GREMLIN Database
DNAI - Primosomal protein DnaI
UniProt: P06567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (259)
Sequences: 1689 (1387)
Seq/√Len: 86.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_E187_E5.0431.00
148_V181_I4.3011.00
41_N44_V3.5661.00
176_F180_A3.2631.00
292_E307_N3.2251.00
67_C70_C3.1011.00
147_H299_A3.0761.00
178_L262_S3.0651.00
266_S269_E2.8081.00
201_V240_V2.7421.00
193_M223_T2.6421.00
178_L227_M2.6361.00
182_A227_M2.6011.00
190_Y224_P2.5091.00
145_F149_T2.4821.00
197_V228_L2.3901.00
178_L260_F2.3841.00
111_K114_Q2.3741.00
246_G250_Q2.3411.00
224_P257_L2.3291.00
149_T153_K2.1871.00
110_Q114_Q2.0311.00
131_F152_L1.9781.00
47_Q51_E1.9721.00
182_A192_S1.9701.00
183_N187_E1.9191.00
151_F155_Y1.9151.00
89_V102_P1.8941.00
165_Y263_S1.8911.00
170_F292_E1.8731.00
181_I260_F1.8681.00
150_D154_S1.8671.00
200_F220_V1.8491.00
87_L90_N1.8451.00
147_H301_I1.8121.00
231_I261_F1.8031.00
131_F180_A1.7961.00
75_N79_L1.7801.00
152_L184_E1.7591.00
144_M177_M1.7481.00
152_L185_L1.7371.00
227_M262_S1.6951.00
126_L129_A1.6691.00
192_S227_M1.6141.00
134_V177_M1.5751.00
104_K108_D1.5441.00
110_Q113_Q1.5371.00
166_L303_L1.5351.00
139_P142_L1.5261.00
129_A179_A1.5041.00
167_Y302_R1.4970.99
205_K237_T1.4820.99
197_V204_L1.4810.99
214_E218_N1.4700.99
151_F164_L1.4620.99
73_D76_C1.4600.99
162_K299_A1.4520.99
167_Y300_P1.4350.99
204_L211_Q1.4220.99
172_V303_L1.4210.99
101_C105_R1.4160.99
133_Q176_F1.4010.99
97_E100_E1.3920.99
151_F258_P1.3890.99
131_F134_V1.3880.99
171_G293_R1.3810.99
232_G264_N1.3740.99
184_E188_K1.3730.99
45_I49_M1.3470.99
107_L110_Q1.3450.99
116_L189_E1.3330.99
193_M219_M1.3260.99
271_K288_A1.3240.99
252_R259_T1.3140.99
196_Y246_G1.3100.99
212_T215_E1.3090.99
198_P233_A1.2990.99
267_P298_A1.2930.99
236_M273_H1.2920.99
72_E82_G1.2920.99
185_L225_V1.2850.98
264_N293_R1.2830.98
289_R293_R1.2820.98
141_R303_L1.2780.98
91_G94_I1.2710.98
217_L248_V1.2710.98
48_K51_E1.2640.98
48_K52_K1.2490.98
67_C71_S1.2340.98
75_N84_H1.2160.98
136_I145_F1.2140.98
34_V38_L1.2110.98
230_D289_R1.2070.98
90_N93_S1.2070.98
248_V252_R1.2030.98
181_I206_N1.1890.97
107_L111_K1.1850.97
148_V164_L1.1820.97
261_F298_A1.1630.97
78_N81_E1.1580.97
264_N289_R1.1570.97
191_S224_P1.1530.97
40_E46_D1.1510.97
259_T298_A1.1480.97
196_Y199_E1.1410.97
45_I89_V1.1330.97
126_L180_A1.1300.96
94_I103_V1.1160.96
34_V41_N1.1130.96
134_V145_F1.1110.96
51_E55_N1.0960.96
59_E67_C1.0960.96
198_P221_K1.0890.96
140_S180_A1.0880.96
197_V201_V1.0860.96
150_D153_K1.0770.95
233_A289_R1.0770.95
221_K243_E1.0720.95
92_R95_D1.0710.95
181_I227_M1.0600.95
129_A175_T1.0600.95
97_E101_C1.0600.95
37_F41_N1.0500.95
163_G297_L1.0490.95
194_I262_S1.0440.95
165_Y294_I1.0430.95
85_P96_I1.0390.94
228_L245_I1.0320.94
103_V107_L1.0280.94
101_C104_K1.0260.94
100_E105_R1.0230.94
289_R294_I1.0220.94
128_G256_Q1.0210.94
144_M148_V1.0120.94
58_Y62_E0.9920.93
141_R301_I0.9890.93
106_K109_Q0.9720.92
109_Q113_Q0.9690.92
46_D49_M0.9630.92
130_T187_E0.9620.92
85_P88_V0.9570.92
261_F294_I0.9530.91
97_E104_K0.9530.91
39_K42_E0.9520.91
291_M295_L0.9500.91
144_M301_I0.9440.91
198_P243_E0.9400.91
196_Y250_Q0.9350.91
90_N107_L0.9330.90
163_G258_P0.9310.90
42_E50_I0.9300.90
198_P247_T0.9220.90
139_P256_Q0.9190.90
260_F297_L0.9160.90
129_A134_V0.9140.90
206_N212_T0.9100.89
53_S56_K0.9100.89
236_M240_V0.9090.89
39_K43_E0.9070.89
185_L239_W0.8970.89
101_C107_L0.8950.89
265_F270_L0.8860.88
36_A40_E0.8850.88
101_C109_Q0.8830.88
218_N222_T0.8790.88
182_A262_S0.8770.88
116_L191_S0.8650.87
250_Q292_E0.8560.86
112_K116_L0.8480.86
65_K68_S0.8450.86
122_I194_I0.8430.85
36_A39_K0.8400.85
233_A264_N0.8370.85
122_I125_D0.8370.85
217_L221_K0.8370.85
169_K288_A0.8330.85
204_L208_L0.8310.85
130_T183_N0.8290.84
34_V69_Y0.8210.84
35_Q39_K0.8210.84
203_E216_K0.8170.84
201_V237_T0.8170.84
47_Q56_K0.8150.83
76_C82_G0.8130.83
79_L83_Y0.8080.83
100_E104_K0.8070.83
126_L179_A0.7940.82
221_K251_H0.7930.82
169_K304_D0.7910.82
76_C101_C0.7910.82
221_K248_V0.7880.81
80_L269_E0.7860.81
204_L217_L0.7860.81
57_L69_Y0.7840.81
154_S157_E0.7840.81
34_V67_C0.7790.81
169_K172_V0.7750.80
233_A242_D0.7650.79
197_V233_A0.7640.79
119_S122_I0.7640.79
56_K59_E0.7570.79
118_K122_I0.7570.79
196_Y245_I0.7560.79
268_D295_L0.7550.78
198_P242_D0.7520.78
108_D111_K0.7420.77
207_S213_L0.7410.77
156_N188_K0.7410.77
116_L186_A0.7400.77
72_E76_C0.7380.77
41_N45_I0.7380.77
125_D256_Q0.7360.77
134_V141_R0.7320.76
92_R107_L0.7290.76
81_E84_H0.7210.75
192_S224_P0.7210.75
169_K227_M0.7200.75
158_T161_G0.7170.75
193_M215_E0.7170.75
87_L94_I0.7160.75
85_P92_R0.7160.75
252_R258_P0.7130.74
172_V205_K0.7070.74
196_Y202_R0.7070.74
88_V91_G0.7050.74
116_L119_S0.7040.74
60_Y256_Q0.7020.73
221_K247_T0.7020.73
128_G133_Q0.6990.73
94_I101_C0.6980.73
144_M303_L0.6970.73
89_V96_I0.6970.73
202_R243_E0.6960.73
178_L225_V0.6960.73
59_E63_Q0.6950.73
70_C76_C0.6950.73
109_Q112_K0.6940.72
204_L220_V0.6910.72
232_G252_R0.6910.72
234_E264_N0.6900.72
237_T243_E0.6870.72
231_I245_I0.6870.72
104_K107_L0.6860.72
62_E65_K0.6820.71
193_M261_F0.6810.71
144_M164_L0.6780.71
251_H255_Q0.6770.71
121_Y175_T0.6760.70
35_Q40_E0.6750.70
151_F201_V0.6730.70
207_S216_K0.6710.70
197_V240_V0.6710.70
174_K229_D0.6710.70
165_Y270_L0.6680.70
134_V176_F0.6670.69
198_P252_R0.6640.69
85_P90_N0.6580.68
44_V132_Q0.6560.68
63_Q66_N0.6560.68
85_P98_Y0.6550.68
234_E274_F0.6540.68
170_F233_A0.6540.68
172_V305_G0.6520.68
225_V260_F0.6510.68
67_C103_V0.6490.67
147_H150_D0.6450.67
241_R273_H0.6440.67
100_E108_D0.6350.66
105_R109_Q0.6340.66
113_Q116_L0.6310.65
141_R144_M0.6290.65
198_P248_V0.6290.65
122_I126_L0.6270.65
90_N94_I0.6240.64
130_T180_A0.6240.64
268_D306_E0.6180.64
146_Q238_S0.6170.63
199_E203_E0.6170.63
196_Y247_T0.6150.63
170_F242_D0.6150.63
243_E247_T0.6140.63
113_Q117_M0.6140.63
143_A147_H0.6130.63
246_G267_P0.6130.63
59_E62_E0.6100.63
230_D233_A0.6090.62
85_P91_G0.6090.62
173_G230_D0.6070.62
194_I227_M0.6070.62
230_D293_R0.6070.62
50_I204_L0.6070.62
96_I99_Y0.6050.62
129_A133_Q0.6050.62
172_V290_L0.6050.62
208_L213_L0.6050.62
241_R290_L0.6040.62
185_L204_L0.6020.62
163_G252_R0.6010.61
144_M246_G0.5970.61
91_G95_D0.5970.61
232_G265_F0.5960.61
80_L83_Y0.5940.61
262_S274_F0.5940.61
90_N95_D0.5920.60
234_E239_W0.5920.60
223_T226_L0.5900.60
196_Y274_F0.5890.60
227_M260_F0.5880.60
237_T295_L0.5870.60
73_D77_N0.5860.60
202_R273_H0.5840.59
142_L150_D0.5830.59
60_Y64_S0.5820.59
47_Q111_K0.5800.59
54_L57_L0.5800.59
36_A157_E0.5790.59
114_Q121_Y0.5780.58
152_L155_Y0.5770.58
68_S218_N0.5760.58
99_Y102_P0.5760.58
125_D129_A0.5750.58
144_M299_A0.5750.58
71_S74_E0.5730.58
121_Y170_F0.5720.58
151_F161_G0.5720.58
62_E109_Q0.5700.57
250_Q254_S0.5680.57
157_E268_D0.5680.57
167_Y267_P0.5670.57
217_L288_A0.5660.57
158_T162_K0.5650.57
251_H254_S0.5650.57
269_E272_H0.5650.57
270_L291_M0.5640.57
34_V53_S0.5630.56
216_K219_M0.5620.56
37_F63_Q0.5610.56
69_Y73_D0.5610.56
93_S105_R0.5570.56
39_K47_Q0.5560.56
198_P237_T0.5540.55
156_N190_Y0.5540.55
225_V258_P0.5540.55
69_Y77_N0.5530.55
87_L93_S0.5520.55
75_N81_E0.5510.55
214_E255_Q0.5510.55
162_K302_R0.5500.55
217_L243_E0.5500.55
205_K208_L0.5490.55
137_S204_L0.5480.54
36_A111_K0.5460.54
232_G274_F0.5420.54
35_Q48_K0.5390.53
85_P94_I0.5390.53
197_V259_T0.5380.53
105_R187_E0.5340.53
208_L240_V0.5330.52
211_Q255_Q0.5320.52
89_V94_I0.5310.52
105_R114_Q0.5300.52
253_M296_Y0.5290.52
129_A135_D0.5290.52
248_V251_H0.5290.52
99_Y105_R0.5280.52
69_Y166_L0.5260.52
155_Y190_Y0.5260.52
141_R163_G0.5250.51
124_Q127_L0.5250.51
48_K139_P0.5240.51
141_R151_F0.5240.51
40_E56_K0.5230.51
193_M225_V0.5220.51
128_G206_N0.5210.51
219_M295_L0.5210.51
101_C108_D0.5210.51
294_I297_L0.5200.51
111_K116_L0.5200.51
119_S132_Q0.5200.51
70_C73_D0.5160.50
200_F245_I0.5150.50
144_M200_F0.5150.50
72_E77_N0.5140.50
144_M176_F0.5080.49
140_S144_M0.5070.49
186_A224_P0.5060.49
92_R101_C0.5060.49
87_L92_R0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m4wJ 3 0.8296 100 0.331 Contact Map
2qgzA 1 0.582 100 0.405 Contact Map
2w58A 2 0.6302 100 0.557 Contact Map
3ec2A 1 0.5659 100 0.597 Contact Map
2z4sA 1 0.5466 99.9 0.626 Contact Map
1l8qA 1 0.5466 99.9 0.648 Contact Map
3bosA 2 0.5338 99.9 0.689 Contact Map
2vhjA 3 0.8039 99.8 0.699 Contact Map
1tueA 1 0.5498 99.7 0.746 Contact Map
2kjqA 1 0.4727 99.7 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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