GREMLIN Database
PTSBC - PTS system sucrose-specific EIIBC component
UniProt: P05306 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (358)
Sequences: 4471 (2508)
Seq/√Len: 132.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
400_Y439_I4.0621.00
393_G443_S3.8561.00
227_A263_A3.7281.00
299_G395_A3.7151.00
346_A445_F3.5411.00
254_V258_V3.2451.00
231_M255_T3.2091.00
400_Y432_H2.9631.00
165_G179_G2.8591.00
396_L443_S2.7171.00
99_L104_R2.6041.00
434_L438_A2.5581.00
242_V250_V2.5471.00
389_A451_M2.4951.00
340_Q380_N2.4681.00
166_V180_A2.3881.00
400_Y404_T2.3631.00
284_Y288_H2.3471.00
388_I392_I2.3441.00
237_W241_V2.3051.00
350_M452_K2.2871.00
404_T432_H2.2491.00
166_V176_P2.2471.00
448_A452_K2.2411.00
320_L327_N2.2271.00
344_G375_V2.2121.00
349_F448_A2.1971.00
239_R247_D2.1801.00
342_G440_A2.1501.00
162_I184_G2.1201.00
238_T254_V2.1141.00
129_L133_I2.0931.00
230_V262_V2.0921.00
446_I450_V2.0601.00
432_H435_I1.9841.00
348_F361_L1.9501.00
273_A277_G1.9231.00
351_A356_T1.9201.00
298_G394_G1.9161.00
349_F444_A1.8991.00
133_I138_W1.8971.00
342_G444_A1.8621.00
127_M154_S1.8481.00
295_L399_A1.8461.00
353_K356_T1.8311.00
233_K236_K1.8121.00
447_A451_M1.8121.00
246_V250_V1.8081.00
108_T172_F1.8021.00
342_G441_A1.7961.00
389_A393_G1.7831.00
389_A447_A1.7581.00
233_K237_W1.7501.00
276_S280_V1.7501.00
401_V436_G1.7411.00
345_L364_A1.7361.00
341_G367_A1.7291.00
443_S447_A1.7211.00
226_L271_G1.7191.00
154_S158_I1.6941.00
376_I387_F1.6941.00
383_Y386_P1.6921.00
238_T242_V1.6841.00
234_V259_T1.6731.00
326_K407_A1.6721.00
303_L391_M1.6721.00
399_A403_F1.6691.00
174_S228_V1.6651.00
442_V446_I1.6621.00
229_Y232_S1.6471.00
162_I180_A1.6421.00
299_G303_L1.6211.00
347_V360_A1.6031.00
294_G398_G1.5861.00
295_L395_A1.5821.00
101_P104_R1.5801.00
433_Y437_M1.5481.00
298_G398_G1.5261.00
107_K171_E1.5251.00
250_V254_V1.5221.00
170_K176_P1.5051.00
169_S228_V1.4831.00
229_Y233_K1.4771.00
356_T383_Y1.4771.00
230_V259_T1.4701.00
445_F449_F1.4451.00
319_G323_D1.4181.00
183_G255_T1.4171.00
385_K454_N1.4131.00
234_V258_V1.4081.00
166_V177_Y1.4081.00
277_G281_A1.4011.00
345_L349_F1.3991.00
383_Y453_I1.3901.00
281_A284_Y1.3891.00
259_T263_A1.3781.00
125_L253_F1.3511.00
168_A229_Y1.3461.00
283_T287_D1.3431.00
302_S337_N1.3421.00
101_P105_F1.3381.00
291_F399_A1.3281.00
396_L439_I1.3211.00
230_V267_I1.3091.00
347_V351_A1.3061.00
294_G402_V1.3021.00
393_G446_I1.3021.00
334_S433_Y1.2751.00
247_D251_T1.2631.00
349_F445_F1.2601.00
167_S177_Y1.2431.00
294_G399_A1.2401.00
393_G444_A1.2381.00
152_F260_G1.2371.00
148_L212_I1.2321.00
397_G439_I1.2181.00
364_A368_F1.2171.00
179_G183_G1.2091.00
274_L277_G1.1970.99
376_I390_A1.1900.99
431_I434_L1.1850.99
238_T251_T1.1840.99
277_G280_V1.1830.99
304_I313_F1.1820.99
400_Y436_G1.1790.99
123_S156_A1.1720.99
291_F403_F1.1700.99
350_M453_I1.1660.99
169_S176_P1.1610.99
346_A449_F1.1590.99
299_G388_I1.1570.99
301_Y332_I1.1550.99
166_V181_V1.1520.99
164_I221_V1.1490.99
400_Y435_I1.1490.99
222_I226_L1.1490.99
126_L153_S1.1480.99
113_F221_V1.1430.99
401_V406_V1.1390.99
182_I256_V1.1360.99
335_M394_G1.1290.99
278_I304_I1.1230.99
130_L146_L1.1210.99
335_M401_V1.1200.99
342_G346_A1.1180.99
169_S179_G1.1150.99
174_S231_M1.1120.99
339_A390_A1.1050.99
350_M448_A1.1020.99
429_N432_H1.0970.99
362_P366_S1.0960.99
169_S174_S1.0950.99
385_K452_K1.0840.99
116_I167_S1.0810.99
393_G397_G1.0800.99
431_I435_I1.0740.99
295_L396_L1.0570.99
232_S236_K1.0570.99
380_N386_P1.0520.99
397_G440_A1.0520.99
182_I224_V1.0480.99
97_E101_P1.0420.99
328_Y331_P1.0380.99
437_M440_A1.0370.99
228_V232_S1.0360.98
234_V238_T1.0350.98
145_L148_L1.0330.98
185_I260_G1.0310.98
155_A184_G1.0220.98
437_M441_A1.0210.98
237_W240_K1.0210.98
183_G224_V1.0210.98
227_A259_T1.0160.98
111_N171_E1.0160.98
97_E100_N1.0130.98
392_I447_A1.0110.98
419_I434_L1.0110.98
108_T112_I1.0090.98
168_A172_F1.0080.98
412_G421_I1.0030.98
282_L328_Y1.0010.98
172_F229_Y1.0010.98
270_L274_L0.9940.98
159_F189_P0.9920.98
173_G236_K0.9880.98
339_A343_A0.9780.98
299_G391_M0.9770.98
175_N235_E0.9750.98
116_I160_L0.9730.98
343_A380_N0.9730.98
449_F453_I0.9730.98
271_G275_G0.9640.98
140_S143_S0.9620.98
243_P246_V0.9600.98
400_Y403_F0.9560.97
334_S418_M0.9520.97
348_F360_A0.9510.97
262_V267_I0.9450.97
244_H247_D0.9390.97
182_I259_T0.9300.97
164_I224_V0.9270.97
289_A292_V0.9250.97
340_Q390_A0.9200.97
165_G224_V0.9190.97
267_I271_G0.9180.97
222_I271_G0.9160.97
343_A390_A0.9160.97
162_I181_V0.9140.97
242_V246_V0.9130.97
102_A105_F0.9130.97
349_F452_K0.9130.97
147_Q150_D0.9090.97
438_A442_V0.9090.97
174_S179_G0.9050.96
258_V261_F0.9040.96
386_P389_A0.9030.96
390_A443_S0.8990.96
338_V341_G0.8990.96
313_F317_E0.8980.96
280_V283_T0.8970.96
449_F452_K0.8970.96
266_A270_L0.8910.96
226_L267_I0.8870.96
303_L387_F0.8860.96
165_G228_V0.8840.96
347_V379_V0.8810.96
98_K104_R0.8790.96
389_A448_A0.8760.96
240_K352_K0.8720.96
130_L153_S0.8720.96
163_L181_V0.8650.95
124_G411_Y0.8650.95
353_K357_K0.8640.95
439_I442_V0.8640.95
336_A340_Q0.8630.95
439_I443_S0.8620.95
181_V185_I0.8590.95
187_I218_Q0.8590.95
168_A225_L0.8570.95
348_F357_K0.8560.95
105_F108_T0.8540.95
343_A386_P0.8530.95
438_A446_I0.8520.95
372_T375_V0.8520.95
152_F185_I0.8510.95
406_V436_G0.8500.95
217_Y223_P0.8480.95
356_T379_V0.8480.95
127_M157_F0.8460.95
112_I225_L0.8450.95
389_A446_I0.8450.95
131_G150_D0.8450.95
273_A276_S0.8440.95
380_N390_A0.8430.95
163_L184_G0.8400.95
367_A372_T0.8380.95
230_V234_V0.8380.95
239_R251_T0.8360.95
227_A262_V0.8340.94
107_K111_N0.8330.94
364_A367_A0.8320.94
174_S235_E0.8310.94
172_F232_S0.8300.94
97_E104_R0.8290.94
242_V251_T0.8250.94
156_A163_L0.8240.94
350_M449_F0.8230.94
262_V266_A0.8220.94
380_N387_F0.8220.94
201_T204_Y0.8210.94
224_V228_V0.8140.94
238_T241_V0.8130.94
404_T435_I0.8120.94
342_G368_F0.8100.94
340_Q375_V0.8070.93
241_V250_V0.8020.93
257_I261_F0.7990.93
300_T303_L0.7970.93
441_A444_A0.7970.93
108_T229_Y0.7940.93
194_P205_M0.7930.93
261_F266_A0.7920.93
123_S155_A0.7920.93
294_G298_G0.7910.93
166_V170_K0.7900.93
345_L445_F0.7850.92
416_I420_A0.7840.92
389_A450_V0.7840.92
404_T439_I0.7820.92
160_L221_V0.7800.92
155_A185_I0.7800.92
294_G332_I0.7790.92
357_K361_L0.7770.92
173_G179_G0.7770.92
386_P448_A0.7770.92
118_P121_V0.7760.92
441_A445_F0.7760.92
96_K104_R0.7760.92
143_S147_Q0.7740.92
359_I363_A0.7740.92
134_N146_L0.7710.92
368_F416_I0.7690.92
165_G180_A0.7670.92
303_L307_T0.7650.91
385_K453_I0.7640.91
230_V233_K0.7640.91
451_M456_D0.7610.91
178_L231_M0.7610.91
94_A97_E0.7600.91
329_L333_W0.7590.91
255_T259_T0.7590.91
154_S188_H0.7590.91
196_G199_E0.7560.91
147_Q151_M0.7550.91
347_V386_P0.7540.91
302_S336_A0.7520.91
280_V284_Y0.7510.91
451_M455_E0.7510.91
246_V369_L0.7490.91
444_A452_K0.7480.91
319_G322_A0.7470.90
291_F295_L0.7430.90
340_Q343_A0.7430.90
165_G183_G0.7410.90
133_I139_M0.7410.90
270_L273_A0.7390.90
132_M136_F0.7370.90
173_G235_E0.7370.90
347_V356_T0.7280.89
114_V311_H0.7270.89
192_L196_G0.7260.89
406_V432_H0.7240.89
356_T455_E0.7220.89
284_Y290_G0.7210.89
275_G309_V0.7180.89
440_A444_A0.7170.89
162_I183_G0.7150.88
112_I168_A0.7110.88
207_L211_D0.7100.88
222_I306_L0.7090.88
300_T391_M0.7070.88
338_V437_M0.7040.88
264_F269_P0.7020.88
296_I299_G0.7000.87
305_V336_A0.6980.87
124_G315_A0.6980.87
307_T377_F0.6940.87
136_F139_M0.6940.87
351_A455_E0.6940.87
132_M138_W0.6910.87
132_M135_A0.6870.86
335_M397_G0.6820.86
350_M455_E0.6820.86
344_G360_A0.6800.86
379_V383_Y0.6790.86
339_A393_G0.6790.86
96_K99_L0.6780.86
340_Q367_A0.6740.85
297_F313_F0.6730.85
363_A366_S0.6730.85
204_Y213_A0.6730.85
302_S376_I0.6720.85
123_S160_L0.6710.85
298_G395_A0.6700.85
405_H428_S0.6690.85
450_V454_N0.6680.85
297_F304_I0.6670.85
155_A188_H0.6660.85
344_G348_F0.6650.85
235_E251_T0.6620.84
142_D147_Q0.6590.84
296_I300_T0.6580.84
284_Y287_D0.6580.84
361_L364_A0.6550.84
414_T418_M0.6550.84
396_L400_Y0.6550.84
134_N150_D0.6540.84
272_R276_S0.6520.83
392_I395_A0.6510.83
242_V254_V0.6510.83
290_G293_A0.6490.83
388_I391_M0.6460.83
145_L207_L0.6460.83
136_F140_S0.6460.83
393_G447_A0.6430.83
424_P429_N0.6420.83
127_M158_I0.6420.83
206_H210_F0.6400.82
183_G231_M0.6400.82
396_L399_A0.6390.82
109_L307_T0.6380.82
226_L229_Y0.6370.82
300_T313_F0.6360.82
344_G364_A0.6350.82
346_A448_A0.6330.82
382_R386_P0.6310.81
213_A272_R0.6300.81
385_K389_A0.6300.81
338_V436_G0.6290.81
369_L417_P0.6260.81
295_L299_G0.6240.81
234_V255_T0.6220.81
173_G176_P0.6210.80
336_A372_T0.6200.80
312_S315_A0.6180.80
428_S431_I0.6170.80
385_K388_I0.6160.80
288_H292_V0.6140.80
358_E362_P0.6120.79
163_L180_A0.6100.79
347_V350_M0.6100.79
361_L365_F0.6100.79
442_V445_F0.6080.79
235_E239_R0.6080.79
406_V430_L0.6080.79
134_N138_W0.6070.79
398_G402_V0.6050.79
228_V231_M0.6050.79
340_Q372_T0.6050.79
248_L251_T0.6050.79
343_A347_V0.6020.78
125_L128_G0.6020.78
410_A421_I0.6020.78
179_G228_V0.6000.78
318_A322_A0.5990.78
258_V262_V0.5950.78
433_Y438_A0.5930.77
338_V415_G0.5930.77
105_F109_L0.5910.77
129_L132_M0.5910.77
191_L195_W0.5900.77
419_I437_M0.5880.77
295_L298_G0.5870.77
317_E327_N0.5860.76
300_T304_I0.5860.76
355_K359_I0.5850.76
387_F390_A0.5840.76
151_M188_H0.5810.76
316_I320_L0.5810.76
337_N372_T0.5800.76
158_I189_P0.5800.76
360_A364_A0.5800.76
120_I311_H0.5800.76
393_G396_L0.5800.76
336_A414_T0.5780.75
122_A256_V0.5780.75
139_M143_S0.5780.75
100_N103_A0.5770.75
341_G364_A0.5760.75
158_I218_Q0.5740.75
302_S387_F0.5720.75
193_N196_G0.5710.75
432_H439_I0.5700.74
144_A205_M0.5670.74
150_D154_S0.5660.74
117_I415_G0.5650.74
137_H140_S0.5620.73
347_V383_Y0.5620.73
297_F332_I0.5610.73
344_G380_N0.5600.73
350_M385_K0.5580.73
148_L205_M0.5530.72
423_A430_L0.5530.72
401_V435_I0.5530.72
100_N104_R0.5530.72
106_A381_L0.5520.72
230_V258_V0.5520.72
315_A318_A0.5520.72
119_A181_V0.5520.72
117_I370_G0.5510.72
128_G294_G0.5500.72
253_F256_V0.5500.72
368_F441_A0.5490.72
122_A183_G0.5460.71
353_K456_D0.5450.71
119_A178_L0.5440.71
274_L309_V0.5440.71
130_L150_D0.5440.71
356_T360_A0.5420.71
302_S340_Q0.5400.70
222_I278_I0.5400.70
309_V316_I0.5400.70
320_L323_D0.5400.70
445_F448_A0.5390.70
353_K455_E0.5370.70
157_F160_L0.5360.70
285_V288_H0.5350.70
134_N141_K0.5350.70
112_I172_F0.5330.70
350_M353_K0.5320.69
285_V296_I0.5320.69
95_A104_R0.5310.69
386_P390_A0.5310.69
406_V414_T0.5310.69
336_A339_A0.5310.69
415_G418_M0.5300.69
450_V456_D0.5280.69
335_M440_A0.5280.69
427_F431_I0.5260.69
289_A293_A0.5250.68
109_L120_I0.5250.68
238_T255_T0.5210.68
305_V340_Q0.5200.68
111_N167_S0.5200.68
323_D326_K0.5190.67
301_Y398_G0.5190.67
191_L194_P0.5180.67
105_F111_N0.5180.67
175_N239_R0.5170.67
407_A427_F0.5160.67
184_G188_H0.5150.67
206_H209_G0.5150.67
227_A231_M0.5140.67
182_I227_A0.5140.67
282_L316_I0.5130.67
126_L253_F0.5130.67
306_L376_I0.5130.67
337_N390_A0.5120.66
334_S401_V0.5110.66
176_P228_V0.5110.66
109_L117_I0.5110.66
202_P206_H0.5090.66
128_G415_G0.5090.66
134_N139_M0.5090.66
306_L351_A0.5080.66
217_Y275_G0.5070.66
452_K455_E0.5070.66
110_S311_H0.5070.66
409_N423_A0.5070.66
116_I163_L0.5060.66
152_F259_T0.5050.65
174_S255_T0.5030.65
138_W143_S0.5030.65
139_M142_D0.5010.65
403_F407_A0.5010.65
343_A448_A0.5000.65
414_T421_I0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.8069 100 0.646 Contact Map
3ipjA 1 0.1996 100 0.786 Contact Map
1ibaA 1 0.167 100 0.798 Contact Map
3bp3A 1 0.1757 100 0.8 Contact Map
4us3A 1 0.6768 41.8 0.974 Contact Map
2h8eA 2 0.1866 40.1 0.974 Contact Map
4n8nA 1 0.102 35.7 0.975 Contact Map
4rfsS 1 0.2169 27.2 0.976 Contact Map
4bxoA 1 0.1518 22.1 0.977 Contact Map
3q9vA 1 0.1171 18.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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