.548	0.61
186_F	327_G	0.547	0.61
179_H	237_L	0.546	0.61
112_D	150_A	0.546	0.61
12_T	15_L	0.545	0.61
27_L	93_Q	0.545	0.61
46_T	101_S	0.545	0.61
256_K	297_K	0.545	0.61
257_T	335_P	0.545	0.61
99_L	137_T	0.544	0.60
24_I	88_K	0.544	0.60
38_P	103_S	0.543	0.60
225_L	306_T	0.542	0.60
48_Q	141_F	0.542	0.60
43_L	268_V	0.541	0.60
305_E	308_T	0.539	0.60
97_L	154_I	0.538	0.60
22_E	75_T	0.538	0.60
34_G	142_N	0.538	0.60
350_F	353_A	0.538	0.60
264_F	341_I	0.537	0.59
230_V	251_S	0.537	0.59
84_A	145_D	0.535	0.59
49_I	147_G	0.535	0.59
30_V	47_Q	0.535	0.59
35_L	100_L	0.535	0.59
31_I	200_I	0.532	0.59
238_K	242_H	0.530	0.58
258_A	358_R	0.530	0.58
42_N	305_E	0.528	0.58
85_L	167_T	0.528	0.58
115_I	218_I	0.527	0.58
10_I	14_L	0.527	0.58
282_P	286_S	0.525	0.58
46_T	141_F	0.525	0.58
19_W	213_R	0.525	0.58
58_K	202_G	0.524	0.58
215_L	310_F	0.523	0.57
151_S	158_T	0.522	0.57
162_K	220_V	0.522	0.57
299_V	363_V	0.522	0.57
194_E	197_K	0.521	0.57
84_A	90_T	0.520	0.57
244_F	274_G	0.519	0.57
34_G	99_L	0.519	0.57
134_N	216_T	0.519	0.57
254_K	261_D	0.518	0.57
330_V	335_P	0.518	0.57
5_I	14_L	0.516	0.56
230_V	233_G	0.516	0.56
205_I	315_L	0.516	0.56
33_I	80_M	0.515	0.56
97_L	151_S	0.515	0.56
167_T	221_Q	0.514	0.56
274_G	363_V	0.514	0.56
341_I	349_Y	0.514	0.56
260_K	263_K	0.514	0.56
115_I	130_V	0.510	0.56
48_Q	151_S	0.508	0.55
307_V	359_V	0.508	0.55
41_E	360_N	0.508	0.55
175_E	350_F	0.506	0.55
29_L	173_L	0.506	0.55
264_F	337_K	0.504	0.55
86_K	197_K	0.504	0.55
216_T	269_T	0.504	0.55
47_Q	124_T	0.504	0.55
48_Q	94_H	0.504	0.55
50_L	153_V	0.501	0.54
87_H	157_L	0.500	0.54
84_A	89_P	0.500	0.54
35_L	79_M	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n54B	5	0.8284	100	0.166	Contact Map
3zbiC	1	0.0724	47.5	0.956	Contact Map
3utkA	1	0.2172	45.6	0.957	Contact Map
3j6da	3	0.3566	18.2	0.965	Contact Map
4fybB	1	0.378	13.4	0.967	Contact Map
4pj0U	1	0.2306	12	0.967	Contact Map
2pptA	2	0.3968	10.2	0.968	Contact Map
1v98A	2	0.244	7.1	0.971	Contact Map
2v25A	1	0.563	6.9	0.971	Contact Map
2jnaA	2	0.2386	6	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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