GREMLIN Database
COTA - Spore coat protein A
UniProt: P07788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 513 (421)
Sequences: 6067 (4238)
Seq/√Len: 206.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_E175_H5.4241.00
69_Y140_H4.7131.00
298_E464_K3.9801.00
67_N140_H3.9751.00
249_K303_I3.8561.00
29_E71_K3.6271.00
71_K138_V3.6061.00
31_T75_N3.3521.00
59_T171_A3.2401.00
254_V302_I3.2191.00
467_I475_L3.0641.00
72_W128_E3.0141.00
294_L300_Y2.8641.00
277_G301_D2.8491.00
29_E73_M2.8471.00
73_M133_Y2.8451.00
272_D288_K2.7651.00
27_Y69_Y2.7521.00
411_I421_I2.6911.00
411_I477_I2.6601.00
410_S476_R2.6421.00
249_K305_D2.5311.00
273_F302_I2.5171.00
171_A255_I2.4831.00
254_V265_L2.4811.00
432_D476_R2.3411.00
408_I478_A2.2531.00
27_Y71_K2.2531.00
272_D290_N2.2421.00
408_I431_L2.2401.00
402_K405_T2.2231.00
129_Q132_P2.2141.00
470_H473_E2.2071.00
201_N205_S2.1971.00
426_V508_I2.1581.00
171_A194_L2.1291.00
245_V306_F2.1271.00
252_F302_I2.1211.00
64_R176_D2.1131.00
152_Y170_G2.0971.00
33_E75_N2.0551.00
267_L304_I2.0271.00
189_Y248_R2.0011.00
115_S134_F1.9991.00
194_L257_A1.9561.00
262_T468_Q1.9551.00
258_S263_Y1.9201.00
26_T66_E1.9191.00
281_G427_S1.8991.00
50_G55_F1.8821.00
292_F300_Y1.8741.00
63_K175_H1.8691.00
428_F477_I1.8611.00
487_R507_D1.8411.00
242_Y336_Q1.8371.00
39_L48_L1.8261.00
67_N142_P1.8141.00
36_T47_R1.8001.00
251_R301_D1.7691.00
410_S474_V1.7641.00
274_I288_K1.7321.00
101_K129_Q1.7041.00
275_Q300_Y1.6981.00
370_R405_T1.6961.00
113_D124_S1.6861.00
169_V196_T1.6841.00
244_E338_R1.6661.00
352_P355_L1.6631.00
299_R465_D1.6591.00
62_V68_V1.6531.00
411_I490_W1.6501.00
423_L479_A1.6461.00
406_T480_T1.6401.00
38_Q45_P1.6161.00
355_L359_P1.6151.00
31_T73_M1.5921.00
278_S300_Y1.5921.00
193_L254_V1.5881.00
71_K133_Y1.5641.00
313_S317_A1.5591.00
59_T192_P1.5441.00
251_R276_I1.5301.00
254_V292_F1.5271.00
400_T507_D1.5121.00
429_R463_W1.5101.00
430_V467_I1.5021.00
32_M51_Y1.4821.00
64_R177_P1.4801.00
489_V503_M1.4771.00
409_W477_I1.4701.00
268_D316_L1.4551.00
371_T410_S1.4531.00
175_H190_D1.4481.00
150_L280_G1.4361.00
32_M72_W1.4251.00
313_S316_L1.4241.00
264_N291_S1.4221.00
292_F302_I1.4151.00
368_N371_T1.4121.00
295_A468_Q1.4081.00
171_A192_P1.4031.00
408_I476_R1.4031.00
28_Y32_M1.3911.00
493_H497_H1.3711.00
498_E503_M1.3701.00
267_L273_F1.3671.00
492_C497_H1.3651.00
433_R473_E1.3611.00
374_L388_L1.3561.00
423_L490_W1.3471.00
62_V143_N1.3431.00
366_I369_I1.3371.00
363_H366_I1.3361.00
69_Y138_V1.3351.00
264_N293_S1.3141.00
351_K357_S1.3051.00
154_D163_N1.2751.00
495_L498_E1.2681.00
51_Y152_Y1.2671.00
72_W104_V1.2651.00
388_L421_I1.2631.00
63_K180_K1.2561.00
37_H50_G1.2481.00
418_T468_Q1.2371.00
376_G379_D1.2371.00
407_E479_A1.2371.00
191_V252_F1.2341.00
420_P494_I1.2301.00
68_V172_Y1.2291.00
273_F304_I1.2251.00
238_K241_P1.2241.00
49_W166_A1.2211.00
315_I335_M1.2171.00
149_I253_R1.2091.00
48_L198_R1.2081.00
63_K177_P1.2051.00
195_I265_L1.2041.00
202_E205_S1.2031.00
487_R505_P1.2031.00
62_V172_Y1.2001.00
400_T509_T1.2001.00
275_Q289_L1.2001.00
155_H492_C1.1961.00
203_D206_L1.1931.00
425_L488_Y1.1891.00
51_Y104_V1.1831.00
352_P357_S1.1821.00
51_Y168_L1.1771.00
169_V257_A1.1721.00
49_W168_L1.1701.00
401_P407_E1.1681.00
432_D474_V1.1681.00
133_Y138_V1.1661.00
312_E316_L1.1641.00
32_M102_T1.1631.00
276_I303_I1.1631.00
313_S319_S1.1601.00
235_V333_N1.1591.00
419_H493_H1.1571.00
314_I317_A1.1531.00
61_E190_D1.1511.00
370_R374_L1.1491.00
353_K356_A1.1461.00
242_Y338_R1.1441.00
58_P152_Y1.1431.00
64_R145_Q1.1411.00
195_I263_Y1.1371.00
419_H492_C1.1371.00
164_V495_L1.1341.00
165_Y259_N1.1341.00
355_L358_Y1.1331.00
196_T234_L1.1261.00
246_E338_R1.1221.00
356_A359_P1.1221.00
491_H497_H1.1211.00
306_F337_F1.1201.00
102_T163_N1.1191.00
245_V250_Y1.1181.00
42_D200_I1.1151.00
72_W102_T1.1061.00
370_R407_E1.0961.00
62_V174_I1.0931.00
401_P481_F1.0901.00
423_L477_I1.0871.00
354_Y357_S1.0811.00
227_A230_G1.0741.00
30_V60_I1.0731.00
179_E182_L1.0711.00
59_T152_Y1.0681.00
347_D350_R1.0671.00
364_E369_I1.0671.00
259_N496_E1.0641.00
428_F467_I1.0631.00
431_L478_A1.0571.00
58_P170_G1.0511.00
352_P358_Y1.0511.00
421_I490_W1.0431.00
63_K66_E1.0401.00
155_H493_H1.0381.00
190_D253_R1.0361.00
253_R301_D1.0271.00
153_H493_H1.0171.00
33_E50_G1.0151.00
252_F304_I1.0131.00
369_I373_K1.0081.00
233_I263_Y1.0051.00
40_H43_L0.9991.00
153_H492_C0.9981.00
271_G337_F0.9981.00
315_I319_S0.9971.00
149_I255_I0.9961.00
125_K134_F0.9951.00
103_V119_P0.9941.00
149_I171_A0.9911.00
316_L320_A0.9891.00
278_S464_K0.9841.00
333_N337_F0.9841.00
49_W76_L0.9791.00
270_G308_A0.9771.00
250_Y306_F0.9701.00
350_R357_S0.9671.00
107_H492_C0.9661.00
419_H497_H0.9651.00
490_W504_R0.9621.00
351_K355_L0.9601.00
119_P156_A0.9570.99
421_I502_M0.9570.99
196_T257_A0.9570.99
55_F169_V0.9560.99
489_V498_E0.9560.99
265_L315_I0.9550.99
367_Q370_R0.9550.99
457_P460_E0.9510.99
334_I337_F0.9480.99
107_H493_H0.9480.99
368_N374_L0.9460.99
25_K28_Y0.9440.99
155_H491_H0.9430.99
134_F139_Y0.9430.99
349_S352_P0.9430.99
351_K354_Y0.9410.99
194_L255_I0.9410.99
419_H422_H0.9380.99
49_W77_P0.9290.99
57_G237_G0.9270.99
350_R353_K0.9230.99
29_E32_M0.9220.99
107_H155_H0.9200.99
361_V365_R0.9170.99
427_S463_W0.9150.99
373_K412_I0.9140.99
143_N172_Y0.9110.99
191_V243_L0.9100.99
267_L271_G0.9040.99
245_V335_M0.9040.99
265_L292_F0.9040.99
233_I331_D0.8980.99
469_A475_L0.8980.99
64_R146_R0.8960.99
262_T295_A0.8930.99
266_S291_S0.8910.99
409_W506_M0.8910.99
38_Q43_L0.8900.99
375_A378_Q0.8840.99
232_T239_V0.8810.99
335_M339_V0.8770.99
350_R355_L0.8740.99
59_T173_I0.8740.99
109_G141_Y0.8740.99
28_Y62_V0.8730.99
28_Y68_V0.8730.99
332_A337_F0.8730.99
280_G427_S0.8690.99
25_K67_N0.8670.99
402_K407_E0.8660.99
153_H419_H0.8610.99
25_K69_Y0.8580.99
70_V106_L0.8560.99
254_V294_L0.8560.99
317_A320_A0.8540.99
349_S357_S0.8520.99
380_E383_R0.8510.99
419_H424_H0.8510.99
107_H497_H0.8490.99
52_N56_P0.8490.99
314_I318_N0.8460.99
340_T343_L0.8460.99
403_V509_T0.8380.99
57_G152_Y0.8340.99
200_I232_T0.8310.99
419_H491_H0.8310.99
128_E134_F0.8290.99
244_E340_T0.8270.99
430_V475_L0.8260.99
403_V485_S0.8190.98
333_N339_V0.8190.98
106_L172_Y0.8190.98
40_H45_P0.8170.98
353_K357_S0.8160.98
313_S336_Q0.8140.98
348_E353_K0.8130.98
338_R341_K0.8110.98
110_V482_G0.8110.98
110_V427_S0.8040.98
199_T206_L0.8030.98
316_L319_S0.8030.98
23_K26_T0.8010.98
64_R144_Q0.7970.98
354_Y358_Y0.7950.98
187_D190_D0.7940.98
201_N209_P0.7920.98
272_D307_T0.7920.98
482_G485_S0.7910.98
423_L426_V0.7910.98
50_G53_G0.7870.98
351_K359_P0.7860.98
364_E368_N0.7850.98
38_Q41_R0.7840.98
349_S359_P0.7840.98
245_V304_I0.7830.98
275_Q287_V0.7830.98
412_I474_V0.7820.98
278_S283_L0.7820.98
164_V169_V0.7820.98
184_L187_D0.7820.98
192_P255_I0.7770.98
26_T32_M0.7750.98
106_L141_Y0.7730.98
33_E37_H0.7690.98
166_A203_D0.7680.98
457_P461_K0.7670.98
304_I335_M0.7660.98
247_P310_E0.7660.98
105_H155_H0.7650.98
416_R472_G0.7650.98
267_L315_I0.7610.97
75_N133_Y0.7600.97
434_R473_E0.7590.97
107_H419_H0.7580.97
413_N471_A0.7570.97
268_D271_G0.7530.97
387_L391_K0.7530.97
368_N372_L0.7530.97
72_W106_L0.7510.97
331_D334_I0.7480.97
155_H497_H0.7470.97
348_E355_L0.7460.97
109_G172_Y0.7440.97
118_Y124_S0.7440.97
188_E250_Y0.7430.97
38_Q47_R0.7420.97
75_N131_G0.7420.97
266_S290_N0.7420.97
149_I190_D0.7390.97
176_D282_L0.7390.97
278_S462_G0.7390.97
313_S318_N0.7390.97
36_T45_P0.7360.97
370_R373_K0.7350.97
273_F289_L0.7350.97
107_H424_H0.7350.97
53_G56_P0.7350.97
423_L428_F0.7340.97
277_G282_L0.7320.97
107_H153_H0.7270.97
424_H491_H0.7270.97
40_H44_P0.7240.97
490_W506_M0.7230.97
262_T293_S0.7220.97
199_T231_E0.7220.97
314_I319_S0.7210.96
402_K509_T0.7210.96
109_G174_I0.7170.96
362_Q365_R0.7160.96
352_P356_A0.7150.96
191_V250_Y0.7110.96
271_G307_T0.7110.96
245_V337_F0.7110.96
425_L484_Y0.7100.96
389_N399_E0.7100.96
155_H419_H0.7090.96
315_I320_A0.7050.96
399_E504_R0.7050.96
76_L130_T0.7040.96
105_H419_H0.7040.96
313_S320_A0.7030.96
47_R205_S0.7020.96
118_Y123_F0.7010.96
200_I231_E0.6990.96
149_I277_G0.6990.96
404_G481_F0.6980.96
38_Q42_D0.6940.96
189_Y246_E0.6930.96
176_D179_E0.6930.96
360_S364_E0.6910.96
105_H424_H0.6900.95
283_L287_V0.6890.95
327_N330_T0.6870.95
310_E313_S0.6870.95
422_H493_H0.6860.95
59_T175_H0.6860.95
365_R369_I0.6860.95
195_I254_V0.6850.95
40_H46_T0.6850.95
422_H492_C0.6850.95
275_Q292_F0.6840.95
378_Q381_Y0.6840.95
190_D251_R0.6810.95
62_V109_G0.6800.95
155_H424_H0.6750.95
107_H491_H0.6750.95
361_V366_I0.6730.95
434_R474_V0.6720.95
41_R44_P0.6720.95
68_V141_Y0.6720.95
224_I228_F0.6720.95
424_H493_H0.6700.95
387_L392_R0.6690.95
32_M128_E0.6680.95
72_W139_Y0.6670.95
453_A456_P0.6670.95
240_W334_I0.6670.95
351_K358_Y0.6660.95
367_Q373_K0.6650.95
330_T334_I0.6630.94
112_P115_S0.6600.94
354_Y359_P0.6550.94
369_I372_L0.6550.94
424_H492_C0.6540.94
145_Q174_I0.6540.94
44_P200_I0.6530.94
351_K356_A0.6510.94
426_V479_A0.6490.94
151_W155_H0.6480.94
375_A414_P0.6460.94
385_V392_R0.6450.94
332_A336_Q0.6430.93
348_E357_S0.6430.93
120_E127_F0.6430.93
312_E336_Q0.6430.93
397_V401_P0.6430.93
365_R368_N0.6410.93
51_Y72_W0.6400.93
336_Q341_K0.6390.93
295_A298_E0.6380.93
278_S298_E0.6380.93
405_T481_F0.6370.93
315_I318_N0.6370.93
178_K181_R0.6370.93
334_I341_K0.6360.93
153_H491_H0.6320.93
52_N58_P0.6310.93
274_I286_S0.6300.93
307_T337_F0.6280.93
233_I319_S0.6280.93
431_L476_R0.6270.93
360_S363_H0.6270.93
364_E373_K0.6270.93
424_H497_H0.6260.93
328_P332_A0.6260.93
314_I320_A0.6260.93
105_H491_H0.6250.92
227_A260_T0.6240.92
162_L166_A0.6210.92
404_G480_T0.6200.92
469_A473_E0.6200.92
247_P307_T0.6190.92
426_V484_Y0.6190.92
37_H48_L0.6170.92
64_R147_G0.6160.92
350_R358_Y0.6150.92
429_R478_A0.6140.92
489_V495_L0.6140.92
312_E320_A0.6130.92
246_E250_Y0.6130.92
59_T172_Y0.6120.92
105_H116_D0.6120.92
26_T30_V0.6100.92
367_Q374_L0.6100.92
60_I172_Y0.6100.92
334_I339_V0.6090.92
324_G329_E0.6080.91
350_R356_A0.6070.91
389_N392_R0.6070.91
396_P504_R0.6040.91
222_P226_P0.6030.91
346_K352_P0.6030.91
347_D357_S0.6030.91
418_T470_H0.6010.91
406_T478_A0.5990.91
201_N206_L0.5990.91
361_V364_E0.5980.91
59_T62_V0.5950.91
361_V367_Q0.5930.90
252_F306_F0.5920.90
374_L504_R0.5920.90
358_Y429_R0.5890.90
484_Y488_Y0.5880.90
55_F196_T0.5880.90
363_H367_Q0.5860.90
258_S296_P0.5860.90
30_V33_E0.5850.90
375_A387_L0.5850.90
314_I337_F0.5850.90
349_S353_K0.5840.90
56_P152_Y0.5840.90
375_A379_D0.5830.90
32_M104_V0.5830.90
432_D475_L0.5820.90
110_V145_Q0.5820.90
106_L425_L0.5810.90
378_Q387_L0.5810.90
386_L500_Y0.5790.89
395_D398_T0.5780.89
312_E315_I0.5770.89
182_L282_L0.5760.89
173_I255_I0.5760.89
479_A506_M0.5750.89
372_L399_E0.5750.89
39_L50_G0.5750.89
123_F505_P0.5740.89
337_F340_T0.5720.89
371_T374_L0.5690.89
113_D118_Y0.5660.88
27_Y140_H0.5650.88
62_V70_V0.5640.88
386_L392_R0.5620.88
329_E332_A0.5610.88
324_G332_A0.5600.88
349_S354_Y0.5590.88
109_G150_L0.5590.88
310_E339_V0.5590.88
270_G307_T0.5580.88
102_T154_D0.5570.87
62_V66_E0.5570.87
387_L390_N0.5550.87
203_D207_F0.5540.87
110_V484_Y0.5530.87
364_E367_Q0.5520.87
204_G208_Y0.5500.87
68_V143_N0.5480.87
271_G313_S0.5480.87
489_V505_P0.5470.87
105_H493_H0.5460.86
123_F489_V0.5450.86
248_R306_F0.5440.86
51_Y54_L0.5440.86
423_L506_M0.5440.86
146_R356_A0.5430.86
32_M168_L0.5430.86
491_H502_M0.5430.86
227_A417_G0.5420.86
169_V194_L0.5410.86
328_P337_F0.5400.86
381_Y386_L0.5400.86
72_W172_Y0.5390.86
106_L111_T0.5390.86
326_V329_E0.5380.86
311_G318_N0.5370.86
312_E317_A0.5370.86
116_D120_E0.5370.86
381_Y384_P0.5350.85
330_T337_F0.5340.85
281_G298_E0.5340.85
369_I410_S0.5310.85
321_G328_P0.5310.85
153_H497_H0.5310.85
25_K32_M0.5310.85
362_Q366_I0.5300.85
311_G316_L0.5300.85
281_G464_K0.5300.85
293_S418_T0.5300.85
57_G168_L0.5290.85
61_E173_I0.5290.85
275_Q283_L0.5270.84
293_S470_H0.5270.84
195_I294_L0.5260.84
337_F341_K0.5250.84
274_I305_D0.5240.84
176_D184_L0.5230.84
325_D328_P0.5230.84
76_L102_T0.5230.84
283_L462_G0.5220.84
398_T505_P0.5220.84
33_E53_G0.5210.84
51_Y57_G0.5210.84
398_T504_R0.5200.84
349_S356_A0.5200.84
51_Y102_T0.5190.84
414_P417_G0.5190.84
107_H422_H0.5160.83
347_D351_K0.5150.83
68_V142_P0.5130.83
26_T62_V0.5130.83
106_L109_G0.5130.83
201_N207_F0.5120.83
78_S163_N0.5120.83
432_D456_P0.5120.83
368_N405_T0.5120.83
244_E247_P0.5110.83
233_I332_A0.5100.83
149_I301_D0.5100.83
186_S189_Y0.5100.83
336_Q340_T0.5100.83
378_Q383_R0.5090.82
228_F496_E0.5090.82
363_H368_N0.5090.82
476_R479_A0.5080.82
368_N408_I0.5080.82
401_P506_M0.5080.82
310_E340_T0.5080.82
102_T168_L0.5070.82
164_V498_E0.5070.82
197_D258_S0.5070.82
103_V120_E0.5060.82
24_E27_Y0.5060.82
197_D200_I0.5060.82
223_S226_P0.5050.82
103_V156_A0.5050.82
48_L55_F0.5050.82
353_K359_P0.5040.82
46_T166_A0.5040.82
481_F484_Y0.5040.82
335_M338_R0.5040.82
229_C417_G0.5040.82
230_G261_R0.5020.82
116_D155_H0.5020.82
372_L376_G0.5010.81
420_P493_H0.5010.81
347_D356_A0.5010.81
243_L335_M0.5000.81
350_R354_Y0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wsdA 1 0.9844 100 0.154 Contact Map
3abgA 1 0.8772 100 0.213 Contact Map
3gyrA 4 0.9786 100 0.226 Contact Map
1zpuA 3 0.8596 100 0.239 Contact Map
1aozA 3 0.8441 100 0.243 Contact Map
2xu9A 1 0.8226 100 0.244 Contact Map
2q9oA 2 0.8986 100 0.247 Contact Map
3sqrA 1 0.8538 100 0.248 Contact Map
2uxtA 1 0.8129 100 0.25 Contact Map
3zx1A 1 0.8499 100 0.252 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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