GREMLIN Database
KHSE - Homoserine kinase
UniProt: P04948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (270)
Sequences: 9518 (7171)
Seq/√Len: 436.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_T33_Y4.1481.00
39_F83_H4.0481.00
119_S122_D3.4771.00
47_E83_H3.4621.00
41_S83_H2.8711.00
38_V109_L2.8541.00
35_K87_W2.8371.00
12_V102_A2.7631.00
265_T273_L2.6931.00
9_S37_T2.6471.00
111_D117_K2.6341.00
107_I123_K2.4881.00
132_G151_E2.3821.00
212_D215_L2.3011.00
252_T263_V2.2141.00
221_K245_E2.1341.00
49_E85_K2.1231.00
227_Q241_E2.0891.00
37_T85_K2.0881.00
169_V260_T2.0611.00
124_L142_V2.0521.00
74_L129_L2.0201.00
69_K73_D2.0001.00
231_A238_S1.9671.00
70_R129_L1.9541.00
111_D116_L1.9301.00
70_R74_L1.9191.00
179_R183_D1.8851.00
237_L261_I1.8721.00
36_L105_A1.8481.00
10_V112_E1.8071.00
168_V265_T1.7971.00
111_D118_L1.7971.00
242_H246_M1.7761.00
50_T53_V1.7191.00
217_G251_G1.7001.00
37_T87_W1.6811.00
40_E80_P1.6721.00
238_S242_H1.6701.00
11_T35_K1.6371.00
60_T69_K1.5911.00
167_V264_M1.5831.00
34_L101_A1.5781.00
243_V247_K1.5761.00
268_G271_E1.5751.00
166_D268_G1.5751.00
64_I67_V1.5691.00
275_E279_L1.5571.00
237_L254_L1.5471.00
177_L180_D1.5411.00
204_L216_V1.5251.00
277_L281_F1.5171.00
41_S81_P1.5171.00
74_L122_D1.4881.00
45_S83_H1.4781.00
69_K72_A1.4741.00
181_A226_H1.4681.00
206_A210_S1.4641.00
71_T116_L1.4601.00
122_D125_H1.4551.00
12_V105_A1.4431.00
274_K278_A1.4301.00
166_D267_K1.4281.00
25_S148_G1.4171.00
271_E274_K1.4091.00
184_V233_L1.4091.00
65_Y69_K1.4041.00
35_K89_D1.4021.00
28_M145_L1.3961.00
70_R126_L1.3821.00
39_F85_K1.3751.00
63_L66_Q1.3751.00
180_D183_D1.3721.00
215_L218_K1.3691.00
67_V70_R1.3611.00
70_R73_D1.3441.00
239_K243_V1.3441.00
74_L126_L1.3421.00
84_V106_A1.3371.00
10_V109_L1.3101.00
207_A215_L1.3091.00
184_V187_K1.2951.00
214_P266_E1.2891.00
166_D270_G1.2881.00
206_A209_M1.2831.00
111_D123_K1.2821.00
176_V257_A1.2711.00
43_K81_P1.2691.00
9_S35_K1.2691.00
71_T107_I1.2511.00
241_E261_I1.2481.00
236_E239_K1.2291.00
174_Y236_E1.2271.00
38_V84_V1.2241.00
176_V181_A1.2191.00
220_M251_G1.2051.00
171_I260_T1.2001.00
149_L156_Q1.1981.00
243_V246_M1.1951.00
241_E252_T1.1941.00
186_P190_P1.1901.00
244_A263_V1.1811.00
170_V240_V1.1791.00
36_L106_A1.1701.00
107_I127_A1.1691.00
68_A72_A1.1631.00
64_I86_V1.1561.00
67_V71_T1.1561.00
205_I209_M1.1511.00
10_V108_E1.1421.00
16_T28_M1.1381.00
77_K80_P1.1371.00
121_A125_H1.1301.00
271_E275_E1.1201.00
176_V230_R1.1201.00
14_G90_I1.1161.00
38_V82_V1.1081.00
199_A203_I1.1071.00
273_L277_L1.1061.00
106_A110_A1.1061.00
252_T261_I1.0991.00
93_A175_E1.0981.00
41_S44_W1.0951.00
253_A262_L1.0931.00
64_I106_A1.0931.00
185_L189_F1.0911.00
227_Q231_A1.0881.00
239_K242_H1.0861.00
41_S45_S1.0771.00
71_T114_C1.0691.00
47_E85_K1.0581.00
243_V280_H1.0541.00
272_E276_Q1.0501.00
170_V263_V1.0481.00
110_A114_C1.0401.00
29_A144_G1.0371.00
178_T181_A1.0361.00
207_A216_V1.0341.00
27_G148_G1.0331.00
276_Q280_H1.0281.00
80_P114_C1.0131.00
111_D120_E1.0121.00
169_V262_L1.0061.00
71_T75_Y0.9981.00
164_D267_K0.9981.00
82_V114_C0.9941.00
21_P185_L0.9921.00
90_I96_L0.9901.00
174_Y234_V0.9891.00
247_K276_Q0.9831.00
38_V113_L0.9811.00
67_V130_E0.9751.00
86_V102_A0.9731.00
154_E157_M0.9721.00
75_Y116_L0.9651.00
244_A252_T0.9621.00
231_A237_L0.9551.00
16_T262_L0.9541.00
226_H232_M0.9491.00
269_K272_E0.9421.00
214_P218_K0.9421.00
270_G274_K0.9381.00
168_V273_L0.9341.00
34_L88_S0.9281.00
241_E245_E0.9231.00
29_A145_L0.9201.00
30_L33_Y0.9171.00
36_L84_V0.9101.00
245_E249_A0.9071.00
64_I70_R0.9051.00
44_W81_P0.9021.00
244_A249_A0.9011.00
18_N201_S0.8991.00
187_K191_Y0.8961.00
168_V270_G0.8931.00
181_A184_V0.8851.00
15_S140_S0.8851.00
111_D119_S0.8801.00
57_P61_D0.8761.00
197_A200_V0.8761.00
75_Y118_L0.8751.00
255_S260_T0.8621.00
245_E252_T0.8611.00
94_R171_I0.8581.00
34_L90_I0.8551.00
64_I69_K0.8541.00
118_L126_L0.8521.00
180_D233_L0.8511.00
203_I219_I0.8501.00
180_D184_V0.8501.00
250_Y266_E0.8491.00
63_L67_V0.8481.00
108_E120_E0.8461.00
49_E83_H0.8411.00
235_P239_K0.8401.00
266_E269_K0.8371.00
120_E142_V0.8361.00
66_Q70_R0.8261.00
128_S151_E0.8211.00
104_V141_L0.8201.00
104_V127_A0.8201.00
49_E87_W0.8181.00
93_A259_P0.8171.00
249_A265_T0.8161.00
124_L127_A0.8161.00
146_V155_T0.8151.00
181_A230_R0.8151.00
72_A114_C0.8131.00
32_R96_L0.8111.00
66_Q69_K0.8091.00
46_F65_Y0.8071.00
140_S143_G0.8071.00
82_V110_A0.8011.00
185_L188_E0.7981.00
63_L103_I0.7971.00
173_F285_E0.7831.00
40_E113_L0.7811.00
231_A241_E0.7761.00
29_A143_G0.7761.00
275_E278_A0.7711.00
274_K286_V0.7711.00
20_G221_K0.7701.00
156_Q209_M0.7691.00
12_V140_S0.7681.00
103_I130_E0.7661.00
44_W48_A0.7621.00
68_A84_V0.7601.00
182_R185_L0.7601.00
125_H129_L0.7561.00
47_E50_T0.7551.00
33_Y90_I0.7501.00
120_E124_L0.7501.00
203_I206_A0.7441.00
10_V36_L0.7441.00
60_T65_Y0.7431.00
124_L138_G0.7421.00
23_F132_G0.7421.00
276_Q279_L0.7421.00
101_A140_S0.7391.00
118_L123_K0.7381.00
265_T270_G0.7371.00
191_Y194_A0.7351.00
108_E123_K0.7351.00
136_N140_S0.7341.00
121_A142_V0.7341.00
122_D126_L0.7321.00
226_H230_R0.7291.00
272_E275_E0.7281.00
263_V273_L0.7241.00
248_G251_G0.7181.00
196_K229_Y0.7181.00
17_A27_G0.7161.00
171_I175_E0.7161.00
136_N147_I0.7151.00
27_G139_A0.7131.00
67_V107_I0.7131.00
198_S201_S0.7111.00
172_P240_V0.7101.00
90_I101_A0.7071.00
149_L154_E0.7051.00
139_A143_G0.7021.00
20_G223_D0.7001.00
71_T126_L0.7001.00
67_V72_A0.6971.00
170_V252_T0.6921.00
190_P193_D0.6921.00
107_I126_L0.6911.00
14_G30_L0.6901.00
184_V188_E0.6901.00
127_A141_L0.6891.00
240_V261_I0.6871.00
109_L113_L0.6821.00
96_L169_V0.6821.00
136_N143_G0.6821.00
15_S139_A0.6791.00
10_V105_A0.6791.00
124_L141_L0.6781.00
62_N65_Y0.6771.00
68_A106_A0.6761.00
13_P29_A0.6731.00
65_Y68_A0.6691.00
168_V274_K0.6651.00
18_N21_P0.6651.00
112_E116_L0.6651.00
56_I59_G0.6641.00
244_A273_L0.6641.00
126_L129_L0.6621.00
42_D80_P0.6611.00
63_L130_E0.6601.00
34_L86_V0.6591.00
201_S205_I0.6591.00
72_A77_K0.6571.00
121_A124_L0.6571.00
147_I205_I0.6551.00
48_A51_E0.6551.00
200_V203_I0.6540.99
151_E154_E0.6540.99
40_E114_C0.6490.99
150_H153_D0.6490.99
124_L128_S0.6480.99
36_L86_V0.6480.99
13_P143_G0.6470.99
86_V106_A0.6440.99
247_K273_L0.6420.99
283_H286_V0.6400.99
218_K222_K0.6380.99
217_G250_Y0.6360.99
64_I72_A0.6310.99
139_A148_G0.6300.99
243_V277_L0.6300.99
75_Y78_E0.6260.99
106_A109_L0.6250.99
203_I215_L0.6250.99
277_L282_P0.6240.99
249_A263_V0.6220.99
127_A137_A0.6190.99
142_V146_V0.6130.99
202_N205_I0.6130.99
114_C117_K0.6110.99
245_E251_G0.6090.99
202_N206_A0.6080.99
100_A140_S0.6080.99
48_A62_N0.6080.99
93_A260_T0.6060.99
164_D266_E0.6060.99
17_A21_P0.6060.99
63_L69_K0.6040.99
170_V284_C0.6040.99
176_V234_V0.5990.99
183_D187_K0.5980.99
111_D114_C0.5970.99
226_H254_L0.5960.99
44_W72_A0.5940.99
176_V259_P0.5940.99
236_E240_V0.5940.99
233_L236_E0.5940.99
108_E141_L0.5930.99
70_R130_E0.5930.99
182_R186_P0.5900.99
46_F81_P0.5880.99
72_A75_Y0.5880.99
203_I207_A0.5870.99
108_E112_E0.5830.99
82_V113_L0.5810.99
178_T182_R0.5770.99
97_G140_S0.5730.99
40_E82_V0.5720.99
207_A212_D0.5720.99
219_I223_D0.5710.99
64_I68_A0.5690.99
16_T167_V0.5690.99
112_E115_G0.5670.99
189_F194_A0.5670.99
29_A140_S0.5660.99
68_A81_P0.5660.99
170_V244_A0.5650.99
120_E123_K0.5610.98
162_N165_I0.5600.98
64_I71_T0.5600.98
46_F82_V0.5590.98
101_A143_G0.5570.98
66_Q71_T0.5560.98
226_H257_A0.5530.98
136_N142_V0.5480.98
140_S146_V0.5460.98
111_D115_G0.5460.98
64_I102_A0.5430.98
228_P238_S0.5420.98
21_P226_H0.5410.98
165_I250_Y0.5400.98
204_L208_I0.5390.98
189_F192_A0.5390.98
13_P33_Y0.5370.98
246_M280_H0.5360.98
171_I259_P0.5340.98
198_S202_N0.5340.98
139_A146_V0.5310.98
26_V158_I0.5300.98
128_S132_G0.5280.98
186_P189_F0.5280.98
30_L169_V0.5280.98
108_E111_D0.5260.98
204_L207_A0.5250.98
273_L281_F0.5240.98
74_L125_H0.5230.98
215_L219_I0.5230.98
273_L276_Q0.5220.98
239_K280_H0.5170.97
156_Q205_I0.5150.97
17_A24_D0.5150.97
102_A106_A0.5130.97
61_D66_Q0.5110.97
38_V106_A0.5100.97
48_A56_I0.5090.97
58_A61_D0.5080.97
157_M160_V0.5080.97
184_V232_M0.5070.97
36_L109_L0.5060.97
249_A252_T0.5060.97
14_G34_L0.5060.97
172_P259_P0.5060.97
93_A100_A0.5050.97
71_T110_A0.5020.97
68_A110_A0.5010.97
176_V180_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hulA 4 0.8997 100 0.291 Contact Map
3pyfA 1 0.9223 100 0.304 Contact Map
4p52A 2 0.9579 100 0.308 Contact Map
1h72C 2 0.9191 100 0.312 Contact Map
4rpfA 2 0.945 100 0.322 Contact Map
1pieA 1 0.9612 100 0.339 Contact Map
2a2cA 1 0.9644 100 0.344 Contact Map
4hacA 2 0.9288 100 0.345 Contact Map
1wuuA 2 0.9612 100 0.353 Contact Map
4n3oA 2 0.9223 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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