GREMLIN Database
SINR - HTH-type transcriptional regulator SinR
UniProt: P06533 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 111 (102)
Sequences: 1192 (1057)
Seq/√Len: 104.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_S22_E3.3341.00
20_L31_L3.3131.00
52_A64_E2.8801.00
18_S28_K2.7931.00
10_R35_E2.5421.00
15_Y53_V2.5051.00
12_E68_T2.3191.00
3_G37_N2.2911.00
2_I6_I2.2501.00
29_S33_S2.2321.00
27_A30_Y2.1571.00
23_K53_V2.1421.00
26_V31_L2.0391.00
58_V62_L1.9551.00
41_N44_I1.8531.00
36_R39_Q1.8171.00
33_S40_T1.8121.00
9_Y54_L1.7491.00
33_S39_Q1.7431.00
20_L54_L1.6721.00
5_R60_T1.6041.00
28_K32_S1.5671.00
59_H64_E1.4871.00
65_K68_T1.4671.00
33_S36_R1.4621.00
27_A33_S1.4081.00
90_V95_F1.3831.00
29_S32_S1.3791.00
30_Y33_S1.3621.00
91_S94_Q1.3440.99
97_E104_W1.3430.99
44_I47_L1.3010.99
98_F101_Y1.2560.99
20_L50_V1.2470.99
19_E22_E1.2410.99
26_V30_Y1.2410.99
51_S64_E1.2340.99
4_Q37_N1.2180.99
15_Y23_K1.1930.99
32_S36_R1.1870.99
2_I44_I1.1700.99
88_S91_S1.1700.99
17_L28_K1.1270.98
98_F102_Q1.0580.97
101_Y104_W1.0570.97
87_T90_V1.0240.97
34_I40_T1.0180.96
99_L103_K1.0020.96
91_S95_F0.9920.96
6_I31_L0.9800.96
87_T91_S0.9760.95
100_D104_W0.9640.95
80_K83_R0.9510.95
92_K95_F0.9200.94
9_Y56_V0.9180.94
25_G49_K0.9120.93
17_L31_L0.8910.93
24_A54_L0.8860.92
13_K23_K0.8830.92
21_A33_S0.8790.92
43_S46_F0.8590.91
5_R66_H0.8540.91
82_V85_A0.8520.91
26_V46_F0.8510.91
34_I46_F0.8360.90
90_V94_Q0.8300.90
47_L62_L0.8220.89
74_L85_A0.8150.89
28_K31_L0.8090.89
96_R99_L0.8030.88
21_A31_L0.7900.87
28_K36_R0.7830.87
5_R8_Q0.7800.87
98_F103_K0.7790.87
28_K43_S0.7770.86
28_K33_S0.7660.86
94_Q97_E0.7650.86
6_I20_L0.7600.85
20_L24_A0.7570.85
20_L53_V0.7560.85
24_A50_V0.7560.85
76_S79_E0.7510.85
78_W82_V0.7490.84
79_E82_V0.7440.84
41_N46_F0.7380.84
74_L78_W0.7360.83
81_L85_A0.7350.83
18_S32_S0.7250.82
56_V60_T0.7210.82
87_T93_K0.7170.82
97_E101_Y0.7120.81
95_F98_F0.7010.80
5_R63_D0.7000.80
9_Y60_T0.6920.79
75_D85_A0.6900.79
80_K84_D0.6870.79
92_K98_F0.6860.79
15_Y19_E0.6850.79
28_K39_Q0.6830.79
34_I43_S0.6830.79
86_M100_D0.6800.78
46_F49_K0.6770.78
47_L58_V0.6720.77
94_Q101_Y0.6590.76
78_W81_L0.6440.74
26_V33_S0.6430.74
71_D74_L0.6420.74
29_S40_T0.6340.73
8_Q12_E0.6340.73
88_S100_D0.6270.72
2_I54_L0.6260.72
77_E81_L0.6260.72
55_D69_E0.6240.72
17_L21_A0.6180.71
24_A53_V0.6180.71
91_S98_F0.6100.70
27_A40_T0.6080.70
47_L59_H0.6080.70
30_Y41_N0.6070.70
78_W85_A0.6060.70
60_T65_K0.5980.69
40_T43_S0.5960.69
98_F104_W0.5940.68
95_F99_L0.5930.68
24_A46_F0.5870.67
42_P59_H0.5860.67
27_A32_S0.5860.67
36_R41_N0.5780.66
16_S19_E0.5700.65
5_R64_E0.5630.64
29_S36_R0.5610.64
16_S29_S0.5610.64
3_G6_I0.5550.63
41_N45_Q0.5450.62
91_S104_W0.5330.60
27_A39_Q0.5310.60
12_E48_E0.5310.60
21_A29_S0.5250.59
29_S39_Q0.5240.59
30_Y40_T0.5240.59
30_Y34_I0.5230.59
32_S42_P0.5230.59
78_W89_G0.5220.58
91_S97_E0.5210.58
21_A28_K0.5190.58
8_Q22_E0.5150.57
97_E103_K0.5130.57
57_S60_T0.5110.57
32_S40_T0.5070.56
26_V29_S0.5040.56
75_D83_R0.5030.56
77_E85_A0.5030.56
26_V34_I0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b0nA 2 0.9279 99.8 0.31 Contact Map
4ndwA 2 0.973 99.8 0.358 Contact Map
3r1fA 2 0.973 99.7 0.37 Contact Map
4o8bA 2 0.8739 99.7 0.381 Contact Map
4jcyA 2 0.7928 99.7 0.393 Contact Map
3qwgA 2 0.6577 99.7 0.396 Contact Map
3op9A 4 0.9369 99.7 0.4 Contact Map
3ivpA 2 0.9369 99.6 0.418 Contact Map
2ebyA 2 0.8559 99.6 0.431 Contact Map
2p5tA 2 0.3694 99.6 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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