LEU3 - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

LEU3 - 3-isopropylmalate dehydrogenase

UniProt:	P05645	Sequences: MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIGGAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLFANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVDTLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKLEHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTRDLARSEEFSSTQAITEEVKAAIMSENTISNV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (333)
Sequences:	6926 (3093)
Seq/√Len:	169.5

ECOLI - LEU3 DMLA IDH
BACSU - LEU3 TTUC IDH
HALSA - Q9HNZ7
SULSO - Q97WN0 LEU3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
181_A	215_D	4.145	1.00
174_R	212_E	3.842	1.00
173_I	206_A	3.084	1.00
20_S	349_T	2.972	1.00
174_R	178_K	2.867	1.00
4_R	37_E	2.731	1.00
23_D	350_E	2.709	1.00
225_N	229_Q	2.637	1.00
329_S	355_A	2.613	1.00
307_R	320_E	2.603	1.00
325_K	355_A	2.425	1.00
26_K	38_F	2.404	1.00
57_E	61_A	2.336	1.00
351_E	354_A	2.325	1.00
166_R	170_E	2.264	1.00
18_L	298_A	2.258	1.00
7_L	22_T	2.194	1.00
20_S	23_D	2.192	1.00
307_R	317_K	2.160	1.00
188_T	219_E	2.106	1.00
41_G	62_A	2.086	1.00
206_A	218_L	2.083	1.00
53_N	57_E	2.057	1.00
186_K	219_E	2.045	1.00
22_T	40_Y	2.022	1.00
326_V	355_A	2.000	1.00
131_V	179_M	1.976	1.00
170_E	208_D	1.955	1.00
6_A	62_A	1.954	1.00
42_L	50_E	1.941	1.00
296_F	352_V	1.936	1.00
64_K	99_L	1.929	1.00
173_I	241_V	1.918	1.00
300_L	323_V	1.915	1.00
312_L	315_E	1.912	1.00
170_E	205_V	1.894	1.00
186_K	217_K	1.889	1.00
299_I	352_V	1.875	1.00
291_G	344_S	1.861	1.00
178_K	213_F	1.861	1.00
233_A	236_Q	1.834	1.00
47_A	56_P	1.804	1.00
61_A	65_N	1.801	1.00
291_G	346_Q	1.797	1.00
317_K	321_D	1.791	1.00
15_P	19_E	1.773	1.00
13_I	293_A	1.751	1.00
207_E	220_H	1.742	1.00
166_R	208_D	1.721	1.00
174_R	213_F	1.718	1.00
208_D	211_Q	1.715	1.00
303_A	320_E	1.712	1.00
349_T	353_K	1.709	1.00
331_K	351_E	1.690	1.00
109_K	324_N	1.664	1.00
277_F	309_S	1.657	1.00
190_V	226_A	1.656	1.00
64_K	98_Q	1.647	1.00
313_E	317_K	1.620	1.00
34_H	312_L	1.617	1.00
170_E	174_R	1.615	1.00
156_Q	166_R	1.607	1.00
205_V	208_D	1.580	1.00
350_E	354_A	1.569	1.00
102_F	271_S	1.559	1.00
162_L	243_E	1.549	1.00
112_E	328_A	1.526	1.00
61_A	64_K	1.509	1.00
344_S	347_A	1.507	1.00
105_L	131_V	1.506	1.00
3_K	312_L	1.499	1.00
147_K	204_E	1.494	1.00
6_A	66_A	1.489	1.00
28_V	319_V	1.488	1.00
60_V	98_Q	1.471	1.00
39_E	65_N	1.459	1.00
21_A	302_A	1.458	1.00
231_I	253_E	1.458	1.00
307_R	316_A	1.446	1.00
209_V	212_E	1.438	1.00
94_S	98_Q	1.436	1.00
46_A	50_E	1.428	1.00
8_L	43_I	1.424	1.00
174_R	209_V	1.422	1.00
133_V	175_E	1.417	1.00
189_S	206_A	1.414	1.00
6_A	41_G	1.409	1.00
23_D	353_K	1.402	1.00
178_K	182_A	1.391	1.00
38_F	302_A	1.385	1.00
39_E	66_A	1.380	1.00
34_H	315_E	1.376	1.00
353_K	356_I	1.369	1.00
22_T	26_K	1.366	1.00
291_G	345_T	1.365	1.00
155_E	167_T	1.359	1.00
184_K	238_D	1.355	1.00
132_I	251_S	1.354	1.00
25_L	36_F	1.353	1.00
27_S	353_K	1.348	1.00
9_P	40_Y	1.346	1.00
162_L	198_S	1.336	1.00
113_S	328_A	1.317	1.00
307_R	313_E	1.315	1.00
76_G	79_W	1.313	1.00
42_L	51_H	1.287	1.00
21_A	70_L	1.280	1.00
296_F	348_I	1.265	1.00
42_L	47_A	1.262	1.00
292_M	334_R	1.261	1.00
326_V	351_E	1.260	1.00
221_M	229_Q	1.255	1.00
227_A	250_L	1.254	1.00
55_L	60_V	1.247	1.00
133_V	179_M	1.246	1.00
189_S	220_H	1.232	1.00
305_L	310_F	1.220	1.00
122_K	126_D	1.214	1.00
173_I	209_V	1.213	1.00
22_T	38_F	1.210	1.00
201_L	205_V	1.206	1.00
21_A	298_A	1.206	1.00
178_K	181_A	1.199	1.00
39_E	62_A	1.194	1.00
185_G	238_D	1.194	1.00
177_F	213_F	1.188	1.00
3_K	310_F	1.185	1.00
221_M	225_N	1.183	1.00
63_C	69_I	1.182	1.00
321_D	325_K	1.180	1.00
221_M	237_F	1.172	1.00
170_E	209_V	1.172	1.00
306_L	315_E	1.170	1.00
207_E	210_A	1.166	1.00
348_I	352_V	1.157	1.00
24_V	319_V	1.142	1.00
4_R	39_E	1.142	1.00
132_I	254_A	1.134	1.00
7_L	40_Y	1.134	1.00
221_M	226_A	1.130	1.00
230_L	240_V	1.128	1.00
204_E	208_D	1.121	1.00
47_A	51_H	1.120	1.00
166_R	205_V	1.117	1.00
351_E	355_A	1.116	1.00
109_K	129_D	1.115	1.00
130_F	230_L	1.111	1.00
160_D	198_S	1.109	1.00
347_A	350_E	1.094	1.00
51_H	58_E	1.082	1.00
177_F	216_V	1.082	1.00
183_R	238_D	1.078	1.00
337_A	340_E	1.071	1.00
6_A	63_C	1.069	1.00
100_D	171_R	1.068	1.00
112_E	126_D	1.068	1.00
105_L	133_V	1.064	1.00
227_A	253_E	1.064	1.00
169_I	173_I	1.058	0.99
28_V	315_E	1.055	0.99
25_L	302_A	1.050	0.99
70_L	302_A	1.043	0.99
318_A	356_I	1.042	0.99
287_I	293_A	1.042	0.99
127_N	235_N	1.042	0.99
187_V	218_L	1.040	0.99
325_K	329_S	1.037	0.99
223_V	249_I	1.035	0.99
23_D	346_Q	1.030	0.99
157_E	163_F	1.021	0.99
145_P	161_T	1.019	0.99
71_L	92_L	1.017	0.99
193_A	203_R	1.014	0.99
291_G	347_A	1.013	0.99
20_S	346_Q	1.005	0.99
19_E	23_D	1.002	0.99
140_L	243_E	0.996	0.99
140_L	162_L	0.995	0.99
167_T	170_E	0.994	0.99
164_Y	243_E	0.990	0.99
296_F	327_L	0.990	0.99
179_M	183_R	0.990	0.99
136_L	268_S	0.990	0.99
190_V	223_V	0.988	0.99
58_E	61_A	0.987	0.99
181_A	185_G	0.985	0.99
229_Q	236_Q	0.982	0.99
21_A	299_I	0.978	0.99
23_D	349_T	0.978	0.99
158_A	201_L	0.969	0.99
4_R	65_N	0.966	0.99
176_G	187_V	0.963	0.99
219_E	236_Q	0.961	0.99
181_A	216_V	0.958	0.99
56_P	59_T	0.955	0.99
24_V	356_I	0.952	0.99
47_A	59_T	0.951	0.99
177_F	210_A	0.950	0.99
49_D	78_K	0.948	0.99
315_E	318_A	0.947	0.99
300_L	320_E	0.947	0.99
232_Y	256_M	0.947	0.99
206_A	241_V	0.945	0.99
24_V	353_K	0.933	0.99
187_V	209_V	0.933	0.99
130_F	254_A	0.931	0.99
191_D	203_R	0.927	0.99
287_I	292_M	0.921	0.99
139_G	162_L	0.920	0.99
103_A	172_V	0.916	0.99
53_N	94_S	0.909	0.98
296_F	323_V	0.906	0.98
187_V	239_V	0.901	0.98
270_S	274_L	0.900	0.98
109_K	320_E	0.899	0.98
28_V	302_A	0.897	0.98
16_E	289_G	0.897	0.98
177_F	187_V	0.894	0.98
326_V	331_K	0.893	0.98
7_L	18_L	0.892	0.98
164_Y	169_I	0.892	0.98
9_P	19_E	0.891	0.98
17_V	298_A	0.890	0.98
20_S	291_G	0.890	0.98
279_P	298_A	0.886	0.98
41_G	66_A	0.876	0.98
229_Q	233_A	0.875	0.98
181_A	213_F	0.873	0.98
317_K	320_E	0.872	0.98
58_E	62_A	0.869	0.98
162_L	199_S	0.867	0.98
139_G	243_E	0.865	0.98
333_T	348_I	0.861	0.98
24_V	299_I	0.861	0.98
17_V	72_G	0.860	0.98
325_K	328_A	0.860	0.98
62_A	66_A	0.858	0.98
287_I	334_R	0.857	0.98
105_L	175_E	0.857	0.98
340_E	347_A	0.855	0.98
326_V	352_V	0.854	0.98
327_L	332_R	0.854	0.98
189_S	218_L	0.848	0.98
41_G	59_T	0.846	0.98
303_A	307_R	0.845	0.98
103_A	175_E	0.844	0.97
187_V	241_V	0.841	0.97
68_A	310_F	0.840	0.97
113_S	324_N	0.839	0.97
7_L	38_F	0.838	0.97
43_I	95_I	0.838	0.97
299_I	323_V	0.837	0.97
152_T	155_E	0.835	0.97
111_F	324_N	0.828	0.97
199_S	246_F	0.827	0.97
108_V	254_A	0.822	0.97
286_D	334_R	0.820	0.97
3_K	34_H	0.814	0.97
28_V	34_H	0.813	0.97
18_L	72_G	0.811	0.97
100_D	137_T	0.811	0.97
190_V	240_V	0.810	0.97
49_D	76_G	0.809	0.97
20_S	350_E	0.809	0.97
191_D	220_H	0.802	0.97
334_R	344_S	0.802	0.97
193_A	222_L	0.801	0.97
8_L	63_C	0.799	0.97
187_V	216_V	0.799	0.97
43_I	91_G	0.798	0.96
290_K	334_R	0.795	0.96
146_S	159_V	0.794	0.96
190_V	250_L	0.793	0.96
140_L	245_M	0.792	0.96
73_A	281_H	0.792	0.96
322_A	326_V	0.792	0.96
188_T	221_M	0.791	0.96
53_N	86_L	0.789	0.96
267_A	277_F	0.788	0.96
302_A	305_L	0.784	0.96
43_I	71_L	0.781	0.96
21_A	25_L	0.779	0.96
275_H	309_S	0.778	0.96
104_N	280_V	0.768	0.96
48_I	54_P	0.764	0.95
123_E	235_N	0.756	0.95
42_L	46_A	0.755	0.95
223_V	227_A	0.753	0.95
20_S	353_K	0.753	0.95
19_E	346_Q	0.753	0.95
162_L	245_M	0.752	0.95
45_G	49_D	0.750	0.95
112_E	324_N	0.750	0.95
36_F	302_A	0.748	0.95
205_V	209_V	0.747	0.95
230_L	254_A	0.747	0.95
173_I	218_L	0.744	0.95
321_D	324_N	0.743	0.95
101_L	276_L	0.743	0.95
108_V	258_T	0.742	0.95
175_E	179_M	0.741	0.95
110_V	128_V	0.740	0.95
45_G	76_G	0.740	0.95
166_R	201_L	0.736	0.94
19_E	40_Y	0.736	0.94
157_E	165_K	0.731	0.94
176_G	241_V	0.728	0.94
207_E	218_L	0.727	0.94
129_D	238_D	0.726	0.94
265_P	304_M	0.725	0.94
41_G	58_E	0.724	0.94
182_A	311_G	0.724	0.94
226_A	240_V	0.723	0.94
346_Q	350_E	0.722	0.94
132_I	250_L	0.719	0.94
223_V	243_E	0.716	0.94
60_V	64_K	0.716	0.94
209_V	213_F	0.716	0.94
115_S	126_D	0.714	0.94
75_G	283_S	0.713	0.94
138_G	168_E	0.713	0.94
64_K	274_L	0.707	0.93
25_L	306_L	0.707	0.93
151_N	154_G	0.704	0.93
286_D	293_A	0.703	0.93
151_N	155_E	0.702	0.93
70_L	298_A	0.701	0.93
133_V	172_V	0.701	0.93
45_G	75_G	0.700	0.93
265_P	300_L	0.696	0.93
162_L	246_F	0.694	0.93
108_V	130_F	0.693	0.93
284_A	287_I	0.693	0.93
350_E	353_K	0.693	0.93
314_E	317_K	0.692	0.92
226_A	237_F	0.688	0.92
73_A	298_A	0.687	0.92
175_E	271_S	0.685	0.92
130_F	257_L	0.685	0.92
177_F	218_L	0.684	0.92
302_A	306_L	0.682	0.92
225_N	261_L	0.681	0.92
178_K	212_E	0.680	0.92
48_I	86_L	0.675	0.92
20_S	299_I	0.674	0.91
122_K	127_N	0.671	0.91
346_Q	349_T	0.670	0.91
145_P	159_V	0.670	0.91
158_A	198_S	0.668	0.91
62_A	65_N	0.668	0.91
203_R	207_E	0.668	0.91
69_I	276_L	0.665	0.91
316_A	320_E	0.663	0.91
191_D	222_L	0.662	0.91
53_N	58_E	0.660	0.91
25_L	38_F	0.658	0.90
18_L	21_A	0.657	0.90
267_A	304_M	0.656	0.90
5_I	305_L	0.654	0.90
170_E	211_Q	0.654	0.90
326_V	348_I	0.653	0.90
86_L	90_K	0.652	0.90
90_K	94_S	0.651	0.90
172_V	241_V	0.650	0.90
46_A	49_D	0.648	0.90
110_V	115_S	0.647	0.90
324_N	328_A	0.647	0.90
91_G	94_S	0.646	0.90
260_S	297_A	0.646	0.90
131_V	239_V	0.644	0.90
169_I	205_V	0.643	0.89
57_E	94_S	0.640	0.89
156_Q	204_E	0.638	0.89
43_I	55_L	0.637	0.89
299_I	319_V	0.636	0.89
47_A	55_L	0.635	0.89
332_R	336_L	0.634	0.89
190_V	242_T	0.630	0.89
210_A	214_P	0.630	0.89
263_M	336_L	0.627	0.88
229_Q	232_Y	0.627	0.88
156_Q	167_T	0.626	0.88
55_L	95_I	0.624	0.88
5_I	36_F	0.622	0.88
280_V	297_A	0.622	0.88
147_K	158_A	0.621	0.88
115_S	121_K	0.621	0.88
331_K	355_A	0.620	0.88
160_D	200_R	0.618	0.88
132_I	240_V	0.617	0.87
100_D	270_S	0.615	0.87
129_D	184_K	0.615	0.87
28_V	33_N	0.614	0.87
210_A	218_L	0.613	0.87
18_L	22_T	0.611	0.87
111_F	300_L	0.611	0.87
54_P	86_L	0.610	0.87
131_V	183_R	0.610	0.87
185_G	215_D	0.610	0.87
333_T	336_L	0.609	0.87
169_I	243_E	0.608	0.87
189_S	202_W	0.607	0.87
192_K	224_D	0.607	0.87
42_L	58_E	0.606	0.87
25_L	319_V	0.605	0.86
23_D	26_K	0.605	0.86
331_K	340_E	0.603	0.86
72_G	298_A	0.603	0.86
159_V	163_F	0.600	0.86
231_I	257_L	0.600	0.86
265_P	297_A	0.599	0.86
115_S	122_K	0.598	0.86
45_G	79_W	0.592	0.85
144_Q	163_F	0.592	0.85
36_F	312_L	0.592	0.85
306_L	319_V	0.590	0.85
47_A	50_E	0.589	0.85
336_L	340_E	0.589	0.85
100_D	167_T	0.587	0.85
59_T	91_G	0.587	0.85
100_D	138_G	0.585	0.85
28_V	318_A	0.584	0.84
318_A	322_A	0.583	0.84
310_F	313_E	0.580	0.84
293_A	334_R	0.579	0.84
63_C	66_A	0.579	0.84
299_I	349_T	0.579	0.84
274_L	277_F	0.577	0.84
199_S	243_E	0.576	0.84
225_N	236_Q	0.573	0.83
5_I	38_F	0.573	0.83
154_G	157_E	0.572	0.83
141_Y	278_E	0.571	0.83
8_L	41_G	0.570	0.83
175_E	178_K	0.564	0.82
76_G	90_K	0.563	0.82
168_E	171_R	0.563	0.82
147_K	197_E	0.560	0.82
84_S	90_K	0.559	0.82
63_C	95_I	0.558	0.82
314_E	318_A	0.558	0.82
84_S	87_R	0.558	0.82
180_A	187_V	0.556	0.82
49_D	79_W	0.554	0.81
54_P	58_E	0.554	0.81
36_F	315_E	0.552	0.81
84_S	200_R	0.548	0.81
128_V	235_N	0.548	0.81
270_S	275_H	0.547	0.80
19_E	22_T	0.545	0.80
306_L	316_A	0.542	0.80
269_L	275_H	0.537	0.79
144_Q	161_T	0.537	0.79
123_E	127_N	0.537	0.79
260_S	263_M	0.536	0.79
243_E	246_F	0.534	0.79
131_V	184_K	0.534	0.79
157_E	166_R	0.531	0.78
40_Y	46_A	0.530	0.78
133_V	176_G	0.530	0.78
331_K	354_A	0.528	0.78
173_I	205_V	0.527	0.78
55_L	59_T	0.526	0.78
225_N	237_F	0.526	0.78
16_E	291_G	0.525	0.78
25_L	28_V	0.524	0.78
55_L	94_S	0.523	0.77
71_L	95_I	0.522	0.77
320_E	324_N	0.521	0.77
291_G	350_E	0.520	0.77
347_A	351_E	0.520	0.77
226_A	250_L	0.519	0.77
181_A	214_P	0.518	0.77
287_I	290_K	0.518	0.77
318_A	353_K	0.517	0.77
99_L	276_L	0.517	0.77
204_E	211_Q	0.517	0.77
13_I	17_V	0.515	0.76
41_G	56_P	0.515	0.76
282_G	285_P	0.514	0.76
151_N	156_Q	0.513	0.76
15_P	46_A	0.513	0.76
18_L	70_L	0.511	0.76
154_G	165_K	0.510	0.76
63_C	99_L	0.509	0.76
97_K	143_G	0.509	0.76
44_G	47_A	0.509	0.76
145_P	162_L	0.506	0.75
178_K	209_V	0.506	0.75
115_S	336_L	0.506	0.75
185_G	216_V	0.505	0.75
317_K	324_N	0.505	0.75
179_M	182_A	0.505	0.75
5_I	68_A	0.504	0.75
43_I	59_T	0.504	0.75
102_F	175_E	0.504	0.75
74_V	283_S	0.503	0.75
248_D	252_D	0.503	0.75
21_A	24_V	0.502	0.75
6_A	39_E	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3u1hA	2	0.9616	100	0.028	Contact Map
3r8wA	2	0.9671	100	0.03	Contact Map
2y3zA	2	0.9589	100	0.035	Contact Map
3uduA	3	0.9616	100	0.035	Contact Map
1a05A	2	0.9644	100	0.038	Contact Map
1cnzA	2	0.9753	100	0.043	Contact Map
3vmkA	2	0.9726	100	0.048	Contact Map
3flkA	3	0.9562	100	0.049	Contact Map
4xxvA	2	0.9589	100	0.05	Contact Map
1vlcA	2	0.9644	100	0.052	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.