GREMLIN Database
SP5E - Stage V sporulation protein E
UniProt: P07373 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (347)
Sequences: 8079 (5538)
Seq/√Len: 297.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
292_G312_I3.7621.00
9_D291_R3.5221.00
292_G357_L3.4041.00
106_G109_A3.1671.00
176_V313_S3.1241.00
97_V102_R2.7491.00
15_I287_V2.7141.00
20_L53_A2.6691.00
270_S278_G2.6641.00
68_Y304_G2.6641.00
218_N221_E2.6141.00
237_V270_S2.6131.00
222_D225_G2.5971.00
308_A357_L2.4851.00
82_C121_A2.4161.00
78_L121_A2.3811.00
63_I352_M2.3751.00
56_G351_L2.3701.00
16_T354_V2.3281.00
41_D47_K2.3121.00
15_I288_L2.1951.00
269_L281_I2.1421.00
311_I357_L2.1081.00
82_C118_M2.0681.00
180_V309_V2.0671.00
91_I94_V2.0571.00
266_F278_G2.0471.00
259_E262_T2.0381.00
60_M358_L2.0301.00
155_F167_G2.0241.00
339_F354_V1.9871.00
289_L316_A1.9561.00
99_N259_E1.9401.00
26_M269_L1.9291.00
339_F350_M1.8991.00
24_L46_A1.8801.00
220_W231_I1.8601.00
44_F48_R1.8501.00
88_L105_I1.8501.00
26_M273_L1.8121.00
230_I332_V1.8091.00
151_V174_C1.7951.00
106_G111_S1.7841.00
294_R298_G1.7811.00
177_M310_G1.7581.00
325_V332_V1.7361.00
324_G330_I1.7191.00
247_L273_L1.6941.00
72_R303_Y1.6851.00
311_I353_A1.6491.00
156_L160_C1.6411.00
292_G308_A1.6411.00
88_L94_V1.6321.00
319_V323_I1.6301.00
223_P231_I1.6081.00
74_W77_L1.5971.00
250_S268_I1.5961.00
50_L54_G1.5831.00
299_A360_V1.5661.00
279_T283_L1.5591.00
124_A307_V1.5441.00
211_K226_S1.5411.00
80_V84_F1.5241.00
22_I269_L1.5221.00
232_Q252_Q1.5171.00
24_L49_Q1.5161.00
200_V203_V1.5111.00
282_L323_I1.5051.00
308_A360_V1.4991.00
245_M251_R1.4961.00
130_L177_M1.4911.00
29_S272_E1.4901.00
304_G360_V1.4891.00
89_V105_I1.4881.00
115_S166_T1.4861.00
243_F276_I1.4831.00
269_L340_L1.4771.00
296_A308_A1.4571.00
87_V91_I1.4471.00
79_M154_A1.4291.00
86_L118_M1.4161.00
52_F344_G1.4131.00
112_I117_F1.4101.00
266_F323_I1.4061.00
20_L351_L1.4061.00
96_M106_G1.4031.00
30_A268_I1.4031.00
47_K50_L1.4011.00
169_V335_I1.4001.00
285_F319_V1.3991.00
173_T314_M1.3591.00
158_I170_M1.3591.00
206_A209_R1.3571.00
336_T346_S1.3531.00
77_L81_I1.3511.00
123_I310_G1.3401.00
96_M111_S1.3401.00
289_L319_V1.3401.00
15_I284_L1.3391.00
177_M306_F1.3371.00
250_S272_E1.3341.00
60_M355_G1.3281.00
289_L312_I1.3181.00
22_I281_I1.3171.00
301_D304_G1.3111.00
207_P210_I1.3091.00
16_T351_L1.3081.00
59_A352_M1.3051.00
242_L275_F1.3011.00
54_G58_I1.2991.00
315_I350_M1.2901.00
122_M170_M1.2891.00
26_M265_I1.2861.00
128_K132_E1.2841.00
83_F153_S1.2761.00
172_G317_I1.2741.00
84_F88_L1.2741.00
230_I328_G1.2721.00
24_L50_L1.2441.00
264_F332_V1.2331.00
53_A347_L1.2241.00
68_Y359_N1.2151.00
103_S115_S1.2121.00
233_S326_V1.2101.00
235_Y252_Q1.2101.00
210_I214_T1.2041.00
275_F279_T1.2011.00
222_D226_S1.1991.00
205_S209_R1.1951.00
207_P211_K1.1831.00
227_G231_I1.1811.00
359_N363_Y1.1751.00
28_Y46_A1.1731.00
88_L91_I1.1671.00
149_G153_S1.1601.00
295_I308_A1.1521.00
47_K51_L1.1441.00
126_L174_C1.1441.00
189_V193_L1.1321.00
118_M154_A1.1311.00
116_E119_K1.1271.00
25_I247_L1.1261.00
184_R187_H1.1251.00
19_L340_L1.1251.00
12_L288_L1.1201.00
58_I62_F1.1171.00
152_F156_L1.1121.00
126_L147_A1.1121.00
228_F258_P1.1071.00
28_Y43_F1.0971.00
282_L319_V1.0951.00
89_V114_P1.0951.00
204_L207_P1.0911.00
293_I312_I1.0901.00
71_W356_V1.0891.00
75_S128_K1.0711.00
72_R128_K1.0701.00
70_T73_T1.0691.00
199_F202_L1.0691.00
72_R131_S1.0601.00
11_L287_V1.0601.00
68_Y301_D1.0581.00
55_I348_T1.0531.00
45_F261_Q1.0511.00
288_L354_V1.0501.00
123_I173_T1.0481.00
239_P245_M1.0381.00
314_M353_A1.0371.00
123_I314_M1.0341.00
307_V360_V1.0331.00
77_L80_V1.0331.00
127_A177_M1.0291.00
76_K80_V1.0271.00
83_F154_A1.0191.00
8_P13_V1.0151.00
13_V358_L1.0141.00
56_G347_L1.0131.00
45_F342_Y1.0131.00
318_Q346_S1.0121.00
64_M355_G1.0111.00
257_L267_A1.0111.00
74_W78_L1.0091.00
211_K214_T1.0041.00
232_Q235_Y0.9941.00
191_L195_G0.9911.00
312_I357_L0.9901.00
281_I340_L0.9901.00
12_L295_I0.9831.00
117_F349_L0.9831.00
242_L276_I0.9711.00
228_F232_Q0.9701.00
98_R111_S0.9691.00
168_T172_G0.9681.00
215_S226_S0.9681.00
68_Y360_V0.9671.00
19_L288_L0.9601.00
190_F194_I0.9581.00
358_L361_S0.9561.00
60_M63_I0.9551.00
64_M359_N0.9491.00
14_I18_L0.9491.00
195_G199_F0.9491.00
49_Q52_F0.9481.00
129_F147_A0.9481.00
234_L328_G0.9481.00
124_A303_Y0.9471.00
44_F47_K0.9471.00
76_K125_F0.9461.00
302_L305_S0.9451.00
103_S165_G0.9441.00
307_V356_V0.9411.00
290_W294_R0.9401.00
262_T342_Y0.9391.00
269_L273_L0.9331.00
27_V30_A0.9281.00
296_A312_I0.9271.00
318_Q336_T0.9261.00
165_G333_T0.9221.00
165_G325_V0.9221.00
220_W234_L0.9191.00
57_V61_F0.9151.00
295_I361_S0.9141.00
325_V333_T0.9141.00
315_I319_V0.9071.00
70_T74_W0.9051.00
233_S267_A0.9041.00
18_L284_L0.9031.00
22_I284_L0.9031.00
48_R52_F0.9021.00
166_T336_T0.8981.00
120_L356_V0.8971.00
67_D70_T0.8951.00
120_L349_L0.8861.00
179_F185_I0.8851.00
171_V175_I0.8841.00
337_L340_L0.8831.00
185_I189_V0.8791.00
203_V210_I0.8781.00
198_G202_L0.8771.00
75_S303_Y0.8761.00
95_G102_R0.8721.00
246_G272_E0.8721.00
48_R51_L0.8701.00
56_G348_T0.8691.00
309_V313_S0.8651.00
11_L291_R0.8651.00
163_D166_T0.8621.00
133_K146_P0.8621.00
219_P231_I0.8611.00
120_L352_M0.8611.00
219_P227_G0.8601.00
222_D227_G0.8571.00
145_V149_G0.8561.00
89_V102_R0.8501.00
48_R342_Y0.8491.00
194_I198_G0.8491.00
355_G359_N0.8431.00
27_V265_I0.8391.00
159_M167_G0.8361.00
90_L160_C0.8361.00
188_F192_G0.8351.00
64_M362_R0.8321.00
79_M83_F0.8321.00
79_M125_F0.8291.00
60_M354_V0.8291.00
173_T176_V0.8271.00
229_Q233_S0.8261.00
140_F187_H0.8261.00
63_I71_W0.8251.00
17_L21_T0.8251.00
130_L181_A0.8241.00
22_I26_M0.8231.00
296_A309_V0.8231.00
283_L287_V0.8181.00
230_I233_S0.8181.00
303_Y307_V0.8141.00
106_G110_F0.8101.00
261_Q342_Y0.8091.00
21_T25_I0.8091.00
86_L157_I0.8081.00
346_S350_M0.8071.00
324_G329_L0.8051.00
257_L260_P0.8001.00
120_L353_A0.7991.00
123_I311_I0.7981.00
278_G327_T0.7950.99
43_F46_A0.7940.99
357_L360_V0.7920.99
56_G355_G0.7920.99
155_F171_V0.7910.99
112_I349_L0.7900.99
180_V313_S0.7890.99
85_L89_V0.7890.99
211_K215_S0.7870.99
125_F150_I0.7870.99
122_M151_V0.7860.99
286_S290_W0.7850.99
75_S121_A0.7850.99
197_S200_V0.7840.99
16_T288_L0.7840.99
164_L209_R0.7820.99
62_F66_V0.7800.99
19_L281_I0.7780.99
250_S253_K0.7780.99
260_P268_I0.7710.99
320_M329_L0.7710.99
46_A50_L0.7700.99
233_S264_F0.7690.99
203_V213_I0.7680.99
83_F87_V0.7670.99
199_F203_V0.7670.99
146_P149_G0.7670.99
158_I166_T0.7650.99
147_A174_C0.7650.99
32_A253_K0.7640.99
359_N362_R0.7610.99
264_F326_V0.7570.99
278_G282_L0.7550.99
325_V330_I0.7550.99
123_I177_M0.7530.99
266_F281_I0.7520.99
164_L168_T0.7500.99
61_F65_N0.7490.99
215_S221_E0.7470.99
59_A348_T0.7470.99
51_L54_G0.7430.99
52_F348_T0.7390.99
187_H191_L0.7380.99
29_S246_G0.7370.99
66_V71_W0.7330.99
127_A303_Y0.7320.99
291_R294_R0.7320.99
76_K128_K0.7310.99
69_W301_D0.7300.99
218_N227_G0.7270.99
235_Y238_G0.7240.99
285_F337_L0.7200.99
101_S161_Q0.7160.99
130_L147_A0.7160.99
230_I264_F0.7150.99
323_I337_L0.7150.99
304_G307_V0.7140.99
323_I327_T0.7130.99
27_V49_Q0.7120.99
28_Y248_G0.7080.99
118_M121_A0.7060.99
308_A312_I0.7050.99
57_V60_M0.7040.99
43_F47_K0.7030.99
268_I272_E0.6990.99
11_L15_I0.6980.99
266_F337_L0.6970.99
85_L112_I0.6970.99
85_L117_F0.6960.99
164_L206_A0.6960.99
41_D44_F0.6950.99
237_V327_T0.6940.99
196_L200_V0.6940.99
68_Y307_V0.6920.99
126_L151_V0.6900.99
293_I313_S0.6890.99
356_V360_V0.6890.99
60_M351_L0.6890.99
265_I340_L0.6840.98
189_V192_G0.6820.98
176_V317_I0.6810.98
350_M353_A0.6790.98
127_A131_S0.6740.98
123_I307_V0.6730.98
103_S162_P0.6700.98
302_L306_F0.6700.98
101_S162_P0.6680.98
299_A304_G0.6670.98
117_F352_M0.6650.98
144_F148_L0.6650.98
151_V155_F0.6610.98
253_K272_E0.6550.98
20_L57_V0.6540.98
15_I291_R0.6540.98
208_Y211_K0.6500.98
215_S219_P0.6490.98
172_G176_V0.6490.98
72_R301_D0.6480.98
198_G201_G0.6470.98
288_L292_G0.6450.98
283_L286_S0.6450.98
321_I330_I0.6450.98
143_G146_P0.6400.98
265_I269_L0.6380.98
313_S317_I0.6350.98
215_S227_G0.6350.98
127_A310_G0.6310.97
197_S201_G0.6310.97
213_I217_L0.6300.97
295_I299_A0.6300.97
273_L277_G0.6280.97
345_S349_L0.6260.97
67_D304_G0.6250.97
80_V83_F0.6250.97
89_V161_Q0.6240.97
87_V90_L0.6210.97
69_W72_R0.6210.97
288_L315_I0.6210.97
99_N261_Q0.6150.97
193_L197_S0.6150.97
186_A190_F0.6140.97
107_V111_S0.6120.97
234_L238_G0.6100.97
99_N102_R0.6080.97
49_Q53_A0.6060.97
285_F339_F0.6060.97
220_W227_G0.6050.97
292_G354_V0.6030.97
232_Q258_P0.6030.97
130_L306_F0.6000.97
130_L178_I0.5990.97
287_V291_R0.5980.96
133_K136_N0.5950.96
62_F65_N0.5950.96
322_N326_V0.5940.96
121_A125_F0.5920.96
144_F178_I0.5890.96
112_I345_S0.5890.96
246_G271_E0.5880.96
250_S271_E0.5870.96
281_I285_F0.5860.96
257_L268_I0.5850.96
218_N222_D0.5830.96
59_A62_F0.5820.96
73_T77_L0.5820.96
183_A188_F0.5810.96
231_I235_Y0.5810.96
221_E227_G0.5800.96
125_F129_F0.5790.96
292_G295_I0.5780.96
113_Q116_E0.5780.96
350_M354_V0.5760.96
55_I59_A0.5730.96
128_K303_Y0.5720.95
86_L162_P0.5720.95
87_V157_I0.5720.95
65_N362_R0.5710.95
96_M102_R0.5690.95
311_I360_V0.5690.95
103_S335_I0.5680.95
214_T218_N0.5660.95
354_V357_L0.5610.95
103_S333_T0.5610.95
293_I297_L0.5600.95
28_Y32_A0.5590.95
200_V204_L0.5580.95
15_I283_L0.5570.95
266_F282_L0.5570.95
321_I325_V0.5560.95
298_G361_S0.5550.95
320_M330_I0.5540.95
124_A356_V0.5530.95
181_A306_F0.5520.95
24_L53_A0.5510.94
64_M358_L0.5500.94
349_L353_A0.5500.94
165_G262_T0.5490.94
7_S362_R0.5490.94
214_T222_D0.5480.94
129_F150_I0.5480.94
63_I355_G0.5480.94
137_I141_R0.5460.94
49_Q347_L0.5450.94
230_I234_L0.5450.94
86_L158_I0.5450.94
45_F48_R0.5420.94
10_L14_I0.5410.94
238_G275_F0.5410.94
236_A257_L0.5390.94
288_L357_L0.5380.94
233_S327_T0.5380.94
79_M150_I0.5360.94
233_S257_L0.5360.94
22_I340_L0.5350.94
127_A307_V0.5340.94
9_D361_S0.5320.93
215_S230_I0.5310.93
214_T221_E0.5310.93
103_S166_T0.5300.93
158_I167_G0.5290.93
15_I18_L0.5290.93
52_F56_G0.5280.93
82_C117_F0.5280.93
280_L283_L0.5280.93
137_I140_F0.5280.93
162_P208_Y0.5270.93
231_I234_L0.5260.93
299_A308_A0.5260.93
222_D228_F0.5250.93
81_I84_F0.5240.93
72_R132_E0.5240.93
170_M174_C0.5220.93
96_M99_N0.5210.93
56_G59_A0.5200.93
215_S222_D0.5200.93
125_F133_K0.5160.92
52_F345_S0.5150.92
175_I192_G0.5150.92
209_R213_I0.5130.92
311_I314_M0.5120.92
131_S134_Q0.5120.92
52_F55_I0.5120.92
149_G152_F0.5110.92
326_V332_V0.5110.92
79_M153_S0.5080.92
133_K143_G0.5070.92
157_I161_Q0.5070.92
103_S161_Q0.5060.92
18_L21_T0.5050.92
192_G196_L0.5050.92
52_F342_Y0.5050.92
98_R102_R0.5040.91
320_M324_G0.5030.91
98_R106_G0.5020.91
69_W73_T0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wu2Z 1 0.1311 3.8 0.976 Contact Map
4qncA 2 0.2077 3.7 0.976 Contact Map
2k9jB 1 0.1175 2.9 0.977 Contact Map
4x5mA 2 0.2404 2.4 0.978 Contact Map
4ogqE 1 0.0847 2.2 0.979 Contact Map
4i0uA 4 0.1721 2.1 0.979 Contact Map
3wu2J 1 0.1066 2.1 0.979 Contact Map
2l9uA 2 0.0929 2.1 0.979 Contact Map
4hw9A 3 0.2432 2.1 0.979 Contact Map
4ev6A 3 0.1913 1.9 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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