GREMLIN Database
SCRB - Sucrose-6-phosphate hydrolase
UniProt: P07819 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (431)
Sequences: 3259 (2480)
Seq/√Len: 119.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_N197_E5.5301.00
76_T86_E4.6041.00
293_R341_E4.4061.00
191_A201_L3.9041.00
53_S76_T3.8391.00
323_L431_F3.8171.00
79_D82_N3.7641.00
225_F294_R3.5371.00
171_T191_A3.5291.00
372_E429_H3.3981.00
385_S464_S3.3471.00
77_T80_V3.3231.00
346_R372_E3.2291.00
427_T443_N3.0631.00
371_T432_L3.0471.00
53_S78_Q3.0251.00
293_R326_Q2.9261.00
300_M436_S2.8391.00
119_G133_C2.7931.00
223_D286_T2.7131.00
34_I75_Y2.6871.00
340_P343_K2.6241.00
36_P41_L2.6081.00
55_H74_H2.4981.00
167_E170_G2.4871.00
191_A199_R2.4801.00
257_V329_L2.4731.00
32_F431_F2.3651.00
30_Q35_M2.3611.00
233_L236_S2.3181.00
430_M439_I2.3141.00
226_S229_G2.3091.00
286_T294_R2.2871.00
164_K223_D2.2771.00
395_S404_T2.2421.00
376_E427_T2.2091.00
295_I339_L2.1681.00
56_V321_M2.1671.00
77_T83_W2.1521.00
372_E431_F2.1441.00
116_F134_L2.1251.00
108_T111_D2.1181.00
58_F85_R2.1151.00
107_V172_W2.1051.00
47_V287_L2.0681.00
374_L427_T2.0481.00
235_V256_F2.0331.00
61_Q69_A2.0041.00
397_H400_E2.0031.00
254_G272_F1.9831.00
116_F174_M1.9521.00
374_L429_H1.9391.00
34_I56_V1.9141.00
114_Y134_L1.8861.00
116_F195_L1.8781.00
29_R35_M1.8471.00
442_N445_E1.8331.00
146_K149_V1.8241.00
328_T337_Q1.8151.00
300_M449_S1.8091.00
76_T84_K1.8081.00
284_P296_L1.7871.00
40_L67_H1.7701.00
67_H70_K1.7681.00
291_Q340_P1.7511.00
48_I108_T1.7441.00
171_T193_D1.7351.00
411_D414_R1.7211.00
295_I324_P1.7131.00
53_S86_E1.7121.00
78_Q84_K1.7071.00
323_L342_L1.7031.00
30_Q320_C1.6971.00
300_M322_T1.6941.00
226_S231_D1.6881.00
120_N130_T1.6871.00
435_S451_R1.6741.00
410_F414_R1.6651.00
112_R138_D1.6491.00
391_T409_S1.6481.00
135_A145_K1.6361.00
390_G455_F1.6251.00
109_K172_W1.6231.00
326_Q340_P1.6211.00
45_N103_S1.6131.00
333_K445_E1.6061.00
47_V56_V1.5881.00
346_R429_H1.5881.00
112_R136_V1.5691.00
49_Y290_D1.5421.00
37_P85_R1.5411.00
261_D264_K1.5361.00
165_V174_M1.5311.00
137_S143_F1.5261.00
432_L437_V1.5251.00
338_P440_F1.5111.00
387_S391_T1.5091.00
337_Q443_N1.4971.00
93_S145_K1.4861.00
160_F176_I1.4811.00
328_T335_I1.4761.00
232_V257_V1.4741.00
137_S140_G1.4691.00
411_D415_T1.4641.00
286_T296_L1.4571.00
392_A437_V1.4561.00
186_Q203_P1.4531.00
223_D294_R1.4131.00
326_Q337_Q1.4121.00
405_L450_A1.4021.00
410_F415_T1.3781.00
376_E425_L1.3771.00
178_A188_V1.3541.00
232_V329_L1.3391.00
403_V441_I1.3331.00
406_E409_S1.3311.00
230_S257_V1.3211.00
180_T184_K1.3111.00
43_D46_G1.3101.00
232_V236_S1.3051.00
187_A219_W1.3041.00
61_Q64_Q1.2941.00
86_E141_L1.2921.00
80_V83_W1.2891.00
230_S259_R1.2891.00
53_S141_L1.2881.00
168_H226_S1.2701.00
383_G397_H1.2650.99
231_D234_I1.2630.99
40_L70_K1.2620.99
282_Y299_W1.2590.99
387_S393_T1.2560.99
343_K429_H1.2520.99
390_G458_N1.2450.99
192_S198_W1.2420.99
109_K167_E1.2380.99
43_D221_C1.2250.99
225_F286_T1.2130.99
281_F298_A1.2130.99
48_I113_L1.2080.99
148_V151_R1.2070.99
51_K139_D1.2060.99
193_D199_R1.2010.99
273_T333_K1.1940.99
108_T113_L1.1930.99
168_H262_Y1.1830.99
410_F413_K1.1790.99
346_R374_L1.1780.99
82_N345_M1.1760.99
394_F403_V1.1720.99
109_K112_R1.1560.99
289_D293_R1.1520.99
231_D259_R1.1480.99
109_K114_Y1.1460.99
31_H370_R1.1450.99
180_T186_Q1.1440.99
187_A233_L1.1420.99
262_Y265_P1.1350.99
231_D236_S1.1340.99
90_L101_C1.1300.99
227_L294_R1.1260.99
277_Q448_L1.1180.99
50_W108_T1.1170.99
164_K286_T1.1170.99
192_S195_L1.1170.99
31_H434_A1.1160.99
140_G143_F1.1100.99
46_G59_Q1.1000.99
277_Q446_E1.1000.99
49_Y54_Y1.0980.99
159_H179_Q1.0940.99
200_F203_P1.0920.98
412_G415_T1.0830.98
43_D299_W1.0820.98
188_V200_F1.0800.98
93_S97_D1.0760.98
436_S440_F1.0750.98
176_I190_F1.0750.98
71_F92_P1.0730.98
330_S335_I1.0610.98
57_F89_A1.0600.98
58_F73_G1.0570.98
116_F165_V1.0520.98
40_L60_W1.0500.98
402_I419_H1.0500.98
394_F405_L1.0470.98
253_S284_P1.0380.98
320_C449_S1.0310.98
300_M320_C1.0310.98
387_S462_T1.0290.98
41_L321_M1.0290.98
146_K150_A1.0220.98
260_L265_P1.0180.98
411_D416_E1.0150.98
405_L448_L1.0140.98
137_S141_L1.0100.97
465_A470_E1.0100.97
173_Y189_L1.0090.97
320_C436_S1.0030.97
281_F296_L1.0030.97
298_A325_R1.0030.97
26_D315_C1.0020.97
47_V297_F1.0010.97
437_V450_A1.0010.97
114_Y172_W0.9970.97
346_R431_F0.9970.97
136_V146_K0.9960.97
106_A115_L0.9870.97
383_G466_T0.9860.97
73_G85_R0.9840.97
161_R220_E0.9740.97
27_P315_C0.9720.97
117_Y135_A0.9710.97
92_P100_G0.9710.97
276_D325_R0.9690.97
71_F91_A0.9690.97
57_F115_L0.9680.97
42_N59_Q0.9630.97
370_R434_A0.9630.97
34_I85_R0.9530.96
147_G150_A0.9520.96
179_Q183_L0.9520.96
236_S253_S0.9510.96
117_Y145_K0.9510.96
156_Y200_F0.9480.96
326_Q341_E0.9400.96
389_R452_Y0.9390.96
47_V285_Q0.9340.96
392_A452_Y0.9330.96
288_E294_R0.9290.96
114_Y195_L0.9280.96
43_D47_V0.9270.96
302_V305_Q0.9270.96
139_D142_S0.9200.96
43_D283_A0.9140.95
170_G193_D0.9140.95
325_R336_Q0.9130.95
295_I341_E0.9120.95
70_K102_Y0.9120.95
172_W192_S0.9040.95
108_T114_Y0.9020.95
164_K285_Q0.8990.95
45_N285_Q0.8990.95
89_A143_F0.8980.95
369_E434_A0.8960.95
43_D282_Y0.8960.95
255_Y329_L0.8940.95
343_K346_R0.8910.95
216_G219_W0.8910.95
157_T179_Q0.8900.95
298_A322_T0.8820.95
373_I430_M0.8820.95
147_G151_R0.8820.95
133_C149_V0.8800.94
97_D100_G0.8800.94
75_Y85_R0.8800.94
403_V428_V0.8790.94
166_W189_L0.8780.94
406_E410_F0.8760.94
327_L336_Q0.8750.94
217_Y239_G0.8730.94
24_N31_H0.8720.94
224_L231_D0.8720.94
50_W113_L0.8710.94
74_H83_W0.8690.94
326_Q339_L0.8660.94
101_C145_K0.8650.94
288_E292_G0.8640.94
336_Q447_V0.8640.94
436_S449_S0.8610.94
342_L431_F0.8610.94
96_F133_C0.8500.93
43_D162_D0.8490.93
146_K196_T0.8480.93
360_S364_P0.8470.93
420_C446_E0.8440.93
251_Y301_A0.8440.93
221_C299_W0.8430.93
35_M320_C0.8390.93
122_R128_R0.8320.93
167_E172_W0.8310.93
45_N221_C0.8300.93
103_S221_C0.8290.92
61_Q67_H0.8290.92
168_H171_T0.8290.92
177_G187_A0.8280.92
49_Y53_S0.8270.92
159_H218_M0.8270.92
279_F450_A0.8260.92
113_L140_G0.8230.92
236_S239_G0.8200.92
289_D340_P0.8180.92
102_Y120_N0.8170.92
90_L115_L0.8170.92
293_R339_L0.8160.92
28_H454_P0.8160.92
396_F428_V0.8140.92
234_I239_G0.8130.92
392_A458_N0.8130.92
87_E141_L0.8130.92
280_D303_P0.8110.92
56_V83_W0.8090.92
283_A299_W0.8070.91
418_R421_R0.8070.91
298_A447_V0.8050.91
250_V302_V0.8020.91
300_M440_F0.8010.91
383_G395_S0.7990.91
227_L329_L0.7990.91
231_D238_Q0.7960.91
433_D438_E0.7940.91
61_Q71_F0.7930.91
61_Q68_G0.7910.91
224_L260_L0.7910.91
56_V297_F0.7900.91
230_S236_S0.7900.91
430_M437_V0.7850.90
281_F322_T0.7830.90
428_V441_I0.7820.90
437_V452_Y0.7810.90
94_D97_D0.7800.90
381_E468_K0.7790.90
256_F267_L0.7770.90
234_I275_L0.7760.90
259_R268_K0.7730.90
97_D145_K0.7720.90
114_Y136_V0.7720.90
230_S329_L0.7700.89
61_Q70_K0.7690.89
30_Q436_S0.7690.89
342_L429_H0.7660.89
343_K372_E0.7620.89
202_G265_P0.7620.89
232_V235_V0.7600.89
281_F284_P0.7570.89
223_D285_Q0.7570.89
381_E386_I0.7560.89
354_I357_H0.7550.89
220_E299_W0.7550.89
375_L428_V0.7520.88
378_I385_S0.7520.88
64_Q67_H0.7500.88
413_K416_E0.7460.88
248_Q251_Y0.7460.88
57_F143_F0.7460.88
73_G87_E0.7450.88
97_D119_G0.7440.88
252_Q274_E0.7440.88
262_Y267_L0.7430.88
71_F88_I0.7430.88
384_F470_E0.7430.88
343_K431_F0.7420.88
50_W53_S0.7410.88
403_V406_E0.7380.87
204_I224_L0.7370.87
258_G267_L0.7360.87
62_P71_F0.7350.87
299_W319_H0.7350.87
251_Y302_V0.7330.87
375_L386_I0.7330.87
57_F74_H0.7330.87
28_H435_S0.7330.87
166_W262_Y0.7300.87
54_Y80_V0.7280.87
249_N252_Q0.7260.87
136_V144_E0.7250.86
392_A397_H0.7230.86
121_V129_E0.7230.86
35_M317_W0.7200.86
289_D295_I0.7190.86
162_D221_C0.7170.86
368_P372_E0.7140.86
59_Q72_W0.7130.86
82_N344_A0.7120.85
357_H360_S0.7120.85
385_S389_R0.7100.85
338_P431_F0.7070.85
252_Q272_F0.7060.85
221_C282_Y0.7050.85
230_S234_I0.7040.85
439_I448_L0.7030.85
59_Q73_G0.7030.85
119_G131_Y0.7020.85
173_Y201_L0.7020.85
83_W89_A0.7020.85
261_D266_E0.6980.84
465_A468_K0.6980.84
441_I448_L0.6970.84
53_S139_D0.6950.84
166_W224_L0.6940.84
69_A92_P0.6940.84
225_F327_L0.6910.84
159_H238_Q0.6910.84
63_F69_A0.6900.84
67_H102_Y0.6890.84
277_Q421_R0.6880.83
338_P342_L0.6880.83
166_W170_G0.6880.83
276_D298_A0.6860.83
59_Q103_S0.6850.83
60_W88_I0.6840.83
389_R432_L0.6840.83
167_E171_T0.6840.83
136_V196_T0.6820.83
220_E282_Y0.6810.83
355_N358_G0.6800.83
384_F396_F0.6800.83
462_T465_A0.6790.83
388_I392_A0.6730.82
403_V422_I0.6730.82
45_N299_W0.6730.82
42_N299_W0.6720.82
234_I238_Q0.6710.82
41_L319_H0.6680.82
115_L143_F0.6660.81
394_F439_I0.6640.81
422_I442_N0.6640.81
264_K268_K0.6640.81
377_D425_L0.6630.81
180_T203_P0.6620.81
287_L297_F0.6580.81
284_P298_A0.6560.80
257_V268_K0.6560.80
146_K151_R0.6550.80
63_F71_F0.6510.80
380_T386_I0.6480.80
335_I445_E0.6420.79
168_H173_Y0.6410.79
133_C150_A0.6410.79
351_K362_A0.6400.79
410_F416_E0.6390.79
385_S395_S0.6390.79
130_T160_F0.6390.79
297_F321_M0.6360.78
102_Y251_Y0.6360.78
105_S165_V0.6350.78
81_V345_M0.6350.78
53_S84_K0.6350.78
295_I326_Q0.6340.78
380_T468_K0.6330.78
386_I430_M0.6310.78
105_S175_V0.6280.78
466_T469_S0.6260.77
120_N128_R0.6260.77
221_C283_A0.6240.77
203_P206_G0.6230.77
31_H35_M0.6220.77
112_R196_T0.6220.77
42_N70_K0.6220.77
225_F234_I0.6220.77
369_E389_R0.6210.77
74_H89_A0.6200.77
57_F140_G0.6170.76
121_V131_Y0.6170.76
442_N446_E0.6160.76
109_K195_L0.6150.76
54_Y287_L0.6150.76
33_H438_E0.6130.76
55_H83_W0.6110.76
139_D143_F0.6110.76
406_E417_A0.6110.76
296_L322_T0.6100.75
356_M470_E0.6090.75
221_C285_Q0.6060.75
275_L296_L0.6040.75
96_F149_V0.6040.75
129_E158_A0.6030.75
263_N267_L0.6020.75
45_N283_A0.6020.75
165_V192_S0.6020.75
130_T303_P0.6000.74
381_E385_S0.5990.74
383_G464_S0.5980.74
417_A421_R0.5980.74
54_Y289_D0.5970.74
279_F304_D0.5960.74
318_I451_R0.5960.74
338_P346_R0.5960.74
238_Q304_D0.5950.74
417_A420_C0.5950.74
359_S365_V0.5950.74
85_R88_I0.5940.74
312_T453_F0.5940.74
397_H401_G0.5930.73
57_F113_L0.5920.73
42_N45_N0.5890.73
418_R422_I0.5890.73
32_F338_P0.5890.73
57_F141_L0.5870.73
32_F440_F0.5850.72
330_S337_Q0.5840.72
107_V195_L0.5830.72
47_V58_F0.5830.72
109_K136_V0.5820.72
190_F200_F0.5810.72
171_T201_L0.5800.72
156_Y203_P0.5800.72
165_V198_W0.5790.72
42_N102_Y0.5790.72
134_L150_A0.5770.71
45_N102_Y0.5770.71
57_F139_D0.5770.71
161_R282_Y0.5770.71
48_I106_A0.5770.71
396_F400_E0.5760.71
46_G72_W0.5760.71
392_A396_F0.5740.71
349_E362_A0.5740.71
116_F151_R0.5700.70
70_K319_H0.5680.70
205_T219_W0.5650.70
60_W70_K0.5640.70
289_D294_R0.5640.70
259_R270_G0.5640.70
88_I91_A0.5640.70
30_Q317_W0.5640.70
418_R450_A0.5640.70
403_V439_I0.5630.70
42_N62_P0.5620.69
380_T385_S0.5620.69
80_V287_L0.5620.69
249_N418_R0.5620.69
379_H385_S0.5600.69
68_G71_F0.5590.69
396_F426_H0.5590.69
267_L270_G0.5580.69
54_Y77_T0.5570.69
55_H76_T0.5570.69
59_Q67_H0.5570.69
249_N274_E0.5570.69
267_L271_E0.5560.69
396_F401_G0.5560.69
403_V420_C0.5560.69
100_G120_N0.5550.68
239_G249_N0.5550.68
255_Y273_T0.5550.68
404_T417_A0.5550.68
137_S142_S0.5540.68
59_Q70_K0.5540.68
392_A406_E0.5540.68
86_E89_A0.5540.68
32_F370_R0.5530.68
362_A365_V0.5530.68
298_A323_L0.5530.68
320_C451_R0.5510.68
357_H363_L0.5510.68
57_F76_T0.5500.68
463_A466_T0.5490.68
234_I253_S0.5480.67
43_D161_R0.5470.67
281_F286_T0.5460.67
122_R126_G0.5460.67
205_T213_D0.5450.67
48_I53_S0.5450.67
233_L238_Q0.5430.67
432_L452_Y0.5430.67
45_N59_Q0.5420.67
322_T449_S0.5420.67
108_T112_R0.5420.67
388_I394_F0.5410.67
23_A35_M0.5400.66
160_F319_H0.5390.66
130_T137_S0.5380.66
164_K225_F0.5380.66
185_G218_M0.5380.66
435_S453_F0.5370.66
276_D281_F0.5360.66
382_S399_D0.5360.66
384_F388_I0.5360.66
378_I382_S0.5360.66
396_F403_V0.5350.66
357_H361_G0.5350.66
132_Q145_K0.5350.66
62_P92_P0.5350.66
291_Q341_E0.5350.66
389_R392_A0.5340.66
337_Q429_H0.5340.66
43_D220_E0.5340.66
461_V464_S0.5340.66
156_Y178_A0.5330.65
119_G218_M0.5330.65
178_A186_Q0.5330.65
26_D316_H0.5330.65
221_C236_S0.5320.65
46_G285_Q0.5310.65
338_P429_H0.5290.65
26_D30_Q0.5290.65
103_S299_W0.5290.65
166_W173_Y0.5290.65
301_A319_H0.5280.65
230_S233_L0.5280.65
33_H433_D0.5280.65
352_I355_N0.5260.64
213_D457_G0.5260.64
227_L328_T0.5260.64
392_A410_F0.5250.64
379_H386_I0.5250.64
42_N72_W0.5230.64
81_V431_F0.5230.64
215_F272_F0.5220.64
202_G260_L0.5220.64
81_V342_L0.5210.64
64_Q69_A0.5210.64
40_L299_W0.5210.64
361_G365_V0.5210.64
42_N221_C0.5200.63
102_Y132_Q0.5200.63
435_S454_P0.5200.63
192_S255_Y0.5200.63
103_S223_D0.5200.63
219_W317_W0.5190.63
206_G213_D0.5190.63
178_A453_F0.5190.63
239_G279_F0.5170.63
152_L155_G0.5170.63
120_N301_A0.5170.63
45_N162_D0.5170.63
24_N27_P0.5170.63
345_M372_E0.5160.63
378_I381_E0.5150.63
56_V287_L0.5150.63
61_Q66_G0.5140.63
197_E200_F0.5140.63
455_F458_N0.5120.62
234_I237_P0.5120.62
113_L137_S0.5120.62
134_L151_R0.5120.62
42_N71_F0.5110.62
118_T220_E0.5110.62
115_L137_S0.5110.62
289_D292_G0.5110.62
359_S363_L0.5080.62
159_H217_Y0.5070.62
56_V75_Y0.5050.61
42_N61_Q0.5040.61
62_P67_H0.5040.61
94_D145_K0.5030.61
280_D301_A0.5030.61
76_T141_L0.5030.61
177_G451_R0.5020.61
47_V59_Q0.5020.61
42_N67_H0.5020.61
152_L157_T0.5010.61
64_Q71_F0.5010.61
173_Y260_L0.5010.61
41_L58_F0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pijA 2 0.9812 100 0.204 Contact Map
1y4wA 1 0.9269 100 0.211 Contact Map
3kf3A 2 0.9061 100 0.222 Contact Map
3ligA 2 0.9791 100 0.222 Contact Map
1w2tA 1 0.8727 100 0.225 Contact Map
4ffhA 1 0.8873 100 0.231 Contact Map
3sc7X 1 0.9123 100 0.231 Contact Map
2ac1A 1 0.9207 100 0.232 Contact Map
4eqvA 3 0.8998 100 0.234 Contact Map
1st8A 1 0.9248 100 0.237 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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