GERAB - BACSU - GREMLIN Contacts

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GERAB - Spore germination protein A2

UniProt:	P07869	Sequences: MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDGWITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVASFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIILLIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTFRYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFLLVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMYSDYLGYIFVSLFLLPFILFFIVALKRRITTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (352)
Sequences:	23254 (14664)
Seq/√Len:	781.6

ECOLI - FRLA YBAT YIFK ADIC LYSP ANSP POTE AROP MMUP PROY PUUP GABP YCAM CYCA ARCD PLAP CADB YJEH PHEP GADC YGJI YJEM TNAB MTR TYRP
BACSU - GERAB GERBB YBGF ROCC YBXG YHDG YNDE YBEC YVBW GABP STET ASPP YDGF YCGH YTNA ARCD HUTM AAPA YECA YFNA ROCE GERKB YDAO YFKT
HALSA - Q9HHU7 Q9HQB3 Q9HSL5
SULSO - Q97U05 Q97WS3 Q97X49 Q97XM0 Q97WD4 Q7LXI7 Q97ZB5 Q97VR4 Q97Z63 Q97U33 Q97VA8 Q97VA6 Q97Y76 Q97YN3 Q97YX9 Q97U39

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
302_T	314_I	4.485	1.00
52_G	229_I	3.509	1.00
305_L	314_I	3.181	1.00
355_I	359_K	3.065	1.00
216_Y	219_R	2.868	1.00
307_T	310_S	2.815	1.00
11_N	212_K	2.779	1.00
213_K	216_Y	2.746	1.00
16_I	223_L	2.731	1.00
302_T	305_L	2.700	1.00
128_L	323_L	2.675	1.00
12_T	223_L	2.528	1.00
167_S	238_I	2.508	1.00
257_S	260_Q	2.482	1.00
136_Y	140_G	2.426	1.00
293_Y	297_N	2.400	1.00
296_A	304_G	2.388	1.00
15_G	211_M	2.346	1.00
219_R	223_L	2.260	1.00
91_G	295_A	2.259	1.00
310_S	313_I	2.226	1.00
79_K	87_G	2.198	1.00
154_T	158_I	2.153	1.00
79_K	84_K	2.138	1.00
307_T	313_I	2.135	1.00
35_L	44_G	2.094	1.00
247_E	261_S	2.083	1.00
11_N	14_Q	2.074	1.00
244_T	247_E	2.061	1.00
12_T	16_I	2.050	1.00
257_S	261_S	2.043	1.00
16_I	227_I	2.039	1.00
210_H	290_I	2.006	1.00
209_E	297_N	1.997	1.00
143_S	147_R	1.991	1.00
78_L	90_I	1.978	1.00
172_D	175_N	1.955	1.00
14_Q	150_P	1.937	1.00
276_L	279_V	1.904	1.00
135_I	319_F	1.888	1.00
135_I	316_I	1.834	1.00
331_V	334_Y	1.825	1.00
64_L	357_A	1.810	1.00
260_Q	266_G	1.808	1.00
53_F	57_F	1.803	1.00
122_P	125_V	1.801	1.00
260_Q	265_K	1.747	1.00
158_I	162_I	1.724	1.00
349_P	352_L	1.710	1.00
109_M	130_F	1.706	1.00
178_P	181_G	1.697	1.00
19_V	224_G	1.691	1.00
113_V	126_I	1.677	1.00
69_H	80_E	1.668	1.00
307_T	312_V	1.666	1.00
273_E	277_L	1.664	1.00
331_V	335_S	1.664	1.00
222_S	226_L	1.649	1.00
51_E	194_V	1.644	1.00
10_L	14_Q	1.633	1.00
301_K	304_G	1.619	1.00
342_F	345_L	1.616	1.00
47_T	190_S	1.604	1.00
267_I	271_R	1.603	1.00
348_L	352_L	1.583	1.00
59_I	225_F	1.577	1.00
59_I	221_A	1.569	1.00
139_V	317_T	1.554	1.00
119_E	122_P	1.554	1.00
14_Q	146_S	1.553	1.00
164_F	234_L	1.548	1.00
128_L	132_C	1.539	1.00
251_L	257_S	1.517	1.00
307_T	311_M	1.511	1.00
106_T	131_I	1.504	1.00
82_L	86_I	1.495	1.00
83_G	86_I	1.492	1.00
327_D	330_Q	1.485	1.00
43_D	187_I	1.484	1.00
12_T	219_R	1.484	1.00
335_S	338_L	1.459	1.00
207_L	286_T	1.446	1.00
226_L	230_I	1.441	1.00
82_L	355_I	1.441	1.00
121_T	125_V	1.432	1.00
163_V	167_S	1.425	1.00
76_E	80_E	1.422	1.00
269_I	272_F	1.418	1.00
320_Y	323_L	1.418	1.00
60_Y	222_S	1.416	1.00
72_P	209_E	1.403	1.00
106_T	281_I	1.395	1.00
167_S	242_A	1.391	1.00
354_F	358_L	1.380	1.00
293_Y	306_S	1.380	1.00
336_D	339_G	1.371	1.00
134_G	281_I	1.371	1.00
169_K	172_D	1.363	1.00
274_S	279_V	1.358	1.00
30_T	108_A	1.358	1.00
168_F	238_I	1.351	1.00
71_Y	76_E	1.346	1.00
230_I	234_L	1.340	1.00
64_L	67_K	1.339	1.00
169_K	174_N	1.336	1.00
124_Q	128_L	1.335	1.00
301_K	305_L	1.329	1.00
251_L	254_P	1.328	1.00
135_I	317_T	1.323	1.00
309_T	313_I	1.323	1.00
45_W	237_I	1.307	1.00
326_D	330_Q	1.302	1.00
349_P	353_F	1.301	1.00
348_L	354_F	1.298	1.00
253_W	257_S	1.294	1.00
88_S	92_L	1.283	1.00
337_Y	341_I	1.282	1.00
49_I	233_I	1.267	1.00
314_I	317_T	1.266	1.00
159_I	272_F	1.266	1.00
213_K	219_R	1.265	1.00
171_F	241_G	1.260	1.00
138_M	282_I	1.258	1.00
237_I	241_G	1.255	1.00
273_E	276_L	1.255	1.00
61_L	350_F	1.241	1.00
15_G	220_Y	1.241	1.00
9_K	212_K	1.237	1.00
13_F	17_S	1.227	1.00
214_K	218_F	1.217	1.00
95_C	292_G	1.215	1.00
318_V	323_L	1.209	1.00
147_R	151_F	1.206	1.00
23_M	228_P	1.200	1.00
62_N	74_L	1.200	1.00
268_F	272_F	1.198	1.00
292_G	315_G	1.195	1.00
170_I	173_I	1.194	1.00
147_R	150_P	1.193	1.00
157_I	161_L	1.193	1.00
19_V	204_M	1.183	1.00
82_L	351_I	1.183	1.00
135_I	139_V	1.182	1.00
351_I	355_I	1.172	1.00
297_N	304_G	1.169	1.00
71_Y	80_E	1.160	1.00
318_V	321_F	1.160	1.00
78_L	348_L	1.159	1.00
137_L	148_L	1.155	1.00
36_T	44_G	1.145	1.00
148_L	152_Y	1.138	1.00
110_A	126_I	1.137	1.00
17_S	150_P	1.135	1.00
274_S	277_L	1.124	1.00
78_L	86_I	1.120	1.00
105_E	280_W	1.112	1.00
305_L	308_K	1.112	1.00
319_F	323_L	1.109	1.00
66_Q	77_Y	1.105	1.00
20_A	227_I	1.101	1.00
10_L	146_S	1.100	1.00
10_L	15_G	1.097	1.00
18_I	207_L	1.096	1.00
129_T	133_C	1.083	1.00
81_G	352_L	1.075	1.00
162_I	166_I	1.047	1.00
172_D	176_L	1.042	1.00
346_F	353_F	1.038	1.00
271_R	275_F	1.037	1.00
321_F	324_W	1.031	1.00
132_C	136_Y	1.030	1.00
353_F	357_A	1.027	1.00
348_L	355_I	1.026	1.00
161_L	165_G	1.025	1.00
270_E	273_E	1.024	1.00
306_S	310_S	1.022	1.00
309_T	312_V	1.020	1.00
171_F	175_N	1.019	1.00
350_F	353_F	1.018	1.00
177_R	180_L	1.016	1.00
85_W	89_I	1.013	1.00
173_I	176_L	1.011	1.00
169_K	173_I	1.010	1.00
126_I	129_T	1.003	1.00
183_G	186_P	0.989	1.00
20_A	228_P	0.987	1.00
229_I	233_I	0.984	1.00
142_L	286_T	0.980	1.00
338_L	341_I	0.979	1.00
208_P	217_T	0.976	1.00
125_V	129_T	0.975	1.00
299_L	303_F	0.972	1.00
109_M	274_S	0.971	1.00
7_P	311_M	0.963	1.00
164_F	238_I	0.957	1.00
272_F	279_V	0.957	1.00
56_I	60_Y	0.956	1.00
9_K	143_S	0.947	1.00
13_F	150_P	0.942	1.00
249_K	253_W	0.940	1.00
184_L	188_A	0.940	1.00
157_I	231_L	0.937	1.00
140_G	310_S	0.932	1.00
133_C	278_V	0.931	1.00
94_I	98_F	0.931	1.00
223_L	227_I	0.930	1.00
104_F	196_I	0.927	1.00
179_V	182_E	0.925	1.00
171_F	174_N	0.923	1.00
334_Y	341_I	0.923	1.00
273_E	279_V	0.920	1.00
330_Q	333_M	0.920	1.00
267_I	270_E	0.917	1.00
28_L	235_T	0.917	1.00
202_E	206_F	0.917	1.00
114_K	123_I	0.916	1.00
140_G	144_D	0.916	1.00
45_W	240_V	0.916	1.00
113_V	117_L	0.915	1.00
242_A	258_L	0.915	1.00
12_T	220_Y	0.913	1.00
136_Y	139_V	0.912	1.00
177_R	181_G	0.910	1.00
290_I	296_A	0.906	1.00
268_F	279_V	0.897	1.00
42_P	46_I	0.897	1.00
189_N	193_V	0.892	1.00
333_M	336_D	0.891	1.00
164_F	168_F	0.891	1.00
308_K	313_I	0.890	1.00
14_Q	147_R	0.890	1.00
52_G	198_F	0.887	1.00
326_D	329_N	0.884	1.00
319_F	322_S	0.883	1.00
170_I	174_N	0.883	1.00
110_A	127_I	0.876	1.00
253_W	256_I	0.874	1.00
352_L	355_I	0.874	1.00
43_D	180_L	0.872	1.00
13_F	147_R	0.872	1.00
44_G	236_Y	0.870	1.00
355_I	358_L	0.868	1.00
144_D	147_R	0.859	1.00
57_F	61_L	0.859	1.00
164_F	235_T	0.858	1.00
332_M	336_D	0.857	1.00
37_T	40_N	0.856	1.00
249_K	252_I	0.852	1.00
46_I	49_I	0.849	1.00
120_R	123_I	0.847	1.00
318_V	322_S	0.842	1.00
259_F	263_E	0.841	1.00
346_F	354_F	0.840	1.00
350_F	357_A	0.838	1.00
24_L	27_G	0.836	1.00
270_E	277_L	0.836	1.00
272_F	277_L	0.835	1.00
9_K	142_L	0.830	1.00
46_I	50_L	0.828	1.00
302_T	306_S	0.827	1.00
170_I	175_N	0.822	1.00
90_I	348_L	0.822	1.00
178_P	182_E	0.821	1.00
16_I	220_Y	0.819	1.00
232_Y	236_Y	0.816	1.00
348_L	353_F	0.813	1.00
332_M	335_S	0.812	1.00
56_I	222_S	0.812	1.00
9_K	13_F	0.810	1.00
75_F	79_K	0.810	1.00
184_L	187_I	0.808	1.00
146_S	150_P	0.803	1.00
64_L	68_K	0.800	1.00
289_V	316_I	0.798	1.00
218_F	221_A	0.797	1.00
270_E	274_S	0.796	1.00
25_G	29_L	0.794	1.00
254_P	259_F	0.793	1.00
65_I	77_Y	0.786	1.00
132_C	323_L	0.786	1.00
55_F	201_M	0.786	1.00
275_F	279_V	0.782	1.00
347_L	351_I	0.781	1.00
132_C	135_I	0.781	1.00
35_L	39_A	0.780	1.00
290_I	295_A	0.779	1.00
139_V	313_I	0.779	1.00
249_K	254_P	0.772	1.00
113_V	130_F	0.771	1.00
134_G	285_F	0.770	1.00
75_F	294_F	0.769	1.00
285_F	289_V	0.769	1.00
38_K	189_N	0.769	1.00
139_V	312_V	0.766	1.00
141_G	144_D	0.766	1.00
132_C	319_F	0.766	1.00
346_F	349_P	0.763	1.00
329_N	332_M	0.760	1.00
244_T	261_S	0.759	1.00
325_P	329_N	0.756	1.00
303_F	314_I	0.756	1.00
188_A	192_T	0.751	1.00
348_L	351_I	0.749	1.00
243_L	247_E	0.748	1.00
22_T	283_Q	0.747	1.00
205_L	221_A	0.742	1.00
124_Q	127_I	0.741	1.00
346_F	350_F	0.739	1.00
58_F	350_F	0.736	1.00
34_A	37_T	0.734	1.00
63_T	67_K	0.732	1.00
259_F	262_F	0.731	1.00
281_I	284_F	0.729	1.00
227_I	231_L	0.728	1.00
119_E	123_I	0.727	1.00
110_A	123_I	0.727	1.00
337_Y	340_Y	0.725	1.00
92_L	299_L	0.725	1.00
248_V	254_P	0.723	1.00
235_T	239_V	0.722	1.00
171_F	176_L	0.721	1.00
338_L	342_F	0.719	1.00
286_T	290_I	0.717	1.00
32_P	236_Y	0.717	1.00
121_T	126_I	0.717	1.00
51_E	195_S	0.714	1.00
106_T	110_A	0.714	1.00
209_E	293_Y	0.713	1.00
75_F	91_G	0.713	1.00
149_F	282_I	0.713	1.00
341_I	345_L	0.710	1.00
334_Y	338_L	0.709	1.00
168_F	234_L	0.709	1.00
22_T	284_F	0.705	1.00
120_R	124_Q	0.703	1.00
153_L	156_T	0.703	1.00
286_T	289_V	0.701	1.00
306_S	313_I	0.700	1.00
211_M	217_T	0.697	1.00
21_N	153_L	0.697	1.00
238_I	241_G	0.693	1.00
103_S	106_T	0.692	1.00
59_I	201_M	0.691	1.00
134_G	282_I	0.691	1.00
23_M	224_G	0.689	1.00
65_I	81_G	0.687	1.00
101_V	104_F	0.687	1.00
24_L	29_L	0.686	1.00
176_L	241_G	0.685	1.00
213_K	218_F	0.685	1.00
299_L	302_T	0.684	1.00
300_K	303_F	0.684	1.00
296_A	303_F	0.683	1.00
107_R	334_Y	0.682	1.00
203_V	287_T	0.682	1.00
217_T	221_A	0.682	1.00
255_T	259_F	0.680	1.00
261_S	265_K	0.678	1.00
180_L	187_I	0.678	1.00
285_F	288_F	0.675	1.00
348_L	358_L	0.669	1.00
109_M	277_L	0.668	1.00
16_I	19_V	0.666	1.00
290_I	293_Y	0.665	1.00
272_F	276_L	0.665	1.00
340_Y	343_V	0.663	1.00
325_P	330_Q	0.662	1.00
163_V	259_F	0.661	1.00
288_F	292_G	0.659	1.00
66_Q	205_L	0.658	1.00
108_A	112_M	0.658	1.00
174_N	177_R	0.658	1.00
138_M	286_T	0.657	1.00
127_I	326_D	0.657	1.00
173_I	241_G	0.656	1.00
139_V	310_S	0.652	1.00
50_L	191_L	0.651	1.00
336_D	340_Y	0.651	1.00
46_I	187_I	0.650	1.00
135_I	285_F	0.648	1.00
323_L	326_D	0.647	1.00
121_T	124_Q	0.647	1.00
19_V	23_M	0.647	1.00
292_G	299_L	0.646	1.00
169_K	175_N	0.644	1.00
340_Y	345_L	0.643	1.00
215_K	219_R	0.641	1.00
292_G	296_A	0.641	1.00
353_F	356_V	0.637	1.00
113_V	274_S	0.637	1.00
269_I	277_L	0.637	1.00
85_W	88_S	0.636	1.00
234_L	238_I	0.636	1.00
223_L	226_L	0.635	1.00
152_Y	279_V	0.631	1.00
354_F	357_A	0.628	1.00
186_P	189_N	0.628	1.00
144_D	148_L	0.627	1.00
35_L	194_V	0.626	1.00
293_Y	296_A	0.623	1.00
66_Q	217_T	0.622	1.00
116_F	274_S	0.622	1.00
271_R	274_S	0.622	1.00
280_W	284_F	0.621	1.00
352_L	356_V	0.619	1.00
109_M	278_V	0.619	1.00
199_L	202_E	0.618	1.00
34_A	38_K	0.616	1.00
254_P	258_L	0.614	1.00
308_K	311_M	0.614	1.00
351_I	354_F	0.614	1.00
111_E	123_I	0.613	1.00
158_I	161_L	0.613	1.00
78_L	87_G	0.612	1.00
56_I	225_F	0.612	1.00
336_D	344_S	0.609	1.00
49_I	53_F	0.608	1.00
250_T	253_W	0.607	1.00
290_I	306_S	0.606	1.00
329_N	333_M	0.602	1.00
109_M	113_V	0.602	1.00
325_P	328_A	0.601	1.00
248_V	251_L	0.600	1.00
110_A	113_V	0.599	1.00
176_L	240_V	0.598	1.00
150_P	154_T	0.597	1.00
177_R	182_E	0.597	1.00
42_P	179_V	0.597	1.00
161_L	231_L	0.596	1.00
346_F	355_I	0.595	1.00
347_L	354_F	0.595	1.00
24_L	156_T	0.592	1.00
254_P	257_S	0.592	1.00
22_T	203_V	0.591	1.00
273_E	280_W	0.590	1.00
43_D	179_V	0.587	1.00
268_F	273_E	0.586	1.00
95_C	99_L	0.586	1.00
268_F	276_L	0.584	1.00
348_L	356_V	0.582	1.00
105_E	108_A	0.582	1.00
74_L	206_F	0.582	1.00
242_A	262_F	0.582	1.00
51_E	54_I	0.579	1.00
75_F	87_G	0.575	1.00
48_L	236_Y	0.574	1.00
138_M	316_I	0.572	1.00
267_I	274_S	0.571	1.00
227_I	230_I	0.570	1.00
87_G	91_G	0.569	1.00
346_F	352_L	0.569	1.00
45_W	233_I	0.568	1.00
111_E	114_K	0.567	1.00
72_P	293_Y	0.567	1.00
187_I	190_S	0.566	1.00
312_V	316_I	0.560	1.00
206_F	287_T	0.559	1.00
13_F	16_I	0.556	1.00
98_F	284_F	0.556	1.00
185_G	188_A	0.555	1.00
336_D	341_I	0.555	1.00
140_G	309_T	0.554	1.00
145_V	286_T	0.553	1.00
115_F	260_Q	0.553	1.00
318_V	326_D	0.553	1.00
235_T	238_I	0.551	1.00
71_Y	209_E	0.550	1.00
47_T	187_I	0.549	1.00
349_P	356_V	0.549	1.00
76_E	79_K	0.549	1.00
308_K	312_V	0.548	1.00
170_I	176_L	0.547	1.00
15_G	207_L	0.546	1.00
243_L	257_S	0.544	1.00
93_L	97_Y	0.544	1.00
74_L	202_E	0.541	1.00
226_L	229_I	0.540	1.00
268_F	274_S	0.538	1.00
35_L	190_S	0.538	1.00
258_L	261_S	0.537	1.00
128_L	327_D	0.537	1.00
43_D	46_I	0.537	1.00
48_L	197_S	0.536	1.00
255_T	263_E	0.536	1.00
122_P	126_I	0.532	1.00
139_V	316_I	0.532	1.00
193_V	197_S	0.532	1.00
130_F	281_I	0.532	1.00
131_I	319_F	0.531	1.00
266_G	270_E	0.530	1.00
68_K	356_V	0.530	1.00
250_T	254_P	0.528	1.00
89_I	93_L	0.528	1.00
77_Y	205_L	0.527	1.00
345_L	349_P	0.526	1.00
221_A	224_G	0.524	1.00
259_F	264_L	0.524	1.00
123_I	127_I	0.523	1.00
327_D	335_S	0.522	1.00
32_P	240_V	0.521	1.00
15_G	18_I	0.521	1.00
59_I	63_T	0.519	1.00
317_T	320_Y	0.519	1.00
335_S	339_G	0.518	1.00
95_C	98_F	0.517	1.00
235_T	255_T	0.516	1.00
8_L	212_K	0.515	1.00
83_G	87_G	0.515	1.00
69_H	81_G	0.514	1.00
20_A	153_L	0.514	1.00
323_L	327_D	0.514	1.00
303_F	315_G	0.513	1.00
142_L	146_S	0.512	1.00
25_G	28_L	0.511	1.00
51_E	198_F	0.510	1.00
189_N	192_T	0.509	1.00
101_V	105_E	0.509	1.00
45_W	48_L	0.508	1.00
273_E	278_V	0.508	1.00
39_A	43_D	0.507	1.00
114_K	126_I	0.505	1.00
38_K	193_V	0.504	1.00
320_Y	324_W	0.503	1.00
56_I	226_L	0.502	1.00
45_W	49_I	0.501	1.00
19_V	220_Y	0.501	1.00
139_V	307_T	0.501	1.00
274_S	278_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l1lA	2	0.9562	100	0.271	Contact Map
3giaA	1	0.9836	100	0.329	Contact Map
4djkA	2	0.9397	100	0.368	Contact Map
2jlnA	1	0.9233	98.6	0.841	Contact Map
3dh4A	3	0.9452	98.5	0.849	Contact Map
2xq2A	2	0.9479	98.4	0.853	Contact Map
4us3A	1	0.9616	97.5	0.88	Contact Map
4xp4A	1	0.9644	97.1	0.888	Contact Map
4wgvA	2	0.9014	96.9	0.892	Contact Map
2a65A	2	0.9562	96.9	0.892	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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