GREMLIN Database
PYRB - Aspartate carbamoyltransferase
UniProt: P05654 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (285)
Sequences: 6937 (3629)
Seq/√Len: 214.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_V261_S4.0901.00
149_T175_R3.9691.00
32_N35_T3.5121.00
149_T177_L3.4211.00
151_S204_S3.1881.00
246_I258_I3.1351.00
198_D239_R3.0471.00
26_K140_E2.8761.00
21_T286_Q2.8191.00
138_I206_V2.7711.00
89_E114_N2.7041.00
205_D241_K2.6081.00
141_E269_R2.5811.00
90_S272_K2.5751.00
245_I269_R2.5731.00
196_S199_E2.5411.00
23_Q139_Y2.4611.00
6_T126_Q2.3311.00
82_Y108_E2.3131.00
20_Q139_Y2.2841.00
40_A93_V2.2811.00
58_E63_M2.2051.00
247_M269_R2.1771.00
16_K139_Y2.1351.00
39_A58_E2.1051.00
23_Q136_M2.0981.00
95_V285_I2.0541.00
131_S168_V2.0341.00
135_L168_V1.9341.00
142_F243_H1.9341.00
179_S200_A1.9201.00
60_K282_M1.8851.00
182_S195_V1.8681.00
201_V207_V1.8441.00
185_Q195_V1.8341.00
169_L176_V1.8171.00
141_E272_K1.8141.00
12_T16_K1.8141.00
90_S275_K1.8141.00
59_K64_N1.7831.00
237_A244_A1.7751.00
253_N256_V1.7691.00
97_V120_A1.7681.00
234_V238_E1.7681.00
11_S14_E1.7131.00
175_R192_G1.6951.00
194_Y199_E1.6591.00
52_F88_L1.6561.00
17_D287_R1.6541.00
142_F148_L1.6011.00
129_T284_V1.5821.00
25_L286_Q1.5731.00
177_L194_Y1.5731.00
69_D72_S1.5701.00
240_M244_A1.5621.00
102_E105_Y1.5591.00
39_A95_V1.5591.00
235_E238_E1.5481.00
18_L287_R1.5361.00
182_S185_Q1.5191.00
244_A267_K1.5181.00
126_Q167_E1.5171.00
165_N208_M1.5051.00
21_T287_R1.4971.00
151_S179_S1.4841.00
184_W226_Y1.4691.00
12_T171_R1.4651.00
12_T146_K1.4641.00
222_S226_Y1.4591.00
206_V245_I1.4581.00
44_F105_Y1.4461.00
95_V289_L1.4391.00
175_R190_T1.4151.00
4_L132_L1.4041.00
151_S177_L1.3871.00
198_D236_R1.3861.00
129_T281_R1.3841.00
180_G185_Q1.3661.00
33_Q286_Q1.3551.00
22_A136_M1.3521.00
208_M273_Q1.3461.00
86_R264_E1.3351.00
153_H201_V1.3281.00
19_L136_M1.3281.00
2_K14_E1.3271.00
203_S241_K1.3211.00
85_I109_L1.3201.00
233_T259_D1.2881.00
8_S167_E1.2751.00
86_R271_F1.2671.00
19_L139_Y1.2641.00
4_L284_V1.2531.00
21_T24_E1.2521.00
197_M236_R1.2501.00
39_A97_V1.2451.00
48_T84_T1.2311.00
7_M168_V1.2251.00
207_V232_L1.2201.00
202_E239_R1.2151.00
237_A246_I1.2141.00
231_G259_D1.2131.00
209_L232_L1.2121.00
48_T78_G1.2091.00
51_R55_E1.2051.00
136_M280_I1.1951.00
144_T148_L1.1921.00
16_K172_L1.1901.00
279_F282_M1.1861.00
255_G260_D1.1771.00
169_L174_A1.1711.00
132_L284_V1.1501.00
48_T74_S1.1441.00
194_Y200_A1.1401.00
148_L206_V1.1391.00
82_Y112_Q1.1331.00
252_V263_V1.1281.00
3_H110_V1.1281.00
59_K65_V1.1261.00
254_R264_E1.1051.00
96_C115_I1.1021.00
201_V236_R1.0991.00
142_F205_D1.0981.00
237_A267_K1.0951.00
275_K279_F1.0881.00
177_L192_G1.0871.00
23_Q140_E1.0751.00
107_E111_S1.0731.00
232_L246_I1.0681.00
96_C109_L1.0551.00
142_F245_I1.0481.00
87_T274_M1.0461.00
58_E65_V1.0451.00
6_T9_E1.0441.00
26_K276_N1.0431.00
166_A178_F1.0421.00
265_S268_S1.0381.00
57_A285_I1.0311.00
46_P76_Q1.0211.00
4_L10_L1.0191.00
179_S194_Y1.0141.00
104_E108_E1.0081.00
16_K20_Q1.0071.00
19_L23_Q1.0061.00
286_Q290_Q1.0051.00
131_S165_N0.9981.00
156_I180_G0.9911.00
15_I172_L0.9821.00
150_V169_L0.9781.00
263_V270_I0.9761.00
150_V165_N0.9711.00
60_K278_V0.9711.00
195_V230_Y0.9681.00
6_T167_E0.9631.00
55_E67_N0.9621.00
19_L280_I0.9591.00
39_A63_M0.9551.00
131_S161_V0.9521.00
86_R112_Q0.9511.00
118_L284_V0.9461.00
226_Y229_K0.9320.99
89_E115_I0.9310.99
52_F68_L0.9310.99
26_K136_M0.9300.99
55_E59_K0.9220.99
135_L172_L0.9190.99
98_I109_L0.9170.99
186_D193_T0.9160.99
138_I148_L0.9160.99
100_H122_D0.9110.99
140_E276_N0.9080.99
222_S225_G0.9060.99
15_I171_R0.9040.99
149_T203_S0.9030.99
95_V118_L0.9030.99
82_Y264_E0.8940.99
144_T147_G0.8880.99
74_S77_K0.8880.99
106_Y122_D0.8870.99
234_V265_S0.8870.99
38_F64_N0.8860.99
103_D107_E0.8820.99
74_S84_T0.8800.99
177_L204_S0.8790.99
199_E202_E0.8770.99
179_S204_S0.8760.99
3_H89_E0.8750.99
7_M131_S0.8690.99
3_H113_V0.8690.99
20_Q24_E0.8640.99
32_N62_G0.8640.99
38_F60_K0.8580.99
136_M140_E0.8550.99
272_K275_K0.8550.99
126_Q164_S0.8530.99
142_F269_R0.8500.99
82_Y86_R0.8450.99
153_H207_V0.8430.99
145_F172_L0.8380.99
132_L280_I0.8370.99
237_A262_L0.8350.99
58_E285_I0.8350.99
254_R263_V0.8350.99
55_E65_V0.8340.99
192_G199_E0.8280.99
235_E239_R0.8220.99
177_L203_S0.8150.99
260_D264_E0.8130.99
74_S78_G0.8110.99
54_F129_T0.8110.99
125_G187_E0.8050.98
138_I145_F0.7960.98
166_A176_V0.7900.98
98_I105_Y0.7890.98
283_A287_R0.7890.98
179_S197_M0.7830.98
200_A204_S0.7820.98
44_F75_V0.7790.98
156_I162_A0.7780.98
198_D202_E0.7770.98
107_E110_V0.7720.98
53_S91_I0.7720.98
137_T269_R0.7690.98
23_Q27_S0.7670.98
5_T110_V0.7660.98
108_E112_Q0.7640.98
37_K94_D0.7640.98
38_F56_V0.7620.98
198_D235_E0.7600.98
17_D21_T0.7600.98
18_L280_I0.7590.98
7_M15_I0.7580.98
166_A186_D0.7570.98
153_H236_R0.7560.98
82_Y260_D0.7520.98
137_T276_N0.7520.98
237_A240_M0.7500.98
85_I113_V0.7490.98
32_N36_G0.7460.97
4_L288_A0.7460.97
224_E256_V0.7450.97
138_I142_F0.7400.97
24_E27_S0.7370.97
15_I168_V0.7330.97
149_T204_S0.7250.97
262_L265_S0.7230.97
162_A178_F0.7220.97
142_F206_V0.7200.97
78_G84_T0.7190.97
221_V224_E0.7190.97
22_A283_A0.7190.97
260_D263_V0.7180.97
165_N169_L0.7180.97
233_T236_R0.7170.97
86_R89_E0.7150.97
254_R260_D0.7130.97
93_V115_I0.7120.97
269_R272_K0.7120.97
100_H105_Y0.7110.97
207_V244_A0.7100.97
18_L283_A0.7090.97
53_S281_R0.7080.97
21_T25_L0.7070.96
143_N147_G0.7050.96
10_L18_L0.7050.96
153_H197_M0.7040.96
22_A280_I0.7000.96
232_L258_I0.6970.96
30_T33_Q0.6920.96
95_V288_A0.6910.96
2_K287_R0.6910.96
34_L63_M0.6910.96
185_Q188_E0.6860.96
40_A96_C0.6830.96
34_L95_V0.6810.96
57_A281_R0.6790.96
73_T78_G0.6790.96
138_I169_L0.6770.96
60_K94_D0.6760.95
138_I245_I0.6730.95
102_E123_G0.6670.95
234_V259_D0.6660.95
252_V258_I0.6650.95
141_E245_I0.6650.95
170_T189_N0.6650.95
7_M10_L0.6640.95
228_N231_G0.6590.95
41_N58_E0.6580.95
48_T77_K0.6570.95
237_A258_I0.6560.95
39_A285_I0.6550.95
13_E16_K0.6530.95
220_A223_Q0.6520.95
225_G228_N0.6510.94
104_E107_E0.6510.94
238_E267_K0.6510.94
15_I132_L0.6500.94
108_E111_S0.6450.94
41_N67_N0.6430.94
211_R215_E0.6420.94
236_R239_R0.6420.94
30_T35_T0.6420.94
56_V66_L0.6400.94
211_R253_N0.6370.94
41_N65_V0.6350.94
73_T77_K0.6340.94
246_I262_L0.6340.94
135_L139_Y0.6330.94
151_S200_A0.6320.94
201_V239_R0.6320.94
7_M126_Q0.6300.93
265_S270_I0.6300.93
219_S222_S0.6290.93
81_L105_Y0.6290.93
80_T264_E0.6270.93
218_Q221_V0.6250.93
150_V208_M0.6240.93
138_I150_V0.6200.93
152_I159_S0.6180.93
122_D125_G0.6180.93
208_M211_R0.6170.93
153_H209_L0.6150.93
197_M201_V0.6150.93
234_V267_K0.6140.93
53_S129_T0.6130.93
208_M247_M0.6120.92
89_E113_V0.6120.92
13_E17_D0.6100.92
54_F281_R0.6090.92
213_Q221_V0.6080.92
48_T73_T0.6050.92
131_S273_Q0.6040.92
135_L145_F0.6040.92
38_F59_K0.6020.92
183_E225_G0.6010.92
185_Q193_T0.6010.92
28_G31_D0.5980.92
46_P74_S0.5940.91
151_S194_Y0.5940.91
121_G160_R0.5930.91
85_I96_C0.5870.91
25_L33_Q0.5870.91
151_S207_V0.5860.91
46_P78_G0.5860.91
118_L288_A0.5840.91
96_C113_V0.5840.91
118_L285_I0.5830.91
5_T107_E0.5820.90
45_E216_R0.5770.90
263_V268_S0.5770.90
201_V240_M0.5760.90
207_V237_A0.5750.90
54_F97_V0.5750.90
131_S135_L0.5740.90
53_S87_T0.5730.90
227_L259_D0.5730.90
168_V172_L0.5710.90
44_F100_H0.5690.89
175_R189_N0.5670.89
43_F47_S0.5660.89
140_E272_K0.5660.89
139_Y144_T0.5640.89
8_S126_Q0.5620.89
232_L237_A0.5620.89
104_E122_D0.5590.89
206_V247_M0.5590.89
47_S50_T0.5580.89
104_E125_G0.5570.89
18_L284_V0.5570.89
87_T90_S0.5550.88
161_V208_M0.5530.88
195_V199_E0.5530.88
170_T176_V0.5520.88
145_F174_A0.5500.88
150_V174_A0.5460.88
54_F120_A0.5450.87
263_V271_F0.5450.87
14_E287_R0.5440.87
180_G186_D0.5440.87
56_V278_V0.5440.87
56_V60_K0.5440.87
170_T190_T0.5430.87
20_Q23_Q0.5390.87
46_P72_S0.5390.87
25_L30_T0.5380.87
148_L205_D0.5380.87
152_I208_M0.5370.87
285_I289_L0.5360.87
84_T88_L0.5350.86
69_D73_T0.5340.86
265_S269_R0.5340.86
17_D20_Q0.5330.86
25_L29_K0.5320.86
223_Q227_L0.5320.86
31_D35_T0.5310.86
255_G261_S0.5300.86
4_L15_I0.5280.86
19_L22_A0.5280.86
85_I117_I0.5280.86
45_E215_E0.5260.86
179_S201_V0.5240.85
87_T271_F0.5240.85
21_T283_A0.5240.85
180_G195_V0.5230.85
31_D36_G0.5220.85
14_E17_D0.5190.85
183_E226_Y0.5180.85
101_S105_Y0.5180.85
250_A271_F0.5170.85
259_D262_L0.5170.85
143_N245_I0.5160.84
43_F50_T0.5150.84
177_L200_A0.5150.84
26_K279_F0.5140.84
6_T107_E0.5130.84
87_T91_I0.5120.84
79_E83_D0.5110.84
161_V165_N0.5110.84
81_L98_I0.5100.84
121_G215_E0.5090.84
47_S51_R0.5090.84
77_K253_N0.5060.83
3_H114_N0.5040.83
8_S171_R0.5030.83
30_T61_L0.5020.83
206_V269_R0.5010.83
221_V256_V0.5010.83
246_I268_S0.5000.83
217_H220_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r7fA 3 0.9572 100 0.036 Contact Map
4nf2A 3 0.9441 100 0.041 Contact Map
2i6uA 3 0.9507 100 0.048 Contact Map
3gd5A 4 0.8816 100 0.048 Contact Map
4oh7A 3 0.9441 100 0.049 Contact Map
1pvvA 6 0.9507 100 0.051 Contact Map
1ml4A 3 0.9507 100 0.055 Contact Map
3tpfA 3 0.9474 100 0.056 Contact Map
1pg5A 4 0.9243 100 0.056 Contact Map
3grfA 3 0.8947 100 0.059 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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