GREMLIN Database
SP0B - Sporulation initiation phosphotransferase B
UniProt: P06535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (170)
Sequences: 189 (158)
Seq/√Len: 12.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_W65_E3.7890.99
38_L85_W3.6550.99
32_W58_M2.9090.95
33_M47_K2.9040.95
43_L151_D2.6330.92
42_N55_I2.4460.88
36_L122_D2.3150.85
98_G103_L2.2720.84
49_D92_L2.1260.80
39_I85_W2.1150.79
51_V54_M2.0100.75
76_L114_M2.0040.75
42_N50_R1.9700.74
38_L54_M1.9620.74
33_M39_I1.9390.73
104_S158_D1.9120.72
103_L110_L1.9000.71
23_H49_D1.8550.69
69_S81_L1.8220.68
36_L66_S1.7890.66
80_F92_L1.7800.66
30_H34_N1.7740.66
47_K150_L1.7190.63
20_E126_S1.6800.61
64_H93_E1.6510.60
29_R65_E1.6210.58
104_S178_F1.6210.58
32_W41_G1.6020.57
18_T155_A1.5790.56
53_E167_Q1.5570.55
40_K85_W1.5550.55
29_R41_G1.5480.55
62_A96_V1.5470.55
116_K167_Q1.5160.53
25_L150_L1.5110.53
27_H65_E1.4870.52
66_S92_L1.4770.51
31_D66_S1.4620.50
35_K54_M1.4610.50
26_G85_W1.4590.50
70_N77_A1.4550.50
20_E127_R1.4290.49
79_D83_F1.4190.48
17_L33_M1.4060.48
34_N37_Q1.4040.47
30_H37_Q1.4040.47
26_G80_F1.3840.46
45_L100_I1.3780.46
33_M79_D1.3590.45
33_M83_F1.3290.44
20_E78_F1.3170.43
183_H186_L1.3100.43
114_M135_V1.2920.42
143_D163_D1.2730.41
103_L136_S1.2570.40
32_W39_I1.2530.40
42_N54_M1.2530.40
57_E156_F1.2310.39
19_N113_L1.2160.38
27_H32_W1.2100.38
69_S133_L1.2080.38
136_S158_D1.1920.37
29_R69_S1.1720.36
59_V113_L1.1650.36
99_E164_D1.1600.36
26_G39_I1.1580.35
78_F82_T1.1540.35
68_L77_A1.1460.35
108_Q144_R1.1440.35
49_D115_R1.1410.35
163_D171_E1.1360.34
22_I156_F1.1200.34
58_M113_L1.1150.34
44_S114_M1.1070.33
49_D56_E1.1050.33
43_L91_T1.0990.33
29_R37_Q1.0960.33
56_E167_Q1.0850.32
50_R96_V1.0760.32
68_L118_F1.0690.31
88_H122_D1.0610.31
47_K151_D1.0600.31
56_E164_D1.0550.31
33_M118_F1.0480.31
53_E71_L1.0470.31
134_T148_L1.0410.30
163_D174_D1.0380.30
64_H117_L1.0280.30
17_L39_I1.0210.29
43_L75_H1.0150.29
18_T36_L1.0120.29
26_G169_G1.0070.29
29_R34_N1.0040.29
38_L44_S1.0000.29
88_H152_F0.9870.28
172_D181_T0.9740.27
95_E136_S0.9700.27
171_E181_T0.9700.27
143_D168_N0.9600.27
35_K61_D0.9560.27
28_S85_W0.9560.27
46_Q134_T0.9530.27
41_G96_V0.9530.27
114_M137_L0.9410.26
32_W92_L0.9410.26
45_L54_M0.9300.26
90_M128_E0.9280.26
68_L148_L0.9240.26
26_G77_A0.9230.25
71_L176_M0.9210.25
43_L133_L0.9190.25
101_K105_A0.9170.25
71_L96_V0.9150.25
48_Y134_T0.9130.25
78_F126_S0.9100.25
49_D118_F0.8970.24
17_L90_M0.8970.24
83_F122_D0.8960.24
22_I92_L0.8900.24
55_I84_N0.8900.24
40_K54_M0.8880.24
63_K176_M0.8830.24
66_S100_I0.8800.24
112_K144_R0.8780.24
59_V118_F0.8760.24
68_L107_D0.8760.24
81_L102_D0.8730.24
41_G65_E0.8700.24
50_R59_V0.8670.23
160_S163_D0.8660.23
140_D179_E0.8610.23
161_A183_H0.8590.23
94_Y116_K0.8580.23
46_Q58_M0.8420.23
35_K38_L0.8390.22
100_I143_D0.8370.22
36_L148_L0.8300.22
160_S175_I0.8230.22
24_L82_T0.8150.22
149_Y153_H0.8140.22
45_L172_D0.8110.21
128_E135_V0.8060.21
70_N85_W0.7940.21
77_A122_D0.7930.21
176_M179_E0.7770.20
35_K51_V0.7740.20
45_L154_G0.7670.20
63_K152_F0.7640.20
28_S130_E0.7570.20
69_S187_I0.7530.20
51_V72_K0.7520.19
85_W90_M0.7500.19
92_L171_E0.7490.19
87_T124_A0.7420.19
169_G180_I0.7410.19
73_T157_A0.7350.19
107_D117_L0.7320.19
123_Q169_G0.7300.19
19_N86_K0.7290.19
69_S73_T0.7280.19
80_F133_L0.7190.18
40_K130_E0.7190.18
18_T135_V0.7170.18
36_L82_T0.7140.18
21_L114_M0.7100.18
76_L107_D0.7100.18
73_T114_M0.7080.18
36_L184_E0.7050.18
181_T187_I0.6980.18
143_D154_G0.6920.18
49_D159_P0.6880.18
54_M66_S0.6880.18
121_F128_E0.6880.18
140_D167_Q0.6860.17
23_H137_L0.6840.17
44_S83_F0.6790.17
20_E24_L0.6780.17
175_I179_E0.6760.17
32_W62_A0.6710.17
24_L86_K0.6710.17
24_L110_L0.6700.17
69_S103_L0.6610.17
167_Q176_M0.6600.17
102_D120_L0.6590.17
40_K68_L0.6560.17
98_G106_Y0.6560.17
36_L51_V0.6500.16
140_D182_S0.6480.16
105_A161_A0.6470.16
63_K130_E0.6430.16
99_E158_D0.6420.16
183_H187_I0.6390.16
22_I86_K0.6370.16
72_K135_V0.6330.16
123_Q158_D0.6280.16
65_E128_E0.6260.16
58_M81_L0.6250.16
158_D163_D0.6230.16
27_H31_D0.6190.16
44_S47_K0.6180.16
74_P172_D0.6100.15
44_S90_M0.6100.15
171_E178_F0.6010.15
19_N58_M0.5990.15
79_D107_D0.5970.15
61_D77_A0.5950.15
66_S94_Y0.5930.15
57_E68_L0.5890.15
115_R128_E0.5880.15
109_K117_L0.5870.15
17_L137_L0.5870.15
31_D34_N0.5860.15
134_T153_H0.5840.15
85_W131_N0.5840.15
44_S54_M0.5840.15
75_H135_V0.5690.14
109_K173_V0.5690.14
40_K131_N0.5680.14
135_V146_L0.5610.14
42_N47_K0.5590.14
25_L84_N0.5540.14
85_W107_D0.5530.14
27_H84_N0.5500.14
28_S38_L0.5490.14
65_E184_E0.5490.14
29_R187_I0.5480.14
45_L93_E0.5460.14
28_S39_I0.5440.14
18_T22_I0.5430.14
51_V57_E0.5400.14
126_S137_L0.5390.14
105_A140_D0.5360.14
130_E136_S0.5350.14
32_W96_V0.5300.13
28_S135_V0.5300.13
143_D187_I0.5280.13
58_M125_V0.5280.13
25_L48_Y0.5220.13
94_Y187_I0.5210.13
46_Q162_F0.5200.13
72_K94_Y0.5200.13
80_F176_M0.5190.13
38_L132_H0.5160.13
113_L149_Y0.5120.13
21_L126_S0.5120.13
99_E110_L0.5100.13
49_D110_L0.5090.13
131_N152_F0.5080.13
40_K84_N0.5070.13
24_L91_T0.5070.13
46_Q183_H0.5040.13
90_M114_M0.5030.13
73_T105_A0.5020.13
37_Q41_G0.5000.13
28_S52_F0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ixmA 2 0.9115 99.8 0.644 Contact Map
3a0rA 2 0.9688 94 0.894 Contact Map
4i5sA 2 0.9115 93.8 0.895 Contact Map
4gczA 2 0.9792 92.9 0.898 Contact Map
2c2aA 2 0.9792 91.8 0.902 Contact Map
4r39A 1 0.9062 90.4 0.905 Contact Map
4q20A 2 0.9375 88.8 0.908 Contact Map
4fppA 2 0.8594 88.4 0.909 Contact Map
3d36A 2 0.9062 86.4 0.911 Contact Map
4ctiA 2 0.8177 85.2 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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