GREMLIN Database
THRC - Threonine synthase
UniProt: P04990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (297)
Sequences: 23434 (12056)
Seq/√Len: 699.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_A101_C4.0011.00
44_E308_K3.4551.00
138_I141_S3.3161.00
33_H44_E3.0881.00
267_E296_K2.7301.00
274_L278_V2.7101.00
169_V310_V2.6491.00
179_V212_R2.6291.00
112_F116_A2.6161.00
77_T102_I2.5201.00
107_N129_D2.5111.00
69_K73_E2.4741.00
100_K124_E2.4571.00
28_N171_E2.3951.00
141_S145_K2.3911.00
217_E264_T2.3561.00
69_K157_Y2.3441.00
102_I124_E2.2821.00
264_T267_E2.2541.00
210_K259_K2.2241.00
46_H308_K2.2081.00
71_K99_M2.2041.00
104_I142_I2.1911.00
201_H208_L2.1371.00
218_G265_D2.0481.00
194_W256_S2.0471.00
102_I126_I2.0451.00
290_S311_A2.0251.00
31_L310_V2.0051.00
28_N172_Q2.0031.00
167_F196_G1.9471.00
304_P307_S1.9461.00
275_I283_A1.9441.00
220_A224_R1.9401.00
68_A97_A1.9321.00
194_W211_M1.9161.00
214_F293_G1.8471.00
162_Q199_E1.8421.00
271_A292_A1.8221.00
274_L295_L1.8221.00
201_H209_P1.7941.00
292_A296_K1.7891.00
46_H173_L1.7691.00
180_L197_F1.7401.00
55_T92_A1.7241.00
212_R259_K1.7071.00
140_R144_E1.6991.00
162_Q195_K1.6971.00
33_H46_H1.6931.00
251_K255_E1.6851.00
184_V213_G1.6791.00
180_L193_Y1.6731.00
178_D308_K1.6501.00
201_H207_G1.6231.00
275_I291_I1.6221.00
115_L127_A1.6141.00
71_K74_G1.6051.00
178_D307_S1.5901.00
175_E308_K1.5891.00
33_H38_S1.5681.00
179_V307_S1.5391.00
261_D293_G1.5251.00
71_K97_A1.5171.00
170_C200_Y1.5161.00
271_A295_L1.5141.00
166_A193_Y1.5101.00
238_I289_A1.5061.00
47_V313_L1.5051.00
112_F115_L1.4951.00
77_T100_K1.4901.00
142_I146_S1.4711.00
64_V68_A1.4641.00
115_L119_V1.4551.00
82_S87_S1.4521.00
198_K258_G1.4431.00
267_E292_A1.4301.00
116_A119_V1.4171.00
40_Q274_L1.4081.00
273_Q277_R1.4021.00
136_L140_R1.3611.00
166_A197_F1.3581.00
181_A297_Q1.3561.00
235_A268_I1.3471.00
66_A155_N1.3471.00
133_D137_K1.3331.00
283_A313_L1.3321.00
181_A214_F1.3231.00
287_S313_L1.3021.00
166_A196_G1.2941.00
143_C150_L1.2881.00
190_I257_N1.2871.00
271_A291_I1.2851.00
196_G200_Y1.2841.00
179_V210_K1.2831.00
217_E262_E1.2741.00
40_Q278_V1.2711.00
270_H274_L1.2591.00
65_M163_K1.2581.00
191_T249_A1.2551.00
220_A262_E1.2491.00
190_I213_G1.2331.00
132_F135_A1.2311.00
155_N158_R1.2271.00
261_D296_K1.2251.00
250_V254_E1.2251.00
126_I138_I1.2231.00
67_V78_I1.2221.00
223_V260_I1.2201.00
263_V292_A1.2171.00
193_Y312_V1.2141.00
118_A123_A1.2091.00
223_V262_E1.2051.00
276_A282_F1.1991.00
36_K279_E1.1971.00
32_I49_T1.1851.00
34_L47_V1.1811.00
179_V309_V1.1761.00
140_R143_C1.1701.00
267_E270_H1.1641.00
105_I118_A1.1621.00
197_F209_P1.1571.00
31_L173_L1.1461.00
30_P52_V1.1451.00
115_L125_I1.1411.00
21_A24_L1.1381.00
20_P24_L1.1301.00
104_I138_I1.1261.00
138_I142_I1.1231.00
167_F171_E1.1191.00
170_C196_G1.1051.00
137_K141_S1.1051.00
31_L169_V1.1051.00
87_S118_A1.1031.00
213_G260_I1.0981.00
177_P310_V1.0971.00
137_K140_R1.0941.00
131_N134_D1.0861.00
234_I269_L1.0831.00
156_P159_I1.0801.00
195_K251_K1.0761.00
45_L294_V1.0731.00
68_A72_E1.0721.00
69_K72_E1.0651.00
173_L177_P1.0591.00
179_V303_I1.0571.00
212_R261_D1.0521.00
42_G305_K1.0511.00
65_M69_K1.0511.00
266_D270_H1.0501.00
65_M160_E1.0441.00
190_I211_M1.0441.00
294_V311_A1.0431.00
35_P39_E1.0391.00
173_L310_V1.0371.00
296_K299_K1.0341.00
303_I307_S1.0291.00
73_E157_Y1.0281.00
78_I94_A1.0271.00
139_V143_C1.0261.00
134_D137_K1.0251.00
107_N130_G1.0201.00
80_C103_V1.0141.00
220_A223_V1.0131.00
105_I127_A1.0131.00
141_S144_E0.9981.00
90_A101_C0.9951.00
170_C201_H0.9941.00
67_V97_A0.9871.00
248_K251_K0.9841.00
95_A101_C0.9811.00
272_Y288_C0.9791.00
92_A121_Y0.9751.00
79_M148_I0.9721.00
21_A65_M0.9721.00
36_K39_E0.9711.00
63_M89_A0.9681.00
67_V93_Y0.9581.00
65_M68_A0.9561.00
259_K302_E0.9551.00
36_K278_V0.9531.00
119_V124_E0.9371.00
79_M142_I0.9261.00
271_A274_L0.9251.00
234_I265_D0.9231.00
163_K167_F0.9201.00
210_K258_G0.9101.00
283_A287_S0.8961.00
196_G199_E0.8891.00
229_E242_N0.8861.00
135_A139_V0.8831.00
181_A294_V0.8811.00
233_T239_R0.8811.00
66_A151_V0.8781.00
210_K307_S0.8781.00
167_F200_Y0.8651.00
181_A212_R0.8611.00
49_T313_L0.8591.00
116_A120_M0.8591.00
221_A224_R0.8561.00
287_S314_T0.8561.00
89_A93_Y0.8491.00
25_H64_V0.8441.00
130_G134_D0.8431.00
184_V190_I0.8381.00
181_A293_G0.8371.00
162_Q196_G0.8351.00
160_E163_K0.8341.00
132_F136_L0.8311.00
182_I193_Y0.8281.00
161_G165_A0.8261.00
222_I243_P0.8251.00
91_A123_A0.8181.00
268_I289_A0.8141.00
29_T53_N0.8111.00
79_M139_V0.8101.00
77_T148_I0.8091.00
95_A121_Y0.8091.00
165_A312_V0.8051.00
179_V297_Q0.8031.00
38_S41_L0.8031.00
136_L139_V0.7991.00
290_S314_T0.7941.00
165_A193_Y0.7921.00
92_A96_R0.7911.00
47_V311_A0.7871.00
291_I313_L0.7871.00
238_I286_G0.7861.00
49_T52_V0.7851.00
65_M157_Y0.7831.00
177_P209_P0.7811.00
20_P33_H0.7791.00
291_I311_A0.7761.00
41_L274_L0.7711.00
254_E257_N0.7711.00
20_P23_T0.7701.00
190_I253_A0.7691.00
159_I249_A0.7661.00
34_L279_E0.7651.00
102_I146_S0.7641.00
165_A189_N0.7581.00
155_N159_I0.7521.00
104_I126_I0.7501.00
170_C197_F0.7451.00
103_V118_A0.7451.00
71_K75_N0.7451.00
173_L308_K0.7411.00
177_P308_K0.7411.00
253_A257_N0.7361.00
183_P314_T0.7341.00
282_F317_G0.7331.00
221_A241_G0.7321.00
252_A256_S0.7311.00
195_K199_E0.7301.00
44_E306_G0.7281.00
251_K254_E0.7281.00
76_D100_K0.7261.00
102_I142_I0.7221.00
81_A132_F0.7201.00
79_M143_C0.7201.00
34_L291_I0.7201.00
235_A238_I0.7191.00
37_L295_L0.7181.00
297_Q302_E0.7181.00
143_C148_I0.7181.00
181_A309_V0.7131.00
119_V127_A0.7121.00
180_L312_V0.7121.00
283_A288_C0.7101.00
295_L299_K0.7101.00
75_N99_M0.7091.00
109_K130_G0.7091.00
77_T146_S0.7071.00
102_I148_I0.7051.00
88_A118_A0.7051.00
159_I195_K0.7041.00
222_I253_A0.7021.00
107_N127_A0.7021.00
39_E42_G0.7011.00
323_T326_D0.6991.00
173_L176_A0.6941.00
269_L285_P0.6931.00
297_Q303_I0.6921.00
35_P38_S0.6921.00
66_A158_R0.6891.00
43_I298_V0.6891.00
41_L295_L0.6891.00
134_D138_I0.6881.00
176_A310_V0.6821.00
165_A169_V0.6811.00
63_M93_Y0.6801.00
184_V260_I0.6801.00
226_E229_E0.6801.00
142_I145_K0.6761.00
275_I279_E0.6741.00
139_V150_L0.6701.00
193_Y197_F0.6701.00
70_A149_A0.6661.00
78_I99_M0.6651.00
128_I138_I0.6641.00
247_D251_K0.6611.00
176_A308_K0.6611.00
210_K302_E0.6601.00
222_I260_I0.6601.00
58_F189_N0.6601.00
272_Y324_A0.6561.00
21_A68_A0.6561.00
179_V304_P0.6561.00
113_G322_N0.6511.00
81_A150_L0.6511.00
112_F119_V0.6501.00
105_I115_L0.6491.00
191_T195_K0.6481.00
88_A117_Q0.6481.00
242_N247_D0.6471.00
48_K168_E0.6471.00
169_V193_Y0.6471.00
168_E172_Q0.6451.00
244_A247_D0.6441.00
56_G316_N0.6411.00
152_N155_N0.6391.00
43_I307_S0.6361.00
78_I101_C0.6351.00
26_E60_D0.6351.00
51_G316_N0.6351.00
322_N326_D0.6341.00
294_V309_V0.6331.00
47_V291_I0.6281.00
174_G177_P0.6241.00
198_K256_S0.6241.00
38_S44_E0.6241.00
240_I243_P0.6231.00
216_A238_I0.6231.00
110_I115_L0.6211.00
114_K236_T0.6211.00
84_G87_S0.6201.00
272_Y318_L0.6191.00
27_G54_P0.6181.00
298_V303_I0.6181.00
291_I295_L0.6151.00
37_L291_I0.6141.00
259_K297_Q0.6111.00
270_H273_Q0.6101.00
49_T281_V0.6091.00
142_I148_I0.6061.00
183_P290_S0.6061.00
182_I190_I0.6051.00
143_C146_S0.6041.00
180_L209_P0.6041.00
70_A74_G0.6031.00
31_L46_H0.6031.00
170_C173_L0.6031.00
214_F261_D0.6011.00
87_S103_V0.6011.00
104_I128_I0.6011.00
133_D136_L0.6011.00
101_C123_A0.5981.00
43_I306_G0.5981.00
40_Q295_L0.5941.00
79_M104_I0.5931.00
184_V222_I0.5931.00
299_K302_E0.5911.00
169_V180_L0.5901.00
43_I309_V0.5891.00
293_G297_Q0.5891.00
22_L25_H0.5891.00
81_A151_V0.5891.00
198_K255_E0.5881.00
51_G281_V0.5861.00
171_E200_Y0.5851.00
275_I313_L0.5851.00
62_G66_A0.5841.00
105_I110_I0.5831.00
38_S43_I0.5831.00
27_G53_N0.5821.00
76_D147_P0.5811.00
263_V293_G0.5801.00
78_I151_V0.5801.00
303_I306_G0.5801.00
272_Y285_P0.5801.00
218_G231_P0.5741.00
100_K148_I0.5721.00
37_L274_L0.5691.00
212_R297_Q0.5681.00
92_A95_A0.5681.00
193_Y211_M0.5661.00
37_L271_A0.5661.00
225_N254_E0.5661.00
31_L172_Q0.5591.00
237_A286_G0.5591.00
69_K75_N0.5591.00
275_I281_V0.5591.00
222_I249_A0.5581.00
148_I152_N0.5581.00
159_I248_K0.5571.00
180_L211_M0.5561.00
215_E221_A0.5551.00
124_E146_S0.5551.00
299_K303_I0.5541.00
180_L310_V0.5541.00
63_M90_A0.5521.00
110_I236_T0.5491.00
160_E195_K0.5491.00
265_D269_L0.5461.00
220_A225_N0.5441.00
163_K195_K0.5431.00
80_C90_A0.5431.00
34_L37_L0.5411.00
47_V283_A0.5411.00
81_A136_L0.5401.00
86_T151_V0.5401.00
47_V281_V0.5361.00
54_P60_D0.5361.00
269_L324_A0.5361.00
34_L38_S0.5361.00
214_F289_A0.5361.00
156_P248_K0.5351.00
37_L41_L0.5341.00
303_I309_V0.5331.00
169_V177_P0.5321.00
169_V312_V0.5321.00
26_E64_V0.5321.00
66_A149_A0.5301.00
117_Q120_M0.5291.00
91_A118_A0.5291.00
66_A157_Y0.5291.00
90_A103_V0.5271.00
60_D92_A0.5261.00
266_D269_L0.5231.00
251_K256_S0.5231.00
75_N149_A0.5221.00
170_C174_G0.5211.00
43_I305_K0.5191.00
138_I145_K0.5151.00
322_N325_V0.5140.99
215_E223_V0.5140.99
167_F199_E0.5120.99
61_R168_E0.5120.99
47_V287_S0.5100.99
224_R228_I0.5100.99
213_G257_N0.5080.99
76_D149_A0.5070.99
77_T124_E0.5060.99
25_H52_V0.5030.99
37_L278_V0.5010.99
178_D310_V0.5000.99
91_A101_C0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aeyA 2 0.9858 100 0.153 Contact Map
2zsjA 2 0.9858 100 0.154 Contact Map
2d1fA 2 0.983 100 0.154 Contact Map
1e5xA 2 0.9489 100 0.196 Contact Map
1tdjA 2 0.9489 100 0.23 Contact Map
2gn0A 2 0.9034 100 0.242 Contact Map
1v71A 2 0.8807 100 0.246 Contact Map
2pqmA 2 0.9148 100 0.253 Contact Map
1ve5A 3 0.8438 100 0.254 Contact Map
2q3bA 2 0.8267 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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