GREMLIN Database
SSPA - Small, acid-soluble spore protein A
UniProt: P04831 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 69 (60)
Sequences: 465 (174)
Seq/√Len: 22.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_T56_L3.4851.00
47_S51_E2.8800.99
32_F51_E2.3770.97
20_A24_M2.3580.97
45_N48_V2.3430.97
28_I55_R2.1100.95
53_T57_V2.0150.93
58_S62_Q1.7920.89
24_M28_I1.7450.87
42_S45_N1.7260.87
52_I56_L1.7070.86
41_T44_A1.6660.85
34_V48_V1.5580.80
51_E54_K1.5500.80
36_L47_S1.4990.78
28_I51_E1.4370.74
52_I66_G1.4100.73
21_I52_I1.3480.70
34_V40_T1.2530.64
28_I48_V1.2350.63
47_S54_K1.2260.62
18_A22_D1.1890.60
42_S54_K1.1050.54
37_G40_T1.1000.54
14_V63_N1.0760.52
38_A57_V1.0470.50
40_T45_N1.0240.48
63_N66_G1.0000.47
7_G20_A0.9820.45
19_Q35_N0.9740.45
37_G45_N0.9490.43
37_G48_V0.9470.43
59_F62_Q0.9310.42
32_F47_S0.9270.42
36_L39_D0.9160.41
22_D64_M0.9080.40
58_S64_M0.9070.40
7_G11_N0.9060.40
34_V39_D0.9030.40
26_L31_E0.8920.39
17_A24_M0.8890.39
51_E55_R0.8820.39
31_E55_R0.8780.38
13_L21_I0.8190.35
8_N61_Q0.8180.35
53_T66_G0.7650.31
12_L15_P0.7360.30
51_E58_S0.7290.29
18_A60_A0.7280.29
44_A60_A0.7190.29
37_G42_S0.7140.28
8_N11_N0.7130.28
54_K62_Q0.7130.28
41_T54_K0.7090.28
58_S63_N0.7010.28
59_F63_N0.6910.27
23_Q60_A0.6890.27
47_S66_G0.6780.27
43_R58_S0.6650.26
11_N15_P0.6610.26
17_A30_S0.6570.25
30_S41_T0.6480.25
17_A20_A0.6450.25
10_N60_A0.6390.24
48_V51_E0.6390.24
16_G58_S0.6370.24
12_L38_A0.6320.24
11_N42_S0.6270.24
22_D26_L0.6270.24
26_L52_I0.6260.24
13_L19_Q0.6130.23
22_D40_T0.6090.23
52_I55_R0.6060.23
10_N48_V0.6040.23
40_T54_K0.5960.22
24_M57_V0.5960.22
36_L40_T0.5960.22
14_V59_F0.5930.22
18_A21_I0.5800.22
34_V42_S0.5780.22
43_R48_V0.5640.21
61_Q64_M0.5570.21
11_N14_V0.5490.20
12_L30_S0.5470.20
17_A64_M0.5470.20
43_R57_V0.5380.20
38_A41_T0.5240.19
44_A63_N0.5240.19
18_A40_T0.5010.18
7_G24_M0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3xA 3 0.8116 99.8 0.344 Contact Map
3frrA 1 0.6667 9.3 0.92 Contact Map
4bzjA 2 0 8.7 0.921 Contact Map
3ggyA 1 0.6232 8.5 0.922 Contact Map
3k44A 1 0.4783 7.4 0.924 Contact Map
4aybA 1 0.9855 5.4 0.928 Contact Map
2qb7A 1 0.3768 4.8 0.93 Contact Map
1wizA 1 0.3478 4.4 0.931 Contact Map
3pf0A 1 0.4783 4 0.933 Contact Map
1txnA 2 0.8551 3.8 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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