GREMLIN Database
YTXC - Uncharacterized protein YtxC
UniProt: P06569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (256)
Sequences: 306 (269)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_E112_R5.7201.00
267_H270_T5.3881.00
264_L267_H4.9071.00
264_L270_T4.7771.00
241_Y267_H4.2361.00
65_E143_Y4.0421.00
253_I261_V3.8261.00
241_Y264_L3.6841.00
241_Y270_T3.4571.00
238_V261_V2.9140.98
155_I158_Y2.4340.95
241_Y266_L2.2470.92
174_Y178_K2.2030.91
240_L261_V2.0760.88
163_E256_V2.0690.88
19_I26_N2.0350.87
226_L250_A2.0280.87
60_F120_L2.0250.87
183_K198_L2.0180.87
98_G161_E1.9690.85
220_M227_L1.9400.85
69_M92_A1.8890.83
92_A226_L1.8810.83
223_D255_N1.8760.82
58_K116_I1.8330.81
33_G36_K1.8250.81
174_Y228_A1.8040.80
252_T260_R1.8010.80
79_F155_I1.7420.77
181_R256_V1.7310.77
231_I256_V1.6810.75
134_S224_S1.6440.73
173_D228_A1.6440.73
52_M95_I1.6320.72
92_A154_A1.6300.72
266_L270_T1.6080.71
171_L252_T1.6000.71
143_Y147_L1.5970.71
224_S270_T1.5910.70
84_E259_E1.5490.68
17_H31_R1.5490.68
219_P224_S1.5440.68
56_L186_H1.5340.68
200_Y256_V1.5040.66
188_V196_W1.4880.65
224_S228_A1.4880.65
134_S167_F1.4860.65
192_S256_V1.4790.65
77_Y152_E1.4740.64
240_L250_A1.4730.64
113_K168_I1.4720.64
138_F252_T1.4610.64
173_D232_S1.4550.63
173_D178_K1.4270.62
139_R230_L1.4190.61
47_P133_R1.4110.61
238_V252_T1.4040.61
237_E262_E1.3960.60
77_Y84_E1.3950.60
187_I226_L1.3950.60
77_Y128_G1.3780.59
179_Q240_L1.3610.58
56_L120_L1.3540.58
167_F171_L1.3480.57
53_E121_Q1.3390.57
166_N270_T1.3230.56
134_S170_T1.3130.55
143_Y180_P1.3120.55
58_K113_K1.3110.55
88_I215_V1.3080.55
157_E219_P1.3080.55
167_F170_T1.3080.55
134_S228_A1.3060.55
167_F230_L1.2990.54
189_H245_P1.2950.54
166_N224_S1.2850.54
134_S241_Y1.2790.53
179_Q261_V1.2680.53
156_D160_M1.2650.52
152_E259_E1.2650.52
172_R259_E1.2490.51
224_S267_H1.2250.50
256_V263_M1.2190.50
138_F230_L1.2180.50
117_L231_I1.2120.49
53_E231_I1.2020.49
166_N170_T1.2020.49
127_E250_A1.1870.48
62_E238_V1.1840.48
18_L25_R1.1820.47
119_E142_S1.1820.47
156_D205_E1.1810.47
88_I154_A1.1690.47
150_I240_L1.1650.46
131_Y134_S1.1570.46
120_L126_E1.1550.46
235_P257_F1.1460.45
119_E197_E1.1310.44
162_Q201_V1.1280.44
211_D228_A1.1260.44
189_H250_A1.1240.44
168_I256_V1.1150.44
167_F210_I1.1130.43
23_D26_N1.1090.43
64_K229_P1.1080.43
143_Y154_A1.1080.43
181_R258_Q1.0960.42
83_D87_Q1.0910.42
73_I116_I1.0900.42
154_A193_F1.0890.42
112_R143_Y1.0890.42
189_H227_L1.0780.41
170_T178_K1.0780.41
130_F135_F1.0720.41
116_I120_L1.0700.41
170_T267_H1.0620.40
242_T246_E1.0600.40
250_A256_V1.0520.40
138_F163_E1.0460.40
254_Q263_M1.0350.39
170_T241_Y1.0300.39
32_E36_K1.0290.39
134_S166_N1.0250.38
178_K228_A1.0210.38
60_F69_M1.0100.38
120_L174_Y1.0070.37
91_L256_V1.0070.37
134_S159_K1.0040.37
87_Q151_T0.9960.37
20_Q24_D0.9920.37
73_I151_T0.9920.37
103_L156_D0.9870.36
44_P82_Q0.9820.36
229_P259_E0.9770.36
160_M271_D0.9710.35
139_R252_T0.9550.35
135_F152_E0.9440.34
134_S178_K0.9390.34
125_L236_D0.9380.34
175_V250_A0.9350.33
67_E168_I0.9330.33
253_I260_R0.9330.33
67_E142_S0.9240.33
65_E193_F0.9230.33
83_D127_E0.9220.33
124_C250_A0.9220.33
17_H24_D0.9210.33
161_E207_M0.9180.33
88_I259_E0.9170.33
255_N258_Q0.9160.32
132_I186_H0.9150.32
180_P215_V0.9090.32
130_F260_R0.9090.32
112_R215_V0.8980.32
180_P238_V0.8980.32
189_H242_T0.8940.31
92_A238_V0.8930.31
224_S241_Y0.8910.31
198_L260_R0.8900.31
132_I159_K0.8890.31
24_D28_I0.8860.31
151_T268_A0.8860.31
64_K256_V0.8840.31
17_H21_H0.8830.31
249_M256_V0.8810.31
223_D249_M0.8790.31
30_V35_R0.8790.31
232_S248_M0.8760.30
248_M253_I0.8760.30
81_D161_E0.8760.30
147_L236_D0.8730.30
80_T137_T0.8720.30
96_I198_L0.8580.30
228_A249_M0.8570.29
160_M248_M0.8490.29
140_L143_Y0.8470.29
222_I226_L0.8440.29
120_L240_L0.8420.29
180_P256_V0.8410.29
184_K237_E0.8300.28
165_Q259_E0.8290.28
223_D228_A0.8280.28
156_D209_Y0.8220.28
134_S267_H0.8190.28
185_V194_T0.8160.27
162_Q224_S0.8140.27
117_L148_R0.8100.27
64_K67_E0.8080.27
135_F226_L0.8040.27
29_I35_R0.8000.27
134_S270_T0.7960.27
56_L130_F0.7950.26
57_V65_E0.7940.26
219_P231_I0.7940.26
239_V264_L0.7920.26
51_F137_T0.7890.26
72_L79_F0.7890.26
37_I126_E0.7870.26
123_I172_R0.7810.26
68_H143_Y0.7780.26
38_G194_T0.7760.26
219_P258_Q0.7750.26
99_E118_D0.7750.26
16_L168_I0.7740.26
61_L94_S0.7740.26
250_A271_D0.7720.25
52_M92_A0.7700.25
245_P248_M0.7700.25
116_I140_L0.7690.25
123_I256_V0.7680.25
249_M260_R0.7670.25
170_T270_T0.7670.25
57_V111_S0.7610.25
166_N171_L0.7570.25
224_S264_L0.7560.25
173_D224_S0.7540.25
145_K262_E0.7540.25
77_Y93_H0.7530.25
82_Q180_P0.7500.24
67_E182_I0.7480.24
88_I222_I0.7470.24
124_C234_A0.7430.24
123_I134_S0.7390.24
79_F111_S0.7380.24
15_F26_N0.7360.24
68_H132_I0.7340.24
48_I250_A0.7320.24
173_D179_Q0.7310.24
203_E220_M0.7300.24
21_H27_N0.7290.24
161_E256_V0.7290.24
84_E201_V0.7290.24
168_I212_R0.7220.23
136_Q140_L0.7220.23
182_I198_L0.7210.23
100_A195_L0.7180.23
27_N184_K0.7130.23
163_E180_P0.7120.23
94_S118_D0.7110.23
189_H193_F0.7080.23
70_L160_M0.7030.22
170_T175_V0.7020.22
184_K198_L0.7000.22
91_L156_D0.7000.22
136_Q204_R0.6980.22
17_H23_D0.6970.22
61_L132_I0.6930.22
22_S26_N0.6860.22
78_C155_I0.6810.22
208_K225_H0.6800.22
20_Q27_N0.6740.21
170_T228_A0.6730.21
74_E104_P0.6660.21
88_I147_L0.6650.21
28_I261_V0.6600.21
62_E126_E0.6590.21
18_L23_D0.6550.21
71_S180_P0.6550.21
16_L30_V0.6510.20
19_I72_L0.6490.20
93_H222_I0.6480.20
101_D184_K0.6480.20
53_E241_Y0.6460.20
64_K249_M0.6420.20
15_F23_D0.6400.20
158_Y162_Q0.6390.20
96_I120_L0.6380.20
185_V197_E0.6370.20
32_E35_R0.6370.20
164_Y175_V0.6350.20
16_L20_Q0.6320.20
163_E176_D0.6300.20
171_L223_D0.6300.20
60_F87_Q0.6290.20
54_P120_L0.6290.20
68_H195_L0.6290.20
241_Y255_N0.6280.20
73_I85_Q0.6280.20
87_Q232_S0.6200.19
242_T263_M0.6190.19
49_Q234_A0.6190.19
235_P238_V0.6150.19
178_K267_H0.6140.19
170_T256_V0.6110.19
86_Q157_E0.6060.19
39_I119_E0.6040.19
119_E227_L0.5970.18
164_Y253_I0.5960.18
157_E265_P0.5960.18
48_I185_V0.5960.18
216_R220_M0.5950.18
92_A220_M0.5940.18
28_I31_R0.5930.18
60_F204_R0.5930.18
161_E253_I0.5910.18
119_E225_H0.5900.18
55_I181_R0.5860.18
159_K228_A0.5850.18
166_N264_L0.5840.18
87_Q130_F0.5840.18
20_Q30_V0.5840.18
70_L79_F0.5840.18
72_L156_D0.5820.18
148_R151_T0.5820.18
20_Q23_D0.5800.18
81_D229_P0.5800.18
118_D223_D0.5790.18
24_D30_V0.5780.18
88_I165_Q0.5770.18
34_I37_I0.5760.18
132_I241_Y0.5760.18
26_N29_I0.5750.18
81_D130_F0.5730.18
90_Q244_Q0.5730.18
233_I265_P0.5720.18
95_I256_V0.5680.17
162_Q232_S0.5670.17
138_F171_L0.5670.17
187_I229_P0.5660.17
230_L238_V0.5650.17
17_H26_N0.5640.17
73_I220_M0.5640.17
140_L233_I0.5620.17
101_D198_L0.5610.17
166_N241_Y0.5600.17
141_G153_A0.5600.17
56_L89_L0.5590.17
171_L261_V0.5590.17
44_P148_R0.5580.17
46_F114_Q0.5560.17
200_Y247_H0.5560.17
51_F54_P0.5550.17
173_D219_P0.5530.17
85_Q199_R0.5520.17
139_R163_E0.5500.17
175_V220_M0.5470.17
71_S118_D0.5470.17
177_A232_S0.5450.17
142_S204_R0.5430.17
175_V246_E0.5430.17
159_K241_Y0.5410.16
116_I122_T0.5390.16
57_V227_L0.5380.16
166_N178_K0.5370.16
226_L249_M0.5370.16
116_I162_Q0.5360.16
173_D177_A0.5320.16
50_R117_L0.5320.16
209_Y258_Q0.5290.16
226_L229_P0.5260.16
235_P252_T0.5250.16
155_I159_K0.5240.16
192_S203_E0.5240.16
139_R167_F0.5230.16
206_K229_P0.5230.16
229_P241_Y0.5220.16
78_C84_E0.5210.16
203_E209_Y0.5200.16
225_H228_A0.5200.16
72_L187_I0.5160.16
134_S229_P0.5160.16
143_Y175_V0.5150.16
169_Q240_L0.5140.16
167_F224_S0.5140.16
130_F239_V0.5130.16
174_Y181_R0.5130.16
102_D151_T0.5130.16
42_A127_E0.5110.16
45_A141_G0.5110.16
78_C152_E0.5100.15
180_P236_D0.5080.15
44_P48_I0.5060.15
99_E252_T0.5050.15
25_R30_V0.5030.15
162_Q248_M0.5030.15
151_T180_P0.5020.15
61_L220_M0.5020.15
15_F38_G0.5020.15
219_P251_R0.5010.15
138_F235_P0.5010.15
145_K196_W0.5010.15
134_S139_R0.5000.15
159_K227_L0.5000.15
66_D69_M0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qc6A 2 0.0961 10.2 0.966 Contact Map
1q80A 1 0.5231 7 0.969 Contact Map
2d74B 1 0.3701 6.8 0.969 Contact Map
3zywA 1 0.1317 6.5 0.969 Contact Map
2dprA 3 0.0747 5 0.971 Contact Map
2w8tA 2 0.2206 4.9 0.971 Contact Map
2adlA 2 0.2313 4.6 0.971 Contact Map
2gqcA 1 0.2384 4.5 0.971 Contact Map
3u3gD 1 0.3345 4.4 0.971 Contact Map
4peoA 2 0.3096 4.3 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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