GREMLIN Database
TRPA - Tryptophan synthase alpha chain
UniProt: P07601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (242)
Sequences: 3770 (2423)
Seq/√Len: 155.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_V26_V3.6681.00
21_D64_R3.2481.00
153_E192_T3.0561.00
103_L111_L3.0491.00
60_R234_E2.8041.00
138_K164_E2.7271.00
28_I81_E2.6061.00
83_K118_D2.4991.00
18_T62_S2.3701.00
202_A222_G2.3571.00
32_K86_G2.2781.00
15_P39_A2.1921.00
111_L114_E2.1791.00
81_E84_K2.1531.00
148_V156_L2.1381.00
109_F137_C2.1381.00
33_S37_A2.1011.00
143_T164_E2.0681.00
71_N74_K2.0041.00
106_E136_E1.9871.00
110_A140_H1.9701.00
37_A247_N1.9651.00
65_A70_M1.9571.00
31_A82_M1.8811.00
80_G114_E1.8651.00
35_Q89_I1.8641.00
74_K77_E1.8511.00
31_A42_L1.8471.00
14_I202_A1.8091.00
4_L8_P1.8041.00
210_R214_I1.7821.00
73_V111_L1.7761.00
100_V122_V1.7571.00
209_N212_Q1.7561.00
12_L222_G1.7421.00
46_V72_I1.7361.00
110_A114_E1.7171.00
95_T100_V1.6691.00
35_Q88_N1.6481.00
113_R140_H1.6381.00
122_V133_L1.6371.00
77_E80_G1.6291.00
171_S203_V1.6261.00
36_K247_N1.6241.00
95_T99_P1.6001.00
194_K201_V1.5971.00
16_F62_S1.5941.00
191_R195_N1.5911.00
194_K221_D1.5881.00
80_G111_L1.5851.00
70_M74_K1.5501.00
169_C201_V1.5331.00
157_K161_E1.5301.00
31_A91_I1.5031.00
231_R235_E1.5021.00
106_E139_S1.4991.00
33_S36_K1.4631.00
203_V216_M1.4501.00
111_L115_N1.4391.00
112_L142_V1.4371.00
107_Y110_A1.4361.00
41_A92_I1.4301.00
30_L233_I1.4261.00
137_C144_Y1.4211.00
157_K196_L1.4061.00
70_M75_A1.4041.00
63_K67_D1.3911.00
107_Y111_L1.3881.00
134_Q138_K1.3851.00
28_I32_K1.3611.00
11_K217_N1.3481.00
73_V103_L1.3461.00
203_V220_S1.3451.00
169_C189_F1.3231.00
202_A224_V1.3231.00
97_Y125_L1.3201.00
21_D234_E1.3021.00
29_E32_K1.3011.00
207_I216_M1.2901.00
207_I223_V1.2851.00
237_K240_L1.2801.00
26_V29_E1.2751.00
77_E81_E1.2621.00
17_I30_L1.2621.00
112_L117_I1.2611.00
156_L193_V1.2541.00
19_A44_L1.2501.00
76_I112_L1.2181.00
100_V108_F1.2171.00
130_S146_S1.2101.00
97_Y105_K1.2051.00
208_S231_R1.2021.00
24_P28_I1.1931.00
92_I145_I1.1821.00
167_V197_S1.1731.00
109_F136_E1.1621.00
24_P74_K1.1601.00
135_E139_S1.1581.00
231_R234_E1.1461.00
21_D230_V1.1421.00
42_L89_I1.1411.00
46_V93_L1.1391.00
158_T161_E1.1381.00
172_S179_R1.1351.00
245_T248_Q1.1291.00
188_P191_R1.1201.00
60_R63_K1.1141.00
163_A199_V1.1111.00
153_E196_L1.1030.99
153_E195_N1.0970.99
185_S188_P1.0910.99
94_F121_L1.0880.99
35_Q87_V1.0830.99
187_Y191_R1.0810.99
211_E215_K1.0790.99
97_Y133_L1.0780.99
73_V107_Y1.0740.99
131_N135_E1.0490.99
103_L107_Y1.0440.99
4_L7_Q1.0410.99
18_T61_A1.0330.99
239_R242_S1.0200.99
228_A232_K1.0200.99
108_F120_L1.0170.99
109_F120_L1.0140.99
214_I218_E1.0120.99
232_K236_L1.0120.99
24_P70_M1.0110.99
113_R141_E1.0020.99
152_S156_L1.0020.99
144_Y164_E0.9980.99
236_L245_T0.9970.99
32_K36_K0.9960.99
28_I78_L0.9920.99
179_R212_Q0.9880.99
73_V77_E0.9870.99
153_E157_K0.9800.99
217_N223_V0.9770.99
15_P229_L0.9750.99
178_V231_R0.9740.99
5_D12_L0.9730.99
57_V178_V0.9630.99
80_G115_N0.9600.99
127_L162_Q0.9580.99
236_L239_R0.9550.99
44_L79_G0.9520.98
189_F192_T0.9520.98
57_V231_R0.9460.98
19_A78_L0.9390.98
14_I41_A0.9330.98
64_R234_E0.9310.98
23_V68_Q0.9240.98
213_V223_V0.9210.98
32_K35_Q0.9190.98
109_F142_V0.9140.98
76_I111_L0.9120.98
109_F133_L0.9080.98
33_S247_N0.9070.98
64_R67_D0.8940.98
13_F229_L0.8910.98
242_S245_T0.8900.98
15_P34_L0.8870.98
106_E110_A0.8850.98
92_I119_G0.8830.98
19_A75_A0.8830.98
158_T162_Q0.8790.97
232_K235_E0.8690.97
106_E140_H0.8630.97
147_L170_V0.8570.97
79_G91_I0.8550.97
148_V163_A0.8530.97
24_P27_S0.8530.97
105_K136_E0.8510.97
235_E245_T0.8460.97
232_K245_T0.8460.97
169_C193_V0.8380.97
80_G84_K0.8370.97
146_S163_A0.8370.97
36_K86_G0.8360.97
35_Q42_L0.8350.97
167_V193_V0.8330.96
16_F45_G0.8310.96
28_I31_A0.8220.96
136_E140_H0.8200.96
26_V30_L0.8180.96
187_Y218_E0.8170.96
27_S78_L0.8130.96
32_K87_V0.8110.96
208_S212_Q0.8000.96
132_S136_E0.7990.96
215_K218_E0.7980.95
30_L246_R0.7960.95
48_Y52_L0.7940.95
146_S162_Q0.7940.95
120_L144_Y0.7920.95
31_A44_L0.7910.95
148_V193_V0.7880.95
187_Y215_K0.7850.95
31_A89_I0.7840.95
130_S134_Q0.7840.95
110_A113_R0.7820.95
238_D241_I0.7800.95
146_S159_I0.7800.95
213_V217_N0.7790.95
91_I117_I0.7780.95
237_K241_I0.7780.95
127_L158_T0.7770.95
5_D10_E0.7770.95
207_I213_V0.7760.95
58_I230_V0.7720.95
24_P68_Q0.7670.94
87_V91_I0.7630.94
24_P77_E0.7610.94
28_I86_G0.7590.94
132_S135_E0.7580.94
24_P78_L0.7560.94
160_I196_L0.7490.94
105_K133_L0.7410.93
164_E199_V0.7390.93
127_L146_S0.7370.93
123_P224_V0.7370.93
131_N162_Q0.7360.93
238_D242_S0.7340.93
160_I197_S0.7330.93
79_G117_I0.7300.93
160_I199_V0.7280.93
82_M91_I0.7260.93
160_I167_V0.7210.92
228_A231_R0.7200.92
204_G226_G0.7160.92
53_A205_F0.7150.92
211_E214_I0.7150.92
105_K109_F0.7150.92
178_V182_F0.7090.92
190_I201_V0.7080.92
73_V76_I0.7070.92
178_V208_S0.7070.92
16_F61_A0.7020.91
229_L232_K0.6960.91
56_P60_R0.6950.91
27_S44_L0.6860.90
105_K132_S0.6850.90
46_V75_A0.6820.90
59_Q90_P0.6800.90
82_M87_V0.6760.90
193_V197_S0.6720.89
15_P41_A0.6720.89
236_L242_S0.6690.89
20_G70_M0.6680.89
93_L117_I0.6680.89
128_E155_R0.6670.89
113_R142_V0.6650.89
136_E139_S0.6620.89
156_L160_I0.6580.89
109_F140_H0.6560.88
192_T195_N0.6550.88
179_R208_S0.6530.88
226_G230_V0.6520.88
225_V228_A0.6520.88
34_L39_A0.6470.88
92_I147_L0.6460.88
79_G93_L0.6440.87
25_E81_E0.6420.87
94_F224_V0.6410.87
11_K223_V0.6390.87
48_Y97_Y0.6330.87
216_M223_V0.6310.86
120_L137_C0.6300.86
41_A202_A0.6280.86
187_Y219_I0.6270.86
146_S167_V0.6270.86
55_G205_F0.6260.86
78_L81_E0.6250.86
121_L166_F0.6220.86
80_G161_E0.6220.86
188_P192_T0.6170.85
153_E156_L0.6150.85
60_R64_R0.6140.85
157_K160_I0.6130.85
91_I118_D0.6130.85
6_L9_S0.6130.85
27_S35_Q0.6110.85
75_A79_G0.6090.84
210_R213_V0.6080.84
54_D121_L0.6050.84
97_Y101_L0.6050.84
12_L40_T0.5990.83
46_V95_T0.5980.83
143_T165_G0.5970.83
19_A79_G0.5940.83
45_G222_G0.5940.83
120_L142_V0.5940.83
197_S201_V0.5930.83
48_Y172_S0.5920.83
184_S188_P0.5870.82
179_R182_F0.5840.82
188_P195_N0.5830.82
48_Y98_N0.5820.82
82_M89_I0.5810.82
82_M86_G0.5810.82
57_V227_S0.5780.81
149_A170_V0.5770.81
154_S158_T0.5760.81
17_I31_A0.5750.81
233_I236_L0.5750.81
44_L91_I0.5750.81
25_E28_I0.5740.81
236_L240_L0.5730.81
123_P169_C0.5730.81
35_Q82_M0.5710.80
157_K195_N0.5680.80
215_K219_I0.5670.80
216_M219_I0.5610.79
156_L192_T0.5610.79
31_A35_Q0.5540.78
148_V186_V0.5530.78
177_G205_F0.5530.78
229_L246_R0.5520.78
52_L97_Y0.5510.78
176_T205_F0.5490.78
241_I245_T0.5490.78
66_L99_P0.5440.77
126_P129_E0.5390.76
29_E33_S0.5380.76
154_S157_K0.5370.76
151_T205_F0.5360.76
7_Q10_E0.5340.76
31_A87_V0.5330.76
28_I82_M0.5320.76
61_A230_V0.5300.75
35_Q86_G0.5300.75
242_S248_Q0.5290.75
90_P118_D0.5290.75
133_L144_Y0.5270.75
24_P65_A0.5270.75
190_I203_V0.5260.75
19_A70_M0.5260.75
134_Q144_Y0.5250.75
48_Y145_I0.5230.74
201_V221_D0.5190.74
12_L202_A0.5170.74
112_L116_H0.5170.74
15_P166_F0.5170.74
180_N209_N0.5150.73
230_V234_E0.5130.73
55_G177_G0.5120.73
22_P30_L0.5120.73
220_S223_V0.5110.73
38_G89_I0.5100.73
120_L133_L0.5090.72
153_E188_P0.5080.72
128_E158_T0.5080.72
127_L159_I0.5060.72
122_V137_C0.5050.72
148_V159_I0.5040.72
25_E29_E0.5040.72
127_L130_S0.5030.71
24_P81_E0.5030.71
54_D146_S0.5030.71
50_D171_S0.5020.71
77_E111_L0.5010.71
55_G176_T0.5000.71
41_A89_I0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ujpA 1 0.8764 100 0.416 Contact Map
3thaA 2 0.9176 100 0.46 Contact Map
2ekcA 1 0.9438 100 0.477 Contact Map
4ht3A 1 0.97 100 0.492 Contact Map
3vndA 3 0.9326 100 0.495 Contact Map
3navA 2 0.9401 100 0.504 Contact Map
1rd5A 6 0.9476 100 0.514 Contact Map
1geqA 1 0.9101 100 0.531 Contact Map
3cu2A 2 0.7828 100 0.632 Contact Map
2f6uA 2 0.7154 100 0.648 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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