SP5E - BACSU - GREMLIN Contacts

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SP5E - Stage V sporulation protein E

UniProt:	P07373	Sequences: MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFFFAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSRSWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMCQPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLNPWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFIGGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTGITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	366 (347)
Sequences:	8079 (5538)
Seq/√Len:	297.3

ECOLI - FTSW RODA
BACSU - SP5E FTSW RODA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
292_G	312_I	3.762	1.00
9_D	291_R	3.522	1.00
292_G	357_L	3.404	1.00
106_G	109_A	3.167	1.00
176_V	313_S	3.124	1.00
97_V	102_R	2.749	1.00
15_I	287_V	2.714	1.00
20_L	53_A	2.669	1.00
270_S	278_G	2.664	1.00
68_Y	304_G	2.664	1.00
218_N	221_E	2.614	1.00
237_V	270_S	2.613	1.00
222_D	225_G	2.597	1.00
308_A	357_L	2.485	1.00
82_C	121_A	2.416	1.00
78_L	121_A	2.381	1.00
63_I	352_M	2.375	1.00
56_G	351_L	2.370	1.00
16_T	354_V	2.328	1.00
41_D	47_K	2.312	1.00
15_I	288_L	2.195	1.00
269_L	281_I	2.142	1.00
311_I	357_L	2.108	1.00
82_C	118_M	2.068	1.00
180_V	309_V	2.067	1.00
91_I	94_V	2.057	1.00
266_F	278_G	2.047	1.00
259_E	262_T	2.038	1.00
60_M	358_L	2.030	1.00
155_F	167_G	2.024	1.00
339_F	354_V	1.987	1.00
289_L	316_A	1.956	1.00
99_N	259_E	1.940	1.00
26_M	269_L	1.929	1.00
339_F	350_M	1.899	1.00
24_L	46_A	1.880	1.00
220_W	231_I	1.860	1.00
44_F	48_R	1.850	1.00
88_L	105_I	1.850	1.00
26_M	273_L	1.812	1.00
230_I	332_V	1.809	1.00
151_V	174_C	1.795	1.00
106_G	111_S	1.784	1.00
294_R	298_G	1.781	1.00
177_M	310_G	1.758	1.00
325_V	332_V	1.736	1.00
324_G	330_I	1.719	1.00
247_L	273_L	1.694	1.00
72_R	303_Y	1.685	1.00
311_I	353_A	1.649	1.00
156_L	160_C	1.641	1.00
292_G	308_A	1.641	1.00
88_L	94_V	1.632	1.00
319_V	323_I	1.630	1.00
223_P	231_I	1.608	1.00
74_W	77_L	1.597	1.00
250_S	268_I	1.596	1.00
50_L	54_G	1.583	1.00
299_A	360_V	1.566	1.00
279_T	283_L	1.559	1.00
124_A	307_V	1.544	1.00
211_K	226_S	1.541	1.00
80_V	84_F	1.524	1.00
22_I	269_L	1.522	1.00
232_Q	252_Q	1.517	1.00
24_L	49_Q	1.516	1.00
200_V	203_V	1.511	1.00
282_L	323_I	1.505	1.00
308_A	360_V	1.499	1.00
245_M	251_R	1.496	1.00
130_L	177_M	1.491	1.00
29_S	272_E	1.490	1.00
304_G	360_V	1.489	1.00
89_V	105_I	1.488	1.00
115_S	166_T	1.486	1.00
243_F	276_I	1.483	1.00
269_L	340_L	1.477	1.00
296_A	308_A	1.457	1.00
87_V	91_I	1.447	1.00
79_M	154_A	1.429	1.00
86_L	118_M	1.416	1.00
52_F	344_G	1.413	1.00
112_I	117_F	1.410	1.00
266_F	323_I	1.406	1.00
20_L	351_L	1.406	1.00
96_M	106_G	1.403	1.00
30_A	268_I	1.403	1.00
47_K	50_L	1.401	1.00
169_V	335_I	1.400	1.00
285_F	319_V	1.399	1.00
173_T	314_M	1.359	1.00
158_I	170_M	1.359	1.00
206_A	209_R	1.357	1.00
336_T	346_S	1.353	1.00
77_L	81_I	1.351	1.00
123_I	310_G	1.340	1.00
96_M	111_S	1.340	1.00
289_L	319_V	1.340	1.00
15_I	284_L	1.339	1.00
177_M	306_F	1.337	1.00
250_S	272_E	1.334	1.00
60_M	355_G	1.328	1.00
289_L	312_I	1.318	1.00
22_I	281_I	1.317	1.00
301_D	304_G	1.311	1.00
207_P	210_I	1.309	1.00
16_T	351_L	1.308	1.00
59_A	352_M	1.305	1.00
242_L	275_F	1.301	1.00
54_G	58_I	1.299	1.00
315_I	350_M	1.290	1.00
122_M	170_M	1.289	1.00
26_M	265_I	1.286	1.00
128_K	132_E	1.284	1.00
83_F	153_S	1.276	1.00
172_G	317_I	1.274	1.00
84_F	88_L	1.274	1.00
230_I	328_G	1.272	1.00
24_L	50_L	1.244	1.00
264_F	332_V	1.233	1.00
53_A	347_L	1.224	1.00
68_Y	359_N	1.215	1.00
103_S	115_S	1.212	1.00
233_S	326_V	1.210	1.00
235_Y	252_Q	1.210	1.00
210_I	214_T	1.204	1.00
275_F	279_T	1.201	1.00
222_D	226_S	1.199	1.00
205_S	209_R	1.195	1.00
207_P	211_K	1.183	1.00
227_G	231_I	1.181	1.00
359_N	363_Y	1.175	1.00
28_Y	46_A	1.173	1.00
88_L	91_I	1.167	1.00
149_G	153_S	1.160	1.00
295_I	308_A	1.152	1.00
47_K	51_L	1.144	1.00
126_L	174_C	1.144	1.00
189_V	193_L	1.132	1.00
118_M	154_A	1.131	1.00
116_E	119_K	1.127	1.00
25_I	247_L	1.126	1.00
184_R	187_H	1.125	1.00
19_L	340_L	1.125	1.00
12_L	288_L	1.120	1.00
58_I	62_F	1.117	1.00
152_F	156_L	1.112	1.00
126_L	147_A	1.112	1.00
228_F	258_P	1.107	1.00
28_Y	43_F	1.097	1.00
282_L	319_V	1.095	1.00
89_V	114_P	1.095	1.00
204_L	207_P	1.091	1.00
293_I	312_I	1.090	1.00
71_W	356_V	1.089	1.00
75_S	128_K	1.071	1.00
72_R	128_K	1.070	1.00
70_T	73_T	1.069	1.00
199_F	202_L	1.069	1.00
72_R	131_S	1.060	1.00
11_L	287_V	1.060	1.00
68_Y	301_D	1.058	1.00
55_I	348_T	1.053	1.00
45_F	261_Q	1.051	1.00
288_L	354_V	1.050	1.00
123_I	173_T	1.048	1.00
239_P	245_M	1.038	1.00
314_M	353_A	1.037	1.00
123_I	314_M	1.034	1.00
307_V	360_V	1.033	1.00
77_L	80_V	1.033	1.00
127_A	177_M	1.029	1.00
76_K	80_V	1.027	1.00
83_F	154_A	1.019	1.00
8_P	13_V	1.015	1.00
13_V	358_L	1.014	1.00
56_G	347_L	1.013	1.00
45_F	342_Y	1.013	1.00
318_Q	346_S	1.012	1.00
64_M	355_G	1.011	1.00
257_L	267_A	1.011	1.00
74_W	78_L	1.009	1.00
211_K	214_T	1.004	1.00
232_Q	235_Y	0.994	1.00
191_L	195_G	0.991	1.00
312_I	357_L	0.990	1.00
281_I	340_L	0.990	1.00
12_L	295_I	0.983	1.00
117_F	349_L	0.983	1.00
242_L	276_I	0.971	1.00
228_F	232_Q	0.970	1.00
98_R	111_S	0.969	1.00
168_T	172_G	0.968	1.00
215_S	226_S	0.968	1.00
68_Y	360_V	0.967	1.00
19_L	288_L	0.960	1.00
190_F	194_I	0.958	1.00
358_L	361_S	0.956	1.00
60_M	63_I	0.955	1.00
64_M	359_N	0.949	1.00
14_I	18_L	0.949	1.00
195_G	199_F	0.949	1.00
49_Q	52_F	0.948	1.00
129_F	147_A	0.948	1.00
234_L	328_G	0.948	1.00
124_A	303_Y	0.947	1.00
44_F	47_K	0.947	1.00
76_K	125_F	0.946	1.00
302_L	305_S	0.945	1.00
103_S	165_G	0.944	1.00
307_V	356_V	0.941	1.00
290_W	294_R	0.940	1.00
262_T	342_Y	0.939	1.00
269_L	273_L	0.933	1.00
27_V	30_A	0.928	1.00
296_A	312_I	0.927	1.00
318_Q	336_T	0.926	1.00
165_G	333_T	0.922	1.00
165_G	325_V	0.922	1.00
220_W	234_L	0.919	1.00
57_V	61_F	0.915	1.00
295_I	361_S	0.914	1.00
325_V	333_T	0.914	1.00
315_I	319_V	0.907	1.00
70_T	74_W	0.905	1.00
233_S	267_A	0.904	1.00
18_L	284_L	0.903	1.00
22_I	284_L	0.903	1.00
48_R	52_F	0.902	1.00
166_T	336_T	0.898	1.00
120_L	356_V	0.897	1.00
67_D	70_T	0.895	1.00
120_L	349_L	0.886	1.00
179_F	185_I	0.885	1.00
171_V	175_I	0.884	1.00
337_L	340_L	0.883	1.00
185_I	189_V	0.879	1.00
203_V	210_I	0.878	1.00
198_G	202_L	0.877	1.00
75_S	303_Y	0.876	1.00
95_G	102_R	0.872	1.00
246_G	272_E	0.872	1.00
48_R	51_L	0.870	1.00
56_G	348_T	0.869	1.00
309_V	313_S	0.865	1.00
11_L	291_R	0.865	1.00
163_D	166_T	0.862	1.00
133_K	146_P	0.862	1.00
219_P	231_I	0.861	1.00
120_L	352_M	0.861	1.00
219_P	227_G	0.860	1.00
222_D	227_G	0.857	1.00
145_V	149_G	0.856	1.00
89_V	102_R	0.850	1.00
48_R	342_Y	0.849	1.00
194_I	198_G	0.849	1.00
355_G	359_N	0.843	1.00
27_V	265_I	0.839	1.00
159_M	167_G	0.836	1.00
90_L	160_C	0.836	1.00
188_F	192_G	0.835	1.00
64_M	362_R	0.832	1.00
79_M	83_F	0.832	1.00
79_M	125_F	0.829	1.00
60_M	354_V	0.829	1.00
173_T	176_V	0.827	1.00
229_Q	233_S	0.826	1.00
140_F	187_H	0.826	1.00
63_I	71_W	0.825	1.00
17_L	21_T	0.825	1.00
130_L	181_A	0.824	1.00
22_I	26_M	0.823	1.00
296_A	309_V	0.823	1.00
283_L	287_V	0.818	1.00
230_I	233_S	0.818	1.00
303_Y	307_V	0.814	1.00
106_G	110_F	0.810	1.00
261_Q	342_Y	0.809	1.00
21_T	25_I	0.809	1.00
86_L	157_I	0.808	1.00
346_S	350_M	0.807	1.00
324_G	329_L	0.805	1.00
257_L	260_P	0.800	1.00
120_L	353_A	0.799	1.00
123_I	311_I	0.798	1.00
278_G	327_T	0.795	0.99
43_F	46_A	0.794	0.99
357_L	360_V	0.792	0.99
56_G	355_G	0.792	0.99
155_F	171_V	0.791	0.99
112_I	349_L	0.790	0.99
180_V	313_S	0.789	0.99
85_L	89_V	0.789	0.99
211_K	215_S	0.787	0.99
125_F	150_I	0.787	0.99
122_M	151_V	0.786	0.99
286_S	290_W	0.785	0.99
75_S	121_A	0.785	0.99
197_S	200_V	0.784	0.99
16_T	288_L	0.784	0.99
164_L	209_R	0.782	0.99
62_F	66_V	0.780	0.99
19_L	281_I	0.778	0.99
250_S	253_K	0.778	0.99
260_P	268_I	0.771	0.99
320_M	329_L	0.771	0.99
46_A	50_L	0.770	0.99
233_S	264_F	0.769	0.99
203_V	213_I	0.768	0.99
83_F	87_V	0.767	0.99
199_F	203_V	0.767	0.99
146_P	149_G	0.767	0.99
158_I	166_T	0.765	0.99
147_A	174_C	0.765	0.99
32_A	253_K	0.764	0.99
359_N	362_R	0.761	0.99
264_F	326_V	0.757	0.99
278_G	282_L	0.755	0.99
325_V	330_I	0.755	0.99
123_I	177_M	0.753	0.99
266_F	281_I	0.752	0.99
164_L	168_T	0.750	0.99
61_F	65_N	0.749	0.99
215_S	221_E	0.747	0.99
59_A	348_T	0.747	0.99
51_L	54_G	0.743	0.99
52_F	348_T	0.739	0.99
187_H	191_L	0.738	0.99
29_S	246_G	0.737	0.99
66_V	71_W	0.733	0.99
127_A	303_Y	0.732	0.99
291_R	294_R	0.732	0.99
76_K	128_K	0.731	0.99
69_W	301_D	0.730	0.99
218_N	227_G	0.727	0.99
235_Y	238_G	0.724	0.99
285_F	337_L	0.720	0.99
101_S	161_Q	0.716	0.99
130_L	147_A	0.716	0.99
230_I	264_F	0.715	0.99
323_I	337_L	0.715	0.99
304_G	307_V	0.714	0.99
323_I	327_T	0.713	0.99
27_V	49_Q	0.712	0.99
28_Y	248_G	0.708	0.99
118_M	121_A	0.706	0.99
308_A	312_I	0.705	0.99
57_V	60_M	0.704	0.99
43_F	47_K	0.703	0.99
268_I	272_E	0.699	0.99
11_L	15_I	0.698	0.99
266_F	337_L	0.697	0.99
85_L	112_I	0.697	0.99
85_L	117_F	0.696	0.99
164_L	206_A	0.696	0.99
41_D	44_F	0.695	0.99
237_V	327_T	0.694	0.99
196_L	200_V	0.694	0.99
68_Y	307_V	0.692	0.99
126_L	151_V	0.690	0.99
293_I	313_S	0.689	0.99
356_V	360_V	0.689	0.99
60_M	351_L	0.689	0.99
265_I	340_L	0.684	0.98
189_V	192_G	0.682	0.98
176_V	317_I	0.681	0.98
350_M	353_A	0.679	0.98
127_A	131_S	0.674	0.98
123_I	307_V	0.673	0.98
103_S	162_P	0.670	0.98
302_L	306_F	0.670	0.98
101_S	162_P	0.668	0.98
299_A	304_G	0.667	0.98
117_F	352_M	0.665	0.98
144_F	148_L	0.665	0.98
151_V	155_F	0.661	0.98
253_K	272_E	0.655	0.98
20_L	57_V	0.654	0.98
15_I	291_R	0.654	0.98
208_Y	211_K	0.650	0.98
215_S	219_P	0.649	0.98
172_G	176_V	0.649	0.98
72_R	301_D	0.648	0.98
198_G	201_G	0.647	0.98
288_L	292_G	0.645	0.98
283_L	286_S	0.645	0.98
321_I	330_I	0.645	0.98
143_G	146_P	0.640	0.98
265_I	269_L	0.638	0.98
313_S	317_I	0.635	0.98
215_S	227_G	0.635	0.98
127_A	310_G	0.631	0.97
197_S	201_G	0.631	0.97
213_I	217_L	0.630	0.97
295_I	299_A	0.630	0.97
273_L	277_G	0.628	0.97
345_S	349_L	0.626	0.97
67_D	304_G	0.625	0.97
80_V	83_F	0.625	0.97
89_V	161_Q	0.624	0.97
87_V	90_L	0.621	0.97
69_W	72_R	0.621	0.97
288_L	315_I	0.621	0.97
99_N	261_Q	0.615	0.97
193_L	197_S	0.615	0.97
186_A	190_F	0.614	0.97
107_V	111_S	0.612	0.97
234_L	238_G	0.610	0.97
99_N	102_R	0.608	0.97
49_Q	53_A	0.606	0.97
285_F	339_F	0.606	0.97
220_W	227_G	0.605	0.97
292_G	354_V	0.603	0.97
232_Q	258_P	0.603	0.97
130_L	306_F	0.600	0.97
130_L	178_I	0.599	0.97
287_V	291_R	0.598	0.96
133_K	136_N	0.595	0.96
62_F	65_N	0.595	0.96
322_N	326_V	0.594	0.96
121_A	125_F	0.592	0.96
144_F	178_I	0.589	0.96
112_I	345_S	0.589	0.96
246_G	271_E	0.588	0.96
250_S	271_E	0.587	0.96
281_I	285_F	0.586	0.96
257_L	268_I	0.585	0.96
218_N	222_D	0.583	0.96
59_A	62_F	0.582	0.96
73_T	77_L	0.582	0.96
183_A	188_F	0.581	0.96
231_I	235_Y	0.581	0.96
221_E	227_G	0.580	0.96
125_F	129_F	0.579	0.96
292_G	295_I	0.578	0.96
113_Q	116_E	0.578	0.96
350_M	354_V	0.576	0.96
55_I	59_A	0.573	0.96
128_K	303_Y	0.572	0.95
86_L	162_P	0.572	0.95
87_V	157_I	0.572	0.95
65_N	362_R	0.571	0.95
96_M	102_R	0.569	0.95
311_I	360_V	0.569	0.95
103_S	335_I	0.568	0.95
214_T	218_N	0.566	0.95
354_V	357_L	0.561	0.95
103_S	333_T	0.561	0.95
293_I	297_L	0.560	0.95
28_Y	32_A	0.559	0.95
200_V	204_L	0.558	0.95
15_I	283_L	0.557	0.95
266_F	282_L	0.557	0.95
321_I	325_V	0.556	0.95
298_G	361_S	0.555	0.95
320_M	330_I	0.554	0.95
124_A	356_V	0.553	0.95
181_A	306_F	0.552	0.95
24_L	53_A	0.551	0.94
64_M	358_L	0.550	0.94
349_L	353_A	0.550	0.94
165_G	262_T	0.549	0.94
7_S	362_R	0.549	0.94
214_T	222_D	0.548	0.94
129_F	150_I	0.548	0.94
63_I	355_G	0.548	0.94
137_I	141_R	0.546	0.94
49_Q	347_L	0.545	0.94
230_I	234_L	0.545	0.94
86_L	158_I	0.545	0.94
45_F	48_R	0.542	0.94
10_L	14_I	0.541	0.94
238_G	275_F	0.541	0.94
236_A	257_L	0.539	0.94
288_L	357_L	0.538	0.94
233_S	327_T	0.538	0.94
79_M	150_I	0.536	0.94
233_S	257_L	0.536	0.94
22_I	340_L	0.535	0.94
127_A	307_V	0.534	0.94
9_D	361_S	0.532	0.93
215_S	230_I	0.531	0.93
214_T	221_E	0.531	0.93
103_S	166_T	0.530	0.93
158_I	167_G	0.529	0.93
15_I	18_L	0.529	0.93
52_F	56_G	0.528	0.93
82_C	117_F	0.528	0.93
280_L	283_L	0.528	0.93
137_I	140_F	0.528	0.93
162_P	208_Y	0.527	0.93
231_I	234_L	0.526	0.93
299_A	308_A	0.526	0.93
222_D	228_F	0.525	0.93
81_I	84_F	0.524	0.93
72_R	132_E	0.524	0.93
170_M	174_C	0.522	0.93
96_M	99_N	0.521	0.93
56_G	59_A	0.520	0.93
215_S	222_D	0.520	0.93
125_F	133_K	0.516	0.92
52_F	345_S	0.515	0.92
175_I	192_G	0.515	0.92
209_R	213_I	0.513	0.92
311_I	314_M	0.512	0.92
131_S	134_Q	0.512	0.92
52_F	55_I	0.512	0.92
149_G	152_F	0.511	0.92
326_V	332_V	0.511	0.92
79_M	153_S	0.508	0.92
133_K	143_G	0.507	0.92
157_I	161_Q	0.507	0.92
103_S	161_Q	0.506	0.92
18_L	21_T	0.505	0.92
192_G	196_L	0.505	0.92
52_F	342_Y	0.505	0.92
98_R	102_R	0.504	0.91
320_M	324_G	0.503	0.91
98_R	106_G	0.502	0.91
69_W	73_T	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wu2Z	1	0.1311	3.8	0.976	Contact Map
4qncA	2	0.2077	3.7	0.976	Contact Map
2k9jB	1	0.1175	2.9	0.977	Contact Map
4x5mA	2	0.2404	2.4	0.978	Contact Map
4ogqE	1	0.0847	2.2	0.979	Contact Map
4i0uA	4	0.1721	2.1	0.979	Contact Map
3wu2J	1	0.1066	2.1	0.979	Contact Map
2l9uA	2	0.0929	2.1	0.979	Contact Map
4hw9A	3	0.2432	2.1	0.979	Contact Map
4ev6A	3	0.1913	1.9	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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