GREMLIN Database
GERAA - Spore germination protein A1
UniProt: P07868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 482 (465)
Sequences: 2253 (1878)
Seq/√Len: 87.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_K192_K7.4451.00
233_V243_A7.0901.00
411_S423_F5.8411.00
168_E199_Q4.9461.00
100_C115_T4.7611.00
183_A188_I4.5241.00
166_I195_L3.9191.00
214_E272_R3.5661.00
366_Q370_E3.5601.00
245_L252_V3.2401.00
298_I409_M3.1511.00
161_T175_A3.1131.00
224_I255_V3.0741.00
176_I192_K3.0181.00
161_T177_M2.9781.00
95_I101_A2.9781.00
150_I245_L2.9711.00
179_I182_K2.9011.00
292_F424_M2.8361.00
144_D147_L2.8301.00
331_A378_L2.7971.00
137_V153_R2.7881.00
205_D249_S2.7871.00
87_T90_K2.7151.00
169_N181_G2.6901.00
14_L41_Y2.6771.00
202_D238_F2.6751.00
101_A112_I2.6731.00
85_V112_I2.6051.00
408_S423_F2.6021.00
150_I177_M2.5251.00
432_T442_F2.5081.00
227_T233_V2.4911.00
179_I237_L2.4231.00
91_T101_A2.3761.00
74_K84_P2.3711.00
156_H169_N2.3181.00
158_K181_G2.3171.00
102_V113_L2.2931.00
412_A420_I2.2461.00
160_I180_E2.2341.00
190_E194_R2.2321.00
164_I196_K2.2251.00
408_S427_V2.2041.00
84_P109_K2.1951.00
135_P270_Y2.1491.00
335_E405_R2.1291.00
126_P138_A2.1191.00
24_N160_I2.1131.00
188_I242_V2.0941.00
191_V255_V2.0911.00
22_K160_I2.0241.00
331_A409_M2.0111.00
263_M287_I2.0081.00
194_R215_D1.9411.00
85_V90_K1.9391.00
166_I174_A1.9351.00
191_V242_V1.8951.00
93_E171_L1.8721.00
200_L212_L1.8561.00
278_L403_V1.8521.00
236_A254_L1.8471.00
164_I192_K1.8431.00
27_L45_F1.8151.00
180_E185_K1.8121.00
418_Y422_L1.7991.00
9_Y12_D1.7871.00
174_A246_V1.7821.00
154_T234_S1.7811.00
31_K39_V1.7741.00
46_S144_D1.7731.00
328_I413_A1.7481.00
189_K193_A1.7381.00
125_E138_A1.7301.00
103_F110_A1.7221.00
448_F453_T1.7131.00
190_E193_A1.7001.00
295_S412_A1.6941.00
23_E162_K1.6841.00
143_I175_A1.6791.00
59_K62_I1.6651.00
11_H39_V1.6531.00
23_E180_E1.6431.00
201_E468_E1.6411.00
177_M252_V1.6371.00
198_I209_L1.6321.00
164_I176_I1.6301.00
286_S391_T1.6281.00
99_N116_G1.6191.00
191_V244_I1.6131.00
94_S112_I1.6111.00
94_S99_N1.5971.00
42_Y102_V1.5771.00
18_L29_K1.5721.00
287_I401_F1.5531.00
269_Y455_D1.5441.00
176_I242_V1.5341.00
185_K189_K1.5301.00
86_E109_K1.5271.00
165_M173_P1.5041.00
206_S246_V1.5001.00
81_D114_T1.4991.00
219_S223_Q1.4951.00
15_A19_P1.4941.00
170_K202_D1.4931.00
257_V262_L1.4921.00
286_S340_L1.4890.99
444_P447_F1.4810.99
147_L161_T1.4650.99
163_K173_P1.4450.99
294_S385_I1.4360.99
241_R261_I1.4300.99
21_L96_L1.4280.99
54_V100_C1.4180.99
91_T110_A1.4160.99
165_M171_L1.3990.99
290_T392_V1.3910.99
10_I103_F1.3890.99
277_S281_S1.3840.99
430_H434_Q1.3810.99
27_L43_L1.3780.99
14_L18_L1.3660.99
29_K41_Y1.3650.99
47_E147_L1.3610.99
193_A197_N1.3550.99
299_T420_I1.3550.99
182_K468_E1.3520.99
224_I253_L1.3500.99
244_I255_V1.3490.99
192_K196_K1.3230.99
14_L31_K1.3220.99
233_V252_V1.3150.99
170_K238_F1.3140.99
154_T238_F1.3070.99
219_S430_H1.3020.99
285_A336_V1.3000.99
50_D117_K1.2970.99
326_P329_F1.2900.99
338_I386_A1.2880.99
281_S285_A1.2870.99
47_E148_A1.2810.98
337_T363_V1.2740.98
143_I245_L1.2650.98
49_T54_V1.2620.98
54_V115_T1.2540.98
10_I105_N1.2530.98
131_V265_S1.2500.98
83_R90_K1.2450.98
139_F150_I1.2430.98
369_V380_I1.2420.98
125_E136_K1.2350.98
339_E406_F1.2250.98
127_T136_K1.2090.98
12_D15_A1.1980.98
123_L137_V1.1790.97
407_I411_S1.1690.97
169_N468_E1.1680.97
158_K180_E1.1550.97
223_Q272_R1.1510.97
328_I410_F1.1460.97
163_K175_A1.1380.97
187_V242_V1.1340.97
147_L177_M1.1300.97
431_L442_F1.1260.97
183_A242_V1.1230.96
101_A110_A1.1100.96
99_N114_T1.1060.96
335_E382_V1.1060.96
52_N56_E1.1050.96
325_F329_F1.1040.96
29_K43_L1.1040.96
409_M413_A1.1020.96
184_K439_S1.1020.96
13_N103_F1.1010.96
34_L40_F1.0880.96
10_I41_Y1.0830.96
30_N82_A1.0790.96
33_M39_V1.0650.95
137_V152_Q1.0640.95
181_G185_K1.0630.95
243_A254_L1.0600.95
174_A244_I1.0590.95
184_K473_N1.0560.95
292_F408_S1.0550.95
242_V255_V1.0540.95
243_A252_V1.0500.95
25_D162_K1.0480.95
47_E144_D1.0470.95
97_N155_S1.0470.95
137_V248_S1.0440.95
137_V149_L1.0400.95
214_E223_Q1.0380.95
193_A196_K1.0370.94
319_N376_S1.0350.94
327_P378_L1.0320.94
233_V254_L1.0310.94
221_F404_L1.0300.94
254_L261_I1.0280.94
16_L20_K1.0280.94
130_K350_N1.0270.94
335_E402_R1.0270.94
118_K142_D1.0210.94
17_V27_L1.0190.94
177_M237_L1.0110.94
191_V437_F1.0110.94
204_Q208_T1.0100.94
164_I195_L1.0100.94
140_V146_N1.0050.94
258_S261_I1.0040.93
23_E160_I0.9990.93
190_E215_D0.9950.93
169_N179_I0.9900.93
132_V267_D0.9870.93
124_T138_A0.9850.93
41_Y103_F0.9850.93
280_R455_D0.9820.93
332_L409_M0.9800.93
263_M284_F0.9800.93
48_M148_A0.9760.93
31_K41_Y0.9750.92
260_G445_N0.9750.92
154_T179_I0.9730.92
295_S408_S0.9700.92
259_L442_F0.9700.92
239_N269_Y0.9690.92
335_E406_F0.9660.92
404_L427_V0.9630.92
345_G353_G0.9630.92
389_S398_G0.9580.92
49_T115_T0.9550.92
99_N112_I0.9550.92
169_N182_K0.9540.92
211_E462_I0.9530.92
298_I331_A0.9520.92
14_L43_L0.9500.91
118_K152_Q0.9470.91
176_I191_V0.9430.91
91_T103_F0.9430.91
301_V327_P0.9420.91
335_E342_R0.9370.91
388_A391_T0.9350.91
221_F430_H0.9340.91
260_G456_S0.9310.91
262_L397_M0.9310.91
16_L88_A0.9270.90
194_R213_I0.9260.90
153_R172_K0.9220.90
150_I159_L0.9190.90
155_S173_P0.9140.90
69_T72_Q0.9130.90
338_I357_G0.9130.90
278_L339_E0.9100.90
93_E165_M0.9010.89
59_K63_K0.8970.89
172_K246_V0.8910.89
150_I233_V0.8870.88
235_S239_N0.8850.88
148_A152_Q0.8840.88
126_P228_E0.8780.88
221_F441_Y0.8750.88
85_V101_A0.8740.88
11_H15_A0.8730.88
85_V91_T0.8730.88
72_Q75_K0.8700.87
211_E459_R0.8690.87
79_Q113_L0.8690.87
356_I386_A0.8670.87
445_N457_I0.8660.87
182_K201_E0.8640.87
26_D151_R0.8630.87
129_E232_K0.8620.87
43_L103_F0.8620.87
460_L465_K0.8610.87
225_Q261_I0.8610.87
224_I437_F0.8610.87
40_F102_V0.8610.87
205_D270_Y0.8600.87
221_F427_V0.8600.87
410_F413_A0.8570.87
303_F414_I0.8560.87
152_Q247_D0.8560.87
221_F431_L0.8530.86
122_S140_V0.8530.86
188_I191_V0.8520.86
64_D67_T0.8520.86
144_D173_P0.8520.86
17_V43_L0.8490.86
21_L24_N0.8480.86
198_I201_E0.8450.86
258_S262_L0.8440.86
90_K93_E0.8400.86
189_K192_K0.8370.85
83_R94_S0.8360.85
88_A103_F0.8350.85
128_T352_L0.8340.85
289_I384_V0.8330.85
348_L390_F0.8330.85
128_T251_F0.8320.85
207_G211_E0.8310.85
342_R345_G0.8280.85
139_F233_V0.8270.85
286_S388_A0.8240.84
131_V266_P0.8240.84
397_M400_S0.8160.84
43_L95_I0.8140.84
153_R248_S0.8130.84
421_I425_L0.8120.84
119_K148_A0.8100.83
169_N201_E0.8100.83
28_V46_S0.8080.83
345_G355_T0.8070.83
120_T145_T0.8050.83
257_V261_I0.8040.83
259_L397_M0.8040.83
142_D173_P0.8000.83
402_R406_F0.7990.83
328_I409_M0.7990.83
319_N377_I0.7970.82
121_R141_E0.7960.82
205_D208_T0.7960.82
345_G354_Q0.7940.82
220_P430_H0.7910.82
408_S411_S0.7890.82
232_K266_P0.7880.82
449_S452_N0.7840.81
20_K92_I0.7830.81
225_Q257_V0.7790.81
25_D147_L0.7790.81
131_V267_D0.7770.81
408_S412_A0.7760.81
443_S452_N0.7700.80
395_Y399_L0.7700.80
451_K454_D0.7670.80
184_K474_E0.7660.80
467_K470_N0.7640.80
339_E342_R0.7640.80
406_F410_F0.7630.80
214_E217_K0.7610.79
227_T243_A0.7610.79
259_L391_T0.7600.79
197_N435_T0.7580.79
21_L92_I0.7570.79
451_K467_K0.7570.79
40_F104_I0.7560.79
204_Q238_F0.7560.79
357_G377_I0.7540.79
140_V145_T0.7530.79
176_I183_A0.7510.79
350_N356_I0.7510.79
91_T95_I0.7500.78
236_A261_I0.7470.78
10_I13_N0.7440.78
142_D145_T0.7420.78
315_T377_I0.7420.78
86_E90_K0.7400.77
370_E376_S0.7390.77
120_T142_D0.7390.77
32_K40_F0.7390.77
71_D109_K0.7390.77
155_S247_D0.7370.77
201_E469_V0.7360.77
294_S335_E0.7340.77
302_S327_P0.7330.77
355_T361_G0.7330.77
277_S460_L0.7310.77
126_P251_F0.7280.76
328_I332_L0.7270.76
290_T401_F0.7260.76
291_L404_L0.7250.76
208_T235_S0.7230.76
432_T446_G0.7210.76
142_D247_D0.7190.75
170_K204_Q0.7160.75
147_L175_A0.7150.75
203_I209_L0.7140.75
327_P357_G0.7140.75
271_E399_L0.7130.75
150_I234_S0.7130.75
404_L407_I0.7130.75
262_L360_G0.7110.75
133_R138_A0.7080.74
207_G212_L0.7070.74
53_K115_T0.7060.74
304_H417_L0.7050.74
278_L336_V0.7040.74
296_I300_L0.7020.74
200_L203_I0.7020.74
382_V406_F0.7010.74
58_I113_L0.7010.74
262_L402_R0.7000.73
235_S264_Q0.6950.73
225_Q262_L0.6940.73
71_D74_K0.6930.73
260_G284_F0.6910.73
320_R323_V0.6910.73
439_S472_P0.6900.72
149_L152_Q0.6900.72
28_V44_Y0.6880.72
258_S439_S0.6880.72
454_D460_L0.6880.72
33_M37_G0.6860.72
47_E118_K0.6860.72
319_N361_G0.6850.72
454_D467_K0.6830.72
133_R210_E0.6810.71
116_G144_D0.6780.71
233_V420_I0.6760.71
18_L43_L0.6760.71
443_S447_F0.6740.71
84_P111_Y0.6730.71
187_V437_F0.6720.70
45_F48_M0.6680.70
385_I409_M0.6670.70
368_A374_V0.6660.70
97_N116_G0.6660.70
366_Q383_S0.6650.70
325_F373_L0.6630.69
124_T127_T0.6630.69
259_L287_I0.6620.69
322_N383_S0.6620.69
24_N27_L0.6610.69
255_V437_F0.6590.69
177_M245_L0.6580.69
17_V41_Y0.6580.69
200_L206_S0.6570.69
213_I437_F0.6560.69
215_D436_S0.6560.69
51_E142_D0.6540.68
324_P343_E0.6540.68
225_Q236_A0.6520.68
27_L179_I0.6520.68
357_G362_V0.6510.68
15_A68_L0.6500.68
334_M378_L0.6490.68
262_L394_Q0.6480.68
337_T384_V0.6470.68
187_V439_S0.6470.68
222_P262_L0.6470.68
143_I247_D0.6440.67
289_I293_L0.6410.67
164_I244_I0.6410.67
162_K176_I0.6410.67
137_V234_S0.6400.67
131_V135_P0.6390.67
203_I208_T0.6380.66
117_K124_T0.6380.66
340_L357_G0.6370.66
359_V386_A0.6370.66
257_V392_V0.6360.66
182_K209_L0.6360.66
42_Y100_C0.6350.66
97_N173_P0.6350.66
452_N468_E0.6330.66
436_S440_P0.6320.66
324_P367_A0.6320.66
346_L351_P0.6320.66
331_A382_V0.6310.66
39_V105_N0.6310.66
23_E192_K0.6310.66
296_I445_N0.6280.65
241_R264_Q0.6270.65
409_M412_A0.6270.65
305_Q327_P0.6260.65
320_R366_Q0.6260.65
313_A352_L0.6250.65
150_I352_L0.6240.65
54_V79_Q0.6240.65
357_G435_T0.6230.65
16_L19_P0.6230.65
77_L82_A0.6230.65
290_T389_S0.6230.65
345_G351_P0.6230.65
292_F420_I0.6210.64
81_D142_D0.6210.64
32_K42_Y0.6180.64
58_I100_C0.6180.64
369_V376_S0.6170.64
243_A255_V0.6150.64
266_P270_Y0.6140.64
258_S357_G0.6140.64
73_V253_L0.6140.64
129_E286_S0.6130.63
226_N251_F0.6120.63
290_T294_S0.6100.63
341_L379_V0.6100.63
179_I195_L0.6090.63
454_D465_K0.6080.63
206_S253_L0.6080.63
271_E396_G0.6080.63
395_Y398_G0.6070.63
428_Y432_T0.6060.62
264_Q280_R0.6040.62
304_H416_G0.6040.62
420_I423_F0.6030.62
220_P403_V0.6030.62
186_S189_K0.6020.62
123_L149_L0.6010.62
335_E409_M0.6000.62
93_E285_A0.6000.62
42_Y113_L0.6000.62
320_R375_S0.5990.62
298_I303_F0.5940.61
348_L361_G0.5920.61
86_E89_K0.5910.61
158_K169_N0.5910.61
216_N223_Q0.5900.60
225_Q254_L0.5900.60
103_F111_Y0.5860.60
372_N447_F0.5860.60
190_E213_I0.5850.60
153_R234_S0.5850.60
31_K74_K0.5840.60
293_L384_V0.5830.60
258_S301_V0.5830.60
58_I78_D0.5820.59
257_V337_T0.5820.59
294_S381_V0.5810.59
17_V103_F0.5810.59
227_T393_P0.5810.59
213_I224_I0.5800.59
81_D154_T0.5800.59
142_D152_Q0.5800.59
342_R404_L0.5790.59
185_K188_I0.5790.59
455_D459_R0.5790.59
11_H31_K0.5770.59
119_K145_T0.5770.59
388_A448_F0.5770.59
17_V29_K0.5760.59
341_L363_V0.5760.59
200_L462_I0.5750.58
120_T140_V0.5750.58
70_L111_Y0.5750.58
9_Y14_L0.5740.58
19_P22_K0.5740.58
46_S51_E0.5740.58
223_Q364_I0.5730.58
220_P275_S0.5720.58
56_E59_K0.5720.58
373_L380_I0.5720.58
25_D163_K0.5700.58
236_A241_R0.5700.58
323_V375_S0.5700.58
348_L352_L0.5680.58
308_L311_A0.5680.58
138_A251_F0.5680.58
194_R436_S0.5670.57
218_Y464_N0.5670.57
455_D465_K0.5670.57
126_P270_Y0.5660.57
263_M397_M0.5660.57
407_I427_V0.5660.57
33_M75_K0.5660.57
94_S166_I0.5640.57
133_R206_S0.5640.57
82_A111_Y0.5630.57
136_K251_F0.5610.57
210_E226_N0.5610.57
327_P362_V0.5600.57
153_R229_R0.5600.57
200_L468_E0.5600.57
453_T456_S0.5590.56
143_I173_P0.5590.56
162_K180_E0.5580.56
449_S470_N0.5570.56
287_I392_V0.5570.56
324_P416_G0.5570.56
198_I212_L0.5570.56
294_S409_M0.5550.56
295_S395_Y0.5540.56
147_L239_N0.5530.56
273_W361_G0.5530.56
341_L359_V0.5480.55
275_S316_I0.5470.55
217_K463_K0.5470.55
308_L351_P0.5470.55
410_F414_I0.5460.55
307_L395_Y0.5460.55
217_K272_R0.5460.55
137_V172_K0.5460.55
203_I246_V0.5450.54
358_L380_I0.5450.54
205_D209_L0.5440.54
48_M152_Q0.5440.54
12_D37_G0.5440.54
459_R462_I0.5430.54
422_L426_V0.5430.54
49_T185_K0.5430.54
225_Q232_K0.5420.54
60_T63_K0.5420.54
286_S471_N0.5400.54
356_I380_I0.5400.54
184_K468_E0.5390.54
229_R254_L0.5390.54
124_T414_I0.5380.54
183_A187_V0.5380.54
424_M427_V0.5370.53
169_N238_F0.5370.53
288_F292_F0.5370.53
296_I417_L0.5360.53
46_S81_D0.5350.53
239_N242_V0.5350.53
190_E197_N0.5350.53
301_V313_A0.5350.53
58_I62_I0.5340.53
21_L156_H0.5340.53
295_S335_E0.5340.53
104_I467_K0.5330.53
361_G364_I0.5330.53
450_L454_D0.5320.53
375_S416_G0.5310.53
408_S424_M0.5310.53
459_R465_K0.5300.52
16_L92_I0.5300.52
40_F82_A0.5300.52
90_K94_S0.5300.52
268_D343_E0.5290.52
267_D392_V0.5280.52
397_M401_F0.5280.52
88_A91_T0.5280.52
20_K88_A0.5270.52
174_A209_L0.5270.52
239_N264_Q0.5250.52
73_V79_Q0.5250.52
168_E185_K0.5250.52
191_V346_L0.5240.52
220_P229_R0.5240.52
409_M415_L0.5220.51
182_K199_Q0.5220.51
296_I420_I0.5220.51
17_V21_L0.5210.51
10_I39_V0.5210.51
363_V431_L0.5210.51
118_K144_D0.5200.51
21_L95_I0.5200.51
445_N456_S0.5200.51
348_L373_L0.5190.51
344_A386_A0.5190.51
181_G474_E0.5190.51
299_T412_A0.5190.51
97_N195_L0.5190.51
297_Y416_G0.5190.51
261_I264_Q0.5190.51
31_K58_I0.5190.51
71_D197_N0.5180.51
187_V473_N0.5160.51
182_K469_V0.5150.50
140_V467_K0.5150.50
298_I413_A0.5150.50
20_K157_P0.5150.50
408_S420_I0.5150.50
49_T117_K0.5150.50
92_I95_I0.5140.50
332_L336_V0.5130.50
338_I345_G0.5130.50
104_I107_L0.5130.50
187_V190_E0.5120.50
310_T366_Q0.5120.50
382_V409_M0.5120.50
140_V289_I0.5120.50
452_N469_V0.5110.50
35_A64_D0.5110.50
263_M316_I0.5110.50
82_A113_L0.5100.50
136_K228_E0.5100.50
318_A322_N0.5100.50
264_Q269_Y0.5090.50
181_G307_L0.5090.50
471_N474_E0.5090.50
343_E367_A0.5090.50
139_F146_N0.5080.50
10_I91_T0.5080.50
58_I340_L0.5080.50
343_E347_R0.5080.50
354_Q360_G0.5070.49
185_K192_K0.5070.49
9_Y17_V0.5070.49
176_I311_A0.5060.49
203_I467_K0.5060.49
149_L153_R0.5060.49
307_L386_A0.5060.49
257_V260_G0.5060.49
269_Y454_D0.5050.49
208_T462_I0.5040.49
407_I426_V0.5030.49
450_L453_T0.5030.49
297_Y311_A0.5030.49
323_V380_I0.5030.49
188_I289_I0.5020.49
211_E387_L0.5020.49
261_I345_G0.5020.49
9_Y199_Q0.5010.49
86_E108_D0.5010.49
140_V173_P0.5000.48
21_L27_L0.5000.48
129_E319_N0.5000.48
199_Q468_E0.5000.48
176_I188_I0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hh1A 2 0.2158 26.1 0.981 Contact Map
3kpeA 3 0.1017 21 0.982 Contact Map
4p0zA 1 0.2075 18.2 0.983 Contact Map
4g3oA 1 0.0913 14.2 0.983 Contact Map
3h0lB 1 0.2261 14 0.984 Contact Map
1ez3A 1 0.2282 13.8 0.984 Contact Map
1t5iA 1 0.3278 12.9 0.984 Contact Map
4bemA 3 0.168 12.3 0.984 Contact Map
2qwvA 2 0.3216 8.9 0.985 Contact Map
1xtiA 1 0.3631 8.5 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.