GYRB - BACSU - GREMLIN Contacts

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GYRB - DNA gyrase subunit B

UniProt:	P05652	Sequences: MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWEIVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHAGGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIGETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKNEYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNNINTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDPQFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKARELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPLRGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAHIRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTPKPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRNFIEANARYVKNLDI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	638 (623)
Sequences:	4828 (2004)
Seq/√Len:	80.3

ECOLI - GYRB PARE
BACSU - GYRB PARE
HALSA - Q9HR30

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_T	76_N	6.489	1.00
141_K	158_I	4.491	1.00
45_I	122_A	4.332	1.00
208_E	217_K	4.014	1.00
130_T	172_V	4.008	1.00
66_E	72_T	3.754	1.00
133_D	146_T	3.691	1.00
173_P	184_Y	3.669	1.00
549_A	558_L	3.491	1.00
148_K	153_V	3.329	1.00
131_E	172_V	3.267	1.00
74_V	168_T	3.231	1.00
137_H	164_H	3.223	1.00
204_N	219_E	3.141	1.00
416_S	421_I	3.016	1.00
590_D	593_S	3.014	1.00
494_H	529_Y	2.981	1.00
60_D	204_N	2.947	1.00
10_E	83_G	2.916	1.00
93_V	134_V	2.876	1.00
133_D	144_R	2.867	1.00
107_D	110_G	2.751	1.00
97_M	169_T	2.748	1.00
66_E	210_K	2.736	1.00
93_V	156_L	2.711	1.00
42_V	189_L	2.695	1.00
197_A	222_Y	2.666	1.00
131_E	146_T	2.659	1.00
491_A	529_Y	2.655	1.00
144_R	157_E	2.645	1.00
88_M	95_V	2.641	1.00
418_D	421_I	2.617	1.00
62_N	206_T	2.568	1.00
135_T	168_T	2.557	1.00
134_V	169_T	2.535	1.00
66_E	170_H	2.527	1.00
72_T	170_H	2.521	1.00
60_D	76_N	2.512	1.00
154_T	157_E	2.509	1.00
302_R	313_N	2.478	1.00
67_K	210_K	2.452	1.00
141_K	161_E	2.432	1.00
424_L	478_L	2.396	1.00
135_T	144_R	2.381	1.00
201_K	248_E	2.366	1.00
93_V	136_V	2.351	1.00
63_I	193_V	2.336	1.00
143_H	158_I	2.325	1.00
82_V	143_H	2.320	1.00
186_Y	218_N	2.306	1.00
62_N	74_V	2.290	1.00
42_V	71_I	2.279	1.00
130_T	175_P	2.276	1.00
65_I	71_I	2.272	1.00
534_Q	597_L	2.250	1.00
629_N	632_Y	2.247	1.00
538_Y	552_D	2.244	1.00
90_R	94_E	2.226	1.00
258_V	327_I	2.206	1.00
419_P	494_H	2.184	1.00
135_T	142_I	2.170	1.00
50_I	203_V	2.149	1.00
474_M	478_L	2.126	1.00
204_N	221_H	2.114	1.00
299_D	303_K	2.113	1.00
186_Y	207_I	2.112	1.00
624_N	628_A	2.101	1.00
10_E	92_A	2.087	1.00
522_R	526_E	2.087	1.00
497_V	596_L	2.086	1.00
133_D	170_H	2.071	1.00
158_I	161_E	2.067	1.00
523_Q	526_E	2.056	1.00
296_V	358_S	2.054	1.00
58_C	76_N	2.050	1.00
72_T	168_T	2.022	1.00
17_E	87_K	2.017	1.00
135_T	170_H	2.008	1.00
281_E	342_T	2.007	1.00
145_Q	152_P	2.006	1.00
541_Q	546_V	1.997	1.00
80_I	96_I	1.995	1.00
149_R	176_E	1.984	1.00
228_S	231_E	1.955	1.00
246_Y	257_E	1.951	1.00
137_H	142_I	1.946	1.00
412_A	437_K	1.925	1.00
415_S	442_R	1.912	1.00
66_E	70_S	1.910	1.00
524_I	530_V	1.862	1.00
272_S	286_E	1.856	1.00
435_S	581_A	1.856	1.00
146_T	153_V	1.856	1.00
274_T	331_H	1.836	1.00
62_N	208_E	1.835	1.00
426_I	450_L	1.831	1.00
194_R	232_Y	1.825	1.00
297_I	365_M	1.823	1.00
142_I	162_T	1.795	1.00
21_A	101_H	1.793	1.00
478_L	496_V	1.784	1.00
238_E	264_D	1.784	1.00
426_I	474_M	1.774	1.00
60_D	206_T	1.770	1.00
64_Q	74_V	1.764	1.00
551_N	554_E	1.764	1.00
90_R	99_V	1.748	1.00
350_R	354_D	1.746	1.00
254_I	352_I	1.723	1.00
314_L	379_G	1.722	1.00
43_W	189_L	1.717	1.00
64_Q	210_K	1.713	1.00
249_G	356_L	1.706	1.00
83_G	139_D	1.699	1.00
272_S	279_T	1.686	1.00
250_E	255_T	1.670	1.00
606_D	609_E	1.666	1.00
398_R	401_A	1.663	1.00
97_M	122_A	1.661	1.00
146_T	154_T	1.653	1.00
368_N	371_A	1.652	1.00
227_K	231_E	1.645	1.00
514_L	530_V	1.641	1.00
142_I	160_G	1.615	1.00
137_H	168_T	1.614	1.00
532_I	599_V	1.608	1.00
487_N	490_K	1.607	1.00
206_T	219_E	1.604	1.00
11_N	86_E	1.590	1.00
17_E	88_M	1.590	1.00
300_Y	372_A	1.589	1.00
478_L	491_A	1.584	1.00
190_A	218_N	1.583	1.00
186_Y	220_Y	1.580	1.00
64_Q	208_E	1.569	1.00
144_R	159_I	1.547	0.99
540_V	558_L	1.546	0.99
289_F	325_A	1.545	0.99
234_N	261_Q	1.535	0.99
122_A	132_L	1.527	0.99
9_D	12_Q	1.519	0.99
71_I	184_Y	1.518	0.99
198_F	232_Y	1.505	0.99
254_I	349_A	1.500	0.99
361_M	365_M	1.485	0.99
83_G	92_A	1.477	0.99
364_F	368_N	1.476	0.99
420_S	494_H	1.459	0.99
289_F	327_I	1.456	0.99
97_M	132_L	1.455	0.99
131_E	148_K	1.453	0.99
555_L	559_L	1.443	0.99
250_E	253_G	1.436	0.99
34_N	347_S	1.434	0.99
416_S	422_S	1.431	0.99
46_V	73_V	1.423	0.99
260_L	323_L	1.415	0.99
147_Y	152_P	1.410	0.99
14_Q	107_D	1.406	0.99
301_A	307_I	1.405	0.99
618_K	621_P	1.401	0.99
349_A	352_I	1.400	0.99
451_R	470_E	1.396	0.99
554_E	557_E	1.385	0.99
83_G	138_R	1.385	0.99
316_G	320_R	1.383	0.99
70_S	172_V	1.380	0.99
523_Q	527_N	1.378	0.99
234_N	324_T	1.359	0.99
422_S	494_H	1.347	0.99
152_P	155_D	1.334	0.98
547_E	561_T	1.324	0.98
74_V	164_H	1.320	0.98
309_E	313_N	1.316	0.98
463_D	467_S	1.312	0.98
542_Q	567_K	1.310	0.98
331_H	349_A	1.307	0.98
103_G	106_F	1.303	0.98
64_Q	72_T	1.301	0.98
571_Q	583_Q	1.299	0.98
321_E	382_A	1.288	0.98
201_K	257_E	1.281	0.98
137_H	165_T	1.276	0.98
469_N	473_S	1.276	0.98
547_E	558_L	1.271	0.98
274_T	279_T	1.267	0.98
604_A	607_A	1.266	0.98
132_L	169_T	1.265	0.98
185_D	188_L	1.259	0.98
424_L	474_M	1.259	0.98
95_V	99_V	1.257	0.98
206_T	217_K	1.251	0.98
454_I	471_V	1.248	0.98
58_C	61_I	1.248	0.98
513_L	517_F	1.245	0.98
50_I	196_L	1.241	0.98
243_E	371_A	1.240	0.98
266_Y	397_R	1.236	0.97
53_A	203_V	1.236	0.97
480_T	486_F	1.235	0.97
172_V	175_P	1.235	0.97
142_I	159_I	1.234	0.97
14_Q	24_K	1.234	0.97
46_V	193_V	1.224	0.97
470_E	473_S	1.223	0.97
539_K	546_V	1.221	0.97
302_R	311_D	1.221	0.97
115_G	277_I	1.217	0.97
496_V	517_F	1.216	0.97
488_L	527_N	1.212	0.97
147_Y	154_T	1.211	0.97
451_R	454_I	1.211	0.97
245_I	260_L	1.205	0.97
84_I	89_G	1.201	0.97
70_S	173_P	1.200	0.97
69_N	183_E	1.197	0.97
30_I	37_G	1.194	0.97
248_E	257_E	1.194	0.97
419_P	422_S	1.187	0.97
226_I	246_Y	1.185	0.97
302_R	309_E	1.183	0.97
360_A	363_T	1.181	0.97
65_I	69_N	1.180	0.97
398_R	413_D	1.180	0.97
280_Y	342_T	1.173	0.97
97_M	134_V	1.171	0.96
421_I	443_H	1.171	0.96
145_Q	154_T	1.170	0.96
227_K	246_Y	1.169	0.96
517_F	530_V	1.164	0.96
57_Y	78_R	1.164	0.96
270_I	290_K	1.163	0.96
297_I	319_V	1.161	0.96
438_Q	581_A	1.160	0.96
547_E	554_E	1.160	0.96
421_I	444_F	1.156	0.96
623_R	627_E	1.155	0.96
454_I	500_T	1.150	0.96
146_T	157_E	1.149	0.96
7_S	12_Q	1.148	0.96
139_D	143_H	1.145	0.96
365_M	372_A	1.140	0.96
540_V	549_A	1.136	0.96
338_G	345_G	1.135	0.96
190_A	220_Y	1.134	0.96
255_T	330_K	1.132	0.96
540_V	555_L	1.130	0.96
256_V	356_L	1.129	0.96
141_K	160_G	1.127	0.96
49_S	169_T	1.125	0.96
559_L	570_L	1.120	0.95
270_I	325_A	1.117	0.95
66_E	69_N	1.114	0.95
147_Y	156_L	1.114	0.95
413_D	492_R	1.113	0.95
378_K	397_R	1.112	0.95
70_S	170_H	1.108	0.95
69_N	172_V	1.107	0.95
585_W	591_P	1.105	0.95
556_E	560_K	1.103	0.95
374_K	377_D	1.103	0.95
281_E	338_G	1.100	0.95
24_K	333_D	1.097	0.95
291_T	354_D	1.097	0.95
480_T	488_L	1.097	0.95
415_S	443_H	1.095	0.95
586_E	590_D	1.094	0.95
426_I	470_E	1.092	0.95
247_I	258_V	1.092	0.95
294_T	316_G	1.088	0.95
549_A	555_L	1.088	0.95
42_V	46_V	1.087	0.95
254_I	331_H	1.085	0.95
462_L	466_L	1.078	0.94
480_T	491_A	1.073	0.94
423_E	497_V	1.073	0.94
542_Q	563_P	1.067	0.94
357_F	361_M	1.066	0.94
70_S	131_E	1.065	0.94
338_G	342_T	1.060	0.94
546_V	549_A	1.058	0.94
557_E	561_T	1.054	0.94
13_I	92_A	1.053	0.94
22_V	100_L	1.051	0.94
510_R	532_I	1.048	0.94
136_V	156_L	1.046	0.93
563_P	567_K	1.046	0.93
301_A	376_V	1.045	0.93
232_Y	609_E	1.044	0.93
186_Y	190_A	1.044	0.93
193_V	207_I	1.040	0.93
329_I	349_A	1.040	0.93
138_R	165_T	1.039	0.93
175_P	182_T	1.039	0.93
256_V	352_I	1.039	0.93
451_R	469_N	1.036	0.93
444_F	591_P	1.035	0.93
235_R	609_E	1.035	0.93
60_D	219_E	1.026	0.93
130_T	176_E	1.023	0.93
337_E	345_G	1.022	0.93
194_R	222_Y	1.021	0.93
491_A	527_N	1.018	0.93
337_E	342_T	1.017	0.92
603_D	606_D	1.013	0.92
137_H	162_T	1.008	0.92
363_T	367_E	1.007	0.92
49_S	97_M	1.006	0.92
74_V	137_H	1.005	0.92
292_G	296_V	1.004	0.92
549_A	554_E	0.999	0.92
149_R	174_D	0.998	0.92
408_P	413_D	0.989	0.91
335_Q	345_G	0.984	0.91
454_I	470_E	0.980	0.91
555_L	568_P	0.977	0.91
274_T	329_I	0.977	0.91
498_I	517_F	0.975	0.91
279_T	345_G	0.973	0.91
354_D	358_S	0.972	0.91
189_L	193_V	0.971	0.91
385_A	389_A	0.969	0.91
142_I	164_H	0.968	0.91
556_E	559_L	0.958	0.90
190_A	207_I	0.954	0.90
91_P	95_V	0.952	0.90
224_G	228_S	0.951	0.90
224_G	227_K	0.949	0.90
454_I	473_S	0.946	0.89
299_D	302_R	0.944	0.89
279_T	338_G	0.944	0.89
472_R	476_T	0.944	0.89
564_Q	567_K	0.943	0.89
287_A	291_T	0.943	0.89
82_V	138_R	0.942	0.89
85_H	92_A	0.942	0.89
41_L	125_V	0.939	0.89
14_Q	87_K	0.934	0.89
7_S	10_E	0.934	0.89
136_V	167_T	0.933	0.89
422_S	529_Y	0.928	0.89
573_Y	583_Q	0.927	0.89
53_A	58_C	0.924	0.88
108_G	333_D	0.923	0.88
59_T	204_N	0.921	0.88
307_I	311_D	0.920	0.88
262_Y	319_V	0.920	0.88
80_I	169_T	0.919	0.88
54_L	58_C	0.918	0.88
351_T	355_T	0.918	0.88
266_Y	378_K	0.918	0.88
412_A	442_R	0.917	0.88
287_A	354_D	0.917	0.88
12_Q	110_G	0.916	0.88
85_H	90_R	0.915	0.88
227_K	243_E	0.915	0.88
80_I	97_M	0.914	0.88
585_W	590_D	0.913	0.88
610_T	613_M	0.913	0.88
122_A	134_V	0.912	0.88
301_A	314_L	0.909	0.88
318_D	386_R	0.908	0.87
454_I	468_N	0.902	0.87
179_S	182_T	0.902	0.87
307_I	313_N	0.901	0.87
45_I	97_M	0.899	0.87
458_E	519_R	0.899	0.87
9_D	83_G	0.896	0.87
359_T	363_T	0.896	0.87
609_E	613_M	0.895	0.87
620_E	624_N	0.895	0.87
243_E	368_N	0.894	0.87
63_I	205_I	0.894	0.87
441_D	444_F	0.893	0.87
63_I	207_I	0.891	0.86
122_A	169_T	0.884	0.86
84_I	88_M	0.883	0.86
518_Y	607_A	0.882	0.86
90_R	152_P	0.877	0.86
91_P	156_L	0.875	0.85
90_R	95_V	0.875	0.85
244_P	259_A	0.871	0.85
474_M	500_T	0.871	0.85
319_V	379_G	0.871	0.85
86_E	89_G	0.870	0.85
425_Y	444_F	0.869	0.85
475_I	516_F	0.868	0.85
468_N	473_S	0.866	0.85
385_A	392_A	0.865	0.85
302_R	307_I	0.864	0.85
274_T	345_G	0.860	0.84
65_I	207_I	0.858	0.84
142_I	158_I	0.857	0.84
410_K	430_D	0.853	0.84
241_H	371_A	0.852	0.84
370_D	374_K	0.849	0.84
196_L	200_T	0.847	0.84
281_E	343_K	0.844	0.83
466_L	471_V	0.843	0.83
470_E	500_T	0.842	0.83
287_A	350_R	0.839	0.83
50_I	205_I	0.838	0.83
174_D	177_I	0.838	0.83
295_R	354_D	0.836	0.83
84_I	90_R	0.835	0.83
224_G	231_E	0.835	0.83
76_N	164_H	0.832	0.82
15_V	88_M	0.831	0.82
539_K	583_Q	0.831	0.82
198_F	222_Y	0.831	0.82
145_Q	156_L	0.830	0.82
92_A	95_V	0.829	0.82
377_D	381_M	0.829	0.82
438_Q	580_N	0.828	0.82
16_L	24_K	0.823	0.82
21_A	27_G	0.820	0.82
144_R	154_T	0.819	0.81
591_P	594_R	0.819	0.81
611_F	615_M	0.817	0.81
69_N	184_Y	0.815	0.81
86_E	92_A	0.815	0.81
373_K	377_D	0.813	0.81
489_E	527_N	0.813	0.81
272_S	338_G	0.813	0.81
139_D	158_I	0.811	0.81
510_R	534_Q	0.809	0.81
194_R	198_F	0.808	0.81
149_R	177_I	0.808	0.81
57_Y	151_V	0.804	0.80
35_S	185_D	0.802	0.80
298_N	302_R	0.801	0.80
437_K	583_Q	0.800	0.80
162_T	165_T	0.793	0.79
358_S	362_E	0.793	0.79
601_L	607_A	0.792	0.79
274_T	336_F	0.790	0.79
582_T	590_D	0.788	0.79
171_F	184_Y	0.787	0.79
241_H	262_Y	0.786	0.79
132_L	145_Q	0.786	0.79
314_L	376_V	0.784	0.79
19_L	100_L	0.781	0.78
241_H	244_P	0.781	0.78
612_E	618_K	0.780	0.78
279_T	337_E	0.778	0.78
624_N	627_E	0.778	0.78
272_S	345_G	0.777	0.78
208_E	213_G	0.776	0.78
88_M	99_V	0.776	0.78
346_N	349_A	0.772	0.77
621_P	624_N	0.771	0.77
248_E	255_T	0.770	0.77
457_V	465_I	0.768	0.77
395_L	398_R	0.767	0.77
256_V	353_T	0.767	0.77
600_T	604_A	0.765	0.77
258_V	289_F	0.764	0.77
43_W	188_L	0.764	0.77
21_A	100_L	0.763	0.77
552_D	556_E	0.763	0.77
258_V	357_F	0.762	0.77
15_V	95_V	0.758	0.76
130_T	174_D	0.757	0.76
17_E	21_A	0.756	0.76
525_I	530_V	0.755	0.76
18_G	22_V	0.754	0.76
130_T	149_R	0.753	0.76
419_P	529_Y	0.753	0.76
59_T	63_I	0.750	0.75
499_M	533_A	0.748	0.75
409_G	442_R	0.747	0.75
425_Y	596_L	0.744	0.75
525_I	601_L	0.744	0.75
436_A	447_I	0.741	0.75
408_P	492_R	0.739	0.74
414_C	492_R	0.739	0.74
474_M	516_F	0.737	0.74
289_F	357_F	0.737	0.74
409_G	477_A	0.736	0.74
480_T	521_M	0.735	0.74
21_A	24_K	0.735	0.74
407_L	442_R	0.734	0.74
606_D	610_T	0.734	0.74
32_S	37_G	0.734	0.74
14_Q	17_E	0.733	0.74
241_H	261_Q	0.733	0.74
469_N	472_R	0.732	0.74
83_G	143_H	0.732	0.74
560_K	563_P	0.731	0.74
270_I	286_E	0.730	0.73
540_V	562_L	0.729	0.73
141_K	159_I	0.729	0.73
422_S	491_A	0.728	0.73
85_H	95_V	0.727	0.73
17_E	151_V	0.727	0.73
291_T	350_R	0.726	0.73
68_D	170_H	0.725	0.73
295_R	358_S	0.725	0.73
272_S	335_Q	0.724	0.73
625_F	630_A	0.724	0.73
296_V	361_M	0.722	0.73
87_K	151_V	0.720	0.72
231_E	243_E	0.719	0.72
82_V	93_V	0.718	0.72
54_L	207_I	0.718	0.72
520_Y	550_Y	0.717	0.72
159_I	162_T	0.717	0.72
19_L	101_H	0.717	0.72
254_I	332_P	0.716	0.72
542_Q	566_P	0.716	0.72
10_E	139_D	0.715	0.72
483_G	520_Y	0.713	0.72
425_Y	585_W	0.713	0.72
583_Q	586_E	0.713	0.72
546_V	586_E	0.710	0.71
260_L	293_L	0.709	0.71
94_E	145_Q	0.708	0.71
249_G	360_A	0.708	0.71
279_T	335_Q	0.707	0.71
625_F	629_N	0.705	0.71
334_P	413_D	0.703	0.71
281_E	347_S	0.702	0.71
451_R	471_V	0.701	0.70
175_P	183_E	0.701	0.70
180_E	183_E	0.700	0.70
416_S	443_H	0.698	0.70
478_L	494_H	0.698	0.70
133_D	148_K	0.698	0.70
478_L	530_V	0.698	0.70
420_S	529_Y	0.696	0.70
142_I	163_D	0.696	0.70
99_V	147_Y	0.696	0.70
131_E	153_V	0.695	0.70
499_M	589_M	0.695	0.70
523_Q	601_L	0.695	0.70
19_L	22_V	0.693	0.70
228_S	473_S	0.691	0.69
457_V	471_V	0.690	0.69
142_I	161_E	0.689	0.69
234_N	263_N	0.689	0.69
335_Q	346_N	0.688	0.69
372_A	376_V	0.687	0.69
137_H	163_D	0.687	0.69
381_M	397_R	0.687	0.69
102_A	123_S	0.687	0.69
278_N	286_E	0.687	0.69
12_Q	107_D	0.686	0.69
281_E	337_E	0.684	0.69
230_V	326_I	0.683	0.68
290_K	320_R	0.681	0.68
473_S	476_T	0.681	0.68
64_Q	70_S	0.680	0.68
12_Q	109_S	0.679	0.68
195_E	229_Y	0.678	0.68
553_K	557_E	0.675	0.68
89_G	151_V	0.674	0.67
93_V	145_Q	0.673	0.67
296_V	362_E	0.673	0.67
8_Y	13_I	0.673	0.67
385_A	396_T	0.673	0.67
102_A	106_F	0.671	0.67
144_R	160_G	0.670	0.67
68_D	172_V	0.669	0.67
131_E	170_H	0.669	0.67
511_T	611_F	0.668	0.67
306_L	376_V	0.667	0.67
447_I	589_M	0.665	0.66
202_G	221_H	0.665	0.66
305_G	310_N	0.664	0.66
364_F	371_A	0.664	0.66
475_I	482_I	0.663	0.66
408_P	473_S	0.663	0.66
553_K	556_E	0.662	0.66
146_T	172_V	0.660	0.66
398_R	403_E	0.660	0.66
451_R	474_M	0.659	0.66
573_Y	586_E	0.659	0.66
201_K	246_Y	0.657	0.65
587_T	594_R	0.657	0.65
95_V	229_Y	0.655	0.65
406_N	476_T	0.655	0.65
84_I	87_K	0.654	0.65
174_D	279_T	0.654	0.65
319_V	467_S	0.654	0.65
507_A	583_Q	0.654	0.65
244_P	247_I	0.652	0.65
155_D	158_I	0.651	0.65
381_M	384_R	0.651	0.65
488_L	491_A	0.650	0.65
611_F	616_G	0.650	0.65
571_Q	585_W	0.649	0.64
560_K	564_Q	0.649	0.64
615_M	619_V	0.648	0.64
548_Y	583_Q	0.648	0.64
286_E	296_V	0.647	0.64
239_V	244_P	0.645	0.64
540_V	559_L	0.643	0.64
25_R	117_L	0.643	0.64
312_P	387_M	0.643	0.64
388_A	392_A	0.643	0.64
22_V	123_S	0.642	0.64
414_C	625_F	0.641	0.64
72_T	210_K	0.641	0.64
92_A	110_G	0.641	0.64
284_T	347_S	0.640	0.63
238_E	618_K	0.640	0.63
272_S	327_I	0.639	0.63
41_L	279_T	0.638	0.63
516_F	521_M	0.638	0.63
547_E	562_L	0.637	0.63
164_H	168_T	0.637	0.63
589_M	594_R	0.635	0.63
143_H	165_T	0.635	0.63
321_E	378_K	0.634	0.63
334_P	457_V	0.632	0.62
106_F	118_H	0.631	0.62
60_D	74_V	0.629	0.62
130_T	146_T	0.629	0.62
172_V	184_Y	0.628	0.62
304_K	376_V	0.627	0.62
558_L	561_T	0.626	0.62
24_K	141_K	0.625	0.62
268_S	320_R	0.624	0.61
91_P	155_D	0.623	0.61
550_Y	558_L	0.623	0.61
253_G	332_P	0.622	0.61
380_L	390_K	0.622	0.61
554_E	595_T	0.621	0.61
415_S	422_S	0.621	0.61
342_T	346_N	0.621	0.61
462_L	465_I	0.620	0.61
301_A	305_G	0.618	0.61
620_E	623_R	0.616	0.60
36_K	280_Y	0.615	0.60
97_M	152_P	0.615	0.60
314_L	380_L	0.615	0.60
72_T	131_E	0.614	0.60
90_R	155_D	0.614	0.60
49_S	61_I	0.614	0.60
15_V	21_A	0.613	0.60
84_I	91_P	0.612	0.60
82_V	141_K	0.611	0.60
534_Q	595_T	0.611	0.60
302_R	310_N	0.610	0.60
83_G	86_E	0.609	0.60
416_S	419_P	0.609	0.60
142_I	147_Y	0.608	0.59
62_N	72_T	0.608	0.59
496_V	530_V	0.608	0.59
451_R	500_T	0.607	0.59
371_A	374_K	0.607	0.59
541_Q	569_G	0.606	0.59
424_L	496_V	0.606	0.59
305_G	309_E	0.605	0.59
329_I	353_T	0.604	0.59
97_M	145_Q	0.604	0.59
189_L	205_I	0.604	0.59
425_Y	495_K	0.604	0.59
46_V	63_I	0.603	0.59
145_Q	155_D	0.603	0.59
412_A	583_Q	0.603	0.59
465_I	471_V	0.601	0.59
97_M	167_T	0.601	0.59
437_K	442_R	0.600	0.58
91_P	152_P	0.600	0.58
84_I	93_V	0.598	0.58
558_L	562_L	0.598	0.58
135_T	207_I	0.598	0.58
274_T	338_G	0.597	0.58
301_A	309_E	0.597	0.58
251_K	352_I	0.596	0.58
455_L	465_I	0.595	0.58
148_K	154_T	0.594	0.58
422_S	443_H	0.594	0.58
451_R	473_S	0.592	0.57
140_G	163_D	0.592	0.57
292_G	361_M	0.592	0.57
239_V	261_Q	0.592	0.57
45_I	124_V	0.592	0.57
69_N	173_P	0.591	0.57
196_L	276_N	0.590	0.57
30_I	33_T	0.590	0.57
423_E	495_K	0.590	0.57
196_L	203_V	0.589	0.57
111_Y	332_P	0.589	0.57
526_E	601_L	0.589	0.57
550_Y	595_T	0.589	0.57
555_L	570_L	0.588	0.57
281_E	346_N	0.586	0.57
390_K	394_E	0.585	0.57
217_K	221_H	0.585	0.57
491_A	524_I	0.585	0.57
424_L	491_A	0.585	0.57
579_M	584_L	0.584	0.56
63_I	212_E	0.584	0.56
247_I	357_F	0.583	0.56
207_I	218_N	0.583	0.56
256_V	365_M	0.583	0.56
11_N	87_K	0.583	0.56
32_S	345_G	0.582	0.56
532_I	617_D	0.581	0.56
7_S	11_N	0.581	0.56
204_N	223_E	0.581	0.56
384_R	461_R	0.581	0.56
60_D	208_E	0.580	0.56
500_T	510_R	0.580	0.56
417_K	557_E	0.579	0.56
421_I	494_H	0.578	0.56
436_A	499_M	0.578	0.56
190_A	273_F	0.578	0.56
286_E	404_I	0.578	0.56
85_H	88_M	0.578	0.56
616_G	626_I	0.577	0.56
563_P	568_P	0.577	0.56
143_H	147_Y	0.577	0.56
83_G	95_V	0.576	0.55
418_D	422_S	0.576	0.55
18_G	101_H	0.575	0.55
273_F	309_E	0.575	0.55
455_L	460_A	0.575	0.55
370_D	373_K	0.575	0.55
88_M	91_P	0.575	0.55
507_A	510_R	0.574	0.55
451_R	466_L	0.574	0.55
475_I	481_G	0.574	0.55
227_K	257_E	0.574	0.55
611_F	618_K	0.574	0.55
455_L	468_N	0.573	0.55
82_V	85_H	0.573	0.55
271_Y	605_M	0.573	0.55
302_R	550_Y	0.572	0.55
519_R	608_D	0.571	0.55
380_L	384_R	0.571	0.55
424_L	480_T	0.570	0.55
49_S	167_T	0.570	0.55
223_E	243_E	0.570	0.55
138_R	256_V	0.569	0.55
439_G	454_I	0.567	0.54
66_E	208_E	0.567	0.54
231_E	244_P	0.567	0.54
387_M	390_K	0.567	0.54
413_D	422_S	0.567	0.54
37_G	340_T	0.566	0.54
572_R	578_E	0.566	0.54
91_P	154_T	0.565	0.54
36_K	342_T	0.565	0.54
489_E	494_H	0.565	0.54
450_L	513_L	0.564	0.54
253_G	331_H	0.564	0.54
233_L	324_T	0.564	0.54
438_Q	442_R	0.563	0.54
69_N	182_T	0.563	0.54
441_D	591_P	0.563	0.54
510_R	597_L	0.562	0.54
396_T	399_K	0.562	0.54
73_V	169_T	0.562	0.54
306_L	380_L	0.561	0.53
322_G	378_K	0.559	0.53
395_L	475_I	0.558	0.53
389_A	392_A	0.557	0.53
200_T	276_N	0.557	0.53
34_N	342_T	0.556	0.53
334_P	492_R	0.556	0.53
440_R	445_Q	0.555	0.53
151_V	174_D	0.555	0.53
439_G	585_W	0.555	0.53
602_E	606_D	0.555	0.53
398_R	402_L	0.555	0.53
514_L	611_F	0.554	0.53
396_T	485_D	0.552	0.52
407_L	412_A	0.551	0.52
454_I	469_N	0.551	0.52
11_N	85_H	0.550	0.52
187_D	190_A	0.548	0.52
27_G	498_I	0.548	0.52
294_T	298_N	0.548	0.52
42_V	65_I	0.547	0.52
12_Q	108_G	0.544	0.51
552_D	555_L	0.544	0.51
274_T	332_P	0.543	0.51
96_I	169_T	0.543	0.51
15_V	194_R	0.542	0.51
109_S	112_K	0.542	0.51
306_L	309_E	0.540	0.51
80_I	93_V	0.539	0.51
27_G	108_G	0.539	0.51
135_T	159_I	0.538	0.50
94_E	114_S	0.537	0.50
192_R	196_L	0.537	0.50
606_D	628_A	0.537	0.50
290_K	316_G	0.537	0.50
331_H	468_N	0.536	0.50
67_K	213_G	0.536	0.50
422_S	492_R	0.536	0.50
227_K	244_P	0.536	0.50
559_L	562_L	0.536	0.50
568_P	631_R	0.535	0.50
332_P	352_I	0.535	0.50
337_E	343_K	0.535	0.50
108_G	332_P	0.535	0.50
302_R	308_K	0.534	0.50
557_E	560_K	0.534	0.50
401_A	404_I	0.534	0.50
460_A	465_I	0.534	0.50
515_T	615_M	0.534	0.50
249_G	263_N	0.534	0.50
398_R	422_S	0.534	0.50
65_I	211_R	0.533	0.50
542_Q	568_P	0.533	0.50
404_I	476_T	0.533	0.50
74_V	135_T	0.533	0.50
15_V	99_V	0.533	0.50
356_L	596_L	0.533	0.50
309_E	379_G	0.533	0.50
6_N	9_D	0.533	0.50
608_D	612_E	0.532	0.50
307_I	380_L	0.532	0.50
538_Y	571_Q	0.532	0.50
33_T	345_G	0.531	0.50
424_L	530_V	0.531	0.50
62_N	204_N	0.531	0.50
69_N	131_E	0.531	0.50
589_M	627_E	0.530	0.49
44_E	48_N	0.529	0.49
35_S	188_L	0.529	0.49
236_S	239_V	0.529	0.49
500_T	507_A	0.528	0.49
278_N	342_T	0.528	0.49
133_D	153_V	0.528	0.49
439_G	507_A	0.527	0.49
522_R	623_R	0.527	0.49
464_K	625_F	0.527	0.49
315_S	393_R	0.527	0.49
542_Q	562_L	0.527	0.49
378_K	389_A	0.526	0.49
236_S	612_E	0.526	0.49
404_I	472_R	0.526	0.49
19_L	127_A	0.526	0.49
299_D	358_S	0.526	0.49
462_L	482_I	0.526	0.49
584_L	587_T	0.526	0.49
401_A	413_D	0.525	0.49
136_V	169_T	0.525	0.49
52_E	78_R	0.525	0.49
34_N	620_E	0.525	0.49
471_V	516_F	0.524	0.49
573_Y	580_N	0.524	0.49
96_I	278_N	0.524	0.49
18_G	24_K	0.524	0.49
16_L	27_G	0.524	0.49
416_S	420_S	0.524	0.49
18_G	21_A	0.523	0.49
286_E	290_K	0.523	0.49
352_I	356_L	0.523	0.49
286_E	363_T	0.523	0.49
579_M	587_T	0.523	0.49
234_N	237_K	0.522	0.48
62_N	217_K	0.521	0.48
133_D	168_T	0.521	0.48
155_D	297_I	0.521	0.48
316_G	322_G	0.521	0.48
426_I	430_D	0.520	0.48
58_C	77_G	0.520	0.48
237_K	612_E	0.520	0.48
43_W	205_I	0.520	0.48
580_N	583_Q	0.519	0.48
45_I	277_I	0.519	0.48
162_T	168_T	0.518	0.48
550_Y	555_L	0.518	0.48
34_N	346_N	0.517	0.48
93_V	132_L	0.517	0.48
310_N	313_N	0.516	0.48
36_K	346_N	0.516	0.48
49_S	384_R	0.516	0.48
104_G	114_S	0.516	0.48
391_K	394_E	0.515	0.48
16_L	22_V	0.514	0.47
54_L	330_K	0.514	0.47
299_D	362_E	0.514	0.47
85_H	438_Q	0.513	0.47
550_Y	573_Y	0.513	0.47
550_Y	554_E	0.512	0.47
342_T	345_G	0.512	0.47
22_V	26_P	0.512	0.47
425_Y	591_P	0.511	0.47
436_A	584_L	0.511	0.47
307_I	310_N	0.511	0.47
99_V	152_P	0.511	0.47
376_V	379_G	0.511	0.47
473_S	500_T	0.510	0.47
321_E	393_R	0.510	0.47
219_E	489_E	0.510	0.47
98_T	152_P	0.510	0.47
93_V	279_T	0.509	0.47
417_K	494_H	0.509	0.47
48_N	51_D	0.509	0.47
59_T	163_D	0.509	0.47
611_F	621_P	0.508	0.47
15_V	18_G	0.508	0.47
82_V	383_A	0.508	0.47
425_Y	510_R	0.508	0.47
71_I	207_I	0.508	0.47
534_Q	550_Y	0.507	0.46
563_P	566_P	0.507	0.46
196_L	334_P	0.507	0.46
16_L	25_R	0.507	0.46
334_P	422_S	0.506	0.46
124_V	128_L	0.505	0.46
518_Y	601_L	0.505	0.46
154_T	158_I	0.504	0.46
221_H	485_D	0.504	0.46
305_G	308_K	0.504	0.46
107_D	302_R	0.504	0.46
175_P	179_S	0.504	0.46
385_A	398_R	0.504	0.46
250_E	561_T	0.504	0.46
389_A	396_T	0.504	0.46
507_A	541_Q	0.504	0.46
36_K	279_T	0.503	0.46
11_N	83_G	0.503	0.46
586_E	593_S	0.503	0.46
251_K	355_T	0.503	0.46
465_I	500_T	0.503	0.46
374_K	529_Y	0.502	0.46
615_M	626_I	0.502	0.46
65_I	186_Y	0.502	0.46
608_D	611_F	0.502	0.46
186_Y	211_R	0.501	0.46
398_R	408_P	0.501	0.46
495_K	531_Y	0.501	0.46
53_A	202_G	0.501	0.46
294_T	320_R	0.500	0.46
15_V	101_H	0.500	0.46
179_S	347_S	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i3hA	2	0.8824	100	0.071	Contact Map
4gfhA	2	0.9107	100	0.137	Contact Map
3zkbA	5	0.6097	100	0.527	Contact Map
4urlA	1	0.569	100	0.552	Contact Map
4wubA	2	0.6003	100	0.554	Contact Map
1zxmA	2	0.547	100	0.557	Contact Map
1pvgA	2	0.5439	100	0.562	Contact Map
3lnuA	1	0.5345	100	0.565	Contact Map
3nuhB	1	0.2947	100	0.566	Contact Map
1kijA	2	0.5987	100	0.575	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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