GREMLIN Database
TRPB - Tryptophan synthase beta chain
UniProt: P07600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (312)
Sequences: 13841 (7447)
Seq/√Len: 421.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_A133_C4.2031.00
75_K372_L3.7651.00
175_E178_R3.4071.00
215_A374_L3.3171.00
63_Y75_K3.1341.00
333_E362_K3.0411.00
136_F179_Y2.9651.00
229_K255_I2.8571.00
139_E163_T2.7941.00
178_R182_Q2.7221.00
253_E325_T2.7201.00
102_K105_G2.6211.00
143_A150_F2.6061.00
260_A330_T2.6011.00
183_H188_F2.5731.00
58_P218_Q2.5681.00
270_A274_S2.5541.00
100_L198_H2.5111.00
230_V247_F2.5031.00
132_S158_E2.4971.00
134_T158_E2.3781.00
244_F322_G2.2241.00
58_P217_D2.2231.00
263_G271_A2.1451.00
368_D371_Q2.1401.00
179_Y183_H2.0391.00
257_A359_K1.9821.00
227_P374_L1.9731.00
61_L374_L1.9691.00
134_T160_V1.9541.00
63_Y77_Y1.9341.00
356_A375_V1.9021.00
228_D371_Q1.8791.00
306_L355_H1.8571.00
63_Y68_T1.8531.00
212_G243_M1.7981.00
275_K279_G1.7851.00
330_T333_E1.7731.00
340_L344_K1.7641.00
109_I134_T1.7441.00
248_L324_V1.7431.00
255_I325_T1.7241.00
97_Q196_G1.7181.00
70_Y340_L1.6971.00
77_Y372_L1.6761.00
340_L361_F1.6671.00
77_Y219_L1.6581.00
228_D372_L1.6431.00
240_A323_R1.6331.00
230_V243_M1.6071.00
341_L349_P1.5941.00
231_V257_A1.5891.00
212_G247_F1.5731.00
231_V363_L1.5691.00
271_A274_S1.5391.00
168_T171_D1.5361.00
150_F153_K1.5251.00
137_M152_M1.5231.00
70_Y344_K1.4911.00
73_G369_R1.4791.00
86_T124_T1.4431.00
229_K371_Q1.4421.00
139_E167_G1.4361.00
177_I181_V1.4351.00
212_G246_A1.4351.00
349_P377_L1.4321.00
209_K213_E1.4311.00
65_D69_E1.4261.00
173_T177_I1.4241.00
271_A275_K1.4151.00
216_K250_E1.3891.00
219_L227_P1.3831.00
303_S334_A1.3751.00
243_M376_C1.3711.00
341_L357_L1.3701.00
337_A358_A1.3681.00
102_K131_F1.3671.00
119_G152_M1.3611.00
229_K253_E1.3601.00
263_G328_S1.3591.00
149_V153_K1.3451.00
55_S95_L1.3431.00
101_A105_G1.3421.00
49_K96_G1.3251.00
61_L219_L1.3061.00
269_H311_I1.3041.00
213_E246_A1.3021.00
231_V360_A1.2991.00
229_K373_I1.2851.00
273_I326_Y1.2771.00
256_G326_Y1.2601.00
261_G331_D1.2571.00
270_A328_S1.2561.00
98_A129_F1.2511.00
301_S307_D1.2431.00
41_P44_R1.2421.00
234_V256_G1.2351.00
338_L383_K1.2301.00
40_D44_R1.2301.00
127_A133_C1.2281.00
219_L374_L1.2251.00
100_L104_M1.2241.00
60_A83_L1.2211.00
174_N178_R1.2201.00
302_I335_V1.2161.00
76_I360_A1.2151.00
244_F254_L1.2091.00
317_Y321_S1.2031.00
71_L361_F1.1961.00
171_D174_N1.1941.00
255_I327_D1.1911.00
66_R69_E1.1861.00
109_I132_S1.1851.00
276_G320_K1.1841.00
62_T80_R1.1811.00
240_A319_H1.1801.00
137_M161_P1.1691.00
149_V161_P1.1681.00
175_E179_Y1.1581.00
234_V326_Y1.1581.00
99_L129_F1.1571.00
342_S348_L1.1571.00
64_A78_L1.1551.00
112_E135_V1.1521.00
48_Y51_L1.1351.00
136_F175_E1.1331.00
327_D359_K1.1331.00
332_E336_D1.1331.00
114_G119_G1.1321.00
337_A357_L1.1201.00
59_T84_N1.1191.00
66_R344_K1.1141.00
102_K106_K1.1141.00
240_A256_G1.1131.00
195_V313_P1.1131.00
353_S378_S1.1021.00
325_T366_G1.1011.00
273_I319_H1.1001.00
61_L215_A1.1001.00
153_K158_E1.0911.00
215_A227_P1.0851.00
339_K343_E1.0821.00
41_P45_E1.0771.00
259_A306_L1.0761.00
152_M157_A1.0721.00
178_R181_V1.0691.00
253_E371_Q1.0661.00
306_L352_E1.0611.00
338_L354_A1.0601.00
194_V241_M1.0561.00
176_A180_W1.0531.00
247_F252_V1.0511.00
270_A326_Y1.0471.00
134_T188_F1.0411.00
183_H187_H1.0411.00
192_G196_G1.0401.00
310_G313_P1.0321.00
216_K247_F1.0261.00
335_V391_V1.0161.00
163_T167_G1.0151.00
122_A133_C1.0111.00
211_I376_C1.0081.00
367_M371_Q1.0061.00
105_G108_K1.0051.00
150_F154_L1.0041.00
52_K55_S1.0021.00
95_L99_L0.9991.00
269_H319_H0.9991.00
232_A243_M0.9991.00
98_A110_I0.9961.00
234_V240_A0.9951.00
234_V269_H0.9941.00
179_Y182_Q0.9941.00
47_Y51_L0.9881.00
336_D340_L0.9871.00
78_L377_L0.9871.00
106_K131_F0.9871.00
231_V255_I0.9801.00
49_K52_K0.9761.00
197_P314_E0.9701.00
211_I239_N0.9641.00
124_T155_L0.9631.00
111_A176_A0.9631.00
47_Y217_D0.9471.00
221_R372_L0.9431.00
260_A328_S0.9411.00
253_E324_V0.9401.00
360_A375_V0.9391.00
68_T73_G0.9341.00
353_S377_L0.9311.00
319_H323_R0.9291.00
295_Q310_G0.9261.00
208_Q249_N0.9201.00
274_S325_T0.9201.00
124_T128_K0.9151.00
257_A327_D0.9141.00
338_L388_L0.9141.00
123_A157_A0.9141.00
68_T75_K0.9131.00
211_I243_M0.9101.00
113_T169_L0.9031.00
337_A361_F0.9001.00
263_G270_A0.8991.00
333_E336_D0.8941.00
67_V357_L0.8941.00
159_V163_T0.8931.00
333_E358_A0.8931.00
127_A155_L0.8891.00
269_H326_Y0.8881.00
317_Y320_K0.8881.00
74_A370_G0.8861.00
174_N177_I0.8831.00
219_L372_L0.8811.00
349_P354_A0.8801.00
74_A371_Q0.8671.00
111_A188_F0.8661.00
387_T390_N0.8641.00
312_G315_H0.8621.00
103_K107_T0.8621.00
44_R47_Y0.8611.00
66_R345_E0.8601.00
177_I180_W0.8581.00
349_P353_S0.8561.00
78_L341_L0.8531.00
75_K370_G0.8531.00
233_C378_S0.8521.00
97_Q191_I0.8511.00
205_R245_Q0.8491.00
261_G299_P0.8481.00
213_E217_D0.8461.00
329_I358_A0.8451.00
215_A243_M0.8421.00
111_A179_Y0.8411.00
341_L377_L0.8401.00
94_A121_A0.8371.00
153_K161_P0.8311.00
149_V159_V0.8191.00
56_G91_I0.8191.00
82_D347_I0.8191.00
133_C157_A0.8171.00
71_L340_L0.8171.00
211_I215_A0.8171.00
205_R318_L0.8121.00
271_A279_G0.8111.00
339_K392_L0.8061.00
359_K363_L0.8061.00
314_E317_Y0.8051.00
205_R314_E0.8051.00
105_G189_Y0.8041.00
80_R377_L0.8021.00
169_L173_T0.8011.00
245_Q249_N0.8001.00
364_A367_M0.7941.00
229_K367_M0.7921.00
216_K220_K0.7921.00
134_T179_Y0.7911.00
61_L77_Y0.7901.00
57_R85_H0.7901.00
278_V316_A0.7891.00
334_A355_H0.7841.00
74_A373_I0.7841.00
97_Q204_V0.7771.00
231_V359_K0.7761.00
276_G279_G0.7761.00
278_V313_P0.7731.00
386_N390_N0.7731.00
91_I124_T0.7691.00
220_K226_M0.7681.00
258_E264_I0.7661.00
42_A45_E0.7651.00
246_A250_E0.7621.00
132_S188_F0.7611.00
240_A254_L0.7611.00
169_L172_A0.7581.00
44_R48_Y0.7541.00
103_K106_K0.7541.00
318_L322_G0.7491.00
141_D304_A0.7471.00
145_Q304_A0.7471.00
216_K246_A0.7461.00
120_V152_M0.7451.00
241_M315_H0.7441.00
158_E183_H0.7421.00
122_A135_V0.7401.00
162_V175_E0.7371.00
108_K179_Y0.7371.00
48_Y52_K0.7361.00
342_S388_L0.7351.00
215_A376_C0.7351.00
139_E161_P0.7341.00
97_Q198_H0.7321.00
167_G171_D0.7321.00
330_T362_K0.7301.00
45_E49_K0.7261.00
357_L375_V0.7191.00
96_G99_L0.7191.00
316_A320_K0.7171.00
305_G352_E0.7171.00
102_K107_T0.7131.00
160_V175_E0.7131.00
232_A240_A0.7121.00
170_K174_N0.7121.00
331_D334_A0.7121.00
335_V351_I0.7101.00
140_E143_A0.7071.00
49_K99_L0.6951.00
50_L95_L0.6941.00
102_K129_F0.6941.00
64_A345_E0.6911.00
110_I131_F0.6901.00
109_I188_F0.6881.00
261_G300_Y0.6871.00
44_R250_E0.6811.00
228_D370_G0.6761.00
206_E209_K0.6751.00
43_F46_E0.6731.00
162_V167_G0.6721.00
80_R347_I0.6701.00
205_R209_K0.6701.00
70_Y361_F0.6691.00
230_V254_L0.6681.00
98_A122_A0.6671.00
327_D362_K0.6660.99
134_T183_H0.6650.99
55_S84_N0.6640.99
264_I272_T0.6640.99
47_Y52_K0.6630.99
136_F162_V0.6600.99
40_D250_E0.6590.99
358_A362_K0.6580.99
115_A305_G0.6560.99
243_M254_L0.6540.99
96_G206_E0.6540.99
71_L360_A0.6530.99
217_D250_E0.6500.99
118_H208_Q0.6500.99
363_L366_G0.6490.99
204_V208_Q0.6470.99
80_R83_L0.6470.99
111_A180_W0.6440.99
227_P252_V0.6420.99
104_M108_K0.6390.99
151_R154_L0.6360.99
76_I375_V0.6340.99
98_A125_V0.6330.99
233_C356_A0.6320.99
226_M252_V0.6290.99
172_A176_A0.6270.99
272_T275_K0.6260.99
120_V151_R0.6230.99
206_E245_Q0.6220.99
313_P317_Y0.6200.99
67_V70_Y0.6160.99
173_T176_A0.6140.99
338_L351_I0.6130.99
113_T176_A0.6130.99
94_A125_V0.6120.99
169_L193_S0.6120.99
360_A364_A0.6120.99
136_F160_V0.6100.99
44_R51_L0.6090.99
315_H326_Y0.6080.99
97_Q100_L0.6070.99
386_N389_M0.6050.99
118_H191_I0.6050.99
65_D68_T0.6030.99
57_R84_N0.6030.99
55_S99_L0.6020.99
248_L254_L0.6000.99
213_E250_E0.5970.99
243_M247_F0.5970.99
367_M373_I0.5950.99
179_Y188_F0.5930.99
387_T391_V0.5930.99
160_V179_Y0.5910.99
68_T76_I0.5900.99
102_K189_Y0.5890.99
96_G100_L0.5880.99
190_M193_S0.5880.99
140_E167_G0.5870.99
272_T279_G0.5870.99
215_A230_V0.5850.99
353_S356_A0.5830.99
40_D249_N0.5820.99
253_E366_G0.5810.99
357_L377_L0.5780.99
99_L103_K0.5780.99
363_L367_M0.5770.99
108_K187_H0.5760.99
45_E48_Y0.5750.99
188_F192_G0.5740.99
248_L321_S0.5730.98
82_D377_L0.5720.98
109_I126_A0.5680.98
61_L218_Q0.5660.98
176_A190_M0.5660.98
180_W188_F0.5650.98
68_T74_A0.5630.98
119_G135_V0.5600.98
255_I359_K0.5590.98
352_E355_H0.5580.98
67_V340_L0.5580.98
79_K214_E0.5580.98
46_E49_K0.5580.98
55_S128_K0.5560.98
348_L381_G0.5520.98
264_I311_I0.5510.98
272_T316_A0.5500.98
192_G195_V0.5480.98
107_T132_S0.5470.98
78_L357_L0.5470.98
248_L322_G0.5470.98
256_G323_R0.5460.98
332_E335_V0.5430.98
334_A354_A0.5410.98
275_K278_V0.5400.98
98_A131_F0.5380.98
56_G95_L0.5380.98
121_A125_V0.5370.98
113_T190_M0.5370.98
191_I195_V0.5360.98
213_E249_N0.5360.98
42_A206_E0.5350.98
177_I190_M0.5350.98
248_L251_D0.5340.98
111_A136_F0.5340.98
362_K365_K0.5340.98
85_H124_T0.5330.98
278_V310_G0.5320.98
141_D149_V0.5310.98
272_T278_V0.5310.98
189_Y192_G0.5300.98
73_G370_G0.5300.98
303_S306_L0.5290.97
257_A355_H0.5260.97
333_E364_A0.5250.97
241_M318_L0.5250.97
329_I359_K0.5250.97
97_Q189_Y0.5230.97
46_E50_L0.5230.97
217_D221_R0.5220.97
335_V339_K0.5220.97
44_R213_E0.5210.97
277_T316_A0.5210.97
52_K56_G0.5190.97
110_I133_C0.5190.97
230_V374_L0.5190.97
151_R344_K0.5190.97
171_D175_E0.5160.97
45_E50_L0.5130.97
91_I128_K0.5120.97
46_E52_K0.5120.97
71_L364_A0.5110.97
106_K129_F0.5110.97
231_V373_I0.5100.97
205_R241_M0.5080.97
257_A329_I0.5060.97
319_H326_Y0.5060.97
163_T171_D0.5050.97
246_A249_N0.5040.97
232_A254_L0.5040.97
110_I126_A0.5010.97
209_K246_A0.5000.96
89_H239_N0.5000.96
64_A67_V0.5000.96
189_Y194_V0.5000.96
98_A109_I0.5000.96
245_Q318_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tdjA 2 0.8175 100 0.284 Contact Map
1x1qA 2 0.96 100 0.293 Contact Map
1v71A 2 0.79 100 0.293 Contact Map
4negA 2 0.8075 100 0.297 Contact Map
2gn0A 2 0.81 100 0.298 Contact Map
2o2eA 2 0.7875 100 0.298 Contact Map
3ss7X 1 0.925 100 0.301 Contact Map
1v8zA 2 0.96 100 0.309 Contact Map
3l6bA 2 0.7925 100 0.312 Contact Map
4ht3B 2 0.975 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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