GREMLIN Database
SACB - Levansucrase
UniProt: P05655 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (401)
Sequences: 168 (108)
Seq/√Len: 5.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
391_L456_T11.9111.00
451_I456_T6.6861.00
108_A412_S5.3950.99
263_A312_A3.9130.91
244_T264_N3.3180.81
167_A177_L3.3030.81
87_S412_S3.1510.78
128_V135_S2.9810.73
107_F121_I2.9620.73
393_K449_L2.9530.73
245_L311_G2.8960.71
421_G424_V2.8910.71
350_N422_N2.7390.66
241_D339_D2.6290.63
123_M139_A2.6110.62
319_N451_I2.4330.57
64_Q424_V2.4160.56
199_V208_I2.4030.56
128_V448_L2.3790.55
218_F327_V2.2940.52
263_A358_D2.1880.48
400_M412_S2.1350.47
175_I215_K2.0720.45
160_T192_L2.0670.44
430_M442_T2.0310.43
264_N311_G2.0140.43
88_W167_A2.0110.43
90_L107_F1.9630.41
43_I333_A1.9440.40
87_S370_T1.9150.39
205_S326_K1.8750.38
319_N326_K1.8730.38
237_Y359_S1.8580.38
87_S108_A1.8520.37
178_F449_L1.8470.37
219_D334_S1.8250.37
162_E167_A1.8250.37
391_L448_L1.8140.36
222_G230_Q1.8010.36
109_L142_V1.7870.35
92_N96_T1.7830.35
129_G356_F1.7650.35
108_A456_T1.7370.34
224_T227_N1.7340.34
122_Y383_S1.7150.33
83_D340_E1.7120.33
231_F239_S1.7070.33
173_G311_G1.6960.33
256_H317_E1.6720.32
48_R368_G1.6710.32
344_A371_S1.6660.32
199_V315_M1.6630.32
218_F254_K1.6440.31
230_Q247_D1.6400.31
99_N437_A1.6360.31
391_L451_I1.6340.31
143_F195_A1.6290.31
117_D161_Q1.6230.31
158_D182_F1.6080.30
340_E358_D1.6030.30
104_H128_V1.5870.30
382_N391_L1.5770.29
333_A386_G1.5700.29
157_K183_S1.5560.29
164_S339_D1.5560.29
178_F389_K1.5530.29
278_F283_Y1.5440.28
382_N456_T1.5280.28
225_Y261_F1.5220.28
290_F328_M1.5150.28
143_F166_S1.5080.27
175_I202_S1.5050.27
106_V317_E1.5000.27
53_Q386_G1.4980.27
426_I429_Y1.4980.27
321_D389_K1.4970.27
247_D353_W1.4920.27
187_Y192_L1.4870.27
206_L371_S1.4840.27
87_S400_M1.4830.27
230_Q353_W1.4750.26
321_D388_Y1.4580.26
88_W124_F1.4520.26
54_I346_V1.4520.26
121_I287_T1.4410.26
226_Q398_L1.4230.25
47_T54_I1.4110.25
169_F332_I1.4080.25
89_P95_G1.4060.25
87_S409_F1.4030.25
84_V124_F1.3940.24
246_R310_N1.3920.24
350_N453_G1.3910.24
89_P306_A1.3890.24
218_F333_A1.3780.24
205_S388_Y1.3700.24
366_I371_S1.3550.23
190_Q246_R1.3530.23
340_E363_K1.3530.23
264_N357_T1.3510.23
313_L456_T1.3470.23
82_L415_A1.3420.23
338_T373_D1.3310.23
287_T394_T1.3290.23
179_Y190_Q1.3250.23
64_Q350_N1.3170.23
57_Q404_P1.3150.22
39_E174_K1.3130.22
107_F135_S1.3090.22
85_W262_E1.3060.22
262_E343_R1.3060.22
86_D343_R1.3060.22
86_D354_Y1.3060.22
262_E354_Y1.3060.22
86_D342_E1.3060.22
262_E342_E1.3060.22
86_D262_E1.3060.22
85_W354_Y1.3060.22
343_R354_Y1.3060.22
85_W343_R1.3060.22
85_W342_E1.3060.22
342_E354_Y1.3060.22
175_I414_F1.3040.22
105_I123_M1.3000.22
331_L384_L1.3000.22
242_N339_D1.2860.22
90_L396_L1.2780.22
53_Q394_T1.2760.22
92_N414_F1.2690.21
346_V370_T1.2560.21
105_I371_S1.2510.21
204_S434_G1.2510.21
230_Q327_V1.2490.21
347_F403_D1.2250.20
187_Y323_T1.2090.20
183_S239_S1.1980.20
73_I340_E1.1930.20
46_I119_T1.1900.20
220_G427_T1.1870.20
344_A403_D1.1860.20
359_S368_G1.1840.20
318_L349_M1.1800.19
101_H449_L1.1790.19
381_S456_T1.1780.19
44_S84_V1.1780.19
338_T363_K1.1780.19
366_I414_F1.1760.19
121_I394_T1.1690.19
384_L417_P1.1530.19
315_M351_G1.1520.19
229_Q449_L1.1490.19
190_Q310_N1.1450.19
123_M178_F1.1430.19
313_L408_T1.1400.19
191_T311_G1.1380.19
210_G380_V1.1360.19
269_D410_T1.1300.18
414_F456_T1.1270.18
276_S307_E1.1220.18
381_S391_L1.1170.18
104_H126_Q1.1060.18
50_D428_S1.1050.18
315_M384_L1.1020.18
217_I442_T1.1020.18
60_N398_L1.1010.18
226_Q247_D1.1010.18
313_L332_I1.0980.18
110_A161_Q1.0960.18
311_G338_T1.0880.18
117_D183_S1.0830.18
100_Y173_G1.0830.18
175_I253_D1.0810.17
39_E173_G1.0760.17
245_L305_T1.0670.17
266_G330_P1.0650.17
179_Y214_Y1.0640.17
98_A246_R1.0510.17
338_T377_L1.0470.17
136_W344_A1.0460.17
357_T375_Y1.0450.17
120_S409_F1.0420.17
212_E434_G1.0410.17
182_F214_Y1.0340.17
51_M264_N1.0290.16
334_S424_V1.0290.16
241_D251_V1.0220.16
171_S382_N1.0220.16
80_K214_Y1.0140.16
76_I80_K1.0100.16
177_L255_G1.0060.16
246_R249_H1.0050.16
110_A338_T1.0050.16
175_I352_K1.0040.16
242_N363_K1.0030.16
386_G395_G1.0020.16
36_P320_D1.0010.16
168_T333_A0.9980.16
54_I394_T0.9920.16
312_A386_G0.9910.16
313_L414_F0.9890.16
111_G441_S0.9880.16
383_S386_G0.9850.16
251_V254_K0.9830.16
381_S385_T0.9810.16
208_I444_A0.9810.16
110_A373_D0.9790.16
160_T185_K0.9780.16
313_L320_D0.9780.16
414_F427_T0.9770.16
178_F190_Q0.9750.15
44_S209_N0.9750.15
245_L357_T0.9740.15
100_Y213_D0.9730.15
313_L452_K0.9720.15
83_D312_A0.9700.15
263_A449_L0.9670.15
126_Q135_S0.9650.15
329_K375_Y0.9640.15
179_Y246_R0.9630.15
136_W380_V0.9620.15
356_F378_G0.9590.15
41_Y281_A0.9580.15
87_S344_A0.9560.15
106_V192_L0.9550.15
318_L376_M0.9520.15
237_Y412_S0.9510.15
291_R294_S0.9500.15
101_H186_H0.9490.15
126_Q372_N0.9480.15
371_S403_D0.9450.15
279_N321_D0.9440.15
88_W143_F0.9440.15
162_E264_N0.9400.15
309_A339_D0.9380.15
108_A143_F0.9360.15
120_S161_Q0.9300.15
47_T284_G0.9150.14
169_F230_Q0.9140.14
314_G342_E0.9110.14
262_E314_G0.9110.14
85_W314_G0.9110.14
314_G354_Y0.9110.14
314_G343_R0.9110.14
86_D314_G0.9110.14
57_Q458_V0.9110.14
258_Y328_M0.9100.14
259_L309_A0.9080.14
329_K423_N0.9040.14
244_T311_G0.9020.14
192_L408_T0.9010.14
59_K64_Q0.9000.14
334_S421_G0.8950.14
358_D412_S0.8950.14
352_K380_V0.8930.14
185_K189_K0.8930.14
338_T364_M0.8900.14
177_L408_T0.8830.14
38_K288_S0.8820.14
100_Y202_S0.8820.14
93_A168_T0.8800.14
103_Y127_K0.8800.14
324_L327_V0.8780.14
203_D320_D0.8780.14
319_N323_T0.8730.14
264_N363_K0.8690.14
97_V121_I0.8680.14
247_D330_P0.8680.14
81_G288_S0.8640.14
162_E193_T0.8620.14
47_T92_N0.8610.14
81_G199_V0.8580.14
333_A387_P0.8540.13
82_L389_K0.8520.13
296_K424_V0.8520.13
344_A358_D0.8500.13
72_T458_V0.8490.13
283_Y430_M0.8480.13
49_H359_S0.8480.13
383_S387_P0.8480.13
122_Y138_N0.8470.13
359_S412_S0.8450.13
264_N305_T0.8440.13
43_I313_L0.8430.13
208_I320_D0.8430.13
400_M409_F0.8430.13
44_S97_V0.8420.13
146_S359_S0.8400.13
178_F317_E0.8400.13
377_L423_N0.8360.13
64_Q421_G0.8360.13
53_Q315_M0.8350.13
192_L247_D0.8330.13
251_V421_G0.8320.13
410_T432_N0.8300.13
158_D195_A0.8280.13
46_I423_N0.8240.13
309_A376_M0.8230.13
130_E382_N0.8230.13
90_L109_L0.8220.13
110_A438_D0.8200.13
109_L338_T0.8180.13
345_N403_D0.8180.13
236_N313_L0.8070.13
350_N380_V0.8070.13
415_A421_G0.8060.13
176_R196_Q0.8050.13
68_F177_L0.8040.13
396_L443_F0.8030.13
264_N373_D0.8020.13
109_L264_N0.8000.13
379_Y412_S0.7990.13
60_N299_Q0.7990.13
119_T360_R0.7990.13
61_E292_Q0.7960.13
209_N319_N0.7950.13
161_Q185_K0.7940.13
318_L391_L0.7920.13
363_K440_Q0.7920.13
166_S190_Q0.7910.13
292_Q296_K0.7910.13
350_N404_P0.7900.13
46_I245_L0.7900.13
408_T438_D0.7890.12
52_L394_T0.7880.12
83_D122_Y0.7870.12
312_A329_K0.7870.12
191_T270_G0.7840.12
119_T403_D0.7780.12
253_D449_L0.7770.12
181_D214_Y0.7750.12
64_Q400_M0.7730.12
181_D412_S0.7640.12
88_W166_S0.7640.12
210_G359_S0.7640.12
202_S209_N0.7640.12
427_T431_T0.7580.12
190_Q266_G0.7530.12
244_T305_T0.7530.12
117_D186_H0.7520.12
381_S387_P0.7490.12
143_F247_D0.7480.12
122_Y249_H0.7480.12
47_T339_D0.7480.12
207_N351_G0.7470.12
138_N315_M0.7470.12
351_G453_G0.7430.12
64_Q440_Q0.7420.12
313_L381_S0.7370.12
335_N451_I0.7370.12
88_W178_F0.7360.12
107_F332_I0.7350.12
166_S310_N0.7350.12
435_F439_K0.7350.12
284_G339_D0.7330.12
185_K388_Y0.7300.12
129_G268_E0.7300.12
51_M245_L0.7290.12
87_S164_S0.7270.12
206_L380_V0.7260.12
397_V442_T0.7250.12
127_K200_S0.7230.12
263_A340_E0.7220.12
268_E451_I0.7220.12
158_D237_Y0.7210.12
166_S247_D0.7210.12
378_G397_V0.7210.12
193_T216_S0.7200.12
49_H254_K0.7170.11
244_T362_S0.7160.11
173_G208_I0.7150.11
171_S431_T0.7150.11
319_N335_N0.7100.11
62_K423_N0.7090.11
115_N423_N0.7080.11
115_N440_Q0.7050.11
113_P340_E0.7050.11
166_S246_R0.7020.11
230_Q459_V0.7010.11
75_N265_T0.7010.11
208_I416_V0.7010.11
332_I460_K0.7000.11
162_E339_D0.6990.11
82_L252_E0.6970.11
320_D456_T0.6960.11
204_S442_T0.6960.11
371_S409_F0.6960.11
287_T291_R0.6930.11
93_A327_V0.6920.11
313_L450_N0.6890.11
103_Y207_N0.6890.11
108_A429_Y0.6890.11
161_Q164_S0.6890.11
298_L379_Y0.6860.11
202_S319_N0.6860.11
178_F335_N0.6840.11
82_L135_S0.6840.11
105_I436_Y0.6830.11
245_L264_N0.6800.11
191_T216_S0.6790.11
278_F385_T0.6780.11
372_N400_M0.6780.11
161_Q183_S0.6750.11
128_V407_V0.6730.11
344_A350_N0.6720.11
207_N431_T0.6700.11
64_Q449_L0.6700.11
46_I379_Y0.6690.11
251_V424_V0.6670.11
223_K450_N0.6670.11
115_N161_Q0.6660.11
210_G270_G0.6640.11
141_R350_N0.6640.11
201_A205_S0.6630.11
87_S372_N0.6620.11
197_V211_V0.6620.11
210_G325_K0.6610.11
354_Y412_S0.6610.11
262_E412_S0.6610.11
342_E412_S0.6610.11
85_W412_S0.6610.11
86_D412_S0.6610.11
343_R412_S0.6610.11
220_G245_L0.6600.11
437_A451_I0.6600.11
292_Q295_Q0.6580.11
87_S99_N0.6580.11
215_K451_I0.6580.11
142_V208_I0.6570.11
64_Q415_A0.6560.11
172_D208_I0.6560.11
117_D185_K0.6540.11
126_Q370_T0.6540.11
191_T367_D0.6520.11
243_H315_M0.6520.11
366_I409_F0.6510.11
327_V346_V0.6490.11
53_Q331_L0.6490.11
363_K377_L0.6480.11
237_Y248_P0.6450.11
62_K121_I0.6440.11
188_G308_L0.6440.11
44_S393_K0.6430.10
263_A329_K0.6430.10
42_G270_G0.6420.10
121_I327_V0.6420.10
160_T237_Y0.6410.10
164_S409_F0.6400.10
105_I291_R0.6400.10
251_V426_I0.6400.10
115_N210_G0.6390.10
181_D409_F0.6370.10
334_S368_G0.6350.10
256_H323_T0.6340.10
108_A178_F0.6310.10
177_L356_F0.6300.10
403_D407_V0.6300.10
39_E287_T0.6300.10
46_I51_M0.6290.10
103_Y310_N0.6280.10
310_N429_Y0.6270.10
92_N103_Y0.6250.10
135_S176_R0.6250.10
259_L310_N0.6240.10
88_W108_A0.6240.10
396_L414_F0.6230.10
344_A400_M0.6230.10
127_K176_R0.6230.10
68_F208_I0.6200.10
61_E299_Q0.6190.10
173_G199_V0.6180.10
191_T443_F0.6160.10
51_M305_T0.6140.10
169_F412_S0.6130.10
142_V244_T0.6110.10
122_Y341_I0.6100.10
54_I421_G0.6100.10
275_E292_Q0.6080.10
320_D452_K0.6080.10
304_R307_E0.6070.10
350_N359_S0.6060.10
65_V107_F0.6050.10
278_F333_A0.6050.10
235_G311_G0.6040.10
227_N256_H0.6030.10
100_Y311_G0.6020.10
186_H388_Y0.6010.10
142_V177_L0.5990.10
453_G458_V0.5980.10
231_F416_V0.5960.10
235_G245_L0.5940.10
182_F231_F0.5930.10
88_W195_A0.5910.10
230_Q330_P0.5910.10
253_D346_V0.5910.10
427_T430_M0.5900.10
266_G429_Y0.5880.10
48_R270_G0.5870.10
391_L415_A0.5870.10
108_A400_M0.5870.10
270_G425_V0.5850.10
46_I344_A0.5850.10
241_D415_A0.5830.10
167_A178_F0.5820.10
415_A424_V0.5810.10
340_E362_S0.5780.10
87_S136_W0.5760.10
263_A341_I0.5760.10
122_Y360_R0.5760.10
315_M331_L0.5750.10
245_L379_Y0.5730.10
102_G355_L0.5730.10
391_L445_P0.5730.10
48_R284_G0.5720.10
39_E455_K0.5700.10
400_M403_D0.5680.10
40_T171_S0.5670.10
171_S223_K0.5670.10
178_F312_A0.5670.10
84_V158_D0.5650.10
177_L454_K0.5640.10
241_D398_L0.5620.10
288_S332_I0.5610.09
60_N410_T0.5610.09
168_T241_D0.5610.09
38_K299_Q0.5590.09
143_F167_A0.5580.09
423_N441_S0.5580.09
72_T431_T0.5560.09
381_S386_G0.5550.09
145_D220_G0.5550.09
210_G367_D0.5550.09
105_I459_V0.5540.09
360_R441_S0.5520.09
202_S391_L0.5520.09
108_A443_F0.5510.09
63_Y336_T0.5510.09
393_K455_K0.5490.09
277_L460_K0.5490.09
175_I268_E0.5480.09
226_Q353_W0.5470.09
409_F440_Q0.5460.09
252_E383_S0.5450.09
72_T227_N0.5450.09
244_T357_T0.5450.09
336_T364_M0.5450.09
200_S334_S0.5450.09
43_I346_V0.5450.09
263_A281_A0.5450.09
312_A385_T0.5430.09
398_L426_I0.5420.09
227_N230_Q0.5420.09
282_Y335_N0.5410.09
331_L454_K0.5410.09
226_Q425_V0.5400.09
168_T318_L0.5400.09
125_Y172_D0.5360.09
54_I143_F0.5340.09
61_E304_R0.5330.09
83_D118_D0.5320.09
164_S362_S0.5310.09
83_D386_G0.5310.09
235_G239_S0.5290.09
97_V312_A0.5290.09
34_Q105_I0.5280.09
406_D443_F0.5270.09
119_T446_S0.5270.09
398_L447_F0.5260.09
319_N328_M0.5240.09
75_N429_Y0.5230.09
177_L417_P0.5220.09
53_Q59_K0.5220.09
426_I432_N0.5220.09
359_S366_I0.5200.09
231_F240_G0.5190.09
193_T205_S0.5190.09
171_S175_I0.5190.09
162_E239_S0.5190.09
142_V351_G0.5180.09
157_K181_D0.5160.09
313_L344_A0.5150.09
197_V325_K0.5150.09
239_S387_P0.5150.09
371_S400_M0.5150.09
317_E328_M0.5140.09
141_R162_E0.5120.09
170_T213_D0.5100.09
203_D457_S0.5100.09
346_V359_S0.5090.09
125_Y451_I0.5080.09
229_Q391_L0.5080.09
121_I385_T0.5070.09
159_Q191_T0.5070.09
347_F449_L0.5060.09
172_D199_V0.5050.09
90_L136_W0.5050.09
429_Y447_F0.5040.09
114_K120_S0.5040.09
211_V425_V0.5020.09
92_N315_M0.5020.09
69_D310_N0.5020.09
44_S146_S0.5010.09
183_S238_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oygA 1 0.9302 100 0.466 Contact Map
2yfrA 2 0.9662 100 0.541 Contact Map
1w18A 1 0.8985 100 0.576 Contact Map
3wpuA 1 0.8943 100 0.583 Contact Map
4d47A 3 0.8076 100 0.659 Contact Map
3vsfA 1 0.6427 99.6 0.913 Contact Map
3pijA 2 0.704 99.6 0.914 Contact Map
3qz4A 1 0.6047 99.6 0.914 Contact Map
1w2tA 1 0.6173 99.6 0.915 Contact Map
3nqhA 2 0.6173 99.5 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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