KHSE - BACSU - GREMLIN Contacts

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KHSE - Homoserine kinase

UniProt:	P04948	Sequences: MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKWSFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAAIVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRVPNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGKIMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQLALHFPHCEVDALTVPKEGSIIERNPLYQVKSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	309 (270)
Sequences:	9518 (7171)
Seq/√Len:	436.4

ECOLI - KHSE GAL1 ISPE
BACSU - KHSE ISPE GAL1
HALSA - KHSE Q9HQI6
SULSO - KHSE MVK PMK Q980I6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_T	33_Y	4.148	1.00
39_F	83_H	4.048	1.00
119_S	122_D	3.477	1.00
47_E	83_H	3.462	1.00
41_S	83_H	2.871	1.00
38_V	109_L	2.854	1.00
35_K	87_W	2.837	1.00
12_V	102_A	2.763	1.00
265_T	273_L	2.693	1.00
9_S	37_T	2.647	1.00
111_D	117_K	2.634	1.00
107_I	123_K	2.488	1.00
132_G	151_E	2.382	1.00
212_D	215_L	2.301	1.00
252_T	263_V	2.214	1.00
221_K	245_E	2.134	1.00
49_E	85_K	2.123	1.00
227_Q	241_E	2.089	1.00
37_T	85_K	2.088	1.00
169_V	260_T	2.061	1.00
124_L	142_V	2.052	1.00
74_L	129_L	2.020	1.00
69_K	73_D	2.000	1.00
231_A	238_S	1.967	1.00
70_R	129_L	1.954	1.00
111_D	116_L	1.930	1.00
70_R	74_L	1.919	1.00
179_R	183_D	1.885	1.00
237_L	261_I	1.872	1.00
36_L	105_A	1.848	1.00
10_V	112_E	1.807	1.00
168_V	265_T	1.797	1.00
111_D	118_L	1.797	1.00
242_H	246_M	1.776	1.00
50_T	53_V	1.719	1.00
217_G	251_G	1.700	1.00
37_T	87_W	1.681	1.00
40_E	80_P	1.672	1.00
238_S	242_H	1.670	1.00
11_T	35_K	1.637	1.00
60_T	69_K	1.591	1.00
167_V	264_M	1.583	1.00
34_L	101_A	1.578	1.00
243_V	247_K	1.576	1.00
268_G	271_E	1.575	1.00
166_D	268_G	1.575	1.00
64_I	67_V	1.569	1.00
275_E	279_L	1.557	1.00
237_L	254_L	1.547	1.00
177_L	180_D	1.541	1.00
204_L	216_V	1.525	1.00
277_L	281_F	1.517	1.00
41_S	81_P	1.517	1.00
74_L	122_D	1.488	1.00
45_S	83_H	1.478	1.00
69_K	72_A	1.474	1.00
181_A	226_H	1.468	1.00
206_A	210_S	1.464	1.00
71_T	116_L	1.460	1.00
122_D	125_H	1.455	1.00
12_V	105_A	1.443	1.00
274_K	278_A	1.430	1.00
166_D	267_K	1.428	1.00
25_S	148_G	1.417	1.00
271_E	274_K	1.409	1.00
184_V	233_L	1.409	1.00
65_Y	69_K	1.404	1.00
35_K	89_D	1.402	1.00
28_M	145_L	1.396	1.00
70_R	126_L	1.382	1.00
39_F	85_K	1.375	1.00
63_L	66_Q	1.375	1.00
180_D	183_D	1.372	1.00
215_L	218_K	1.369	1.00
67_V	70_R	1.361	1.00
70_R	73_D	1.344	1.00
239_K	243_V	1.344	1.00
74_L	126_L	1.342	1.00
84_V	106_A	1.337	1.00
10_V	109_L	1.310	1.00
207_A	215_L	1.309	1.00
184_V	187_K	1.295	1.00
214_P	266_E	1.289	1.00
166_D	270_G	1.288	1.00
206_A	209_M	1.283	1.00
111_D	123_K	1.282	1.00
176_V	257_A	1.271	1.00
43_K	81_P	1.269	1.00
9_S	35_K	1.269	1.00
71_T	107_I	1.251	1.00
241_E	261_I	1.248	1.00
236_E	239_K	1.229	1.00
174_Y	236_E	1.227	1.00
38_V	84_V	1.224	1.00
176_V	181_A	1.219	1.00
220_M	251_G	1.205	1.00
171_I	260_T	1.200	1.00
149_L	156_Q	1.198	1.00
243_V	246_M	1.195	1.00
241_E	252_T	1.194	1.00
186_P	190_P	1.190	1.00
244_A	263_V	1.181	1.00
170_V	240_V	1.179	1.00
36_L	106_A	1.170	1.00
107_I	127_A	1.169	1.00
68_A	72_A	1.163	1.00
64_I	86_V	1.156	1.00
67_V	71_T	1.156	1.00
205_I	209_M	1.151	1.00
10_V	108_E	1.142	1.00
16_T	28_M	1.138	1.00
77_K	80_P	1.137	1.00
121_A	125_H	1.130	1.00
271_E	275_E	1.120	1.00
176_V	230_R	1.120	1.00
14_G	90_I	1.116	1.00
38_V	82_V	1.108	1.00
199_A	203_I	1.107	1.00
273_L	277_L	1.106	1.00
106_A	110_A	1.106	1.00
252_T	261_I	1.099	1.00
93_A	175_E	1.098	1.00
41_S	44_W	1.095	1.00
253_A	262_L	1.093	1.00
64_I	106_A	1.093	1.00
185_L	189_F	1.091	1.00
227_Q	231_A	1.088	1.00
239_K	242_H	1.086	1.00
41_S	45_S	1.077	1.00
71_T	114_C	1.069	1.00
47_E	85_K	1.058	1.00
243_V	280_H	1.054	1.00
272_E	276_Q	1.050	1.00
170_V	263_V	1.048	1.00
110_A	114_C	1.040	1.00
29_A	144_G	1.037	1.00
178_T	181_A	1.036	1.00
207_A	216_V	1.034	1.00
27_G	148_G	1.033	1.00
276_Q	280_H	1.028	1.00
80_P	114_C	1.013	1.00
111_D	120_E	1.012	1.00
169_V	262_L	1.006	1.00
71_T	75_Y	0.998	1.00
164_D	267_K	0.998	1.00
82_V	114_C	0.994	1.00
21_P	185_L	0.992	1.00
90_I	96_L	0.990	1.00
174_Y	234_V	0.989	1.00
247_K	276_Q	0.983	1.00
38_V	113_L	0.981	1.00
67_V	130_E	0.975	1.00
86_V	102_A	0.973	1.00
154_E	157_M	0.972	1.00
75_Y	116_L	0.965	1.00
244_A	252_T	0.962	1.00
231_A	237_L	0.955	1.00
16_T	262_L	0.954	1.00
226_H	232_M	0.949	1.00
269_K	272_E	0.942	1.00
214_P	218_K	0.942	1.00
270_G	274_K	0.938	1.00
168_V	273_L	0.934	1.00
34_L	88_S	0.928	1.00
241_E	245_E	0.923	1.00
29_A	145_L	0.920	1.00
30_L	33_Y	0.917	1.00
36_L	84_V	0.910	1.00
245_E	249_A	0.907	1.00
64_I	70_R	0.905	1.00
44_W	81_P	0.902	1.00
244_A	249_A	0.901	1.00
18_N	201_S	0.899	1.00
187_K	191_Y	0.896	1.00
168_V	270_G	0.893	1.00
181_A	184_V	0.885	1.00
15_S	140_S	0.885	1.00
111_D	119_S	0.880	1.00
57_P	61_D	0.876	1.00
197_A	200_V	0.876	1.00
75_Y	118_L	0.875	1.00
255_S	260_T	0.862	1.00
245_E	252_T	0.861	1.00
94_R	171_I	0.858	1.00
34_L	90_I	0.855	1.00
64_I	69_K	0.854	1.00
118_L	126_L	0.852	1.00
180_D	233_L	0.851	1.00
203_I	219_I	0.850	1.00
180_D	184_V	0.850	1.00
250_Y	266_E	0.849	1.00
63_L	67_V	0.848	1.00
108_E	120_E	0.846	1.00
49_E	83_H	0.841	1.00
235_P	239_K	0.840	1.00
266_E	269_K	0.837	1.00
120_E	142_V	0.836	1.00
66_Q	70_R	0.826	1.00
128_S	151_E	0.821	1.00
104_V	141_L	0.820	1.00
104_V	127_A	0.820	1.00
49_E	87_W	0.818	1.00
93_A	259_P	0.817	1.00
249_A	265_T	0.816	1.00
124_L	127_A	0.816	1.00
146_V	155_T	0.815	1.00
181_A	230_R	0.815	1.00
72_A	114_C	0.813	1.00
32_R	96_L	0.811	1.00
66_Q	69_K	0.809	1.00
46_F	65_Y	0.807	1.00
140_S	143_G	0.807	1.00
82_V	110_A	0.801	1.00
185_L	188_E	0.798	1.00
63_L	103_I	0.797	1.00
173_F	285_E	0.783	1.00
40_E	113_L	0.781	1.00
231_A	241_E	0.776	1.00
29_A	143_G	0.776	1.00
275_E	278_A	0.771	1.00
274_K	286_V	0.771	1.00
20_G	221_K	0.770	1.00
156_Q	209_M	0.769	1.00
12_V	140_S	0.768	1.00
103_I	130_E	0.766	1.00
44_W	48_A	0.762	1.00
68_A	84_V	0.760	1.00
182_R	185_L	0.760	1.00
125_H	129_L	0.756	1.00
47_E	50_T	0.755	1.00
33_Y	90_I	0.750	1.00
120_E	124_L	0.750	1.00
203_I	206_A	0.744	1.00
10_V	36_L	0.744	1.00
60_T	65_Y	0.743	1.00
124_L	138_G	0.742	1.00
23_F	132_G	0.742	1.00
276_Q	279_L	0.742	1.00
101_A	140_S	0.739	1.00
118_L	123_K	0.738	1.00
265_T	270_G	0.737	1.00
191_Y	194_A	0.735	1.00
108_E	123_K	0.735	1.00
136_N	140_S	0.734	1.00
121_A	142_V	0.734	1.00
122_D	126_L	0.732	1.00
226_H	230_R	0.729	1.00
272_E	275_E	0.728	1.00
263_V	273_L	0.724	1.00
248_G	251_G	0.718	1.00
196_K	229_Y	0.718	1.00
17_A	27_G	0.716	1.00
171_I	175_E	0.716	1.00
136_N	147_I	0.715	1.00
27_G	139_A	0.713	1.00
67_V	107_I	0.713	1.00
198_S	201_S	0.711	1.00
172_P	240_V	0.710	1.00
90_I	101_A	0.707	1.00
149_L	154_E	0.705	1.00
139_A	143_G	0.702	1.00
20_G	223_D	0.700	1.00
71_T	126_L	0.700	1.00
67_V	72_A	0.697	1.00
170_V	252_T	0.692	1.00
190_P	193_D	0.692	1.00
107_I	126_L	0.691	1.00
14_G	30_L	0.690	1.00
184_V	188_E	0.690	1.00
127_A	141_L	0.689	1.00
240_V	261_I	0.687	1.00
109_L	113_L	0.682	1.00
96_L	169_V	0.682	1.00
136_N	143_G	0.682	1.00
15_S	139_A	0.679	1.00
10_V	105_A	0.679	1.00
124_L	141_L	0.678	1.00
62_N	65_Y	0.677	1.00
68_A	106_A	0.676	1.00
13_P	29_A	0.673	1.00
65_Y	68_A	0.669	1.00
168_V	274_K	0.665	1.00
18_N	21_P	0.665	1.00
112_E	116_L	0.665	1.00
56_I	59_G	0.664	1.00
244_A	273_L	0.664	1.00
126_L	129_L	0.662	1.00
42_D	80_P	0.661	1.00
63_L	130_E	0.660	1.00
34_L	86_V	0.659	1.00
201_S	205_I	0.659	1.00
72_A	77_K	0.657	1.00
121_A	124_L	0.657	1.00
147_I	205_I	0.655	1.00
48_A	51_E	0.655	1.00
200_V	203_I	0.654	0.99
151_E	154_E	0.654	0.99
40_E	114_C	0.649	0.99
150_H	153_D	0.649	0.99
124_L	128_S	0.648	0.99
36_L	86_V	0.648	0.99
13_P	143_G	0.647	0.99
86_V	106_A	0.644	0.99
247_K	273_L	0.642	0.99
283_H	286_V	0.640	0.99
218_K	222_K	0.638	0.99
217_G	250_Y	0.636	0.99
64_I	72_A	0.631	0.99
139_A	148_G	0.630	0.99
243_V	277_L	0.630	0.99
75_Y	78_E	0.626	0.99
106_A	109_L	0.625	0.99
203_I	215_L	0.625	0.99
277_L	282_P	0.624	0.99
249_A	263_V	0.622	0.99
127_A	137_A	0.619	0.99
142_V	146_V	0.613	0.99
202_N	205_I	0.613	0.99
114_C	117_K	0.611	0.99
245_E	251_G	0.609	0.99
202_N	206_A	0.608	0.99
100_A	140_S	0.608	0.99
48_A	62_N	0.608	0.99
93_A	260_T	0.606	0.99
164_D	266_E	0.606	0.99
17_A	21_P	0.606	0.99
63_L	69_K	0.604	0.99
170_V	284_C	0.604	0.99
176_V	234_V	0.599	0.99
183_D	187_K	0.598	0.99
111_D	114_C	0.597	0.99
226_H	254_L	0.596	0.99
44_W	72_A	0.594	0.99
176_V	259_P	0.594	0.99
236_E	240_V	0.594	0.99
233_L	236_E	0.594	0.99
108_E	141_L	0.593	0.99
70_R	130_E	0.593	0.99
182_R	186_P	0.590	0.99
46_F	81_P	0.588	0.99
72_A	75_Y	0.588	0.99
203_I	207_A	0.587	0.99
108_E	112_E	0.583	0.99
82_V	113_L	0.581	0.99
178_T	182_R	0.577	0.99
97_G	140_S	0.573	0.99
40_E	82_V	0.572	0.99
207_A	212_D	0.572	0.99
219_I	223_D	0.571	0.99
64_I	68_A	0.569	0.99
16_T	167_V	0.569	0.99
112_E	115_G	0.567	0.99
189_F	194_A	0.567	0.99
29_A	140_S	0.566	0.99
68_A	81_P	0.566	0.99
170_V	244_A	0.565	0.99
120_E	123_K	0.561	0.98
162_N	165_I	0.560	0.98
64_I	71_T	0.560	0.98
46_F	82_V	0.559	0.98
101_A	143_G	0.557	0.98
66_Q	71_T	0.556	0.98
226_H	257_A	0.553	0.98
136_N	142_V	0.548	0.98
140_S	146_V	0.546	0.98
111_D	115_G	0.546	0.98
64_I	102_A	0.543	0.98
228_P	238_S	0.542	0.98
21_P	226_H	0.541	0.98
165_I	250_Y	0.540	0.98
204_L	208_I	0.539	0.98
189_F	192_A	0.539	0.98
13_P	33_Y	0.537	0.98
246_M	280_H	0.536	0.98
171_I	259_P	0.534	0.98
198_S	202_N	0.534	0.98
139_A	146_V	0.531	0.98
26_V	158_I	0.530	0.98
128_S	132_G	0.528	0.98
186_P	189_F	0.528	0.98
30_L	169_V	0.528	0.98
108_E	111_D	0.526	0.98
204_L	207_A	0.525	0.98
273_L	281_F	0.524	0.98
74_L	125_H	0.523	0.98
215_L	219_I	0.523	0.98
273_L	276_Q	0.522	0.98
239_K	280_H	0.517	0.97
156_Q	205_I	0.515	0.97
17_A	24_D	0.515	0.97
102_A	106_A	0.513	0.97
61_D	66_Q	0.511	0.97
38_V	106_A	0.510	0.97
48_A	56_I	0.509	0.97
58_A	61_D	0.508	0.97
157_M	160_V	0.508	0.97
184_V	232_M	0.507	0.97
36_L	109_L	0.506	0.97
249_A	252_T	0.506	0.97
14_G	34_L	0.506	0.97
172_P	259_P	0.506	0.97
93_A	100_A	0.505	0.97
71_T	110_A	0.502	0.97
68_A	110_A	0.501	0.97
176_V	180_D	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hulA	4	0.8997	100	0.291	Contact Map
3pyfA	1	0.9223	100	0.304	Contact Map
4p52A	2	0.9579	100	0.308	Contact Map
1h72C	2	0.9191	100	0.312	Contact Map
4rpfA	2	0.945	100	0.322	Contact Map
1pieA	1	0.9612	100	0.339	Contact Map
2a2cA	1	0.9644	100	0.344	Contact Map
4hacA	2	0.9288	100	0.345	Contact Map
1wuuA	2	0.9612	100	0.353	Contact Map
4n3oA	2	0.9223	100	0.355	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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