GREMLIN Database
SP0A - Stage 0 sporulation protein A
UniProt: P06534 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (226)
Sequences: 19562 (16467)
Seq/√Len: 1095.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_V36_Y3.3851.00
16_V34_V3.3141.00
20_S34_V3.2321.00
75_D78_K2.9111.00
9_A41_C2.8871.00
144_S151_K2.8561.00
46_K74_S2.7581.00
42_L70_R2.6821.00
69_E100_L2.6061.00
38_G62_L2.5641.00
39_Q61_H2.4301.00
55_L67_V2.4241.00
63_D66_A2.3871.00
33_G50_P2.3361.00
5_K30_E2.2121.00
160_I165_G2.1661.00
37_N61_H2.0831.00
70_R74_S2.0721.00
45_F71_L2.0371.00
33_G44_L2.0041.00
35_A44_L1.9991.00
81_N129_V1.9881.00
103_S122_V1.9851.00
7_C35_A1.9661.00
68_L82_V1.9651.00
26_Q116_V1.9631.00
36_Y40_E1.9621.00
104_Y118_H1.9321.00
33_G48_K1.9191.00
70_R73_E1.9071.00
37_N40_E1.8381.00
62_L70_R1.7251.00
58_I88_F1.7201.00
44_L48_K1.7091.00
81_N125_N1.6461.00
5_K33_G1.6211.00
155_A160_I1.6161.00
96_K100_L1.6101.00
38_G67_V1.6031.00
44_L50_P1.5981.00
22_Y112_M1.5831.00
5_K48_K1.5561.00
83_I118_H1.5371.00
68_L84_M1.5081.00
159_S163_E1.5071.00
103_S125_N1.4741.00
44_L47_E1.4661.00
62_L66_A1.4591.00
53_L71_L1.4561.00
104_Y121_Q1.4371.00
41_C67_V1.4191.00
75_D80_P1.4161.00
69_E96_K1.4151.00
126_A130_T1.4021.00
66_A69_E1.4011.00
6_V29_M1.4001.00
20_S24_E1.3811.00
84_M97_A1.3581.00
10_D16_V1.3471.00
65_L97_A1.3431.00
53_L80_P1.3361.00
54_V119_I1.3311.00
219_A222_V1.3011.00
225_S235_L1.2981.00
117_G121_Q1.2871.00
132_R135_S1.2701.00
53_L82_V1.2651.00
55_L82_V1.2491.00
96_K99_D1.2411.00
42_L62_L1.2401.00
39_Q43_S1.2381.00
57_I84_M1.2341.00
11_D56_D1.2231.00
35_A41_C1.2231.00
84_M102_A1.2221.00
215_A219_A1.2131.00
156_S159_S1.2081.00
71_L82_V1.2051.00
160_I163_E1.2021.00
42_L67_V1.1871.00
68_L102_A1.1851.00
200_D233_S1.1811.00
52_V119_I1.1611.00
132_R136_S1.1511.00
55_L84_M1.1331.00
128_S132_R1.1311.00
43_S47_E1.1301.00
72_R103_S1.1181.00
52_V123_S1.1141.00
57_I65_L1.1071.00
114_N118_H1.1041.00
23_I119_I1.1011.00
15_L18_L1.0941.00
95_K99_D1.0831.00
196_V200_D1.0811.00
214_R218_H1.0801.00
91_E94_T1.0771.00
69_E73_E1.0761.00
116_V120_R1.0661.00
57_I93_V1.0611.00
40_E43_S1.0581.00
15_L110_F1.0541.00
39_Q62_L1.0521.00
99_D104_Y1.0511.00
159_S162_H1.0241.00
43_S46_K1.0201.00
42_L46_K1.0201.00
8_V19_L1.0171.00
54_V115_L1.0141.00
25_G28_D1.0121.00
212_V236_F1.0111.00
153_L156_S0.9911.00
17_S20_S0.9901.00
5_K50_P0.9881.00
81_N126_A0.9851.00
13_R17_S0.9801.00
66_A70_R0.9781.00
118_H122_V0.9761.00
110_F115_L0.9751.00
124_G127_S0.9741.00
29_M120_R0.9701.00
139_S142_R0.9681.00
213_E216_I0.9661.00
65_L96_K0.9651.00
81_N103_S0.9651.00
51_D126_A0.9611.00
9_A53_L0.9571.00
67_V71_L0.9561.00
17_S34_V0.9551.00
212_V240_V0.9491.00
55_L68_L0.9421.00
83_I122_V0.9401.00
21_E25_G0.9401.00
35_A38_G0.9361.00
91_E95_K0.9351.00
114_N117_G0.9331.00
92_D95_K0.9311.00
55_L71_L0.9271.00
38_G59_M0.9221.00
135_S139_S0.9191.00
35_A40_E0.9161.00
26_Q120_R0.9161.00
9_A67_V0.9151.00
123_S127_S0.9141.00
7_C50_P0.9131.00
194_T236_F0.9121.00
38_G42_L0.9011.00
7_C45_F0.9011.00
131_H136_S0.8961.00
17_S21_E0.8961.00
187_I191_G0.8921.00
125_N129_V0.8911.00
45_F50_P0.8911.00
45_F80_P0.8891.00
5_K51_D0.8891.00
136_S139_S0.8851.00
19_L115_L0.8851.00
54_V83_I0.8821.00
139_S143_S0.8811.00
174_L177_R0.8701.00
191_G217_R0.8691.00
75_D79_Q0.8671.00
7_C44_L0.8651.00
214_R217_R0.8641.00
12_N15_L0.8611.00
59_M62_L0.8531.00
131_H135_S0.8521.00
9_A38_G0.8521.00
41_C45_F0.8511.00
223_A226_R0.8471.00
124_G128_S0.8461.00
57_I63_D0.8461.00
187_I224_W0.8451.00
40_E44_L0.8421.00
217_R221_E0.8371.00
72_R81_N0.8331.00
13_R16_V0.8291.00
216_I220_I0.8271.00
158_T162_H0.8231.00
10_D59_M0.8201.00
19_L85_L0.8161.00
111_D114_N0.8151.00
89_G107_L0.8131.00
22_Y116_V0.8101.00
152_N156_S0.8091.00
58_I90_Q0.8081.00
93_V96_K0.8021.00
118_H121_Q0.8021.00
9_A59_M0.8001.00
45_F75_D0.7961.00
191_G195_K0.7951.00
85_L110_F0.7911.00
90_Q93_V0.7881.00
46_K70_R0.7871.00
68_L100_L0.7871.00
7_C41_C0.7851.00
79_Q129_V0.7831.00
112_M116_V0.7811.00
158_T161_I0.7711.00
138_S142_R0.7651.00
194_T212_V0.7641.00
31_V34_V0.7561.00
94_T114_N0.7541.00
9_A35_A0.7541.00
182_M186_D0.7541.00
227_G231_S0.7521.00
71_L80_P0.7511.00
120_R124_G0.7501.00
54_V85_L0.7491.00
53_L67_V0.7461.00
8_V20_S0.7441.00
37_N59_M0.7441.00
195_K199_P0.7351.00
135_S138_S0.7311.00
113_E117_G0.7291.00
134_P138_S0.7291.00
45_F53_L0.7261.00
191_G221_E0.7151.00
212_V233_S0.7141.00
81_N122_V0.7121.00
14_E18_L0.7111.00
58_I63_D0.7081.00
94_T98_V0.7061.00
207_T210_S0.7051.00
192_S196_V0.7001.00
55_L59_M0.6971.00
140_I143_S0.6901.00
187_I190_L0.6901.00
218_H221_E0.6851.00
123_S126_A0.6841.00
8_V31_V0.6811.00
57_I97_A0.6811.00
20_S31_V0.6801.00
88_F93_V0.6801.00
179_A185_N0.6761.00
59_M67_V0.6751.00
223_A231_S0.6701.00
8_V16_V0.6681.00
11_D59_M0.6651.00
136_S140_I0.6651.00
92_D96_K0.6651.00
106_I110_F0.6591.00
38_G61_H0.6561.00
7_C33_G0.6551.00
79_Q133_A0.6541.00
213_E217_R0.6511.00
93_V105_F0.6501.00
202_A210_S0.6471.00
129_V132_R0.6471.00
89_G94_T0.6461.00
155_A158_T0.6441.00
219_A223_A0.6431.00
117_G120_R0.6411.00
191_G194_T0.6411.00
62_L67_V0.6401.00
212_V216_I0.6391.00
197_L233_S0.6381.00
52_V81_N0.6371.00
58_I87_A0.6371.00
56_D108_K0.6341.00
153_L160_I0.6291.00
133_A136_S0.6281.00
18_L22_Y0.6271.00
152_N155_A0.6261.00
235_L239_T0.6241.00
186_D189_L0.6211.00
11_D87_A0.6211.00
199_P203_K0.6191.00
128_S131_H0.6101.00
72_R80_P0.6101.00
212_V217_R0.6071.00
125_N128_S0.6061.00
97_A102_A0.6001.00
30_E33_G0.5971.00
197_L201_I0.5971.00
65_L93_V0.5931.00
138_S143_S0.5921.00
71_L74_S0.5901.00
201_I205_F0.5881.00
233_S237_G0.5881.00
210_S214_R0.5871.00
225_S228_N0.5841.00
23_I116_V0.5811.00
87_A109_P0.5781.00
29_M116_V0.5781.00
6_V23_I0.5741.00
16_V20_S0.5731.00
13_R36_Y0.5721.00
196_V199_P0.5701.00
164_I183_V0.5651.00
218_H222_V0.5641.00
154_D161_I0.5631.00
98_V102_A0.5611.00
63_D96_K0.5611.00
45_F67_V0.5591.00
131_H134_P0.5581.00
84_M100_L0.5581.00
135_S143_S0.5541.00
181_S185_N0.5541.00
11_D86_T0.5521.00
29_M123_S0.5521.00
134_P137_Q0.5501.00
61_H67_V0.5441.00
133_A137_Q0.5421.00
129_V133_A0.5411.00
85_L88_F0.5401.00
26_Q29_M0.5401.00
207_T211_R0.5381.00
155_A159_S0.5371.00
28_D31_V0.5371.00
236_F239_T0.5361.00
52_V83_I0.5351.00
49_D75_D0.5341.00
156_S160_I0.5311.00
74_S78_K0.5311.00
198_Y202_A0.5301.00
160_I166_V0.5281.00
98_V104_Y0.5271.00
200_D204_K0.5271.00
103_S118_H0.5271.00
228_N231_S0.5221.00
30_E48_K0.5211.00
50_P80_P0.5201.00
58_I93_V0.5201.00
68_L72_R0.5201.00
126_A129_V0.5181.00
156_S164_I0.5181.00
119_I123_S0.5181.00
202_A208_T0.5181.00
12_N87_A0.5161.00
228_N232_I0.5121.00
9_A55_L0.5081.00
153_L166_V0.5081.00
231_S234_S0.5061.00
216_I219_A0.5031.00
6_V54_V0.5021.00
39_Q70_R0.5011.00
137_Q141_I0.5011.00
215_A218_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3breA 4 0.985 100 0.446 Contact Map
3dzdA 2 0.9101 100 0.456 Contact Map
4g97A 1 0.4906 100 0.466 Contact Map
3n0rA 1 0.4607 100 0.467 Contact Map
4l4uA 2 0.9438 100 0.467 Contact Map
3rqiA 2 0.633 99.9 0.479 Contact Map
1yioA 1 0.7416 99.9 0.481 Contact Map
3lufA 2 0.4757 99.9 0.487 Contact Map
3eq2A 2 0.9176 99.9 0.488 Contact Map
1s8nA 1 0.7079 99.9 0.49 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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