YTXC - BACSU - GREMLIN Contacts

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YTXC - Uncharacterized protein YtxC

UniProt:	P06569	Sequences: MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANPAFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADDLPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKMEQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDHPMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPVKHSEG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	281 (256)
Sequences:	306 (269)
Seq/√Len:	16.8

BACSU - YTXC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_E	112_R	5.720	1.00
267_H	270_T	5.388	1.00
264_L	267_H	4.907	1.00
264_L	270_T	4.777	1.00
241_Y	267_H	4.236	1.00
65_E	143_Y	4.042	1.00
253_I	261_V	3.826	1.00
241_Y	264_L	3.684	1.00
241_Y	270_T	3.457	1.00
238_V	261_V	2.914	0.98
155_I	158_Y	2.434	0.95
241_Y	266_L	2.247	0.92
174_Y	178_K	2.203	0.91
240_L	261_V	2.076	0.88
163_E	256_V	2.069	0.88
19_I	26_N	2.035	0.87
226_L	250_A	2.028	0.87
60_F	120_L	2.025	0.87
183_K	198_L	2.018	0.87
98_G	161_E	1.969	0.85
220_M	227_L	1.940	0.85
69_M	92_A	1.889	0.83
92_A	226_L	1.881	0.83
223_D	255_N	1.876	0.82
58_K	116_I	1.833	0.81
33_G	36_K	1.825	0.81
174_Y	228_A	1.804	0.80
252_T	260_R	1.801	0.80
79_F	155_I	1.742	0.77
181_R	256_V	1.731	0.77
231_I	256_V	1.681	0.75
134_S	224_S	1.644	0.73
173_D	228_A	1.644	0.73
52_M	95_I	1.632	0.72
92_A	154_A	1.630	0.72
266_L	270_T	1.608	0.71
171_L	252_T	1.600	0.71
143_Y	147_L	1.597	0.71
224_S	270_T	1.591	0.70
84_E	259_E	1.549	0.68
17_H	31_R	1.549	0.68
219_P	224_S	1.544	0.68
56_L	186_H	1.534	0.68
200_Y	256_V	1.504	0.66
188_V	196_W	1.488	0.65
224_S	228_A	1.488	0.65
134_S	167_F	1.486	0.65
192_S	256_V	1.479	0.65
77_Y	152_E	1.474	0.64
240_L	250_A	1.473	0.64
113_K	168_I	1.472	0.64
138_F	252_T	1.461	0.64
173_D	232_S	1.455	0.63
173_D	178_K	1.427	0.62
139_R	230_L	1.419	0.61
47_P	133_R	1.411	0.61
238_V	252_T	1.404	0.61
237_E	262_E	1.396	0.60
77_Y	84_E	1.395	0.60
187_I	226_L	1.395	0.60
77_Y	128_G	1.378	0.59
179_Q	240_L	1.361	0.58
56_L	120_L	1.354	0.58
167_F	171_L	1.348	0.57
53_E	121_Q	1.339	0.57
166_N	270_T	1.323	0.56
134_S	170_T	1.313	0.55
143_Y	180_P	1.312	0.55
58_K	113_K	1.311	0.55
88_I	215_V	1.308	0.55
157_E	219_P	1.308	0.55
167_F	170_T	1.308	0.55
134_S	228_A	1.306	0.55
167_F	230_L	1.299	0.54
189_H	245_P	1.295	0.54
166_N	224_S	1.285	0.54
134_S	241_Y	1.279	0.53
179_Q	261_V	1.268	0.53
156_D	160_M	1.265	0.52
152_E	259_E	1.265	0.52
172_R	259_E	1.249	0.51
224_S	267_H	1.225	0.50
256_V	263_M	1.219	0.50
138_F	230_L	1.218	0.50
117_L	231_I	1.212	0.49
53_E	231_I	1.202	0.49
166_N	170_T	1.202	0.49
127_E	250_A	1.187	0.48
62_E	238_V	1.184	0.48
18_L	25_R	1.182	0.47
119_E	142_S	1.182	0.47
156_D	205_E	1.181	0.47
88_I	154_A	1.169	0.47
150_I	240_L	1.165	0.46
131_Y	134_S	1.157	0.46
120_L	126_E	1.155	0.46
235_P	257_F	1.146	0.45
119_E	197_E	1.131	0.44
162_Q	201_V	1.128	0.44
211_D	228_A	1.126	0.44
189_H	250_A	1.124	0.44
168_I	256_V	1.115	0.44
167_F	210_I	1.113	0.43
23_D	26_N	1.109	0.43
64_K	229_P	1.108	0.43
143_Y	154_A	1.108	0.43
181_R	258_Q	1.096	0.42
83_D	87_Q	1.091	0.42
73_I	116_I	1.090	0.42
154_A	193_F	1.089	0.42
112_R	143_Y	1.089	0.42
189_H	227_L	1.078	0.41
170_T	178_K	1.078	0.41
130_F	135_F	1.072	0.41
116_I	120_L	1.070	0.41
170_T	267_H	1.062	0.40
242_T	246_E	1.060	0.40
250_A	256_V	1.052	0.40
138_F	163_E	1.046	0.40
254_Q	263_M	1.035	0.39
170_T	241_Y	1.030	0.39
32_E	36_K	1.029	0.39
134_S	166_N	1.025	0.38
178_K	228_A	1.021	0.38
60_F	69_M	1.010	0.38
120_L	174_Y	1.007	0.37
91_L	256_V	1.007	0.37
134_S	159_K	1.004	0.37
87_Q	151_T	0.996	0.37
20_Q	24_D	0.992	0.37
73_I	151_T	0.992	0.37
103_L	156_D	0.987	0.36
44_P	82_Q	0.982	0.36
229_P	259_E	0.977	0.36
160_M	271_D	0.971	0.35
139_R	252_T	0.955	0.35
135_F	152_E	0.944	0.34
134_S	178_K	0.939	0.34
125_L	236_D	0.938	0.34
175_V	250_A	0.935	0.33
67_E	168_I	0.933	0.33
253_I	260_R	0.933	0.33
67_E	142_S	0.924	0.33
65_E	193_F	0.923	0.33
83_D	127_E	0.922	0.33
124_C	250_A	0.922	0.33
17_H	24_D	0.921	0.33
161_E	207_M	0.918	0.33
88_I	259_E	0.917	0.33
255_N	258_Q	0.916	0.32
132_I	186_H	0.915	0.32
180_P	215_V	0.909	0.32
130_F	260_R	0.909	0.32
112_R	215_V	0.898	0.32
180_P	238_V	0.898	0.32
189_H	242_T	0.894	0.31
92_A	238_V	0.893	0.31
224_S	241_Y	0.891	0.31
198_L	260_R	0.890	0.31
132_I	159_K	0.889	0.31
24_D	28_I	0.886	0.31
151_T	268_A	0.886	0.31
64_K	256_V	0.884	0.31
17_H	21_H	0.883	0.31
249_M	256_V	0.881	0.31
223_D	249_M	0.879	0.31
30_V	35_R	0.879	0.31
232_S	248_M	0.876	0.30
248_M	253_I	0.876	0.30
81_D	161_E	0.876	0.30
147_L	236_D	0.873	0.30
80_T	137_T	0.872	0.30
96_I	198_L	0.858	0.30
228_A	249_M	0.857	0.29
160_M	248_M	0.849	0.29
140_L	143_Y	0.847	0.29
222_I	226_L	0.844	0.29
120_L	240_L	0.842	0.29
180_P	256_V	0.841	0.29
184_K	237_E	0.830	0.28
165_Q	259_E	0.829	0.28
223_D	228_A	0.828	0.28
156_D	209_Y	0.822	0.28
134_S	267_H	0.819	0.28
185_V	194_T	0.816	0.27
162_Q	224_S	0.814	0.27
117_L	148_R	0.810	0.27
64_K	67_E	0.808	0.27
135_F	226_L	0.804	0.27
29_I	35_R	0.800	0.27
134_S	270_T	0.796	0.27
56_L	130_F	0.795	0.26
57_V	65_E	0.794	0.26
219_P	231_I	0.794	0.26
239_V	264_L	0.792	0.26
51_F	137_T	0.789	0.26
72_L	79_F	0.789	0.26
37_I	126_E	0.787	0.26
123_I	172_R	0.781	0.26
68_H	143_Y	0.778	0.26
38_G	194_T	0.776	0.26
219_P	258_Q	0.775	0.26
99_E	118_D	0.775	0.26
16_L	168_I	0.774	0.26
61_L	94_S	0.774	0.26
250_A	271_D	0.772	0.25
52_M	92_A	0.770	0.25
245_P	248_M	0.770	0.25
116_I	140_L	0.769	0.25
123_I	256_V	0.768	0.25
249_M	260_R	0.767	0.25
170_T	270_T	0.767	0.25
57_V	111_S	0.761	0.25
166_N	171_L	0.757	0.25
224_S	264_L	0.756	0.25
173_D	224_S	0.754	0.25
145_K	262_E	0.754	0.25
77_Y	93_H	0.753	0.25
82_Q	180_P	0.750	0.24
67_E	182_I	0.748	0.24
88_I	222_I	0.747	0.24
124_C	234_A	0.743	0.24
123_I	134_S	0.739	0.24
79_F	111_S	0.738	0.24
15_F	26_N	0.736	0.24
68_H	132_I	0.734	0.24
48_I	250_A	0.732	0.24
173_D	179_Q	0.731	0.24
203_E	220_M	0.730	0.24
21_H	27_N	0.729	0.24
161_E	256_V	0.729	0.24
84_E	201_V	0.729	0.24
168_I	212_R	0.722	0.23
136_Q	140_L	0.722	0.23
182_I	198_L	0.721	0.23
100_A	195_L	0.718	0.23
27_N	184_K	0.713	0.23
163_E	180_P	0.712	0.23
94_S	118_D	0.711	0.23
189_H	193_F	0.708	0.23
70_L	160_M	0.703	0.22
170_T	175_V	0.702	0.22
184_K	198_L	0.700	0.22
91_L	156_D	0.700	0.22
136_Q	204_R	0.698	0.22
17_H	23_D	0.697	0.22
61_L	132_I	0.693	0.22
22_S	26_N	0.686	0.22
78_C	155_I	0.681	0.22
208_K	225_H	0.680	0.22
20_Q	27_N	0.674	0.21
170_T	228_A	0.673	0.21
74_E	104_P	0.666	0.21
88_I	147_L	0.665	0.21
28_I	261_V	0.660	0.21
62_E	126_E	0.659	0.21
18_L	23_D	0.655	0.21
71_S	180_P	0.655	0.21
16_L	30_V	0.651	0.20
19_I	72_L	0.649	0.20
93_H	222_I	0.648	0.20
101_D	184_K	0.648	0.20
53_E	241_Y	0.646	0.20
64_K	249_M	0.642	0.20
15_F	23_D	0.640	0.20
158_Y	162_Q	0.639	0.20
96_I	120_L	0.638	0.20
185_V	197_E	0.637	0.20
32_E	35_R	0.637	0.20
164_Y	175_V	0.635	0.20
16_L	20_Q	0.632	0.20
163_E	176_D	0.630	0.20
171_L	223_D	0.630	0.20
60_F	87_Q	0.629	0.20
54_P	120_L	0.629	0.20
68_H	195_L	0.629	0.20
241_Y	255_N	0.628	0.20
73_I	85_Q	0.628	0.20
87_Q	232_S	0.620	0.19
242_T	263_M	0.619	0.19
49_Q	234_A	0.619	0.19
235_P	238_V	0.615	0.19
178_K	267_H	0.614	0.19
170_T	256_V	0.611	0.19
86_Q	157_E	0.606	0.19
39_I	119_E	0.604	0.19
119_E	227_L	0.597	0.18
164_Y	253_I	0.596	0.18
157_E	265_P	0.596	0.18
48_I	185_V	0.596	0.18
216_R	220_M	0.595	0.18
92_A	220_M	0.594	0.18
28_I	31_R	0.593	0.18
60_F	204_R	0.593	0.18
161_E	253_I	0.591	0.18
119_E	225_H	0.590	0.18
55_I	181_R	0.586	0.18
159_K	228_A	0.585	0.18
166_N	264_L	0.584	0.18
87_Q	130_F	0.584	0.18
20_Q	30_V	0.584	0.18
70_L	79_F	0.584	0.18
72_L	156_D	0.582	0.18
148_R	151_T	0.582	0.18
20_Q	23_D	0.580	0.18
81_D	229_P	0.580	0.18
118_D	223_D	0.579	0.18
24_D	30_V	0.578	0.18
88_I	165_Q	0.577	0.18
34_I	37_I	0.576	0.18
132_I	241_Y	0.576	0.18
26_N	29_I	0.575	0.18
81_D	130_F	0.573	0.18
90_Q	244_Q	0.573	0.18
233_I	265_P	0.572	0.18
95_I	256_V	0.568	0.17
162_Q	232_S	0.567	0.17
138_F	171_L	0.567	0.17
187_I	229_P	0.566	0.17
230_L	238_V	0.565	0.17
17_H	26_N	0.564	0.17
73_I	220_M	0.564	0.17
140_L	233_I	0.562	0.17
101_D	198_L	0.561	0.17
166_N	241_Y	0.560	0.17
141_G	153_A	0.560	0.17
56_L	89_L	0.559	0.17
171_L	261_V	0.559	0.17
44_P	148_R	0.558	0.17
46_F	114_Q	0.556	0.17
200_Y	247_H	0.556	0.17
51_F	54_P	0.555	0.17
173_D	219_P	0.553	0.17
85_Q	199_R	0.552	0.17
139_R	163_E	0.550	0.17
175_V	220_M	0.547	0.17
71_S	118_D	0.547	0.17
177_A	232_S	0.545	0.17
142_S	204_R	0.543	0.17
175_V	246_E	0.543	0.17
159_K	241_Y	0.541	0.16
116_I	122_T	0.539	0.16
57_V	227_L	0.538	0.16
166_N	178_K	0.537	0.16
226_L	249_M	0.537	0.16
116_I	162_Q	0.536	0.16
173_D	177_A	0.532	0.16
50_R	117_L	0.532	0.16
209_Y	258_Q	0.529	0.16
226_L	229_P	0.526	0.16
235_P	252_T	0.525	0.16
155_I	159_K	0.524	0.16
192_S	203_E	0.524	0.16
139_R	167_F	0.523	0.16
206_K	229_P	0.523	0.16
229_P	241_Y	0.522	0.16
78_C	84_E	0.521	0.16
203_E	209_Y	0.520	0.16
225_H	228_A	0.520	0.16
72_L	187_I	0.516	0.16
134_S	229_P	0.516	0.16
143_Y	175_V	0.515	0.16
169_Q	240_L	0.514	0.16
167_F	224_S	0.514	0.16
130_F	239_V	0.513	0.16
174_Y	181_R	0.513	0.16
102_D	151_T	0.513	0.16
42_A	127_E	0.511	0.16
45_A	141_G	0.511	0.16
78_C	152_E	0.510	0.15
180_P	236_D	0.508	0.15
44_P	48_I	0.506	0.15
99_E	252_T	0.505	0.15
25_R	30_V	0.503	0.15
162_Q	248_M	0.503	0.15
151_T	180_P	0.502	0.15
61_L	220_M	0.502	0.15
15_F	38_G	0.502	0.15
219_P	251_R	0.501	0.15
138_F	235_P	0.501	0.15
145_K	196_W	0.501	0.15
134_S	139_R	0.500	0.15
159_K	227_L	0.500	0.15
66_D	69_M	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qc6A	2	0.0961	10.2	0.966	Contact Map
1q80A	1	0.5231	7	0.969	Contact Map
2d74B	1	0.3701	6.8	0.969	Contact Map
3zywA	1	0.1317	6.5	0.969	Contact Map
2dprA	3	0.0747	5	0.971	Contact Map
2w8tA	2	0.2206	4.9	0.971	Contact Map
2adlA	2	0.2313	4.6	0.971	Contact Map
2gqcA	1	0.2384	4.5	0.971	Contact Map
3u3gD	1	0.3345	4.4	0.971	Contact Map
4peoA	2	0.3096	4.3	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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