SP0B - BACSU - GREMLIN Contacts

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SP0B - Sporulation initiation phosphotransferase B

UniProt:	P06535	Sequences: MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLSLQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKDLSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPSAFDDIRQNGYEDVDIMRFEITSHECLIEIGLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	192 (170)
Sequences:	189 (158)
Seq/√Len:	12.1

BACSU - SP0B

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_W	65_E	3.789	0.99
38_L	85_W	3.655	0.99
32_W	58_M	2.909	0.95
33_M	47_K	2.904	0.95
43_L	151_D	2.633	0.92
42_N	55_I	2.446	0.88
36_L	122_D	2.315	0.85
98_G	103_L	2.272	0.84
49_D	92_L	2.126	0.80
39_I	85_W	2.115	0.79
51_V	54_M	2.010	0.75
76_L	114_M	2.004	0.75
42_N	50_R	1.970	0.74
38_L	54_M	1.962	0.74
33_M	39_I	1.939	0.73
104_S	158_D	1.912	0.72
103_L	110_L	1.900	0.71
23_H	49_D	1.855	0.69
69_S	81_L	1.822	0.68
36_L	66_S	1.789	0.66
80_F	92_L	1.780	0.66
30_H	34_N	1.774	0.66
47_K	150_L	1.719	0.63
20_E	126_S	1.680	0.61
64_H	93_E	1.651	0.60
29_R	65_E	1.621	0.58
104_S	178_F	1.621	0.58
32_W	41_G	1.602	0.57
18_T	155_A	1.579	0.56
53_E	167_Q	1.557	0.55
40_K	85_W	1.555	0.55
29_R	41_G	1.548	0.55
62_A	96_V	1.547	0.55
116_K	167_Q	1.516	0.53
25_L	150_L	1.511	0.53
27_H	65_E	1.487	0.52
66_S	92_L	1.477	0.51
31_D	66_S	1.462	0.50
35_K	54_M	1.461	0.50
26_G	85_W	1.459	0.50
70_N	77_A	1.455	0.50
20_E	127_R	1.429	0.49
79_D	83_F	1.419	0.48
17_L	33_M	1.406	0.48
34_N	37_Q	1.404	0.47
30_H	37_Q	1.404	0.47
26_G	80_F	1.384	0.46
45_L	100_I	1.378	0.46
33_M	79_D	1.359	0.45
33_M	83_F	1.329	0.44
20_E	78_F	1.317	0.43
183_H	186_L	1.310	0.43
114_M	135_V	1.292	0.42
143_D	163_D	1.273	0.41
103_L	136_S	1.257	0.40
32_W	39_I	1.253	0.40
42_N	54_M	1.253	0.40
57_E	156_F	1.231	0.39
19_N	113_L	1.216	0.38
27_H	32_W	1.210	0.38
69_S	133_L	1.208	0.38
136_S	158_D	1.192	0.37
29_R	69_S	1.172	0.36
59_V	113_L	1.165	0.36
99_E	164_D	1.160	0.36
26_G	39_I	1.158	0.35
78_F	82_T	1.154	0.35
68_L	77_A	1.146	0.35
108_Q	144_R	1.144	0.35
49_D	115_R	1.141	0.35
163_D	171_E	1.136	0.34
22_I	156_F	1.120	0.34
58_M	113_L	1.115	0.34
44_S	114_M	1.107	0.33
49_D	56_E	1.105	0.33
43_L	91_T	1.099	0.33
29_R	37_Q	1.096	0.33
56_E	167_Q	1.085	0.32
50_R	96_V	1.076	0.32
68_L	118_F	1.069	0.31
88_H	122_D	1.061	0.31
47_K	151_D	1.060	0.31
56_E	164_D	1.055	0.31
33_M	118_F	1.048	0.31
53_E	71_L	1.047	0.31
134_T	148_L	1.041	0.30
163_D	174_D	1.038	0.30
64_H	117_L	1.028	0.30
17_L	39_I	1.021	0.29
43_L	75_H	1.015	0.29
18_T	36_L	1.012	0.29
26_G	169_G	1.007	0.29
29_R	34_N	1.004	0.29
38_L	44_S	1.000	0.29
88_H	152_F	0.987	0.28
172_D	181_T	0.974	0.27
95_E	136_S	0.970	0.27
171_E	181_T	0.970	0.27
143_D	168_N	0.960	0.27
35_K	61_D	0.956	0.27
28_S	85_W	0.956	0.27
46_Q	134_T	0.953	0.27
41_G	96_V	0.953	0.27
114_M	137_L	0.941	0.26
32_W	92_L	0.941	0.26
45_L	54_M	0.930	0.26
90_M	128_E	0.928	0.26
68_L	148_L	0.924	0.26
26_G	77_A	0.923	0.25
71_L	176_M	0.921	0.25
43_L	133_L	0.919	0.25
101_K	105_A	0.917	0.25
71_L	96_V	0.915	0.25
48_Y	134_T	0.913	0.25
78_F	126_S	0.910	0.25
49_D	118_F	0.897	0.24
17_L	90_M	0.897	0.24
83_F	122_D	0.896	0.24
22_I	92_L	0.890	0.24
55_I	84_N	0.890	0.24
40_K	54_M	0.888	0.24
63_K	176_M	0.883	0.24
66_S	100_I	0.880	0.24
112_K	144_R	0.878	0.24
59_V	118_F	0.876	0.24
68_L	107_D	0.876	0.24
81_L	102_D	0.873	0.24
41_G	65_E	0.870	0.24
50_R	59_V	0.867	0.23
160_S	163_D	0.866	0.23
140_D	179_E	0.861	0.23
161_A	183_H	0.859	0.23
94_Y	116_K	0.858	0.23
46_Q	58_M	0.842	0.23
35_K	38_L	0.839	0.22
100_I	143_D	0.837	0.22
36_L	148_L	0.830	0.22
160_S	175_I	0.823	0.22
24_L	82_T	0.815	0.22
149_Y	153_H	0.814	0.22
45_L	172_D	0.811	0.21
128_E	135_V	0.806	0.21
70_N	85_W	0.794	0.21
77_A	122_D	0.793	0.21
176_M	179_E	0.777	0.20
35_K	51_V	0.774	0.20
45_L	154_G	0.767	0.20
63_K	152_F	0.764	0.20
28_S	130_E	0.757	0.20
69_S	187_I	0.753	0.20
51_V	72_K	0.752	0.19
85_W	90_M	0.750	0.19
92_L	171_E	0.749	0.19
87_T	124_A	0.742	0.19
169_G	180_I	0.741	0.19
73_T	157_A	0.735	0.19
107_D	117_L	0.732	0.19
123_Q	169_G	0.730	0.19
19_N	86_K	0.729	0.19
69_S	73_T	0.728	0.19
80_F	133_L	0.719	0.18
40_K	130_E	0.719	0.18
18_T	135_V	0.717	0.18
36_L	82_T	0.714	0.18
21_L	114_M	0.710	0.18
76_L	107_D	0.710	0.18
73_T	114_M	0.708	0.18
36_L	184_E	0.705	0.18
181_T	187_I	0.698	0.18
143_D	154_G	0.692	0.18
49_D	159_P	0.688	0.18
54_M	66_S	0.688	0.18
121_F	128_E	0.688	0.18
140_D	167_Q	0.686	0.17
23_H	137_L	0.684	0.17
44_S	83_F	0.679	0.17
20_E	24_L	0.678	0.17
175_I	179_E	0.676	0.17
32_W	62_A	0.671	0.17
24_L	86_K	0.671	0.17
24_L	110_L	0.670	0.17
69_S	103_L	0.661	0.17
167_Q	176_M	0.660	0.17
102_D	120_L	0.659	0.17
40_K	68_L	0.656	0.17
98_G	106_Y	0.656	0.17
36_L	51_V	0.650	0.16
140_D	182_S	0.648	0.16
105_A	161_A	0.647	0.16
63_K	130_E	0.643	0.16
99_E	158_D	0.642	0.16
183_H	187_I	0.639	0.16
22_I	86_K	0.637	0.16
72_K	135_V	0.633	0.16
123_Q	158_D	0.628	0.16
65_E	128_E	0.626	0.16
58_M	81_L	0.625	0.16
158_D	163_D	0.623	0.16
27_H	31_D	0.619	0.16
44_S	47_K	0.618	0.16
74_P	172_D	0.610	0.15
44_S	90_M	0.610	0.15
171_E	178_F	0.601	0.15
19_N	58_M	0.599	0.15
79_D	107_D	0.597	0.15
61_D	77_A	0.595	0.15
66_S	94_Y	0.593	0.15
57_E	68_L	0.589	0.15
115_R	128_E	0.588	0.15
109_K	117_L	0.587	0.15
17_L	137_L	0.587	0.15
31_D	34_N	0.586	0.15
134_T	153_H	0.584	0.15
85_W	131_N	0.584	0.15
44_S	54_M	0.584	0.15
75_H	135_V	0.569	0.14
109_K	173_V	0.569	0.14
40_K	131_N	0.568	0.14
135_V	146_L	0.561	0.14
42_N	47_K	0.559	0.14
25_L	84_N	0.554	0.14
85_W	107_D	0.553	0.14
27_H	84_N	0.550	0.14
28_S	38_L	0.549	0.14
65_E	184_E	0.549	0.14
29_R	187_I	0.548	0.14
45_L	93_E	0.546	0.14
28_S	39_I	0.544	0.14
18_T	22_I	0.543	0.14
51_V	57_E	0.540	0.14
126_S	137_L	0.539	0.14
105_A	140_D	0.536	0.14
130_E	136_S	0.535	0.14
32_W	96_V	0.530	0.13
28_S	135_V	0.530	0.13
143_D	187_I	0.528	0.13
58_M	125_V	0.528	0.13
25_L	48_Y	0.522	0.13
94_Y	187_I	0.521	0.13
46_Q	162_F	0.520	0.13
72_K	94_Y	0.520	0.13
80_F	176_M	0.519	0.13
38_L	132_H	0.516	0.13
113_L	149_Y	0.512	0.13
21_L	126_S	0.512	0.13
99_E	110_L	0.510	0.13
49_D	110_L	0.509	0.13
131_N	152_F	0.508	0.13
40_K	84_N	0.507	0.13
24_L	91_T	0.507	0.13
46_Q	183_H	0.504	0.13
90_M	114_M	0.503	0.13
73_T	105_A	0.502	0.13
37_Q	41_G	0.500	0.13
28_S	52_F	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ixmA	2	0.9115	99.8	0.644	Contact Map
3a0rA	2	0.9688	94	0.894	Contact Map
4i5sA	2	0.9115	93.8	0.895	Contact Map
4gczA	2	0.9792	92.9	0.898	Contact Map
2c2aA	2	0.9792	91.8	0.902	Contact Map
4r39A	1	0.9062	90.4	0.905	Contact Map
4q20A	2	0.9375	88.8	0.908	Contact Map
4fppA	2	0.8594	88.4	0.909	Contact Map
3d36A	2	0.9062	86.4	0.911	Contact Map
4ctiA	2	0.8177	85.2	0.913	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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