GREMLIN Database
YTXB - TVP38/TMEM64 family membrane protein YtxB
UniProt: P06568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (175)
Sequences: 8961 (6629)
Seq/√Len: 501.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_A151_A4.0681.00
200_I204_K2.8781.00
150_K153_P2.7941.00
80_T167_I2.7691.00
198_P202_R2.4721.00
75_G78_L2.4171.00
103_A116_Q2.3821.00
88_M159_A2.3661.00
92_A155_F2.3651.00
124_F153_P2.1981.00
124_F157_A2.1701.00
128_F160_V2.1001.00
196_S200_I2.0871.00
49_F70_G2.0491.00
75_G79_G1.9621.00
54_I93_V1.9401.00
84_L163_I1.9161.00
122_N125_F1.8801.00
113_E117_K1.8481.00
50_I82_Y1.7841.00
116_Q120_E1.7611.00
71_G173_G1.7541.00
76_P80_T1.7301.00
96_F100_L1.6661.00
83_T166_T1.6181.00
151_A155_F1.6031.00
80_T170_N1.5781.00
38_V45_A1.5761.00
99_G148_N1.5671.00
195_I198_P1.5411.00
98_A146_L1.5381.00
201_F205_M1.5231.00
88_M155_F1.4941.00
50_I86_G1.4821.00
102_S105_K1.4731.00
50_I85_F1.4671.00
199_F203_K1.4671.00
171_V175_S1.4511.00
76_P171_V1.4191.00
54_I89_C1.3971.00
188_L192_I1.3761.00
182_P186_M1.3761.00
70_G79_G1.3661.00
46_P82_Y1.3541.00
96_F151_A1.3491.00
98_A145_G1.3441.00
78_L81_L1.3421.00
105_K109_Y1.3371.00
79_G170_N1.3351.00
152_L156_A1.3291.00
182_P185_F1.3291.00
35_R39_L1.3281.00
78_L82_Y1.3161.00
195_I199_F1.3091.00
91_S158_T1.2961.00
127_I157_A1.2951.00
111_R114_A1.2891.00
36_V39_L1.2631.00
84_L159_A1.2531.00
77_L80_T1.2501.00
92_A96_F1.2381.00
49_F83_T1.2251.00
186_M190_L1.2221.00
131_R158_T1.2041.00
202_R206_Q1.2021.00
71_G170_N1.1891.00
203_K207_N1.1801.00
164_P167_I1.1751.00
53_S56_R1.1691.00
67_S83_T1.1661.00
187_V202_R1.1571.00
113_E116_Q1.1541.00
45_A74_F1.1531.00
83_T170_N1.1471.00
185_F189_A1.1321.00
80_T84_L1.1301.00
103_A107_G1.1141.00
158_T162_I1.1101.00
77_L81_L1.1081.00
116_Q148_N1.1051.00
201_F204_K1.1041.00
50_I54_I1.1001.00
100_L104_K1.0731.00
53_S57_P1.0701.00
183_A186_M1.0581.00
189_A193_V1.0551.00
67_S170_N1.0521.00
194_F198_P1.0451.00
204_K207_N1.0421.00
36_V40_S1.0351.00
80_T171_V1.0311.00
187_V191_Y1.0241.00
190_L194_F1.0201.00
132_I164_P1.0191.00
155_F159_A1.0021.00
105_K108_H0.9861.00
152_L155_F0.9811.00
125_F129_L0.9791.00
110_E114_A0.9741.00
166_T170_N0.9721.00
53_S67_S0.9691.00
117_K121_D0.9641.00
37_W41_F0.9641.00
74_F79_G0.9621.00
124_F156_A0.9611.00
127_I149_V0.9611.00
141_S158_T0.9541.00
70_G83_T0.9531.00
130_L140_V0.9501.00
153_P157_A0.9481.00
116_Q147_S0.9441.00
82_Y86_G0.9391.00
69_A73_A0.9331.00
70_G74_F0.9301.00
183_A187_V0.9301.00
87_S162_I0.9241.00
160_V163_I0.9231.00
81_L85_F0.9111.00
84_L166_T0.9101.00
56_R138_D0.9101.00
137_F162_I0.9041.00
84_L88_M0.9041.00
53_S66_I0.9041.00
94_S142_Y0.9031.00
192_I196_S0.8911.00
187_V190_L0.8911.00
119_M144_A0.8901.00
118_Q126_Y0.8851.00
128_F157_A0.8841.00
137_F165_G0.8801.00
76_P170_N0.8791.00
46_P78_L0.8701.00
67_S71_G0.8661.00
103_A106_N0.8631.00
91_S141_S0.8601.00
91_S151_A0.8551.00
95_F154_Y0.8501.00
50_I89_C0.8481.00
43_V47_L0.8441.00
69_A72_L0.8401.00
44_F48_M0.8281.00
56_R90_A0.8251.00
77_L171_V0.8181.00
81_L84_L0.8101.00
131_R141_S0.8011.00
124_F128_F0.7971.00
106_N109_Y0.7941.00
199_F202_R0.7881.00
41_F48_M0.7851.00
94_S138_D0.7841.00
198_P203_K0.7841.00
186_M189_A0.7821.00
157_A161_G0.7801.00
184_F187_V0.7771.00
190_L205_M0.7761.00
33_E37_W0.7671.00
47_L51_G0.7671.00
198_P205_M0.7661.00
64_S169_L0.7631.00
119_M123_G0.7561.00
129_L133_L0.7541.00
61_F138_D0.7531.00
33_E36_V0.7521.00
153_P156_A0.7491.00
128_F161_G0.7441.00
167_I171_V0.7391.00
202_R205_M0.7371.00
197_L201_F0.7361.00
88_M162_I0.7341.00
203_K206_Q0.7311.00
196_S199_F0.7311.00
95_F99_G0.7241.00
89_C93_V0.7201.00
114_A117_K0.7181.00
176_F179_G0.7111.00
168_A172_L0.7091.00
96_F99_G0.7061.00
91_S131_R0.6991.00
117_K120_E0.6911.00
46_P75_G0.6841.00
67_S166_T0.6791.00
140_V144_A0.6771.00
156_A160_V0.6671.00
185_F192_I0.6631.00
95_F151_A0.6621.00
64_S137_F0.6601.00
133_L136_N0.6601.00
118_Q121_D0.6561.00
138_D141_S0.6511.00
141_S145_G0.6511.00
107_G113_E0.6431.00
76_P167_I0.6421.00
184_F195_I0.6401.00
191_Y195_I0.6381.00
130_L144_A0.6341.00
97_A101_F0.6331.00
60_L138_D0.6321.00
127_I144_A0.6311.00
42_G45_A0.6301.00
162_I165_G0.6281.00
128_F164_P0.6281.00
198_P204_K0.6251.00
67_S87_S0.6141.00
84_L162_I0.6100.99
202_R207_N0.6090.99
56_R63_V0.6060.99
192_I195_I0.6020.99
58_L94_S0.5990.99
172_L175_S0.5930.99
88_M158_T0.5930.99
91_S154_Y0.5900.99
53_S86_G0.5880.99
90_A94_S0.5870.99
126_Y140_V0.5850.99
56_R66_I0.5820.99
72_L180_N0.5800.99
63_V165_G0.5790.99
82_Y85_F0.5770.99
95_F147_S0.5750.99
112_L116_Q0.5720.99
128_F132_I0.5720.99
103_A148_N0.5680.99
115_I136_N0.5660.99
160_V164_P0.5660.99
56_R61_F0.5650.99
54_I57_P0.5630.99
176_F180_N0.5630.99
46_P50_I0.5620.99
190_L198_P0.5600.99
71_G79_G0.5590.99
175_S179_G0.5560.99
98_A142_Y0.5560.99
163_I167_I0.5550.99
187_V195_I0.5530.99
46_P86_G0.5500.99
59_V94_S0.5500.99
106_N112_L0.5460.99
88_M163_I0.5450.99
101_F104_K0.5450.99
54_I86_G0.5440.99
126_Y130_L0.5420.99
195_I202_R0.5400.99
200_I203_K0.5390.99
165_G169_L0.5350.99
44_F47_L0.5340.99
107_G116_Q0.5320.99
80_T163_I0.5310.99
198_P201_F0.5280.99
141_S147_S0.5260.99
104_K108_H0.5250.99
189_A192_I0.5240.98
37_W45_A0.5220.98
55_V58_L0.5210.98
110_E113_E0.5190.98
61_F66_I0.5180.98
102_S145_G0.5130.98
87_S131_R0.5120.98
85_F88_M0.5100.98
174_A177_L0.5090.98
187_V194_F0.5030.98
107_G112_L0.5030.98
119_M126_Y0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlbA 1 0.7042 68.2 0.905 Contact Map
4huqS 1 0.7183 38.5 0.92 Contact Map
2xq2A 2 0.7793 36 0.922 Contact Map
3qnqA 2 0.9437 26.6 0.927 Contact Map
4tkrA 2 0.7512 22.4 0.929 Contact Map
3w9iA 3 0.8592 21.6 0.93 Contact Map
2a65A 2 0.8075 17.5 0.933 Contact Map
4mt1A 3 0.8451 15.3 0.935 Contact Map
4z7fA 2 0.7277 14.4 0.935 Contact Map
2rddB 1 0.1502 14.4 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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