GREMLIN Database
GERAB - Spore germination protein A2
UniProt: P07869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (352)
Sequences: 23254 (14664)
Seq/√Len: 781.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_T314_I4.4851.00
52_G229_I3.5091.00
305_L314_I3.1811.00
355_I359_K3.0651.00
216_Y219_R2.8681.00
307_T310_S2.8151.00
11_N212_K2.7791.00
213_K216_Y2.7461.00
16_I223_L2.7311.00
302_T305_L2.7001.00
128_L323_L2.6751.00
12_T223_L2.5281.00
167_S238_I2.5081.00
257_S260_Q2.4821.00
136_Y140_G2.4261.00
293_Y297_N2.4001.00
296_A304_G2.3881.00
15_G211_M2.3461.00
219_R223_L2.2601.00
91_G295_A2.2591.00
310_S313_I2.2261.00
79_K87_G2.1981.00
154_T158_I2.1531.00
79_K84_K2.1381.00
307_T313_I2.1351.00
35_L44_G2.0941.00
247_E261_S2.0831.00
11_N14_Q2.0741.00
244_T247_E2.0611.00
12_T16_I2.0501.00
257_S261_S2.0431.00
16_I227_I2.0391.00
210_H290_I2.0061.00
209_E297_N1.9971.00
143_S147_R1.9911.00
78_L90_I1.9781.00
172_D175_N1.9551.00
14_Q150_P1.9371.00
276_L279_V1.9041.00
135_I319_F1.8881.00
135_I316_I1.8341.00
331_V334_Y1.8251.00
64_L357_A1.8101.00
260_Q266_G1.8081.00
53_F57_F1.8031.00
122_P125_V1.8011.00
260_Q265_K1.7471.00
158_I162_I1.7241.00
349_P352_L1.7101.00
109_M130_F1.7061.00
178_P181_G1.6971.00
19_V224_G1.6911.00
113_V126_I1.6771.00
69_H80_E1.6681.00
307_T312_V1.6661.00
273_E277_L1.6641.00
331_V335_S1.6641.00
222_S226_L1.6491.00
51_E194_V1.6441.00
10_L14_Q1.6331.00
301_K304_G1.6191.00
342_F345_L1.6161.00
47_T190_S1.6041.00
267_I271_R1.6031.00
348_L352_L1.5831.00
59_I225_F1.5771.00
59_I221_A1.5691.00
139_V317_T1.5541.00
119_E122_P1.5541.00
14_Q146_S1.5531.00
164_F234_L1.5481.00
128_L132_C1.5391.00
251_L257_S1.5171.00
307_T311_M1.5111.00
106_T131_I1.5041.00
82_L86_I1.4951.00
83_G86_I1.4921.00
327_D330_Q1.4851.00
43_D187_I1.4841.00
12_T219_R1.4841.00
335_S338_L1.4591.00
207_L286_T1.4461.00
226_L230_I1.4411.00
82_L355_I1.4411.00
121_T125_V1.4321.00
163_V167_S1.4251.00
76_E80_E1.4221.00
269_I272_F1.4181.00
320_Y323_L1.4181.00
60_Y222_S1.4161.00
72_P209_E1.4031.00
106_T281_I1.3951.00
167_S242_A1.3911.00
354_F358_L1.3801.00
293_Y306_S1.3801.00
336_D339_G1.3711.00
134_G281_I1.3711.00
169_K172_D1.3631.00
274_S279_V1.3581.00
30_T108_A1.3581.00
168_F238_I1.3511.00
71_Y76_E1.3461.00
230_I234_L1.3401.00
64_L67_K1.3391.00
169_K174_N1.3361.00
124_Q128_L1.3351.00
301_K305_L1.3291.00
251_L254_P1.3281.00
135_I317_T1.3231.00
309_T313_I1.3231.00
45_W237_I1.3071.00
326_D330_Q1.3021.00
349_P353_F1.3011.00
348_L354_F1.2981.00
253_W257_S1.2941.00
88_S92_L1.2831.00
337_Y341_I1.2821.00
49_I233_I1.2671.00
314_I317_T1.2661.00
159_I272_F1.2661.00
213_K219_R1.2651.00
171_F241_G1.2601.00
138_M282_I1.2581.00
237_I241_G1.2551.00
273_E276_L1.2551.00
61_L350_F1.2411.00
15_G220_Y1.2411.00
9_K212_K1.2371.00
13_F17_S1.2271.00
214_K218_F1.2171.00
95_C292_G1.2151.00
318_V323_L1.2091.00
147_R151_F1.2061.00
23_M228_P1.2001.00
62_N74_L1.2001.00
268_F272_F1.1981.00
292_G315_G1.1951.00
170_I173_I1.1941.00
147_R150_P1.1931.00
157_I161_L1.1931.00
19_V204_M1.1831.00
82_L351_I1.1831.00
135_I139_V1.1821.00
351_I355_I1.1721.00
297_N304_G1.1691.00
71_Y80_E1.1601.00
318_V321_F1.1601.00
78_L348_L1.1591.00
137_L148_L1.1551.00
36_T44_G1.1451.00
148_L152_Y1.1381.00
110_A126_I1.1371.00
17_S150_P1.1351.00
274_S277_L1.1241.00
78_L86_I1.1201.00
105_E280_W1.1121.00
305_L308_K1.1121.00
319_F323_L1.1091.00
66_Q77_Y1.1051.00
20_A227_I1.1011.00
10_L146_S1.1001.00
10_L15_G1.0971.00
18_I207_L1.0961.00
129_T133_C1.0831.00
81_G352_L1.0751.00
162_I166_I1.0471.00
172_D176_L1.0421.00
346_F353_F1.0381.00
271_R275_F1.0371.00
321_F324_W1.0311.00
132_C136_Y1.0301.00
353_F357_A1.0271.00
348_L355_I1.0261.00
161_L165_G1.0251.00
270_E273_E1.0241.00
306_S310_S1.0221.00
309_T312_V1.0201.00
171_F175_N1.0191.00
350_F353_F1.0181.00
177_R180_L1.0161.00
85_W89_I1.0131.00
173_I176_L1.0111.00
169_K173_I1.0101.00
126_I129_T1.0031.00
183_G186_P0.9891.00
20_A228_P0.9871.00
229_I233_I0.9841.00
142_L286_T0.9801.00
338_L341_I0.9791.00
208_P217_T0.9761.00
125_V129_T0.9751.00
299_L303_F0.9721.00
109_M274_S0.9711.00
7_P311_M0.9631.00
164_F238_I0.9571.00
272_F279_V0.9571.00
56_I60_Y0.9561.00
9_K143_S0.9471.00
13_F150_P0.9421.00
249_K253_W0.9401.00
184_L188_A0.9401.00
157_I231_L0.9371.00
140_G310_S0.9321.00
133_C278_V0.9311.00
94_I98_F0.9311.00
223_L227_I0.9301.00
104_F196_I0.9271.00
179_V182_E0.9251.00
171_F174_N0.9231.00
334_Y341_I0.9231.00
273_E279_V0.9201.00
330_Q333_M0.9201.00
267_I270_E0.9171.00
28_L235_T0.9171.00
202_E206_F0.9171.00
114_K123_I0.9161.00
140_G144_D0.9161.00
45_W240_V0.9161.00
113_V117_L0.9151.00
242_A258_L0.9151.00
12_T220_Y0.9131.00
136_Y139_V0.9121.00
177_R181_G0.9101.00
290_I296_A0.9061.00
268_F279_V0.8971.00
42_P46_I0.8971.00
189_N193_V0.8921.00
333_M336_D0.8911.00
164_F168_F0.8911.00
308_K313_I0.8901.00
14_Q147_R0.8901.00
52_G198_F0.8871.00
326_D329_N0.8841.00
319_F322_S0.8831.00
170_I174_N0.8831.00
110_A127_I0.8761.00
253_W256_I0.8741.00
352_L355_I0.8741.00
43_D180_L0.8721.00
13_F147_R0.8721.00
44_G236_Y0.8701.00
355_I358_L0.8681.00
144_D147_R0.8591.00
57_F61_L0.8591.00
164_F235_T0.8581.00
332_M336_D0.8571.00
37_T40_N0.8561.00
249_K252_I0.8521.00
46_I49_I0.8491.00
120_R123_I0.8471.00
318_V322_S0.8421.00
259_F263_E0.8411.00
346_F354_F0.8401.00
350_F357_A0.8381.00
24_L27_G0.8361.00
270_E277_L0.8361.00
272_F277_L0.8351.00
9_K142_L0.8301.00
46_I50_L0.8281.00
302_T306_S0.8271.00
170_I175_N0.8221.00
90_I348_L0.8221.00
178_P182_E0.8211.00
16_I220_Y0.8191.00
232_Y236_Y0.8161.00
348_L353_F0.8131.00
332_M335_S0.8121.00
56_I222_S0.8121.00
9_K13_F0.8101.00
75_F79_K0.8101.00
184_L187_I0.8081.00
146_S150_P0.8031.00
64_L68_K0.8001.00
289_V316_I0.7981.00
218_F221_A0.7971.00
270_E274_S0.7961.00
25_G29_L0.7941.00
254_P259_F0.7931.00
65_I77_Y0.7861.00
132_C323_L0.7861.00
55_F201_M0.7861.00
275_F279_V0.7821.00
347_L351_I0.7811.00
132_C135_I0.7811.00
35_L39_A0.7801.00
290_I295_A0.7791.00
139_V313_I0.7791.00
249_K254_P0.7721.00
113_V130_F0.7711.00
134_G285_F0.7701.00
75_F294_F0.7691.00
285_F289_V0.7691.00
38_K189_N0.7691.00
139_V312_V0.7661.00
141_G144_D0.7661.00
132_C319_F0.7661.00
346_F349_P0.7631.00
329_N332_M0.7601.00
244_T261_S0.7591.00
325_P329_N0.7561.00
303_F314_I0.7561.00
188_A192_T0.7511.00
348_L351_I0.7491.00
243_L247_E0.7481.00
22_T283_Q0.7471.00
205_L221_A0.7421.00
124_Q127_I0.7411.00
346_F350_F0.7391.00
58_F350_F0.7361.00
34_A37_T0.7341.00
63_T67_K0.7321.00
259_F262_F0.7311.00
281_I284_F0.7291.00
227_I231_L0.7281.00
119_E123_I0.7271.00
110_A123_I0.7271.00
337_Y340_Y0.7251.00
92_L299_L0.7251.00
248_V254_P0.7231.00
235_T239_V0.7221.00
171_F176_L0.7211.00
338_L342_F0.7191.00
286_T290_I0.7171.00
32_P236_Y0.7171.00
121_T126_I0.7171.00
51_E195_S0.7141.00
106_T110_A0.7141.00
209_E293_Y0.7131.00
75_F91_G0.7131.00
149_F282_I0.7131.00
341_I345_L0.7101.00
334_Y338_L0.7091.00
168_F234_L0.7091.00
22_T284_F0.7051.00
120_R124_Q0.7031.00
153_L156_T0.7031.00
286_T289_V0.7011.00
306_S313_I0.7001.00
211_M217_T0.6971.00
21_N153_L0.6971.00
238_I241_G0.6931.00
103_S106_T0.6921.00
59_I201_M0.6911.00
134_G282_I0.6911.00
23_M224_G0.6891.00
65_I81_G0.6871.00
101_V104_F0.6871.00
24_L29_L0.6861.00
176_L241_G0.6851.00
213_K218_F0.6851.00
299_L302_T0.6841.00
300_K303_F0.6841.00
296_A303_F0.6831.00
107_R334_Y0.6821.00
203_V287_T0.6821.00
217_T221_A0.6821.00
255_T259_F0.6801.00
261_S265_K0.6781.00
180_L187_I0.6781.00
285_F288_F0.6751.00
348_L358_L0.6691.00
109_M277_L0.6681.00
16_I19_V0.6661.00
290_I293_Y0.6651.00
272_F276_L0.6651.00
340_Y343_V0.6631.00
325_P330_Q0.6621.00
163_V259_F0.6611.00
288_F292_G0.6591.00
66_Q205_L0.6581.00
108_A112_M0.6581.00
174_N177_R0.6581.00
138_M286_T0.6571.00
127_I326_D0.6571.00
173_I241_G0.6561.00
139_V310_S0.6521.00
50_L191_L0.6511.00
336_D340_Y0.6511.00
46_I187_I0.6501.00
135_I285_F0.6481.00
323_L326_D0.6471.00
121_T124_Q0.6471.00
19_V23_M0.6471.00
292_G299_L0.6461.00
169_K175_N0.6441.00
340_Y345_L0.6431.00
215_K219_R0.6411.00
292_G296_A0.6411.00
353_F356_V0.6371.00
113_V274_S0.6371.00
269_I277_L0.6371.00
85_W88_S0.6361.00
234_L238_I0.6361.00
223_L226_L0.6351.00
152_Y279_V0.6311.00
354_F357_A0.6281.00
186_P189_N0.6281.00
144_D148_L0.6271.00
35_L194_V0.6261.00
293_Y296_A0.6231.00
66_Q217_T0.6221.00
116_F274_S0.6221.00
271_R274_S0.6221.00
280_W284_F0.6211.00
352_L356_V0.6191.00
109_M278_V0.6191.00
199_L202_E0.6181.00
34_A38_K0.6161.00
254_P258_L0.6141.00
308_K311_M0.6141.00
351_I354_F0.6141.00
111_E123_I0.6131.00
158_I161_L0.6131.00
78_L87_G0.6121.00
56_I225_F0.6121.00
336_D344_S0.6091.00
49_I53_F0.6081.00
250_T253_W0.6071.00
290_I306_S0.6061.00
329_N333_M0.6021.00
109_M113_V0.6021.00
325_P328_A0.6011.00
248_V251_L0.6001.00
110_A113_V0.5991.00
176_L240_V0.5981.00
150_P154_T0.5971.00
177_R182_E0.5971.00
42_P179_V0.5971.00
161_L231_L0.5961.00
346_F355_I0.5951.00
347_L354_F0.5951.00
24_L156_T0.5921.00
254_P257_S0.5921.00
22_T203_V0.5911.00
273_E280_W0.5901.00
43_D179_V0.5871.00
268_F273_E0.5861.00
95_C99_L0.5861.00
268_F276_L0.5841.00
348_L356_V0.5821.00
105_E108_A0.5821.00
74_L206_F0.5821.00
242_A262_F0.5821.00
51_E54_I0.5791.00
75_F87_G0.5751.00
48_L236_Y0.5741.00
138_M316_I0.5721.00
267_I274_S0.5711.00
227_I230_I0.5701.00
87_G91_G0.5691.00
346_F352_L0.5691.00
45_W233_I0.5681.00
111_E114_K0.5671.00
72_P293_Y0.5671.00
187_I190_S0.5661.00
312_V316_I0.5601.00
206_F287_T0.5591.00
13_F16_I0.5561.00
98_F284_F0.5561.00
185_G188_A0.5551.00
336_D341_I0.5551.00
140_G309_T0.5541.00
145_V286_T0.5531.00
115_F260_Q0.5531.00
318_V326_D0.5531.00
235_T238_I0.5511.00
71_Y209_E0.5501.00
47_T187_I0.5491.00
349_P356_V0.5491.00
76_E79_K0.5491.00
308_K312_V0.5481.00
170_I176_L0.5471.00
15_G207_L0.5461.00
243_L257_S0.5441.00
93_L97_Y0.5441.00
74_L202_E0.5411.00
226_L229_I0.5401.00
268_F274_S0.5381.00
35_L190_S0.5381.00
258_L261_S0.5371.00
128_L327_D0.5371.00
43_D46_I0.5371.00
48_L197_S0.5361.00
255_T263_E0.5361.00
122_P126_I0.5321.00
139_V316_I0.5321.00
193_V197_S0.5321.00
130_F281_I0.5321.00
131_I319_F0.5311.00
266_G270_E0.5301.00
68_K356_V0.5301.00
250_T254_P0.5281.00
89_I93_L0.5281.00
77_Y205_L0.5271.00
345_L349_P0.5261.00
221_A224_G0.5241.00
259_F264_L0.5241.00
123_I127_I0.5231.00
327_D335_S0.5221.00
32_P240_V0.5211.00
15_G18_I0.5211.00
59_I63_T0.5191.00
317_T320_Y0.5191.00
335_S339_G0.5181.00
95_C98_F0.5171.00
235_T255_T0.5161.00
8_L212_K0.5151.00
83_G87_G0.5151.00
69_H81_G0.5141.00
20_A153_L0.5141.00
323_L327_D0.5141.00
303_F315_G0.5131.00
142_L146_S0.5121.00
25_G28_L0.5111.00
51_E198_F0.5101.00
189_N192_T0.5091.00
101_V105_E0.5091.00
45_W48_L0.5081.00
273_E278_V0.5081.00
39_A43_D0.5071.00
114_K126_I0.5051.00
38_K193_V0.5041.00
320_Y324_W0.5031.00
56_I226_L0.5021.00
45_W49_I0.5011.00
19_V220_Y0.5011.00
139_V307_T0.5011.00
274_S278_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9562 100 0.271 Contact Map
3giaA 1 0.9836 100 0.329 Contact Map
4djkA 2 0.9397 100 0.368 Contact Map
2jlnA 1 0.9233 98.6 0.841 Contact Map
3dh4A 3 0.9452 98.5 0.849 Contact Map
2xq2A 2 0.9479 98.4 0.853 Contact Map
4us3A 1 0.9616 97.5 0.88 Contact Map
4xp4A 1 0.9644 97.1 0.888 Contact Map
4wgvA 2 0.9014 96.9 0.892 Contact Map
2a65A 2 0.9562 96.9 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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