GREMLIN Database
SSPD - Small, acid-soluble spore protein D
UniProt: P04833 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 64 (59)
Sequences: 429 (147)
Seq/√Len: 19.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_T51_L3.0250.99
42_S46_E2.7390.98
27_F46_E2.6270.98
40_N43_V2.2800.95
15_A19_F2.2300.94
19_F23_V1.9520.89
23_V50_R1.9220.88
37_A40_N1.8940.87
53_Q57_S1.7990.84
29_V43_V1.7610.83
47_M51_L1.7120.81
46_E49_K1.4710.70
21_L47_M1.4460.68
23_V46_E1.4380.68
23_V43_V1.4360.68
31_L42_S1.4340.68
16_L47_M1.3780.65
33_S52_V1.3550.63
29_V35_T1.2670.58
58_Q61_G1.1960.54
42_S49_K1.1170.48
37_A49_K1.0850.46
8_V16_L1.0710.46
36_V39_A1.0710.46
13_E17_D1.0650.45
17_D21_L1.0620.45
48_T52_V1.0600.45
26_E50_R1.0540.45
35_T40_N1.0490.44
42_S61_G1.0390.44
53_Q59_L1.0160.42
32_G43_V0.9920.41
46_E53_Q0.9890.40
21_L26_E0.9800.40
32_G35_T0.9710.39
54_Q57_S0.9560.38
47_M61_G0.9360.37
12_V15_A0.8810.34
32_G37_A0.8790.34
5_N55_A0.8750.34
36_V49_K0.8570.33
27_F42_S0.8520.32
14_Q30_N0.8500.32
48_T61_G0.8410.32
9_V58_Q0.8130.30
46_E50_R0.8100.30
38_R43_V0.7950.29
6_K10_P0.7890.29
39_A55_A0.7820.29
16_L55_A0.7790.29
32_G40_N0.7770.28
43_V46_E0.7710.28
12_V19_F0.7690.28
25_Q55_A0.7120.25
29_V32_G0.7090.25
29_V34_D0.7030.25
38_R53_Q0.6880.24
17_D59_L0.6850.24
4_R37_A0.6690.23
12_V25_Q0.6680.23
56_Q59_L0.6630.23
14_Q60_N0.6600.23
29_V37_A0.6560.23
19_F52_V0.6410.22
4_R58_Q0.6340.22
8_V14_Q0.6310.22
31_L34_D0.6300.21
33_S36_V0.6210.21
7_L11_G0.6120.21
11_G17_D0.6110.21
13_E35_T0.6060.20
9_V16_L0.6020.20
7_L10_P0.5890.20
19_F60_N0.5780.19
5_N59_L0.5750.19
28_G47_M0.5650.19
53_Q58_Q0.5620.19
32_G57_S0.5570.18
35_T49_K0.5550.18
11_G53_Q0.5360.18
54_Q58_Q0.5260.17
26_E40_N0.5210.17
5_N43_V0.5150.17
3_S56_Q0.5090.17
32_G42_S0.5070.17
28_G51_L0.5040.17
11_G60_N0.5040.17
12_V59_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3xA 3 0.875 99.8 0.326 Contact Map
4bzjA 2 0 14.5 0.911 Contact Map
3frrA 1 0.6406 13 0.913 Contact Map
1a7jA 5 0.5469 9.9 0.917 Contact Map
3ggyA 1 0.5938 7.4 0.921 Contact Map
1wvfA 2 0.9375 5.6 0.926 Contact Map
4w23H 1 0.9219 5.2 0.927 Contact Map
5bwjA 2 0.3906 5.1 0.927 Contact Map
3sjrA 2 0.9219 4.7 0.929 Contact Map
2cdqA 2 1 4.4 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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