PTSBC - BACSU - GREMLIN Contacts

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PTSBC - PTS system sucrose-specific EIIBC component

UniProt:	P05306	Sequences: MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQVEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPAARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFLPILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQGTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGSGITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWSMANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMIGGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFVMKINEDEERKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	461 (358)
Sequences:	4471 (2508)
Seq/√Len:	132.5

ECOLI - PTV3B PTTBC PTIBC PTYBC PTGCB PTOCB
BACSU - PTSBC PTV3B SACX PTTBC PTXBC PTWCB PTOCB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
400_Y	439_I	4.062	1.00
393_G	443_S	3.856	1.00
227_A	263_A	3.728	1.00
299_G	395_A	3.715	1.00
346_A	445_F	3.541	1.00
254_V	258_V	3.245	1.00
231_M	255_T	3.209	1.00
400_Y	432_H	2.963	1.00
165_G	179_G	2.859	1.00
396_L	443_S	2.717	1.00
99_L	104_R	2.604	1.00
434_L	438_A	2.558	1.00
242_V	250_V	2.547	1.00
389_A	451_M	2.495	1.00
340_Q	380_N	2.468	1.00
166_V	180_A	2.388	1.00
400_Y	404_T	2.363	1.00
284_Y	288_H	2.347	1.00
388_I	392_I	2.344	1.00
237_W	241_V	2.305	1.00
350_M	452_K	2.287	1.00
404_T	432_H	2.249	1.00
166_V	176_P	2.247	1.00
448_A	452_K	2.241	1.00
320_L	327_N	2.227	1.00
344_G	375_V	2.212	1.00
349_F	448_A	2.197	1.00
239_R	247_D	2.180	1.00
342_G	440_A	2.150	1.00
162_I	184_G	2.120	1.00
238_T	254_V	2.114	1.00
129_L	133_I	2.093	1.00
230_V	262_V	2.092	1.00
446_I	450_V	2.060	1.00
432_H	435_I	1.984	1.00
348_F	361_L	1.950	1.00
273_A	277_G	1.923	1.00
351_A	356_T	1.920	1.00
298_G	394_G	1.916	1.00
349_F	444_A	1.899	1.00
133_I	138_W	1.897	1.00
342_G	444_A	1.862	1.00
127_M	154_S	1.848	1.00
295_L	399_A	1.846	1.00
353_K	356_T	1.831	1.00
233_K	236_K	1.812	1.00
447_A	451_M	1.812	1.00
246_V	250_V	1.808	1.00
108_T	172_F	1.802	1.00
342_G	441_A	1.796	1.00
389_A	393_G	1.783	1.00
389_A	447_A	1.758	1.00
233_K	237_W	1.750	1.00
276_S	280_V	1.750	1.00
401_V	436_G	1.741	1.00
345_L	364_A	1.736	1.00
341_G	367_A	1.729	1.00
443_S	447_A	1.721	1.00
226_L	271_G	1.719	1.00
154_S	158_I	1.694	1.00
376_I	387_F	1.694	1.00
383_Y	386_P	1.692	1.00
238_T	242_V	1.684	1.00
234_V	259_T	1.673	1.00
326_K	407_A	1.672	1.00
303_L	391_M	1.672	1.00
399_A	403_F	1.669	1.00
174_S	228_V	1.665	1.00
442_V	446_I	1.662	1.00
229_Y	232_S	1.647	1.00
162_I	180_A	1.642	1.00
299_G	303_L	1.621	1.00
347_V	360_A	1.603	1.00
294_G	398_G	1.586	1.00
295_L	395_A	1.582	1.00
101_P	104_R	1.580	1.00
433_Y	437_M	1.548	1.00
298_G	398_G	1.526	1.00
107_K	171_E	1.525	1.00
250_V	254_V	1.522	1.00
170_K	176_P	1.505	1.00
169_S	228_V	1.483	1.00
229_Y	233_K	1.477	1.00
356_T	383_Y	1.477	1.00
230_V	259_T	1.470	1.00
445_F	449_F	1.445	1.00
319_G	323_D	1.418	1.00
183_G	255_T	1.417	1.00
385_K	454_N	1.413	1.00
234_V	258_V	1.408	1.00
166_V	177_Y	1.408	1.00
277_G	281_A	1.401	1.00
345_L	349_F	1.399	1.00
383_Y	453_I	1.390	1.00
281_A	284_Y	1.389	1.00
259_T	263_A	1.378	1.00
125_L	253_F	1.351	1.00
168_A	229_Y	1.346	1.00
283_T	287_D	1.343	1.00
302_S	337_N	1.342	1.00
101_P	105_F	1.338	1.00
291_F	399_A	1.328	1.00
396_L	439_I	1.321	1.00
230_V	267_I	1.309	1.00
347_V	351_A	1.306	1.00
294_G	402_V	1.302	1.00
393_G	446_I	1.302	1.00
334_S	433_Y	1.275	1.00
247_D	251_T	1.263	1.00
349_F	445_F	1.260	1.00
167_S	177_Y	1.243	1.00
294_G	399_A	1.240	1.00
393_G	444_A	1.238	1.00
152_F	260_G	1.237	1.00
148_L	212_I	1.232	1.00
397_G	439_I	1.218	1.00
364_A	368_F	1.217	1.00
179_G	183_G	1.209	1.00
274_L	277_G	1.197	0.99
376_I	390_A	1.190	0.99
431_I	434_L	1.185	0.99
238_T	251_T	1.184	0.99
277_G	280_V	1.183	0.99
304_I	313_F	1.182	0.99
400_Y	436_G	1.179	0.99
123_S	156_A	1.172	0.99
291_F	403_F	1.170	0.99
350_M	453_I	1.166	0.99
169_S	176_P	1.161	0.99
346_A	449_F	1.159	0.99
299_G	388_I	1.157	0.99
301_Y	332_I	1.155	0.99
166_V	181_V	1.152	0.99
164_I	221_V	1.149	0.99
400_Y	435_I	1.149	0.99
222_I	226_L	1.149	0.99
126_L	153_S	1.148	0.99
113_F	221_V	1.143	0.99
401_V	406_V	1.139	0.99
182_I	256_V	1.136	0.99
335_M	394_G	1.129	0.99
278_I	304_I	1.123	0.99
130_L	146_L	1.121	0.99
335_M	401_V	1.120	0.99
342_G	346_A	1.118	0.99
169_S	179_G	1.115	0.99
174_S	231_M	1.112	0.99
339_A	390_A	1.105	0.99
350_M	448_A	1.102	0.99
429_N	432_H	1.097	0.99
362_P	366_S	1.096	0.99
169_S	174_S	1.095	0.99
385_K	452_K	1.084	0.99
116_I	167_S	1.081	0.99
393_G	397_G	1.080	0.99
431_I	435_I	1.074	0.99
295_L	396_L	1.057	0.99
232_S	236_K	1.057	0.99
380_N	386_P	1.052	0.99
397_G	440_A	1.052	0.99
182_I	224_V	1.048	0.99
97_E	101_P	1.042	0.99
328_Y	331_P	1.038	0.99
437_M	440_A	1.037	0.99
228_V	232_S	1.036	0.98
234_V	238_T	1.035	0.98
145_L	148_L	1.033	0.98
185_I	260_G	1.031	0.98
155_A	184_G	1.022	0.98
437_M	441_A	1.021	0.98
237_W	240_K	1.021	0.98
183_G	224_V	1.021	0.98
227_A	259_T	1.016	0.98
111_N	171_E	1.016	0.98
97_E	100_N	1.013	0.98
392_I	447_A	1.011	0.98
419_I	434_L	1.011	0.98
108_T	112_I	1.009	0.98
168_A	172_F	1.008	0.98
412_G	421_I	1.003	0.98
282_L	328_Y	1.001	0.98
172_F	229_Y	1.001	0.98
270_L	274_L	0.994	0.98
159_F	189_P	0.992	0.98
173_G	236_K	0.988	0.98
339_A	343_A	0.978	0.98
299_G	391_M	0.977	0.98
175_N	235_E	0.975	0.98
116_I	160_L	0.973	0.98
343_A	380_N	0.973	0.98
449_F	453_I	0.973	0.98
271_G	275_G	0.964	0.98
140_S	143_S	0.962	0.98
243_P	246_V	0.960	0.98
400_Y	403_F	0.956	0.97
334_S	418_M	0.952	0.97
348_F	360_A	0.951	0.97
262_V	267_I	0.945	0.97
244_H	247_D	0.939	0.97
182_I	259_T	0.930	0.97
164_I	224_V	0.927	0.97
289_A	292_V	0.925	0.97
340_Q	390_A	0.920	0.97
165_G	224_V	0.919	0.97
267_I	271_G	0.918	0.97
222_I	271_G	0.916	0.97
343_A	390_A	0.916	0.97
162_I	181_V	0.914	0.97
242_V	246_V	0.913	0.97
102_A	105_F	0.913	0.97
349_F	452_K	0.913	0.97
147_Q	150_D	0.909	0.97
438_A	442_V	0.909	0.97
174_S	179_G	0.905	0.96
258_V	261_F	0.904	0.96
386_P	389_A	0.903	0.96
390_A	443_S	0.899	0.96
338_V	341_G	0.899	0.96
313_F	317_E	0.898	0.96
280_V	283_T	0.897	0.96
449_F	452_K	0.897	0.96
266_A	270_L	0.891	0.96
226_L	267_I	0.887	0.96
303_L	387_F	0.886	0.96
165_G	228_V	0.884	0.96
347_V	379_V	0.881	0.96
98_K	104_R	0.879	0.96
389_A	448_A	0.876	0.96
240_K	352_K	0.872	0.96
130_L	153_S	0.872	0.96
163_L	181_V	0.865	0.95
124_G	411_Y	0.865	0.95
353_K	357_K	0.864	0.95
439_I	442_V	0.864	0.95
336_A	340_Q	0.863	0.95
439_I	443_S	0.862	0.95
181_V	185_I	0.859	0.95
187_I	218_Q	0.859	0.95
168_A	225_L	0.857	0.95
348_F	357_K	0.856	0.95
105_F	108_T	0.854	0.95
343_A	386_P	0.853	0.95
438_A	446_I	0.852	0.95
372_T	375_V	0.852	0.95
152_F	185_I	0.851	0.95
406_V	436_G	0.850	0.95
217_Y	223_P	0.848	0.95
356_T	379_V	0.848	0.95
127_M	157_F	0.846	0.95
112_I	225_L	0.845	0.95
389_A	446_I	0.845	0.95
131_G	150_D	0.845	0.95
273_A	276_S	0.844	0.95
380_N	390_A	0.843	0.95
163_L	184_G	0.840	0.95
367_A	372_T	0.838	0.95
230_V	234_V	0.838	0.95
239_R	251_T	0.836	0.95
227_A	262_V	0.834	0.94
107_K	111_N	0.833	0.94
364_A	367_A	0.832	0.94
174_S	235_E	0.831	0.94
172_F	232_S	0.830	0.94
97_E	104_R	0.829	0.94
242_V	251_T	0.825	0.94
156_A	163_L	0.824	0.94
350_M	449_F	0.823	0.94
262_V	266_A	0.822	0.94
380_N	387_F	0.822	0.94
201_T	204_Y	0.821	0.94
224_V	228_V	0.814	0.94
238_T	241_V	0.813	0.94
404_T	435_I	0.812	0.94
342_G	368_F	0.810	0.94
340_Q	375_V	0.807	0.93
241_V	250_V	0.802	0.93
257_I	261_F	0.799	0.93
300_T	303_L	0.797	0.93
441_A	444_A	0.797	0.93
108_T	229_Y	0.794	0.93
194_P	205_M	0.793	0.93
261_F	266_A	0.792	0.93
123_S	155_A	0.792	0.93
294_G	298_G	0.791	0.93
166_V	170_K	0.790	0.93
345_L	445_F	0.785	0.92
416_I	420_A	0.784	0.92
389_A	450_V	0.784	0.92
404_T	439_I	0.782	0.92
160_L	221_V	0.780	0.92
155_A	185_I	0.780	0.92
294_G	332_I	0.779	0.92
357_K	361_L	0.777	0.92
173_G	179_G	0.777	0.92
386_P	448_A	0.777	0.92
118_P	121_V	0.776	0.92
441_A	445_F	0.776	0.92
96_K	104_R	0.776	0.92
143_S	147_Q	0.774	0.92
359_I	363_A	0.774	0.92
134_N	146_L	0.771	0.92
368_F	416_I	0.769	0.92
165_G	180_A	0.767	0.92
303_L	307_T	0.765	0.91
385_K	453_I	0.764	0.91
230_V	233_K	0.764	0.91
451_M	456_D	0.761	0.91
178_L	231_M	0.761	0.91
94_A	97_E	0.760	0.91
329_L	333_W	0.759	0.91
255_T	259_T	0.759	0.91
154_S	188_H	0.759	0.91
196_G	199_E	0.756	0.91
147_Q	151_M	0.755	0.91
347_V	386_P	0.754	0.91
302_S	336_A	0.752	0.91
280_V	284_Y	0.751	0.91
451_M	455_E	0.751	0.91
246_V	369_L	0.749	0.91
444_A	452_K	0.748	0.91
319_G	322_A	0.747	0.90
291_F	295_L	0.743	0.90
340_Q	343_A	0.743	0.90
165_G	183_G	0.741	0.90
133_I	139_M	0.741	0.90
270_L	273_A	0.739	0.90
132_M	136_F	0.737	0.90
173_G	235_E	0.737	0.90
347_V	356_T	0.728	0.89
114_V	311_H	0.727	0.89
192_L	196_G	0.726	0.89
406_V	432_H	0.724	0.89
356_T	455_E	0.722	0.89
284_Y	290_G	0.721	0.89
275_G	309_V	0.718	0.89
440_A	444_A	0.717	0.89
162_I	183_G	0.715	0.88
112_I	168_A	0.711	0.88
207_L	211_D	0.710	0.88
222_I	306_L	0.709	0.88
300_T	391_M	0.707	0.88
338_V	437_M	0.704	0.88
264_F	269_P	0.702	0.88
296_I	299_G	0.700	0.87
305_V	336_A	0.698	0.87
124_G	315_A	0.698	0.87
307_T	377_F	0.694	0.87
136_F	139_M	0.694	0.87
351_A	455_E	0.694	0.87
132_M	138_W	0.691	0.87
132_M	135_A	0.687	0.86
335_M	397_G	0.682	0.86
350_M	455_E	0.682	0.86
344_G	360_A	0.680	0.86
379_V	383_Y	0.679	0.86
339_A	393_G	0.679	0.86
96_K	99_L	0.678	0.86
340_Q	367_A	0.674	0.85
297_F	313_F	0.673	0.85
363_A	366_S	0.673	0.85
204_Y	213_A	0.673	0.85
302_S	376_I	0.672	0.85
123_S	160_L	0.671	0.85
298_G	395_A	0.670	0.85
405_H	428_S	0.669	0.85
450_V	454_N	0.668	0.85
297_F	304_I	0.667	0.85
155_A	188_H	0.666	0.85
344_G	348_F	0.665	0.85
235_E	251_T	0.662	0.84
142_D	147_Q	0.659	0.84
296_I	300_T	0.658	0.84
284_Y	287_D	0.658	0.84
361_L	364_A	0.655	0.84
414_T	418_M	0.655	0.84
396_L	400_Y	0.655	0.84
134_N	150_D	0.654	0.84
272_R	276_S	0.652	0.83
392_I	395_A	0.651	0.83
242_V	254_V	0.651	0.83
290_G	293_A	0.649	0.83
388_I	391_M	0.646	0.83
145_L	207_L	0.646	0.83
136_F	140_S	0.646	0.83
393_G	447_A	0.643	0.83
424_P	429_N	0.642	0.83
127_M	158_I	0.642	0.83
206_H	210_F	0.640	0.82
183_G	231_M	0.640	0.82
396_L	399_A	0.639	0.82
109_L	307_T	0.638	0.82
226_L	229_Y	0.637	0.82
300_T	313_F	0.636	0.82
344_G	364_A	0.635	0.82
346_A	448_A	0.633	0.82
382_R	386_P	0.631	0.81
213_A	272_R	0.630	0.81
385_K	389_A	0.630	0.81
338_V	436_G	0.629	0.81
369_L	417_P	0.626	0.81
295_L	299_G	0.624	0.81
234_V	255_T	0.622	0.81
173_G	176_P	0.621	0.80
336_A	372_T	0.620	0.80
312_S	315_A	0.618	0.80
428_S	431_I	0.617	0.80
385_K	388_I	0.616	0.80
288_H	292_V	0.614	0.80
358_E	362_P	0.612	0.79
163_L	180_A	0.610	0.79
347_V	350_M	0.610	0.79
361_L	365_F	0.610	0.79
442_V	445_F	0.608	0.79
235_E	239_R	0.608	0.79
406_V	430_L	0.608	0.79
134_N	138_W	0.607	0.79
398_G	402_V	0.605	0.79
228_V	231_M	0.605	0.79
340_Q	372_T	0.605	0.79
248_L	251_T	0.605	0.79
343_A	347_V	0.602	0.78
125_L	128_G	0.602	0.78
410_A	421_I	0.602	0.78
179_G	228_V	0.600	0.78
318_A	322_A	0.599	0.78
258_V	262_V	0.595	0.78
433_Y	438_A	0.593	0.77
338_V	415_G	0.593	0.77
105_F	109_L	0.591	0.77
129_L	132_M	0.591	0.77
191_L	195_W	0.590	0.77
419_I	437_M	0.588	0.77
295_L	298_G	0.587	0.77
317_E	327_N	0.586	0.76
300_T	304_I	0.586	0.76
355_K	359_I	0.585	0.76
387_F	390_A	0.584	0.76
151_M	188_H	0.581	0.76
316_I	320_L	0.581	0.76
337_N	372_T	0.580	0.76
158_I	189_P	0.580	0.76
360_A	364_A	0.580	0.76
120_I	311_H	0.580	0.76
393_G	396_L	0.580	0.76
336_A	414_T	0.578	0.75
122_A	256_V	0.578	0.75
139_M	143_S	0.578	0.75
100_N	103_A	0.577	0.75
341_G	364_A	0.576	0.75
158_I	218_Q	0.574	0.75
302_S	387_F	0.572	0.75
193_N	196_G	0.571	0.75
432_H	439_I	0.570	0.74
144_A	205_M	0.567	0.74
150_D	154_S	0.566	0.74
117_I	415_G	0.565	0.74
137_H	140_S	0.562	0.73
347_V	383_Y	0.562	0.73
297_F	332_I	0.561	0.73
344_G	380_N	0.560	0.73
350_M	385_K	0.558	0.73
148_L	205_M	0.553	0.72
423_A	430_L	0.553	0.72
401_V	435_I	0.553	0.72
100_N	104_R	0.553	0.72
106_A	381_L	0.552	0.72
230_V	258_V	0.552	0.72
315_A	318_A	0.552	0.72
119_A	181_V	0.552	0.72
117_I	370_G	0.551	0.72
128_G	294_G	0.550	0.72
253_F	256_V	0.550	0.72
368_F	441_A	0.549	0.72
122_A	183_G	0.546	0.71
353_K	456_D	0.545	0.71
119_A	178_L	0.544	0.71
274_L	309_V	0.544	0.71
130_L	150_D	0.544	0.71
356_T	360_A	0.542	0.71
302_S	340_Q	0.540	0.70
222_I	278_I	0.540	0.70
309_V	316_I	0.540	0.70
320_L	323_D	0.540	0.70
445_F	448_A	0.539	0.70
353_K	455_E	0.537	0.70
157_F	160_L	0.536	0.70
285_V	288_H	0.535	0.70
134_N	141_K	0.535	0.70
112_I	172_F	0.533	0.70
350_M	353_K	0.532	0.69
285_V	296_I	0.532	0.69
95_A	104_R	0.531	0.69
386_P	390_A	0.531	0.69
406_V	414_T	0.531	0.69
336_A	339_A	0.531	0.69
415_G	418_M	0.530	0.69
450_V	456_D	0.528	0.69
335_M	440_A	0.528	0.69
427_F	431_I	0.526	0.69
289_A	293_A	0.525	0.68
109_L	120_I	0.525	0.68
238_T	255_T	0.521	0.68
305_V	340_Q	0.520	0.68
111_N	167_S	0.520	0.68
323_D	326_K	0.519	0.67
301_Y	398_G	0.519	0.67
191_L	194_P	0.518	0.67
105_F	111_N	0.518	0.67
175_N	239_R	0.517	0.67
407_A	427_F	0.516	0.67
184_G	188_H	0.515	0.67
206_H	209_G	0.515	0.67
227_A	231_M	0.514	0.67
182_I	227_A	0.514	0.67
282_L	316_I	0.513	0.67
126_L	253_F	0.513	0.67
306_L	376_I	0.513	0.67
337_N	390_A	0.512	0.66
334_S	401_V	0.511	0.66
176_P	228_V	0.511	0.66
109_L	117_I	0.511	0.66
202_P	206_H	0.509	0.66
128_G	415_G	0.509	0.66
134_N	139_M	0.509	0.66
306_L	351_A	0.508	0.66
217_Y	275_G	0.507	0.66
452_K	455_E	0.507	0.66
110_S	311_H	0.507	0.66
409_N	423_A	0.507	0.66
116_I	163_L	0.506	0.66
152_F	259_T	0.505	0.65
174_S	255_T	0.503	0.65
138_W	143_S	0.503	0.65
139_M	142_D	0.501	0.65
403_F	407_A	0.501	0.65
343_A	448_A	0.500	0.65
414_T	421_I	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qnqA	2	0.8069	100	0.646	Contact Map
3ipjA	1	0.1996	100	0.786	Contact Map
1ibaA	1	0.167	100	0.798	Contact Map
3bp3A	1	0.1757	100	0.8	Contact Map
4us3A	1	0.6768	41.8	0.974	Contact Map
2h8eA	2	0.1866	40.1	0.974	Contact Map
4n8nA	1	0.102	35.7	0.975	Contact Map
4rfsS	1	0.2169	27.2	0.976	Contact Map
4bxoA	1	0.1518	22.1	0.977	Contact Map
3q9vA	1	0.1171	18.9	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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